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3201. Reduction of major adverse cardiac events with intracoronary compared with intravenous bolus application of abciximab in patients with acute myocardial infarction or unstable angina undergoing coronary angioplasty.
作者: Jochen Wöhrle.;Olaf C Grebe.;Thorsten Nusser.;Eyas Al-Khayer.;Stefan Schaible.;Matthias Kochs.;Vinzenz Hombach.;Martin Höher.
来源: Circulation. 2003年107卷14期1840-3页
In patients with acute myocardial infarction or unstable angina undergoing coronary angioplasty, abciximab reduces major adverse cardiac events (MACE). Clinical trials have studied intravenous administration only. Intracoronary bolus application of abciximab causes very high local drug concentrations and may be more effective. We studied whether intracoronary bolus administration of abciximab is associated with a reduced MACE rate compared with the standard intravenous bolus application.
3202. Early detection of Fabry cardiomyopathy by tissue Doppler imaging.
作者: Maurizio Pieroni.;Cristina Chimenti.;Roberta Ricci.;Patrizio Sale.;Matteo Antonio Russo.;Andrea Frustaci.
来源: Circulation. 2003年107卷15期1978-84页
Fabry cardiomyopathy is diagnosed by detection of left ventricular hypertrophy (LVH) in patients with alpha-Galactosidase A deficiency. Conventional noninvasive tools are unable to provide a preclinical diagnosis allowing prompt institution of enzymatic therapy.
3203. Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure.
作者: Martin G St John Sutton.;Ted Plappert.;William T Abraham.;Andrew L Smith.;David B DeLurgio.;Angel R Leon.;Evan Loh.;Dusan Z Kocovic.;Westby G Fisher.;Myrvin Ellestad.;John Messenger.;Kristin Kruger.;Kathryn E Hilpisch.;Michael R S Hill.; .
来源: Circulation. 2003年107卷15期1985-90页
Cardiac resynchronization therapy (CRT) has recently emerged as an effective treatment for patients with moderate to severe systolic heart failure and ventricular dyssynchrony. The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT.
3204. Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST).
作者: Taya V Glotzer.;Anne S Hellkamp.;John Zimmerman.;Michael O Sweeney.;Raymond Yee.;Roger Marinchak.;James Cook.;Alexander Paraschos.;John Love.;Glauco Radoslovich.;Kerry L Lee.;Gervasio A Lamas.; .
来源: Circulation. 2003年107卷12期1614-9页
Some current pacing systems can automatically detect and record atrial tachyarrhythmias that may be asymptomatic. We prospectively studied a 312-patient (pt) subgroup of MOST (MOde Selection Trial), a 2010-patient, 6-year randomized trial of DDDR versus VVIR pacing in sinus node dysfunction (SND). The purpose of the study was to correlate atrial high rate events (AHREs) detected by pacemaker diagnostics with clinical outcomes.
3205. Relationships between low-density lipoprotein particle size, plasma lipoproteins, and progression of coronary artery disease: the Diabetes Atherosclerosis Intervention Study (DAIS).
作者: Juha Vakkilainen.;George Steiner.;Jean-Claude Ansquer.;Francois Aubin.;Stephanie Rattier.;Christelle Foucher.;Anders Hamsten.;Marja-Riitta Taskinen.; .
来源: Circulation. 2003年107卷13期1733-7页
The Diabetes Atherosclerosis Intervention Study showed that treatment with fenofibrate decreases progression of coronary atherosclerosis in subjects with type 2 diabetes. We determined whether on-treatment plasma lipid concentrations and LDL particle size contribute to the favorable effect of fenofibrate on the progression of coronary artery disease (CAD).
3206. Effect of chronic right atrial stretch on atrial electrical remodeling in patients with an atrial septal defect.
作者: Joseph B Morton.;Prashanthan Sanders.;Jitendra K Vohra.;Paul B Sparks.;John G Morgan.;Steven J Spence.;Leeanne E Grigg.;Jonathan M Kalman.
来源: Circulation. 2003年107卷13期1775-82页
Adults with an atrial septal defect (ASD) frequently develop late atrial arrhythmias. We sought to characterize the pattern and persistence of atrial electrical remodeling caused by chronic right atrial (RA) stretch in this group.
3207. Stent-induced expression and activation of the leukocyte integrin Mac-1 is associated with neointimal thickening and restenosis.
作者: Teruo Inoue.;Toshihiko Uchida.;Isao Yaguchi.;Yoshihiko Sakai.;Kan Takayanagi.;Shigenori Morooka.
来源: Circulation. 2003年107卷13期1757-63页
Increased expression of the beta2 integrin Mac-1 (CD11b/CD18, alphaMbeta2), which is responsible for firm leukocyte adhesion to platelets and fibrinogen at injured vessels, is found in association with neointimal hyperplasia after coronary interventions. The role of Mac-1 in the pathophysiology of restenosis is incompletely defined. To clarify further the role of Mac-1, we determined whether coronary stenting induced activation of Mac-1, which is required for high-affinity receptor-ligand interactions.
3208. Intracoronary radiation therapy improves the clinical and angiographic outcomes of diffuse in-stent restenotic lesions: results of the Washington Radiation for In-Stent Restenosis Trial for Long Lesions (Long WRIST) Studies.
作者: Ron Waksman.;Edouard Cheneau.;Andrew E Ajani.;R Larry White.;Ellen Pinnow.;Rebecca Torguson.;Regina Deible.;Lowell F Satler.;Augusto D Pichard.;Kenneth M Kent.;Paul S Teirstein.;Joseph Lindsay.; .
来源: Circulation. 2003年107卷13期1744-9页
The Washington Radiation for In-Stent Restenosis Trial for long lesions (Long WRIST) was designed to determine the safety and efficacy of vascular brachytherapy for the treatment of diffuse in-stent restenosis.
3209. Relation of inflammation and benefit of statins after percutaneous coronary interventions.
作者: Albert W Chan.;Deepak L Bhatt.;Derek P Chew.;Joel Reginelli.;Jakob P Schneider.;Eric J Topol.;Stephen G Ellis.
来源: Circulation. 2003年107卷13期1750-6页
Beyond lipid lowering, statins are known to possess antiinflammatory and antithrombotic properties. Recent studies suggested an association between statins and early reduction in death or myocardial infarction (MI) after percutaneous coronary interventions (PCIs). We sought to examine the interrelationship between inflammation, statin use, and PCI outcomes.
3210. Noninvasive determination of coronary blood flow velocity with cardiovascular magnetic resonance in patients after stent deployment.
作者: Eike Nagel.;Thomas Thouet.;Christoph Klein.;Simon Schalla.;Axel Bornstedt.;Bernhard Schnackenburg.;Jürgen Hug.;Ernst Wellnhofer.;Eckart Fleck.
来源: Circulation. 2003年107卷13期1738-43页
In patients with coronary artery stents, no direct noninvasive coronary artery imaging is possible with magnetic resonance (MR). A well-established method for the assessment of the functional significance of a coronary lesion is the measurement of coronary flow reserve by invasive intracoronary Doppler. The purpose of the study was to determine coronary flow velocity reserve (CFVR) with MR after stent deployment.
3211. Twin-twin transfusion syndrome: the influence of intrauterine laser photocoagulation on arterial distensibility in childhood.
作者: Helena M Gardiner.;Myles J O Taylor.;Ageliki Karatza.;Tina Vanderheyden.;Agnes Huber.;Stephen E Greenwald.;Nicholas M Fisk.;Kurt Hecher.
来源: Circulation. 2003年107卷14期1906-11页
In twin-twin transfusion syndrome (TTTS), the donor and recipient fetus are exposed to differing volume loads and show discordant intertwin vascular compliance in childhood despite identical genotype. We hypothesized that discordance is prevented by intrauterine endoscopic laser ablation of placental anastomoses, which abolishes intertwin transfusion. We tested this by examining pulse wave velocity (PWV) in brachial arteries of twin survivors of TTTS treated with and without laser therapy.
3212. Pilot trial of oral rapamycin for recalcitrant restenosis.
作者: Prabhtej S Brara.;Mehran Moussavian.;Mark A Grise.;John P Reilly.;Mindy Fernandez.;Richard A Schatz.;Paul S Teirstein.
来源: Circulation. 2003年107卷13期1722-4页
Sirolimus-coated stents are a promising new therapy for restenosis. We treated a select group of patients at especially high risk for restenosis with oral sirolimus.
3213. Influence of inhaled iloprost on transpulmonary gradient of big endothelin in patients with pulmonary hypertension.
作者: H Wilkens.;M Bauer.;N Forestier.;J König.;A Eichler.;S Schneider.;H J Schäfers.;G W Sybrecht.
来源: Circulation. 2003年107卷11期1509-13页
The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. In healthy individuals, 40% to 50% of circulating ET-1 is removed on each passage through the lungs resulting in an arteriovenous ratio of <1, whereas many patients with pulmonary arterial hypertension (PAH) have ratios >1, indicating reduced clearance or increased release of endothelin. The influence of inhaled prostanoids on endothelin clearance is unknown.
3214. Adjunctive platelet glycoprotein IIb/IIIa receptor inhibition with tirofiban before primary angioplasty improves angiographic outcomes: results of the TIrofiban Given in the Emergency Room before Primary Angioplasty (TIGER-PA) pilot trial.
作者: David P Lee.;Niall A Herity.;Bonnie L Hiatt.;William F Fearon.;Mehrdad Rezaee.;Andrew J Carter.;Michelle Huston.;Donald Schreiber.;Peter M DiBattiste.;Alan C Yeung.; .
来源: Circulation. 2003年107卷11期1497-501页
Previous work has suggested that platelet glycoprotein IIb/IIIa receptor blockade may confer benefit in the treatment of acute myocardial infarction. The TIGER-PA pilot trial was a single-center randomized study to evaluate the safety, feasibility, and utility of early tirofiban administration before planned primary angioplasty in patients presenting with acute myocardial infarction.
3215. Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans.
作者: Francesco Cipollone.;Maria Fazia.;Annalisa Iezzi.;Mirco Zucchelli.;Barbara Pini.;Domenico De Cesare.;Sante Ucchino.;Francesco Spigonardo.;Guido Bajocchi.;Roberto Bei.;Raffaella Muraro.;Luciano Artese.;Adriano Piattelli.;Francesco Chiarelli.;Franco Cuccurullo.;Andrea Mezzetti.
来源: Circulation. 2003年107卷11期1479-85页
The clinical benefits of statins are attributed to changes in plaque composition that lead to reduced metalloproteinase (MMP) activity and plaque stabilization. However, the molecular mechanism of this effect is unclear. Recently, we demonstrated enhanced expression of isoforms of inducible cyclooxygenase (COX) and PGE synthase (COX-2/mPGES) in human symptomatic plaque and provided evidence that this is associated with MMP-induced plaque rupture. The aim of this study was to characterize the effect of simvastatin on inflammatory infiltration and the expression of COX-2/mPGES and MMPs in human carotid plaques.
3216. The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis.
作者: Timothy D Henry.;Brian H Annex.;George R McKendall.;Michael A Azrin.;John J Lopez.;Frank J Giordano.;P K Shah.;James T Willerson.;Raymond L Benza.;Daniel S Berman.;C Michael Gibson.;Alex Bajamonde.;Amy Chen Rundle.;Jennifer Fine.;Edward R McCluskey.; .
来源: Circulation. 2003年107卷10期1359-65页
Recombinant human vascular endothelial growth factor protein (rhVEGF) stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials. VIVA (Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis) is a double-blind, placebo-controlled trial designed to evaluate the safety and efficacy of intracoronary and intravenous infusions of rhVEGF.
3217. Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study.
作者: J Malcolm O Arnold.;Salim Yusuf.;James Young.;James Mathew.;David Johnstone.;Alvaro Avezum.;Eva Lonn.;Janice Pogue.;Jackie Bosch.; .
来源: Circulation. 2003年107卷9期1284-90页
Previous trials in the prevention of heart failure have been restricted to patients with low ejection fraction or hypertension. We assessed an angiotensin-converting enzyme (ACE) inhibitor, ramipril, to prevent the development of heart failure in high-risk patients without known low ejection fraction or heart failure.
3218. Changes in brain natriuretic peptide and norepinephrine over time and mortality and morbidity in the Valsartan Heart Failure Trial (Val-HeFT).
作者: Inder S Anand.;Lloyd D Fisher.;Yann-Tong Chiang.;Roberto Latini.;Serge Masson.;Aldo P Maggioni.;Robert D Glazer.;Gianni Tognoni.;Jay N Cohn.; .
来源: Circulation. 2003年107卷9期1278-83页
Neurohormones are considered markers of heart failure progression. We examined whether changes in brain natriuretic peptide (BNP) and norepinephrine (NE) over time are associated with corresponding changes in mortality and morbidity in the Valsartan Heart Failure Trial.
3219. Heparin-coated stent placement for the treatment of stenoses in small coronary arteries of symptomatic patients.
作者: Michael Haude.;Thomas F M Konorza.;Uldis Kalnins.;Andrejs Erglis.;Kari Saunamäki.;Helmut D Glogar.;Eberhard Grube.;Robert Gil.;Antonio Serra.;Hans G Richardt.;Peter Sick.;Raimund Erbel.; .
来源: Circulation. 2003年107卷9期1265-70页
The role of stents, especially of heparin-coated stents for the treatment of stenoses in small coronary arteries, is still unclear. Therefore, we performed this prospective, randomized trial to evaluate the angiographic and clinical outcome after treatment of stenoses in small coronary arteries (2.0 to 2.6 mm) of symptomatic patients.
3220. Antibiotic therapy after acute myocardial infarction: a prospective randomized study.
作者: Ralf Zahn.;Steffen Schneider.;Birgit Frilling.;Karlheinz Seidl.;Ulrich Tebbe.;Michael Weber.;Martin Gottwik.;Ernst Altmann.;Friedrich Seidel.;Jürgen Rox.;Ulrich Höffler.;Karl-Ludwig Neuhaus.;Jochen Senges.; .
来源: Circulation. 2003年107卷9期1253-9页
Infection with Chlamydia pneumoniae is suspected to contribute to the pathogenesis of human atherosclerosis. We investigated whether treatment with the macrolide antibiotic roxithromycin would reduce mortality or morbidity in patients with an acute myocardial infarction.
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