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301. A randomized controlled trial of angiotensin-converting enzyme inhibition for skeletal muscle dysfunction in COPD.
作者: Dinesh Shrikrishna.;Rebecca J Tanner.;Jen Y Lee.;Amanda Natanek.;Amy Lewis.;Patrick B Murphy.;Nicholas Hart.;John Moxham.;Hugh E Montgomery.;Paul R Kemp.;Michael I Polkey.;Nicholas S Hopkinson.
来源: Chest. 2014年146卷4期932-940页
Skeletal muscle impairment is a recognized complication of COPD, predicting mortality in severe disease. Increasing evidence implicates the renin-angiotensin system in control of muscle phenotype. We hypothesized that angiotensin-converting enzyme (ACE) inhibition would improve quadriceps function and exercise performance in COPD.
302. Attentional modulation of reflex cough.
作者: Thomas Janssens.;Mitchell Silva.;Paul W Davenport.;Ilse Van Diest.;Lieven J Dupont.;Omer Van den Bergh.
来源: Chest. 2014年146卷1期135-141页
Reflex cough is a defensive response generated in the brainstem in response to chemical and mechanical stimulation of the airways. However, converging evidence shows that reflex cough is also influenced by central neural control processes. In this study, we investigate whether reflex cough can be modulated by attentional focus on either external stimuli or internal cough-related stimuli.
303. Multidisciplinary Approach to Management of Maternal Asthma (MAMMA): a randomized controlled trial.
作者: Angelina S Lim.;Kay Stewart.;Michael J Abramson.;Susan P Walker.;Catherine L Smith.;Johnson George.
来源: Chest. 2014年145卷5期1046-1054页
Uncontrolled asthma during pregnancy is associated with maternal and perinatal hazards. A pharmacist-led intervention directed at improving maternal asthma control, involving multidisciplinary care, education, and regular monitoring to help reduce these risks, was developed and evaluated.
304. Cross-sectional survey on lobectomy approach (X-SOLA).
作者: Christopher Cao.;David H Tian.;Kevin Wolak.;Jonathan Oparka.;Jianxing He.;Joel Dunning.;William S Walker.;Tristan D Yan.
来源: Chest. 2014年146卷2期292-298页
Lobectomy for non-small cell lung cancer (NSCLC) can be performed either through open thoracotomy or video-assisted thoracoscopic surgery (VATS). To improve the understanding of current attitudes of the thoracic community toward VATS lobectomy, the Collaborative Research Group conducted the Cross-sectional Survey on Lobectomy Approach (X-SOLA) study. We surveyed a large cohort of lobectomy-performing thoracic surgeons to examine their adoption of VATS lobectomy and their opinions of this technique vs conventional open thoracotomy.
305. Endobronchial ultrasound-guided transbronchial needle aspiration vs conventional transbronchial needle aspiration in the diagnosis of sarcoidosis.
作者: Dheeraj Gupta.;Devendra S Dadhwal.;Ritesh Agarwal.;Nalini Gupta.;Amanjit Bal.;Ashutosh N Aggarwal.
来源: Chest. 2014年146卷3期547-556页
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is superior to conventional transbronchial needle aspiration (cTBNA) in the staging of lung cancer. However, its efficiency in diagnosis of sarcoidosis when combined with endobronchial biopsy (EBB) and transbronchial lung biopsy (TBLB) has not been studied. This randomized controlled trial compares diagnostic yield of EBUS-TBNA vs cTBNA in combination with EBB and TBLB.
306. Once-daily umeclidinium/vilanterol 125/25 mcg in COPD: a randomized, controlled study.
作者: Bartolome Celli.;Glenn Crater.;Sally Kilbride.;Rashmi Mehta.;Maggie Tabberer.;Chris J Kalberg.;Alison Church.
来源: Chest. 2014年145卷5期981-991页
Combination long-acting bronchodilator therapy may be more effective than long-acting bronchodilator monotherapy in chronic obstructive pulmonary disease (COPD).
307. Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: a double-blind, randomized, controlled trial.
作者: Abdullah A Alangari.;Nidal Malhis.;Mohamed Mubasher.;Najwa Al-Ghamedi.;Mohamad Al-Tannir.;Muhammad Riaz.;Dale T Umetsu.;Saleh Al-Tamimi.
来源: Chest. 2014年145卷4期772-778页
Inhaled corticosteroids, known to be effective as a maintenance medication in chronic asthma, have also been suggested as a therapy for acute asthma when given at high doses.
308. Neurobehavioral functioning and survival following lung transplantation.
作者: Patrick J Smith.;James A Blumenthal.;Robert M Carney.;Kenneth E Freedland.;C Virginia F O'Hayer.;Elbert P Trulock.;Tereza Martinu.;Todd A Schwartz.;Benson M Hoffman.;Gary G Koch.;R Duane Davis.;Scott M Palmer.
来源: Chest. 2014年145卷3期604-611页
Neurobehavioral functioning is widely recognized as being an important consideration in lung transplant candidates, but little is known about whether these factors are related to clinical outcomes. The present study examined the relationship of neurobehavioral functioning, including measures of executive function and memory, depression, and anxiety, to long-term survival among lung transplant recipients.
309. Bosentan for sarcoidosis-associated pulmonary hypertension: a double-blind placebo controlled randomized trial.
作者: Robert P Baughman.;Daniel A Culver.;Francis C Cordova.;Maria Padilla.;Kevin F Gibson.;Elyse E Lower.;Peter J Engel.
来源: Chest. 2014年145卷4期810-817页
Sarcoidosis-associated pulmonary hypertension (SAPH) is a common problem in patients with persistent dyspneic sarcoidosis. The objective of this study was to determine the effect of bosentan therapy on pulmonary arterial hemodynamics in patients with SAPH.
310. The emotional and cognitive impact of unexpected simulated patient death: a randomized controlled trial.
作者: Kristin Fraser.;James Huffman.;Irene Ma.;Matthew Sobczak.;Joanne McIlwrick.;Bruce Wright.;Kevin McLaughlin.
来源: Chest. 2014年145卷5期958-963页
Observational studies suggest that emotions experienced during simulation training may affect cognitive load and learning outcomes. The objective of this study was to manipulate emotions during simulation training and assess the impact on cognitive load and learning.
311. Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study.
作者: Jinping Zheng.;Jinghua Yang.;Xiangdong Zhou.;Li Zhao.;Fuxin Hui.;Haoyan Wang.;Chunxue Bai.;Ping Chen.;Huiping Li.;Jian Kang.;Manja Brose.;Frank Richard.;Udo-Michael Goehring.;Nanshan Zhong.
来源: Chest. 2014年145卷1期44-52页
Roflumilast is the only oral phosphodiesterase 4 inhibitor indicated for use in the treatment of COPD. Previous studies of roflumilast have predominantly involved European and North American populations. A large study was necessary to determine the efficacy and safety of roflumilast in a predominantly ethnic Chinese population.
312. Effect of isoniazid therapy for latent TB infection on QuantiFERON-TB gold in-tube responses in adults with positive tuberculin skin test results in a high TB incidence area: a controlled study.
作者: John L Johnson.;Hendrik Geldenhuys.;Bonnie A Thiel.;Asma Toefy.;Sara Suliman.;Bernadette Pienaar.;Phalkun Chheng.;Thomas Scriba.;W Henry Boom.;Willem Hanekom.;Mark Hatherill.
来源: Chest. 2014年145卷3期612-7页
T-cell interferon-γ release assays (IGRAs) are used in the diagnosis of Mycobacterium tuberculosis infection and could be useful biomarkers of response to treatment of latent TB infection for clinical trials, infection control units, and TB programs.
313. Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary embolism.
作者: Peiman Nazerian.;Simone Vanni.;Giovanni Volpicelli.;Chiara Gigli.;Maurizio Zanobetti.;Maurizio Bartolucci.;Antonio Ciavattone.;Alessandro Lamorte.;Andrea Veltri.;Andrea Fabbri.;Stefano Grifoni.
来源: Chest. 2014年145卷5期950-957页
Presenting signs and symptoms of pulmonary embolism (PE) are nonspecific, favoring a large use of second-line diagnostic tests such as multidetector CT pulmonary angiography (MCTPA), thus exposing patients to high-dose radiation and to potential serious complications. We investigated the diagnostic performance of multiorgan ultrasonography (lung, heart, and leg vein ultrasonography) and whether multiorgan ultrasonography combined to Wells score and D-dimer could safely reduce MCTPA tests.
314. A validated risk model to predict 90-day VTE events in postsurgical patients.
作者: Christopher J Pannucci.;Sandra Laird.;Justin B Dimick.;Darrell A Campbell.;Peter K Henke.
来源: Chest. 2014年145卷3期567-573页
VTE is the proximate cause of 100,000 deaths in the United States each year. Perioperative VTE risk among surgical patients varies by 20-fold, which highlights the importance of risk stratification to identify high-risk patients, in whom chemoprophylaxis can decrease VTE risk, and low-risk patients, for whom the risk-benefit relationship of prophylaxis may be unfavorable.
315. Hypothalamic-pituitary-adrenal axis effects of mometasone furoate/formoterol fumarate vs fluticasone propionate/salmeterol administered through metered-dose inhaler.
作者: Teddy Kosoglou.;James Hubbell.;David L Cutler.;Amy O Johnson-Levonas.;Danlin Xu.;Bhavna S Kantesaria.;Kenneth Kim.;S David Miller.
来源: Chest. 2013年144卷6期1795-1802页
The effects of mometasone furoate and fluticasone propionate on the hypothalamic-pituitary-adrenal axis were compared when administered from combination metered-dose inhaler (MDI) products.
316. The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated.
作者: John Muscedere.;Tasnim Sinuff.;Daren K Heyland.;Peter M Dodek.;Sean P Keenan.;Gordon Wood.;Xuran Jiang.;Andrew G Day.;Denny Laporta.;Michael Klompas.; .
来源: Chest. 2013年144卷5期1453-1460页
Ventilator-associated conditions (VACs) and infection-related ventilator-associated complications (iVACs) are the Centers for Disease Control and Prevention's new surveillance paradigms for patients who are mechanically ventilated. Little is known regarding the clinical impact and preventability of VACs and iVACs and their relationship to ventilator-associated pneumonia (VAP). We evaluated these using data from a large, multicenter, quality-improvement initiative.
317. Development of a novel composite stroke and bleeding risk score in patients with atrial fibrillation: the AMADEUS Study.
作者: Gregory Y H Lip.;Deirdre A Lane.;Harry Buller.;Stavros Apostolakis.
来源: Chest. 2013年144卷6期1839-1847页
The aim of the current analysis was to identify independent predictors of the overall clinical outcome of patients with atrial fibrillation (AF), including both stroke/thromboembolism and/or major bleeding. Given the overlap between stroke and bleeding risk factors, a composite risk-stratification score for stroke/thromboembolism or bleeding could potentially be developed.
318. A randomized controlled trial of balance training during pulmonary rehabilitation for individuals with COPD.
作者: Marla K Beauchamp.;Tania Janaudis-Ferreira.;Verônica Parreira.;Julia M Romano.;Lynda Woon.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2013年144卷6期1803-1810页
Deficits in balance are increasingly recognized among the important secondary impairments in COPD. The purpose of this study was to investigate the effect of a balance-training program on measures of balance and physical function in patients with COPD enrolled in pulmonary rehabilitation (PR).
319. Albuterol administration is commonly associated with increases in serum lactate in patients with asthma treated for acute exacerbation of asthma.
作者: Lawrence M Lewis.;Ian Ferguson.;Stacey L House.;Kristen Aubuchon.;John Schneider.;Kirk Johnson.;Kazuko Matsuda.
来源: Chest. 2014年145卷1期53-59页
Controversy exists around the incidence and cause of hyperlactatemia during asthma exacerbations. We evaluated the incidence, potential causes, and adverse events of hyperlactatemia in patients with acute asthma exacerbation.
320. Evaluation of the predictive value of a clinical worsening definition using 2-year outcomes in patients with pulmonary arterial hypertension: a REVEAL Registry analysis.
作者: Adaani E Frost.;David B Badesch.;Dave P Miller.;Raymond L Benza.;Leslie A Meltzer.;Michael D McGoon.
来源: Chest. 2013年144卷5期1521-1529页
Time to clinical worsening has been proposed as a primary end point in clinical trials of pulmonary arterial hypertension (PAH); however, neither standardized nor validated definitions of clinical worsening across PAH trials exist. This study aims to evaluate a proposed definition of clinical worsening within a large prospective, observational registry of patients with PAH with respect to its value as a predictor of proximate (within 1 year) risk for subsequent major events (ie, death, transplantation, or atrial septostomy).
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