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301. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial.
作者: .;Parham Sadeghipour.;Azita H Talasaz.;Farid Rashidi.;Babak Sharif-Kashani.;Mohammad Taghi Beigmohammadi.;Mohsen Farrokhpour.;Seyed Hashem Sezavar.;Pooya Payandemehr.;Ali Dabbagh.;Keivan Gohari Moghadam.;Sepehr Jamalkhani.;Hossein Khalili.;Mahdi Yadollahzadeh.;Taghi Riahi.;Parisa Rezaeifar.;Ouria Tahamtan.;Samira Matin.;Atefeh Abedini.;Somayeh Lookzadeh.;Hamid Rahmani.;Elnaz Zoghi.;Keyhan Mohammadi.;Pardis Sadeghipour.;Homa Abri.;Sanaz Tabrizi.;Seyed Masoud Mousavian.;Shaghayegh Shahmirzaei.;Hooman Bakhshandeh.;Ahmad Amin.;Farnaz Rafiee.;Elahe Baghizadeh.;Bahram Mohebbi.;Seyed Ehsan Parhizgar.;Rasoul Aliannejad.;Vahid Eslami.;Alireza Kashefizadeh.;Hessam Kakavand.;Seyed Hossein Hosseini.;Shadi Shafaghi.;Samrand Fattah Ghazi.;Atabak Najafi.;David Jimenez.;Aakriti Gupta.;Mahesh V Madhavan.;Sanjum S Sethi.;Sahil A Parikh.;Manuel Monreal.;Naser Hadavand.;Alireza Hajighasemi.;Majid Maleki.;Saeed Sadeghian.;Gregory Piazza.;Ajay J Kirtane.;Benjamin W Van Tassell.;Paul P Dobesh.;Gregg W Stone.;Gregory Y H Lip.;Harlan M Krumholz.;Samuel Z Goldhaber.;Behnood Bikdeli.
来源: JAMA. 2021年325卷16期1620-1630页
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.
302. Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial.
作者: Christine M Albert.;Nancy R Cook.;Julie Pester.;M Vinayaga Moorthy.;Claire Ridge.;Jacqueline S Danik.;Baris Gencer.;Hasan K Siddiqi.;Chee Ng.;Heike Gibson.;Samia Mora.;Julie E Buring.;JoAnn E Manson.
来源: JAMA. 2021年325卷11期1061-1073页
Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to have both benefits and risks with respect to incident AF, but large-scale, long-term randomized trial data are lacking.
303. Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19.
作者: Kathryn E Stephenson.;Mathieu Le Gars.;Jerald Sadoff.;Anne Marit de Groot.;Dirk Heerwegh.;Carla Truyers.;Caroline Atyeo.;Carolin Loos.;Abishek Chandrashekar.;Katherine McMahan.;Lisa H Tostanoski.;Jingyou Yu.;Makda S Gebre.;Catherine Jacob-Dolan.;Zhenfeng Li.;Shivani Patel.;Lauren Peter.;Jinyan Liu.;Erica N Borducchi.;Joseph P Nkolola.;Morgana Souza.;Chen Sabrina Tan.;Rebecca Zash.;Boris Julg.;Ruvandhi R Nathavitharana.;Roger L Shapiro.;Ahmed Abdul Azim.;Carolyn D Alonso.;Kate Jaegle.;Jessica L Ansel.;Diane G Kanjilal.;Caitlin J Guiney.;Connor Bradshaw.;Anna Tyler.;Tatenda Makoni.;Katherine E Yanosick.;Michael S Seaman.;Douglas A Lauffenburger.;Galit Alter.;Frank Struyf.;Macaya Douoguih.;Johan Van Hoof.;Hanneke Schuitemaker.;Dan H Barouch.
来源: JAMA. 2021年325卷15期1535-1544页
Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines.
304. Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial.
作者: Zoher Ghogawala.;Norma Terrin.;Melissa R Dunbar.;Janis L Breeze.;Karen M Freund.;Adam S Kanter.;Praveen V Mummaneni.;Erica F Bisson.;Fred G Barker.;J Sanford Schwartz.;James S Harrop.;Subu N Magge.;Robert F Heary.;Michael G Fehlings.;Todd J Albert.;Paul M Arnold.;K Daniel Riew.;Michael P Steinmetz.;Marjorie C Wang.;Robert G Whitmore.;John G Heller.;Edward C Benzel.
来源: JAMA. 2021年325卷10期942-951页
Cervical spondylotic myelopathy is the most common cause of spinal cord dysfunction worldwide. It remains unknown whether a ventral or dorsal surgical approach provides the best results.
305. Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.
作者: Eduardo López-Medina.;Pío López.;Isabel C Hurtado.;Diana M Dávalos.;Oscar Ramirez.;Ernesto Martínez.;Jesus A Díazgranados.;José M Oñate.;Hector Chavarriaga.;Sócrates Herrera.;Beatriz Parra.;Gerardo Libreros.;Roberto Jaramillo.;Ana C Avendaño.;Dilian F Toro.;Miyerlandi Torres.;Maria C Lesmes.;Carlos A Rios.;Isabella Caicedo.
来源: JAMA. 2021年325卷14期1426-1435页
Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit.
306. Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
作者: Franco Locatelli.;Gerhard Zugmaier.;Carmelo Rizzari.;Joan D Morris.;Bernd Gruhn.;Thomas Klingebiel.;Rosanna Parasole.;Christin Linderkamp.;Christian Flotho.;Arnaud Petit.;Concetta Micalizzi.;Noemi Mergen.;Abeera Mohammad.;William N Kormany.;Cornelia Eckert.;Anja Möricke.;Mary Sartor.;Ondrej Hrusak.;Christina Peters.;Vaskar Saha.;Luciana Vinti.;Arend von Stackelberg.
来源: JAMA. 2021年325卷9期843-854页
Blinatumomab is a CD3/CD19-directed bispecific T-cell engager molecule with efficacy in children with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).
307. Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
作者: Patrick A Brown.;Lingyun Ji.;Xinxin Xu.;Meenakshi Devidas.;Laura E Hogan.;Michael J Borowitz.;Elizabeth A Raetz.;Gerhard Zugmaier.;Elad Sharon.;Melanie B Bernhardt.;Stephanie A Terezakis.;Lia Gore.;James A Whitlock.;Michael A Pulsipher.;Stephen P Hunger.;Mignon L Loh.
来源: JAMA. 2021年325卷9期833-842页
Standard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and young adults is associated with high rates of severe toxicities, subsequent relapse, and death, especially for patients with early relapse (high risk) or late relapse with residual disease after reinduction chemotherapy (intermediate risk). Blinatumomab, a bispecific CD3 to CD19 T cell-engaging antibody construct, is efficacious in relapsed/refractory B-ALL and has a favorable toxicity profile.
308. Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial.
作者: Thomas A Wadden.;Timothy S Bailey.;Liana K Billings.;Melanie Davies.;Juan P Frias.;Anna Koroleva.;Ildiko Lingvay.;Patrick M O'Neil.;Domenica M Rubino.;Dorthe Skovgaard.;Signe O R Wallenstein.;W Timothy Garvey.; .
来源: JAMA. 2021年325卷14期1403-1413页
Weight loss improves cardiometabolic risk factors in people with overweight or obesity. Intensive lifestyle intervention and pharmacotherapy are the most effective noninvasive weight loss approaches.
309. Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial.
作者: Mickael Vourc'h.;Charlotte Garret.;Arnaud Gacouin.;Jean-Claude Lacherade.;Maud Jonas.;Kada Klouche.;Martine Ferrandiere.;Samir Jaber.;Laurent Flet.;Eric Dailly.;Caroline Pouplet.;Adel Maamar.;Jean Reignier.;Antoine Roquilly.;Fanny Feuillet.;Pierre-Joachim Mahe.;Karim Asehnoune.; .
来源: JAMA. 2021年325卷8期732-741页
Unhealthy alcohol use can lead to agitation in the intensive care unit (ICU).
310. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
作者: Jonathan E Sevransky.;Richard E Rothman.;David N Hager.;Gordon R Bernard.;Samuel M Brown.;Timothy G Buchman.;Laurence W Busse.;Craig M Coopersmith.;Christine DeWilde.;E Wesley Ely.;Lindsay M Eyzaguirre.;Alpha A Fowler.;David F Gaieski.;Michelle N Gong.;Alex Hall.;Jeremiah S Hinson.;Michael H Hooper.;Gabor D Kelen.;Akram Khan.;Mark A Levine.;Roger J Lewis.;Chris J Lindsell.;Jessica S Marlin.;Anna McGlothlin.;Brooks L Moore.;Katherine L Nugent.;Samuel Nwosu.;Carmen C Polito.;Todd W Rice.;Erin P Ricketts.;Caroline C Rudolph.;Fred Sanfilippo.;Kert Viele.;Greg S Martin.;David W Wright.; .
来源: JAMA. 2021年325卷8期742-750页
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.
311. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.
作者: Igor H Murai.;Alan L Fernandes.;Lucas P Sales.;Ana J Pinto.;Karla F Goessler.;Camila S C Duran.;Carla B R Silva.;André S Franco.;Marina B Macedo.;Henrique H H Dalmolin.;Janaina Baggio.;Guilherme G M Balbi.;Bruna Z Reis.;Leila Antonangelo.;Valeria F Caparbo.;Bruno Gualano.;Rosa M R Pereira.
来源: JAMA. 2021年325卷11期1053-1060页
The efficacy of vitamin D3 supplementation in coronavirus disease 2019 (COVID-19) remains unclear.
312. Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial.
作者: Stephen P Messier.;Shannon L Mihalko.;Daniel P Beavers.;Barbara J Nicklas.;Paul DeVita.;J Jeffery Carr.;David J Hunter.;Mary Lyles.;Ali Guermazi.;Kim L Bennell.;Richard F Loeser.
来源: JAMA. 2021年325卷7期646-657页
Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms.
313. Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial.
作者: Gregory Ducrocq.;Jose R Gonzalez-Juanatey.;Etienne Puymirat.;Gilles Lemesle.;Marine Cachanado.;Isabelle Durand-Zaleski.;Joan Albert Arnaiz.;Manuel Martínez-Sellés.;Johanne Silvain.;Albert Ariza-Solé.;Emile Ferrari.;Gonzalo Calvo.;Nicolas Danchin.;Cristina Avendaño-Solá.;Jerome Frenkiel.;Alexandra Rousseau.;Eric Vicaut.;Tabassome Simon.;Philippe Gabriel Steg.; .
来源: JAMA. 2021年325卷6期552-560页
The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear.
314. Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
作者: Stephan Mueller.;Ephraim B Winzer.;André Duvinage.;Andreas B Gevaert.;Frank Edelmann.;Bernhard Haller.;Elisabeth Pieske-Kraigher.;Paul Beckers.;Anna Bobenko.;Jennifer Hommel.;Caroline M Van de Heyning.;Katrin Esefeld.;Pia von Korn.;Jeffrey W Christle.;Mark J Haykowsky.;Axel Linke.;Ulrik Wisløff.;Volker Adams.;Burkert Pieske.;Emeline M van Craenenbroeck.;Martin Halle.; .
来源: JAMA. 2021年325卷6期542-551页
Endurance exercise is effective in improving peak oxygen consumption (peak V̇o2) in patients with heart failure with preserved ejection fraction (HFpEF). However, it remains unknown whether differing modes of exercise have different effects.
315. Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin.
作者: Martin Ebinger.;Bob Siegerink.;Alexander Kunz.;Matthias Wendt.;Joachim E Weber.;Eugen Schwabauer.;Frederik Geisler.;Erik Freitag.;Julia Lange.;Janina Behrens.;Hebun Erdur.;Ramanan Ganeshan.;Thomas Liman.;Jan F Scheitz.;Ludwig Schlemm.;Peter Harmel.;Katja Zieschang.;Irina Lorenz-Meyer.;Ira Napierkowski.;Carolin Waldschmidt.;Christian H Nolte.;Ulrike Grittner.;Edzard Wiener.;Georg Bohner.;Darius G Nabavi.;Ingo Schmehl.;Axel Ekkernkamp.;Gerhard J Jungehulsing.;Bruno-Marcel Mackert.;Andreas Hartmann.;Jessica L Rohmann.;Matthias Endres.;Heinrich J Audebert.; .
来源: JAMA. 2021年325卷5期454-466页
Effects of thrombolysis in acute ischemic stroke are time-dependent. Ambulances that can administer thrombolysis (mobile stroke units [MSUs]) before arriving at the hospital have been shown to reduce time to treatment.
316. Effect of Behavioral Therapy With In-Clinic or Telephone Group Visits vs In-Clinic Individual Visits on Weight Loss Among Patients With Obesity in Rural Clinical Practice: A Randomized Clinical Trial.
作者: Christie A Befort.;Jeffrey J VanWormer.;Cyrus Desouza.;Edward F Ellerbeck.;Byron Gajewski.;Kim S Kimminau.;K Allen Greiner.;Michael G Perri.;Alexandra R Brown.;Ram D Pathak.;Terry T-K Huang.;Leslie Eiland.;Andjela Drincic.
来源: JAMA. 2021年325卷4期363-372页
Rural populations have a higher prevalence of obesity and poor access to weight loss programs. Effective models for treating obesity in rural clinical practice are needed.
317. Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
作者: Robert L Gottlieb.;Ajay Nirula.;Peter Chen.;Joseph Boscia.;Barry Heller.;Jason Morris.;Gregory Huhn.;Jose Cardona.;Bharat Mocherla.;Valentina Stosor.;Imad Shawa.;Princy Kumar.;Andrew C Adams.;Jacob Van Naarden.;Kenneth L Custer.;Michael Durante.;Gerard Oakley.;Andrew E Schade.;Timothy R Holzer.;Philip J Ebert.;Richard E Higgs.;Nicole L Kallewaard.;Janelle Sabo.;Dipak R Patel.;Paul Klekotka.;Lei Shen.;Daniel M Skovronsky.
来源: JAMA. 2021年325卷7期632-644页
Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19.
318. Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial.
作者: Renato D Lopes.;Ariane V S Macedo.;Pedro G M de Barros E Silva.;Renata J Moll-Bernardes.;Tiago M Dos Santos.;Lilian Mazza.;André Feldman.;Guilherme D'Andréa Saba Arruda.;Denílson C de Albuquerque.;Angelina S Camiletti.;Andréa S de Sousa.;Thiago C de Paula.;Karla G D Giusti.;Rafael A M Domiciano.;Márcia M Noya-Rabelo.;Alan M Hamilton.;Vitor A Loures.;Rodrigo M Dionísio.;Thyago A B Furquim.;Fábio A De Luca.;Ítalo B Dos Santos Sousa.;Bruno S Bandeira.;Cleverson N Zukowski.;Ricardo G G de Oliveira.;Noara B Ribeiro.;Jeffer L de Moraes.;João L F Petriz.;Adriana M Pimentel.;Jacqueline S Miranda.;Bárbara E de Jesus Abufaiad.;C Michael Gibson.;Christopher B Granger.;John H Alexander.;Olga F de Souza.; .
来源: JAMA. 2021年325卷3期254-264页
It is unknown whether angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have a positive, neutral, or negative effect on clinical outcomes in patients with coronavirus disease 2019 (COVID-19).
319. Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial.
作者: Wenjie Zi.;Zhongming Qiu.;Fengli Li.;Hongfei Sang.;Deping Wu.;Weidong Luo.;Shuai Liu.;Junjie Yuan.;Jiaxing Song.;Zhonghua Shi.;Wenguo Huang.;Min Zhang.;Wenhua Liu.;Zhangbao Guo.;Tao Qiu.;Qiang Shi.;Peiyang Zhou.;Li Wang.;Xinmin Fu.;Shudong Liu.;Shiquan Yang.;Shuai Zhang.;Zhiming Zhou.;Xianjun Huang.;Yan Wang.;Jun Luo.;Yongjie Bai.;Min Zhang.;Youlin Wu.;Guoyong Zeng.;Yue Wan.;Changming Wen.;Hongbin Wen.;Wentong Ling.;Zhuo Chen.;Miao Peng.;Zhibing Ai.;Fuqiang Guo.;Huagang Li.;Jing Guo.;Haitao Guan.;Zhiyi Wang.;Yong Liu.;Jie Pu.;Zhen Wang.;Hansheng Liu.;Luming Chen.;Jiacheng Huang.;Guoqiang Yang.;Zili Gong.;Jie Shuai.;Raul G Nogueira.;Qingwu Yang.; .
来源: JAMA. 2021年325卷3期234-243页
For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared with intravenous thrombolysis plus endovascular treatment (standard treatment) can achieve similar functional outcomes.
320. Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial.
作者: Kentaro Suzuki.;Yuji Matsumaru.;Masataka Takeuchi.;Masafumi Morimoto.;Ryuzaburo Kanazawa.;Yohei Takayama.;Yuki Kamiya.;Keigo Shigeta.;Seiji Okubo.;Mikito Hayakawa.;Norihiro Ishii.;Yorio Koguchi.;Tomoji Takigawa.;Masato Inoue.;Hiromichi Naito.;Takahiro Ota.;Teruyuki Hirano.;Noriyuki Kato.;Toshihiro Ueda.;Yasuyuki Iguchi.;Kazunori Akaji.;Wataro Tsuruta.;Kazunori Miki.;Shigeru Fujimoto.;Tetsuhiro Higashida.;Mitsuhiro Iwasaki.;Junya Aoki.;Yasuhiro Nishiyama.;Toshiaki Otsuka.;Kazumi Kimura.; .
来源: JAMA. 2021年325卷3期244-253页
Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patients with acute large vessel occlusion stroke is unclear.
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