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3161. Improving guideline adherence: a randomized trial evaluating strategies to increase beta-blocker use in heart failure.
作者: Maria Ansari.;Michael G Shlipak.;Paul A Heidenreich.;Denise Van Ostaeyen.;Elizabeth C Pohl.;Warren S Browner.;Barry M Massie.
来源: Circulation. 2003年107卷22期2799-804页
The dissemination of clinical practice guidelines often has not been accompanied by desired improvements in guideline adherence. This study evaluated interventions for implementing a new practice guideline advocating the use of beta-blockers for heart failure patients.
3162. Microvascular filtration is increased in postural tachycardia syndrome.
Postural tachycardia syndrome (POTS) is related to defective peripheral vasoconstriction of dependent extremities with redistributive hypovolemia.
3163. Phased-array intracardiac echocardiography monitoring during pulmonary vein isolation in patients with atrial fibrillation: impact on outcome and complications.
作者: Nassir F Marrouche.;David O Martin.;Oussama Wazni.;A Marc Gillinov.;Allan Klein.;Mandeep Bhargava.;Eduardo Saad.;Dianna Bash.;Hirotsugu Yamada.;Wael Jaber.;Robert Schweikert.;Patrick Tchou.;Ahmad Abdul-Karim.;Walid Saliba.;Andrea Natale.
来源: Circulation. 2003年107卷21期2710-6页
The objective of this study was to assess the impact of intracardiac echocardiography (ICE) on the long-term success and complications in patients undergoing pulmonary vein isolation (PVI) for treatment of atrial fibrillation (AF).
3164. Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation.
作者: Richard C Saumarez.;Lidia Chojnowska.;Richard Derksen.;Mariusz Pytkowski.;Maciej Sterlinski.;Christopher L-H Huang.;Nicolas Sadoul.;Richard N W Hauer.;Witold Ruzyłło.;Andrew A Grace.
来源: Circulation. 2003年107卷20期2595-600页
Slowed or delayed myocardial activation and dispersed refractoriness predispose to reentrant excitation that may lead to ventricular fibrillation (VF). Increased ventricular electrogram duration (DeltaED) in response to extrastimuli and increased S1S2 coupling intervals at which electrogram duration starts to increase (S1S2delay) are seen both in hypertrophic cardiomyopathy (HCM) in those at risk of VF and in patients with idiopathic VF (IVF).
3165. Effects of continuous enhanced vagal tone on dual atrioventricular node and accessory pathways.
作者: Chuen-Wang Chiou.;Shih-Ann Chen.;Ming-Ho Kung.;Mau-Song Chang.;Eric N Prystowsky.
来源: Circulation. 2003年107卷20期2583-8页
The aim of this study was to test the electrophysiological effects of continuous enhanced vagal tone on dual atrioventricular (AV) nodal and accessory pathways.
3166. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.
作者: Steven Reiken.;Xander H T Wehrens.;John A Vest.;Alessandro Barbone.;Stefan Klotz.;Donna Mancini.;Daniel Burkhoff.;Andrew R Marks.
来源: Circulation. 2003年107卷19期2459-66页
Chronic beta-adrenergic receptor (beta-AR) blockade improves cardiac contractility and prolongs survival in patients with heart failure; however, the mechanisms underlying these favorable responses are poorly understood. Stress-induced activation of the sympathetic nervous system results in protein kinase A (PKA)-mediated phosphorylation of the calcium (Ca2+) release channel/cardiac ryanodine receptor (RyR2), required for cardiac excitation-contraction (EC) coupling, activating the RyR2 channel, and increasing cardiac contractility. The hyperadrenergic state of heart failure results in leaky RyR2 channels attributable to PKA hyperphosphorylation and depletion of the stabilizing FK506 binding protein, FKBP12.6. We tested the hypothesis that improved cardiac muscle function attributable to beta-AR blockade is associated with restoration of normal RyR2 channel function in patients with heart failure.
3167. Longitudinal myocardial function assessed by tissue velocity, strain, and strain rate tissue Doppler echocardiography in patients with AL (primary) cardiac amyloidosis.
AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were more sensitive than tissue Doppler and could detect early regional myocardial dysfunction before the onset of congestive heart failure (CHF) in patients with AL (primary) amyloidosis.
3168. Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events.
作者: S Matthijs Boekholdt.;Willem R P Agema.;Ron J G Peters.;Aeilko H Zwinderman.;Ernst E van der Wall.;Pieter H Reitsma.;John J P Kastelein.;J Wouter Jukema.; .
来源: Circulation. 2003年107卷19期2416-21页
Atherosclerosis is increasingly considered to be a chronic inflammatory process. We examined whether genetic variants of the toll-like receptor 4 (TLR4), which are correlated with impaired innate immunity and with progression of carotid atherosclerosis, are also associated with coronary atherosclerosis and predict the risk of cardiovascular events.
3169. Elevated production of interleukin-6 is associated with a lower incidence of disease-related ischemic events in patients with giant-cell arteritis: angiogenic activity of interleukin-6 as a potential protective mechanism.
作者: José Hernández-Rodríguez.;Marta Segarra.;Carme Vilardell.;Montse Sánchez.;Ana García-Martínez.;María-José Esteban.;Josep M Grau.;Alvaro Urbano-Márquez.;Dolors Colomer.;Hynda K Kleinman.;Maria C Cid.
来源: Circulation. 2003年107卷19期2428-34页
Patients with giant-cell arteritis (GCA) who develop a strong acute-phase response are at low risk of disease-related ischemic events.
3170. Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones.
作者: Nerea Varo.;David Vicent.;Peter Libby.;Rebecca Nuzzo.;Alfonso L Calle-Pascual.;María Rosa Bernal.;Arturo Fernández-Cruz.;Aristidis Veves.;Petr Jarolim.;Jose Javier Varo.;Allison Goldfine.;Edward Horton.;Uwe Schönbeck.
来源: Circulation. 2003年107卷21期2664-9页
Considerable evidence implicates the proinflammatory cytokine CD40 ligand (CD40L) in atherosclerosis and accumulating data link type 1 and 2 diabetes, conditions associated with accelerated atherosclerosis, to inflammation. This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation.
3171. Prognostic role of brain natriuretic peptide in acute pulmonary embolism.
Rapid, noninvasive, and accurate prognostic assessment with an inexpensive cardiac biomarker is an appealing approach for patients with acute pulmonary embolism (PE).
3172. Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention.
作者: Manas K Sinha.;David C Gaze.;John R Tippins.;Paul O Collinson.;Juan Carlos Kaski.
来源: Circulation. 2003年107卷19期2403-5页
Ischemia modified albumin (IMA; Ischemia Technologies, Inc) blood levels rise in patients who develop ischemia during percutaneous coronary intervention (PCI). It is not known whether IMA elevations correlate with increases in other markers of oxidative stress, ie, 8-iso prostaglandin F2-A (iP).
3173. Cardiopulmonary bypass to repair an atrial septal defect does not affect cognitive function in children.
Changes in neurocognitive function after cardiopulmonary bypass (CPB) are difficult to assess in children with congenital cardiovascular malformations in part because identification of a suitable control group of children is difficult.
3174. Effects of intravenous nesiritide on human coronary vasomotor regulation and myocardial oxygen uptake.
作者: Andrew D Michaels.;Andrew Klein.;James A Madden.;Kanu Chatterjee.
来源: Circulation. 2003年107卷21期2697-701页
Nesiritide, recombinant human B-type natriuretic peptide, has been shown to be efficacious in the treatment of decompensated heart failure. The effects of intravenous nesiritide on the human coronary vasculature have not been studied.
3175. Cerebral microembolism is blocked by tirofiban, a selective nonpeptide platelet glycoprotein IIb/IIIa receptor antagonist.
Microembolic signals (MES) as detected by transcranial Doppler ultrasound define an individual stroke risk in patients with carotid artery disease. To study the composition of MES in vivo, we used the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonist tirofiban, a highly selective platelet aggregation inhibitor.
3176. Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets.
作者: Jan Kristian Damås.;Torgun Waehre.;Arne Yndestad.;Kari Otterdal.;Aina Hognestad.;Nils Olav Solum.;Lars Gullestad.;Stig S Frøland.;Pål Aukrust.
来源: Circulation. 2003年107卷21期2670-6页
Atherogenesis and plaque destabilization involve immune-mediated mechanisms, but the actual mediators have not been fully clarified. Interleukin (IL)-7 is a regulator of T-cell homeostasis but also may be involved in inflammation. We hypothesized that IL-7 could be involved in the inflammatory processes observed in atherosclerosis and acute coronary syndromes.
3177. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT).
作者: Marja Hedman.;Juha Hartikainen.;Mikko Syvänne.;Joachim Stjernvall.;Antti Hedman.;Antti Kivelä.;Esko Vanninen.;Hanna Mussalo.;Esa Kauppila.;Sakari Simula.;Outi Närvänen.;Arto Rantala.;Keijo Peuhkurinen.;Markku S Nieminen.;Markku Laakso.;Seppo Ylä-Herttuala.
来源: Circulation. 2003年107卷21期2677-83页
Catheter-based intracoronary vascular endothelial growth factor (VEGF) gene transfer is a potential treatment for coronary heart disease. However, only limited data are available about local VEGF gene transfer given during angioplasty (PTCA) and stenting.
3178. Incomplete resolution of ST-segment elevation is a marker of transient microcirculatory dysfunction after stenting for acute myocardial infarction.
作者: Laurent J Feldman.;Pierre Coste.;Alain Furber.;Patrick Dupouy.;Michel S Slama.;Jean-Pierre Monassier.;Christophe Tron.;Antoine Lafont.;Marc Faraggi.;Dominique Le Guludec.;Jean-Luc Dubois-Randé.;P Gabriel Steg.; .
来源: Circulation. 2003年107卷21期2684-9页
Incomplete ST-segment resolution (STR) after successful primary angioplasty for acute myocardial infarction (AMI) is associated with a poor prognosis. We used intracoronary Doppler velocimetry to investigate whether incomplete STR after primary angioplasty is a marker of severe microcirculatory dysfunction.
3179. Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial.
作者: Mihai Gheorghiade.;Imran Niazi.;John Ouyang.;Frank Czerwiec.;Jun-ichi Kambayashi.;Manuela Zampino.;Cesare Orlandi.; .
来源: Circulation. 2003年107卷21期2690-6页
In this study, we evaluated the effects of tolvaptan (OPC-41061), a novel, oral, nonpeptide vasopressin V2-receptor antagonist in patients with chronic heart failure (CHF).
3180. Use of rapamycin slows progression of cardiac transplantation vasculopathy.
作者: Donna Mancini.;Sean Pinney.;Daniel Burkhoff.;John LaManca.;Silviu Itescu.;Elizabeth Burke.;Niloo Edwards.;Mehmet Oz.;Andrew R Marks.
来源: Circulation. 2003年108卷1期48-53页
Cardiac transplantation vasculopathy is the leading cause of late death in heart transplantation recipients. Rapamycin is an immunosuppressant drug with potent antiproliferative and antimigratory effects. We investigated whether rapamycin could prevent progression of graft vasculopathy in 46 patients (age, 54+/-10 years; 4.3+/-2.3 years after transplantation) with severe disease.
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