当前位置: 首页 >> 检索结果
3101. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.
作者: R B Nadelman.;J Nowakowski.;D Fish.;R C Falco.;K Freeman.;D McKenna.;P Welch.;R Marcus.;M E Agüero-Rosenfeld.;D T Dennis.;G P Wormser.; .
来源: N Engl J Med. 2001年345卷2期79-84页
It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease.
3102. Safety and efficacy of recombinant human alpha-galactosidase A replacement therapy in Fabry's disease.
作者: C M Eng.;N Guffon.;W R Wilcox.;D P Germain.;P Lee.;S Waldek.;L Caplan.;G E Linthorst.;R J Desnick.; .
来源: N Engl J Med. 2001年345卷1期9-16页
Fabry's disease, lysosomal alpha-galactosidase A deficiency, results from the progressive accumulation of globotriaosylceramide and related glycosphingolipids. Affected patients have microvascular disease of the kidneys, heart, and brain.
3103. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
作者: B Schmidt.;P Davis.;D Moddemann.;A Ohlsson.;R S Roberts.;S Saigal.;A Solimano.;M Vincer.;L L Wright.; .
来源: N Engl J Med. 2001年344卷26期1966-72页
The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known.
3104. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events.
作者: P M Ridker.;N Rifai.;M Clearfield.;J R Downs.;S E Weis.;J S Miles.;A M Gotto.; .
来源: N Engl J Med. 2001年344卷26期1959-65页
Elevated levels of C-reactive protein, even in the absence of hyperlipidemia, are associated with an increased risk of coronary events. Statin therapy reduces the level of C-reactive protein independently of its effect on lipid levels. We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia.
3105. Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction.
作者: G Montalescot.;P Barragan.;O Wittenberg.;P Ecollan.;S Elhadad.;P Villain.;J M Boulenc.;M C Morice.;L Maillard.;M Pansiéri.;R Choussat.;P Pinton.; .
来源: N Engl J Med. 2001年344卷25期1895-903页
When administered in conjunction with primary coronary stenting for the treatment of acute myocardial infarction, a platelet glycoprotein IIb/IIIa inhibitor may provide additional clinical benefit, but data on this combination therapy are limited.
3106. Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization.
作者: E J Topol.;D J Moliterno.;H C Herrmann.;E R Powers.;C L Grines.;D J Cohen.;E A Cohen.;M Bertrand.;F J Neumann.;G W Stone.;P M DiBattiste.;L Demopoulos.; .
来源: N Engl J Med. 2001年344卷25期1888-94页
In the setting of percutaneous coronary revascularization, agents in the class known as platelet glycoprotein IIb/IIIa inhibitors have significantly reduced the incidence of death or nonfatal myocardial infarction at 30 days. We assessed whether there are differences in safety or efficacy between two such inhibitors, tirofiban and abciximab.
3107. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.
作者: C P Cannon.;W S Weintraub.;L A Demopoulos.;R Vicari.;M J Frey.;N Lakkis.;F J Neumann.;D H Robertson.;P T DeLucca.;P M DiBattiste.;C M Gibson.;E Braunwald.; .
来源: N Engl J Med. 2001年344卷25期1879-87页
There is continued debate as to whether a routine, early invasive strategy is superior to a conservative strategy for the management of unstable angina and myocardial infarction without ST-segment elevation.
3108. A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure.
作者: .;Eric J Eichhorn.;Michael J Domanski.;Heidi Krause-Steinrauf.;Michael R Bristow.;Philip W Lavori.
来源: N Engl J Med. 2001年344卷22期1659-67页
Although beta-adrenergic-receptor antagonists reduce morbidity and mortality in patients with mild-to-moderate chronic heart failure, their effect on survival in patients with more advanced heart failure is unknown.
3109. Effect of carvedilol on survival in severe chronic heart failure.
作者: M Packer.;A J Coats.;M B Fowler.;H A Katus.;H Krum.;P Mohacsi.;J L Rouleau.;M Tendera.;A Castaigne.;E B Roecker.;M K Schultz.;D L DeMets.; .
来源: N Engl J Med. 2001年344卷22期1651-8页
Beta-blocking agents reduce the risk of hospitalization and death in patients with mild-to-moderate heart failure, but little is known about their effects in severe heart failure.
3110. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.
作者: R M Neer.;C D Arnaud.;J R Zanchetta.;R Prince.;G A Gaich.;J Y Reginster.;A B Hodsman.;E F Eriksen.;S Ish-Shalom.;H K Genant.;O Wang.;B H Mitlak.
来源: N Engl J Med. 2001年344卷19期1434-41页
Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown.
3111. The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead.
作者: W J Rogan.;K N Dietrich.;J H Ware.;D W Dockery.;M Salganik.;J Radcliffe.;R L Jones.;N B Ragan.;J J Chisolm.;G G Rhoads.; .
来源: N Engl J Med. 2001年344卷19期1421-6页
Thousands of children, especially poor children living in deteriorated urban housing, are exposed to enough lead to produce cognitive impairment. It is not known whether treatment to reduce blood lead levels prevents or reduces such impairment.
3112. Use of transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation.
作者: A L Klein.;R A Grimm.;R D Murray.;C Apperson-Hansen.;R W Asinger.;I W Black.;R Davidoff.;R Erbel.;J L Halperin.;D A Orsinelli.;T R Porter.;M F Stoddard.; .
来源: N Engl J Med. 2001年344卷19期1411-20页
The conventional treatment strategy for patients with atrial fibrillation who are to undergo electrical cardioversion is to prescribe warfarin for anticoagulation for three weeks before cardioversion. It has been proposed that if transesophageal echocardiography reveals no atrial thrombus, cardioversion may be performed safely after only a short period of anticoagulant therapy.
3113. Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure.
作者: C W Yancy.;M B Fowler.;W S Colucci.;E M Gilbert.;M R Bristow.;J N Cohn.;M A Lukas.;S T Young.;M Packer.; .
来源: N Engl J Med. 2001年344卷18期1358-65页
The benefits of angiotensin-converting-enzyme inhibitors and beta-blockers may be smaller in black patients than in patients of other races, but it is unknown whether race influences the response to carvedilol in patients with chronic heart failure.
3114. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.
作者: J Tuomilehto.;J Lindström.;J G Eriksson.;T T Valle.;H Hämäläinen.;P Ilanne-Parikka.;S Keinänen-Kiukaanniemi.;M Laakso.;A Louheranta.;M Rastas.;V Salminen.;M Uusitupa.; .
来源: N Engl J Med. 2001年344卷18期1343-50页
Type 2 diabetes mellitus is increasingly common, primarily because of increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known.
3115. Fluvoxamine for the treatment of anxiety disorders in children and adolescents. The Research Unit on Pediatric Psychopharmacology Anxiety Study Group.
来源: N Engl J Med. 2001年344卷17期1279-85页
Drugs that selectively inhibit serotonin reuptake are effective treatments for adults with mood and anxiety disorders, but limited data are available on the safety and efficacy of serotonin-reuptake inhibitors in children with anxiety disorders.
3116. The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children.
作者: F Y Lin.;V A Ho.;H B Khiem.;D D Trach.;P V Bay.;T C Thanh.;Z Kossaczka.;D A Bryla.;J Shiloach.;J B Robbins.;R Schneerson.;S C Szu.
来源: N Engl J Med. 2001年344卷17期1263-9页
Typhoid fever is common in developing countries. The licensed typhoid vaccines confer only about 70 percent immunity, do not protect young children, and are not used for routine vaccination. A newly devised conjugate of the capsular polysaccharide of Salmonella typhi, Vi, bound to nontoxic recombinant Pseudomonas aeruginosa exotoxin A (rEPA), has enhanced immunogenicity in adults and in children 5 to 14 years old and has elicited a booster response in children 2 to 4 years old.
3117. Cognitive function in postmenopausal women treated with raloxifene.
作者: K Yaffe.;K Krueger.;S Sarkar.;D Grady.;E Barrett-Connor.;D A Cox.;T Nickelsen.; .
来源: N Engl J Med. 2001年344卷16期1207-13页
In postmenopausal women, estrogen may have a beneficial effect on cognition or reduce the risk of decline in cognitive function. Whether raloxifene, a selective estrogen-receptor modulator, might have similar actions is not known.
3118. Effect of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years.
作者: J L Paradise.;H M Feldman.;T F Campbell.;C A Dollaghan.;D K Colborn.;B S Bernard.;H E Rockette.;J E Janosky.;D L Pitcairn.;D L Sabo.;M Kurs-Lasky.;C G Smith.
来源: N Engl J Med. 2001年344卷16期1179-87页
A main indication for the insertion of tympanostomy tubes in infants and young children is persistent otitis media with effusion, reflecting concern that this condition may cause lasting impairments of speech, language, cognitive, and psychosocial development. However, evidence of such relations is inconclusive, and evidence is lacking that the insertion of tympanostomy tubes prevents developmental impairment.
3119. Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease.
作者: P W Serruys.;F Unger.;J E Sousa.;A Jatene.;H J Bonnier.;J P Schönberger.;N Buller.;R Bonser.;M J van den Brand.;L A van Herwerden.;M A Morel.;B A van Hout.; .
来源: N Engl J Med. 2001年344卷15期1117-24页
The recent recognition that coronary-artery stenting has improved the short- and long-term outcomes of patients treated with angioplasty has made it necessary to reevaluate the relative benefits of bypass surgery and percutaneous interventions in patients with multivessel disease.
3120. Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen.
作者: F K Chan.;S C Chung.;B Y Suen.;Y T Lee.;W K Leung.;V K Leung.;J C Wu.;J Y Lau.;Y Hui.;M S Lai.;H L Chan.;J J Sung.
来源: N Engl J Med. 2001年344卷13期967-73页
Many patients who have had upper gastrointestinal bleeding continue to take low-dose aspirin for cardiovascular prophylaxis or other non-steroidal antiinflammatory drugs (NSAIDs) for musculoskeletal pain. It is uncertain whether infection with Helicobacter pylori is a risk factor for bleeding in such patients.
|