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3081. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy.
作者: Victor L Serebruany.;Alexander H Glassman.;Alex I Malinin.;Charles B Nemeroff.;Dominique L Musselman.;Louis T van Zyl.;Mitchell S Finkel.;K Ranga R Krishnan.;Michael Gaffney.;Wilma Harrison.;Robert M Califf.;Christopher M O'Connor.; .
来源: Circulation. 2003年108卷8期939-44页
Depression after acute coronary syndromes (ACSs) has been identified as an independent risk factor for subsequent cardiac death. Enhanced platelet activation has been hypothesized to represent 1 of the mechanisms underlying this association. Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit platelet activity. Whether treatment of depressed post-ACS patients with SSRIs alters platelet function was not known. Accordingly, we serially assessed the release of established platelet/endothelial biomarkers in patients treated with sertraline vs placebo in the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART).
3082. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial.
作者: Marguerite M Engler.;Mary B Engler.;Mary J Malloy.;Elisa Y Chiu.;Monique C Schloetter.;Steven M Paul.;Markus Stuehlinger.;Ken Y Lin.;John P Cooke.;Jason D Morrow.;Paul M Ridker.;Nader Rifai.;Elizabeth Miller.;Joseph L Witztum.;Michele Mietus-Snyder.
来源: Circulation. 2003年108卷9期1059-63页
Hyperlipidemia is associated with endothelial dysfunction, an early event in atherosclerosis and predictor of risk for future coronary artery disease. Epidemiological studies suggest that increased dietary intake of antioxidants reduces the risk of coronary artery disease. The purpose of this study was to determine whether antioxidant vitamin therapy improves endothelial function and affects surrogate biomarkers for oxidative stress and inflammation in hyperlipidemic children.
3083. Hemodynamic profile after the Norwood procedure with right ventricle to pulmonary artery conduit.
作者: Kevin O Maher.;Christian Pizarro.;Samuel S Gidding.;Katarzyna Januszewska.;Edward Malec.;William I Norwood.;John D Murphy.
来源: Circulation. 2003年108卷7期782-4页
The balance of systemic, pulmonary, and coronary blood flow after the Norwood operation for hypoplastic left heart syndrome (HLHS) is critical to early survival. We hypothesized that a right ventricle to pulmonary artery conduit (instead of a systemic to pulmonary artery shunt) would result in hemodynamic changes consistent with a more stable balance of systemic, pulmonary, and coronary perfusion.
3084. Role of a decreased expression of the local renin-angiotensin system in the etiology of cerebral aneurysms.
作者: Hiroki Ohkuma.;Shigeharu Suzuki.;Seiichiroh Fujita.;Wataru Nakamura.
来源: Circulation. 2003年108卷7期785-7页
Local renin-angiotensin systems (RAS) have been implicated as playing an important role in vascular remodeling. The relationship of this system to the etiology of cerebral aneurysm was investigated.
3085. Effects of unilateral and bilateral carotid baroreflex stimulation on cardiac and neural sympathetic discharge oscillatory patterns.
作者: Raffaello Furlan.;André Diedrich.;Alexandra Rimoldi.;Laura Palazzolo.;Cesare Porta.;Laura Diedrich.;Paul A Harris.;Peter Sleight.;Italo Biagioni.;David Robertson.;Luciano Bernardi.
来源: Circulation. 2003年108卷6期717-23页
Left and right carotid baroreflex afferents participate in generating the spontaneous variability of heart rate (HR), arterial pressure (AP), and muscle sympathetic nerve activity (MSNA), but the relative contribution of each side is unclear. Pathophysiological conditions unilaterally affecting carotid baroreceptor function might result in abnormal changes of HR, AP, and MSNA variability, thus markedly affecting prognosis. We tested the hypothesis that unilateral carotid baroreceptor perturbation might differentially affect HR, AP, and MSNA variability compared with stimulation of the opposite side.
3086. Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension.
作者: Adam Torbicki.;Marcin Kurzyna.;Paweł Kuca.;Anna Fijałkowska.;Jarosław Sikora.;Michał Florczyk.;Piotr Pruszczyk.;Janusz Burakowski.;Lilianna Wawrzyńska.
来源: Circulation. 2003年108卷7期844-8页
Right ventricular failure is a leading cause of death in patients with chronic pulmonary hypertension (PH). We checked whether detection of cardiac troponin T (cTnT), a specific marker of myocyte injury, could be useful in prognostic stratification of those patients.
3087. Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair.
作者: Arnt E Fiane.;Vibeke Videm.;Per S Lingaas.;Lars Heggelund.;Erik W Nielsen.;Odd R Geiran.;Michael Fung.;Tom E Mollnes.
来源: Circulation. 2003年108卷7期849-56页
Complement activation contributes to ischemia-reperfusion injury. Patients undergoing thoracoabdominal aortic aneurysm (TAAA) repair suffer extensive ischemia-reperfusion and considerable systemic inflammation.
3088. Effect of lower dose of oral conjugated equine estrogen on size and oxidative susceptibility of low-density lipoprotein particles in postmenopausal women.
作者: Akihiko Wakatsuki.;Yuji Okatani.;Nobuo Ikenoue.;Koichi Shinohara.;Kazushi Watanabe.;Takao Fukaya.
来源: Circulation. 2003年108卷7期808-13页
Estrogen replacement therapy (ERT) has an antioxidant effect that opposes the oxidation of LDL. Oral ERT-induced increases in plasma triglyceride, however, are associated with decreased LDL size, which may counteract this antioxidant effect. Because lower doses of oral estrogen do not affect plasma triglyceride concentrations, LDL size might not change, and the antioxidant effect of estrogen might be preserved. We investigated whether a lower dose of oral estrogen could eliminate the adverse effects of high-dose oral ERT on the size and oxidative susceptibility of LDL in postmenopausal women.
3089. Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions.
作者: Antonio Colombo.;Janusz Drzewiecki.;Adrian Banning.;Eberhard Grube.;Karl Hauptmann.;Sigmund Silber.;Dariusz Dudek.;Stephen Fort.;Francois Schiele.;Krysztof Zmudka.;Giulio Guagliumi.;Mary E Russell.; .
来源: Circulation. 2003年108卷7期788-94页
Early clinical studies demonstrated the feasibility of local paclitaxel delivery in reducing restenosis after treatment of de novo coronary lesions in small patient populations.
3090. Is pulmonary vein isolation necessary for curing atrial fibrillation?
作者: Giuseppe Stabile.;Pietro Turco.;Vincenzo La Rocca.;Pasquale Nocerino.;Eugenio Stabile.;Antonio De Simone.
来源: Circulation. 2003年108卷6期657-60页
Pulmonary veins (PVs) play a pivotal role in initiating and perpetuating atrial fibrillation (AF). We investigated if PV electrical isolation from the left atrium is required for curing AF.
3091. Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly.
作者: Guido Grassi.;Gino Seravalle.;Carlo Turri.;Giovanni Bertinieri.;Raffaella Dell'Oro.;Giuseppe Mancia.
来源: Circulation. 2003年108卷6期729-35页
Human aging is characterized by a marked increase in muscle sympathetic nerve traffic (MSNA). No information exists, however, on the effects of aging on skin sympathetic nerve traffic (SSNA) and on its reflex modulation by thermoregulatory mechanisms.
3092. Norepinephrine precursor therapy in neurogenic orthostatic hypotension.
作者: Horacio Kaufmann.;Daniela Saadia.;Andrei Voustianiouk.;David S Goldstein.;Courtney Holmes.;Melvin D Yahr.;Rachel Nardin.;Roy Freeman.
来源: Circulation. 2003年108卷6期724-8页
In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture.
3093. Effect of 7-year infancy-onset dietary intervention on serum lipoproteins and lipoprotein subclasses in healthy children in the prospective, randomized Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study.
作者: Tuuli Kaitosaari.;Tapani Rönnemaa.;Olli Raitakari.;Sanna Talvia.;Katariina Kallio.;Iina Volanen.;Aila Leino.;Eero Jokinen.;Ilkka Välimäki.;Jorma Viikari.;Olli Simell.
来源: Circulation. 2003年108卷6期672-7页
We previously showed that low-saturated-fat dietary intervention from infancy until 5 years of age safely and effectively reduced serum cholesterol concentration. We now report how such intervention influenced serum lipids, LDL particle size, and HDL subfractions in children when they reached the age of 7 years.
3094. Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention for Endpoint reduction in Hypertension (LIFE) Study.
作者: Peter M Okin.;Richard B Devereux.;Sverker Jern.;Sverre E Kjeldsen.;Stevo Julius.;Markku S Nieminen.;Steven Snapinn.;Katherine E Harris.;Peter Aurup.;Jonathan M Edelman.;Bjorn Dahlof.; .
来源: Circulation. 2003年108卷6期684-90页
Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular morbidity and mortality, and regression of ECG LVH may predict improved prognosis in hypertensive patients. However, uncertainty persists as to how best to regress ECG LVH.
3095. Characterization of endocardial electrophysiological substrate in patients with nonischemic cardiomyopathy and monomorphic ventricular tachycardia.
Although catheter mapping has been used to define the endocardial electrogram characteristics in patients with ventricular tachycardia (VT) and coronary disease, characterization of the electrophysiological substrate in patients with VT and nonischemic cardiomyopathy is limited.
3096. Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
作者: Koichi Node.;Masashi Fujita.;Masafumi Kitakaze.;Masatsugu Hori.;James K Liao.
来源: Circulation. 2003年108卷7期839-43页
Chronic heart failure is associated with inflammation and neurohormonal imbalance. The 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, exert anti-inflammatory and vascular protective effects. We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure.
3097. Prognostic value of lead aVR in patients with a first non-ST-segment elevation acute myocardial infarction.
作者: José A Barrabés.;Jaume Figueras.;Cristina Moure.;Josefa Cortadellas.;Jordi Soler-Soler.
来源: Circulation. 2003年108卷7期814-9页
ST-segment elevation in lead aVR has been associated with severe coronary artery lesions in patients with acute coronary syndromes, but the prognostic significance of this finding is unknown.
3098. Randomized comparison of distal protection with a filter-based catheter and a balloon occlusion and aspiration system during percutaneous intervention of diseased saphenous vein aorto-coronary bypass grafts.
作者: Gregg W Stone.;Campbell Rogers.;James Hermiller.;Robert Feldman.;Patrick Hall.;Robert Haber.;A Masud.;Patrick Cambier.;Ron P Caputo.;Mark Turco.;Richard Kovach.;Bruce Brodie.;Howard C Herrmann.;Richard E Kuntz.;Jeffrey J Popma.;Steve Ramee.;David A Cox.; .
来源: Circulation. 2003年108卷5期548-53页
The high rate of periprocedural complications resulting from atherothrombotic embolization after percutaneous intervention in diseased saphenous vein grafts is reduced by distal microcirculatory protection using a balloon occlusion and aspiration system. Whether filter-based catheters, which offer the inherent advantages of maintained perfusion and ease of use, are as effective for this purpose has not been established.
3099. Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery.
作者: N Zimmermann.;A Wenk.;U Kim.;P Kienzle.;A-A Weber.;E Gams.;K Schrör.;T Hohlfeld.
来源: Circulation. 2003年108卷5期542-7页
Aspirin inhibits platelet activation and reduces atherothrombotic complications in patients at risk of myocardial infarction and stroke. However, a sufficient inhibition of platelet function by aspirin is not always achieved. The causes of this aspirin resistance are unknown.
3100. Evidence for longitudinal and transverse fiber conduction in human pulmonary veins: relevance for catheter ablation.
作者: Javier E Sanchez.;Vance J Plumb.;Andrew E Epstein.;G Neal Kay.
来源: Circulation. 2003年108卷5期590-7页
Segmental ostial ablation of the pulmonary veins (PVs) allows for successful control of paroxysmal atrial fibrillation in many patients. We hypothesized that mapping of the left atrial-PV junction with a 64-electrode basket catheter would allow characterization of conduction patterns that would identify sites where ablation is required to electrically isolate the PV.
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