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3041. Restenosis after coronary stent placement and randomization to a 4-week combined antiplatelet or anticoagulant therapy: six-month angiographic follow-up of the Intracoronary Stenting and Antithrombotic Regimen (ISAR) Trial.
作者: A Kastrati.;H Schühlen.;J Hausleiter.;H Walter.;E Zitzmann-Roth.;M Hadamitzky.;S Elezi.;K Ulm.;J Dirschinger.;F J Neumann.;A Schömig.
来源: Circulation. 1997年96卷2期462-7页
Platelets and mural thrombus at the lesion site may play a key role in initiating the restenosis process after coronary interventions. The ISAR Trial provides a comparison of the outcomes of patients randomized to two different antithrombotic regimens administered for 4 weeks after successful coronary stent placement: combined antiplatelet therapy (aspirin plus ticlopidine) or a conventional anticoagulant regimen (phenprocoumon with initial overlapping heparin plus aspirin). Within the first 4 weeks after stent placement, combined antiplatelet therapy has been associated with a significant reduction of ischemic complications. In the present study, we examined whether combined antiplatelet therapy administered for 4 weeks after stent placement is able to reduce the process of restenosis at 6 months.
3042. Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators.
作者: D E Vaughan.;J L Rouleau.;P M Ridker.;J M Arnold.;F J Menapace.;M A Pfeffer.
来源: Circulation. 1997年96卷2期442-7页
The long-term administration of ACE inhibitors to selected patients with left ventricular dysfunction appears to reduce the incidence of recurrent myocardial infarction (MI) and unstable angina pectoris. The mechanisms responsible for the reduction in ischemic events are unknown, but likely candidates include effects on the atherosclerotic process, thrombosis, and/or vascular tone.
3043. Functional evaluation of lipid-lowering therapy by pravastatin in the Regression Growth Evaluation Statin Study (REGRESS).
作者: W R Aengevaeren.;G J Uijen.;J W Jukema.;A V Bruschke.;T van der Werf.
来源: Circulation. 1997年96卷2期429-35页
Lipid-lowering therapy during 2 years in the Regression Growth Evaluation Statin Study (REGRESS) was associated with less progression of coronary atherosclerosis in the pravastatin group compared with the placebo group. The effect of lipid-lowering therapy on the functional state of the coronary circulation is less well known. The purpose of this study was to evaluate this effect.
3044. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction.
作者: S Gupta.;E W Leatham.;D Carrington.;M A Mendall.;J C Kaski.;A J Camm.
来源: Circulation. 1997年96卷2期404-7页
The clinical significance of the association between elevated anti-Chlamydia pneumoniae (Cp) antibody titres and coronary heart disease (CHD) is unclear. We explored the relationship between antibodies against Cp and future cardiovascular events in male survivors of myocardial infarction (MI). The effect of azithromycin antibiotic therapy was assessed in a subgroup of post-MI patients.
3045. Crystalloid versus cold blood cardioplegia and cardiac troponin I release.
作者: H Pichon.;S Chocron.;K Alwan.;G Toubin.;D Kaili.;P Falcoz.;L Latini.;F Clement.;J F Viel.;J P Etievent.
来源: Circulation. 1997年96卷1期316-20页
Cardiac troponin I (CTnI) has been shown to be a marker of myocardial injury. The aim of this study was to compare antegrade crystalloid cardioplegia with antegrade cold blood cardioplegia with warm reperfusion using CTnI release as the criteria for evaluating the adequacy of myocardial protection.
3046. Sympathetic and vascular effects of short-term passive smoke exposure in healthy nonsmokers.
The physiological effects of cigarette smoking have been widely studied; however, little is known about the effects of acute exposure to sidestream smoke (passive smoking). We examined the effects of sidestream smoke on muscle sympathetic nerve activity (MSNA) and forearm vascular resistance (FVR) at rest and during stressful stimuli, including the cold pressor test (CPT), sustained handgrip (SHG), and mental stress (MS).
3047. Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial.
作者: P Alboni.;C Menozzi.;M Brignole.;N Paparella.;G Gaggioli.;G Lolli.;R Cappato.
来源: Circulation. 1997年96卷1期260-6页
Pacemakers and theophylline are currently being used to relieve symptoms in patients with sick sinus syndrome (SSS). However, the impact of either therapy on the natural course of the disease is unknown. We conducted a randomized controlled trial to prospectively assess the effects of pacemakers and theophylline in patients with SSS.
3048. Effects of RheothRx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction. Collaborative Organization for RheothRx Evaluation (CORE).
来源: Circulation. 1997年96卷1期192-201页
Previous studies suggested that RheothRx (poloxamer 188) reduces infarct size and improves left ventricular (LV) function in acute myocardial infarction (AMI). We therefore evaluated the effects of various doses of RheothRx in 2948 patients presenting with AMI.
3049. Beneficial effects of intravenous and oral carvedilol treatment in acute myocardial infarction. A placebo-controlled, randomized trial.
作者: S Basu.;R Senior.;U Raval.;R van der Does.;T Bruckner.;A Lahiri.
来源: Circulation. 1997年96卷1期183-91页
Evidence of efficacy and safety of beta-blockers after thrombolysis for acute myocardial infarction (AMI) is equivocal. Newer beta-blockers such as carvedilol have not been tested in this setting.
3050. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I) trial. An observational study.
作者: P B Berger.;D R Holmes.;A L Stebbins.;E R Bates.;R M Califf.;E J Topol.
来源: Circulation. 1997年96卷1期122-7页
Although retrospective analyses have revealed an association between survival and coronary angiography and angioplasty in patients with acute myocardial infarction complicated by cardiogenic shock, the degree to which bias in the selection of patients to undergo these procedures contributes to this observation remains unclear.
3051. End-systolic volume index at 90 to 180 minutes into reperfusion therapy for acute myocardial infarction is a strong predictor of early and late mortality. The Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I Angiographic Investigators.
作者: R Q Migrino.;J B Young.;S G Ellis.;H D White.;C F Lundergan.;D P Miller.;C B Granger.;A M Ross.;R M Califf.;E J Topol.
来源: Circulation. 1997年96卷1期116-21页
Left ventricular remodeling is an important sequela of myocardial infarction (MI). Although remodeling occurs soon after MI, the effect of early left ventricular dilatation on outcome is not established and may be useful for early risk stratification. We assessed whether end-systolic volume index (ESVI) at 90 to 180 minutes into thrombolytic therapy for MI is associated with adverse outcomes.
3052. Randomized comparison of angioplasty of complex coronary lesions at a single center. Excimer Laser, Rotational Atherectomy, and Balloon Angioplasty Comparison (ERBAC) Study.
作者: N Reifart.;M Vandormael.;M Krajcar.;S Göhring.;W Preusler.;F Schwarz.;H Störger.;M Hofmann.;J Klöpper.;S Müller.;J Haase.
来源: Circulation. 1997年96卷1期91-8页
The purpose of this study was to test whether coronary revascularization with ablation of either excimer laser or rotational atherectomy can improve the initial angiographic and clinical outcomes compared with dilatation (balloon angioplasty) alone.
3053. First chronic platelet glycoprotein IIb/IIIa integrin blockade. A randomized, placebo-controlled pilot study of xemilofiban in unstable angina with percutaneous coronary interventions.
作者: C Simpfendorfer.;K Kottke-Marchant.;M Lowrie.;R J Anders.;D M Burns.;D P Miller.;C S Cove.;A C DeFranco.;S G Ellis.;D J Moliterno.;R E Raymond.;J M Sutton.;E J Topol.
来源: Circulation. 1997年96卷1期76-81页
Clinical studies have demonstrated the efficacy of intravenous administration of agents that block platelet glycoprotein IIb/IIIa receptors in the setting of percutaneous coronary revascularization. Although the optimal duration of treatment has not been determined, more prolonged receptor blockade has been associated with increased efficacy. Orally active glycoprotein IIb/IIIa receptor antagonists may be advantageous and required for chronic therapy.
3054. Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC).
作者: W Klein.;A Buchwald.;S E Hillis.;S Monrad.;G Sanz.;A G Turpie.;J van der Meer.;E Olaisson.;S Undeland.;K Ludwig.
来源: Circulation. 1997年96卷1期61-8页
Low-molecular-weight heparin has a number of pharmacological and pharmacokinetic advantages over unfractionated heparin that make it potentially suitable, when used in combination with aspirin, for the treatment of unstable coronary artery disease.
3055. Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial.
作者: M A Pfeffer.;S C Greaves.;J M Arnold.;R J Glynn.;F S LaMotte.;R T Lee.;F J Menapace.;E Rapaport.;P M Ridker.;J L Rouleau.;S D Solomon.;C H Hennekens.
来源: Circulation. 1997年95卷12期2643-51页
Although ACE inhibitor therapy has been shown to reduce mortality in patients with acute myocardial infarction (MI), the optimal dose and the timing of its initiation have not been determined.
3056. Plasma angiotensin-converting enzyme activity and left ventricular dilation after myocardial infarction.
作者: M Oosterga.;A A Voors.;P J de Kam.;H Schunkert.;Y M Pinto.;J H Kingma.;W H van Gilst.
来源: Circulation. 1997年95卷12期2607-9页
Left ventricular dilation after acute myocardial infarction (MI) is mainly determined by infarct size. In addition, this detrimental structural adaptation seems to be augmented in patients with the ACE DD genotype. The ACE DD genotype is associated with increased ACE activity. The aim of the present study was to evaluate whether ACE activity per se may carry prognostic significance for subsequent left ventricular dilation as assessed by echocardiography during 1-year follow-up after acute MI.
3057. Preconditioning of human myocardium with adenosine during coronary angioplasty.
It is unknown whether adenosine can precondition human myocardium against ischemia in vivo.
3058. Fibrinolytic variables and cardiovascular prognosis in patients with stable angina pectoris treated with verapamil or metoprolol. Results from the Angina Prognosis study in Stockholm.
作者: C Held.;P Hjemdahl.;N Rehnqvist.;N H Wallén.;I Björkander.;S V Eriksson.;L Forslund.;B Wiman.
来源: Circulation. 1997年95卷10期2380-6页
Disturbed fibrinolytic function may influence the progression of coronary atherosclerosis and contribute to thrombotic cardiovascular (CV) events.
3059. Randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of AS-013, a prostaglandin E1 prodrug, in patients with intermittent claudication.
作者: J J Belch.;P R Bell.;D Creissen.;J A Dormandy.;R C Kester.;R D McCollum.;Y Mizushima.;C V Ruckley.;J H Scurr.;J H Wolfe.
来源: Circulation. 1997年95卷9期2298-302页
Intermittent claudication due to peripheral arterial occlusive disease (PAOD) is a common cause of pain and disability in the middle-aged. Clinical trials of the potent vasodilator prostaglandin E1 have been disappointing. This is the first report of a controlled clinical trial of AS-0:3, a novel prodrug of prostaglandin E1 incorporated into lipid microspheres that has been developed to improve delivery of the active compound to blood vessel walls.
3060. Differential effects of captopril and nitrates on muscle sympathetic nerve activity in volunteers.
The sympathetic nervous system (SNS) is an important regulator of cardiovascular function. Activation of SNS plays an important role in the pathophysiology and the prognosis of cardiovascular diseases such as heart failure, acute coronary syndromes, arrhythmia, and possibly hypertension. Vasodilators such as adenosine and sodium nitroprusside are known to activate SNS via baroreflex mechanisms. Because vasodilators are widely used in the treatment of patients with cardiovascular diseases, the aim of the present study was to assess the influence of clinically used dosages of isosorbide dinitrate and captopril on sympathetic nerve activity at rest and during stimulatory maneuvers.
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