当前位置: 首页 >> 检索结果
3021. Phentolamine prevents adaptation to ischemia during coronary angioplasty: role of alpha-adrenergic receptors in ischemic preconditioning.
作者: F Tomai.;F Crea.;A Gaspardone.;F Versaci.;A S Ghini.;R De Paulis.;L Chiariello.;P A Gioffrè.
来源: Circulation. 1997年96卷7期2171-7页
Experimental studies indicate that alpha-adrenergic receptors are involved in ischemic preconditioning. Their role in humans is unknown.
3022. Myocardial infarction and cardiac mortality in the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial.
作者: B R Chaitman.;A D Rosen.;D O Williams.;M G Bourassa.;F V Aguirre.;B Pitt.;P M Rautaharju.;W J Rogers.;B Sharaf.;M Attubato.;R M Hardison.;S Srivatsa.;N T Kouchoukos.;K Stocke.;G Sopko.;K Detre.;R Frye.
来源: Circulation. 1997年96卷7期2162-70页
Cardiac mortality and myocardial infarction (MI) rates are used to evaluate the efficacy of coronary artery bypass grafting (CABG) and percutaneous transluminal coronary angioplasty (PTCA). We compared 5-year cardiac mortality and MI rates in 1829 patients with multivessel disease randomized to CABG or PTCA.
3023. Randomized, double-blind comparison of hirulog versus heparin in patients receiving streptokinase and aspirin for acute myocardial infarction (HERO). Hirulog Early Reperfusion/Occlusion (HERO) Trial Investigators.
作者: H D White.;P E Aylward.;M J Frey.;A A Adgey.;R Nair.;W S Hillis.;Y Shalev.;M A Brown.;J K French.;R Collins.;J Maraganore.;B Adelman.
来源: Circulation. 1997年96卷7期2155-61页
Thrombolytic therapy improves survival after myocardial infarction through reperfusion of the infarct-related artery. Thrombin generated during thrombolytic administration may reduce the efficacy of thrombolysis. A direct thrombin inhibitor may improve early patency rates.
3024. Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group.
作者: M H Frick.;M Syvänne.;M S Nieminen.;H Kauma.;S Majahalme.;V Virtanen.;Y A Kesäniemi.;A Pasternack.;M R Taskinen.
来源: Circulation. 1997年96卷7期2137-43页
Studies have shown that treatment of hyperlipidemia, especially lowering of plasma LDL levels, retards the progression of coronary atherosclerosis and prevents clinical cardiovascular events. No such studies have focused on subjects with low levels of HDL cholesterol.
3025. Predictors of arrhythmic death and cardiac arrest in the ESVEM trial. Electrophysiologic Study Versus Electromagnetic Monitoring.
The purpose of this study was to determine if the presenting ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation/cardiac arrest) predicted the type of arrhythmia recurrence in patients treated with antiarrhythmic drugs.
3026. Attenuation of unfavorable remodeling by exercise training in postinfarction patients with left ventricular dysfunction: results of the Exercise in Left Ventricular Dysfunction (ELVD) trial.
作者: P Giannuzzi.;P L Temporelli.;U Corrà.;M Gattone.;A Giordano.;L Tavazzi.
来源: Circulation. 1997年96卷6期1790-7页
Exercise is currently recommended for patients after myocardial infarction; however, the effects of regular exercise on the remodeling process remain to be defined. The aim of this multicenter, randomized study was to investigate whether a long-term physical training program influences left ventricular size and function in postinfarction patients with systolic dysfunction.
3027. Influence of diabetes on 5-year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients with multivessel disease: the Bypass Angioplasty Revascularization Investigation (BARI).
来源: Circulation. 1997年96卷6期1761-9页
Patients with diabetes mellitus have increased morbidity and mortality after coronary revascularization. The Bypass Angioplasty Revascularization Investigation (BARI), a trial of percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass graft surgery (CABG) in patients with multivessel disease, reported a 5-year survival advantage of CABG over PTCA in patients with treated diabetes mellitus (TDM). This report examines these findings in more detail.
3028. High homocysteine levels are independently related to isolated systolic hypertension in older adults.
The association between homocysteine and isolated systolic hypertension in older adults was evaluated using a case-control design, and the relationship between homocysteine and clinical or subclinical atherosclerosis was explored.
3029. Enalapril does not enhance exercise capacity in patients after Fontan procedure.
作者: A A Kouatli.;J A Garcia.;T M Zellers.;E M Weinstein.;L Mahony.
来源: Circulation. 1997年96卷5期1507-12页
Angiotensin-converting enzyme inhibitors improve exercise capacity in adults with congestive heart failure by decreasing systemic vascular resistance and improving ventricular diastolic function. Patients who have undergone the Fontan procedure have decreased cardiac output, increased systemic vascular resistance, abnormal diastolic function, and decreased exercise capacity compared with normal people.
3030. Effects of octreotide treatment on restenosis after coronary angioplasty: results of the VERAS study. VErringerung der Restenoserate nach Angioplastie durch ein Somatostatin-analogon.
作者: R von Essen.;R Ostermaier.;E Grube.;W Mäurer.;U Tebbe.;R Erbel.;M Roth.;W Oel.;J Brom.;G Weidinger.
来源: Circulation. 1997年96卷5期1482-7页
The VERAS study (VErringerung der Restenoserate nach Angioplastie durch ein Somatostatin-analogon [Prevention of Restenosis Following Angioplasty With a Somatostatin Analogue]) was a placebo-controlled trial to evaluate the effects of octreotide for the prevention of restenosis after coronary angioplasty. Octreotide is a somatostatin analogue with antiproliferative properties on smooth muscle cell growth in vitro that limits myointimal thickening of arteries in balloon injury models.
3031. Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. The RESTORE Investigators. Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis.
来源: Circulation. 1997年96卷5期1445-53页
Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platelet glycoprotein (GP) IIb/IIIa that inhibits ex vivo platelet aggregation in response to a variety of agonists.
3032. Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial.
作者: K Wenke.;B Meiser.;J Thiery.;D Nagel.;W von Scheidt.;G Steinbeck.;D Seidel.;B Reichart.
来源: Circulation. 1997年96卷5期1398-402页
Accelerated graft vessel disease (GVD) represents the most serious long-term complication of heart transplantation. A possible cause underlying this progressive coronary vascular disease is believed to be post-transplantation hypercholesterolemia.
3033. Sustained platelet glycoprotein IIb/IIIa blockade with oral xemilofiban in 170 patients after coronary stent deployment.
作者: D J Kereiakes.;N Kleiman.;J J Ferguson.;J P Runyon.;T M Broderick.;N A Higby.;L H Martin.;G Hantsbarger.;S McDonald.;R J Anders.
来源: Circulation. 1997年96卷4期1117-21页
Inhibition of platelet aggregation with parenteral glycoprotein (GP) IIb/IIIa receptor blockers can reduce the ischemic complications of angioplasty. Sustained efficacy and safety of protracted GP IIb/IIIa blockade with an orally administered agent have not previously been determined. This study is the first randomized, dose-ranging, single-blind, placebo-controlled trial of xemilofiban, an oral platelet GP IIb/IIIa receptor antagonist, administered to patients after intracoronary stent deployment. The pharmacodynamic efficacy of xemilofiban-induced platelet inhibition and clinical safety of this agent was evaluated during chronic therapy.
3034. Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina.
作者: F Cipollone.;P Patrignani.;A Greco.;M R Panara.;R Padovano.;F Cuccurullo.;C Patrono.;A G Rebuzzi.;G Liuzzo.;G Quaranta.;A Maseri.
来源: Circulation. 1997年96卷4期1109-16页
We have previously reported aspirin failure in suppressing enhanced thromboxane (TX) biosynthesis in a subset of episodes of platelet activation during the acute phase of unstable angina. The recent discovery of a second prostaglandin H synthase (PGHS-2), inducible in response to inflammatory or mitogenic stimuli, prompted us to reexamine TXA2 biosynthesis in unstable angina as modified by two cyclooxygenase inhibitors differentially affecting PGHS-2 despite a comparable impact on platelet PGHS-1.
3035. Comparative effects of enalapril and verapamil on myocardial blood flow in systemic hypertension.
作者: O Parodi.;D Neglia.;C Palombo.;G Sambuceti.;A Giorgetti.;C Marabotti.;M Gallopin.;I Simonetti.;A L'Abbate.
来源: Circulation. 1997年96卷3期864-73页
The comparative effects of calcium channel blockers and ACE inhibitors on myocardial blood flow (MBF) in hypertensive patients after long-term treatment are still unknown.
3036. Effect of the calcium antagonist felodipine as supplementary vasodilator therapy in patients with chronic heart failure treated with enalapril: V-HeFT III. Vasodilator-Heart Failure Trial (V-HeFT) Study Group.
作者: J N Cohn.;S Ziesche.;R Smith.;I Anand.;W B Dunkman.;H Loeb.;G Cintron.;W Boden.;L Baruch.;P Rochin.;L Loss.
来源: Circulation. 1997年96卷3期856-63页
Despite therapy with diuretics, ACE inhibitors and digoxin morbidity and mortality in heart failure remain high and might respond favorably to an additional vasodilator.
3037. Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators.
作者: G A Lamas.;G F Mitchell.;G C Flaker.;S C Smith.;B J Gersh.;L Basta.;L Moyé.;E Braunwald.;M A Pfeffer.
来源: Circulation. 1997年96卷3期827-33页
Mitral regurgitation (MR) may complicate acute myocardial infarction (MI). However, it is not known whether mild MR is an independent predictor of post-MI outcome.
3038. Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: a pilot study. Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators.
来源: Circulation. 1997年96卷3期769-77页
Despite the use of aspirin and heparin, patients with acute ischemic syndromes are at risk of myocardial infarction (MI) or refractory ischemia. Therefore, evaluation of more potent antithrombotic therapies is warranted.
3039. Danish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction.
作者: J K Madsen.;P Grande.;K Saunamäki.;P Thayssen.;E Kassis.;U Eriksen.;K Rasmussen.;S Haunsø.;T T Nielsen.;T Haghfelt.;P Fritz-Hansen.;E Hjelms.;P K Paulsen.;P Alstrup.;H Arendrup.;U Niebuhr-Jørgensen.;L I Andersen.
来源: Circulation. 1997年96卷3期748-55页
The aim of the DANish trial in Acute Myocardial Infarction (DANAMI) study was to compare an invasive strategy of percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG) with a conservative strategy in patients with inducible myocardial ischemia who received thrombolytic treatment for a first acute myocardial infarction (AMI).
3040. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training.
作者: H E Montgomery.;P Clarkson.;C M Dollery.;K Prasad.;M A Losi.;H Hemingway.;D Statters.;M Jubb.;M Girvain.;A Varnava.;M World.;J Deanfield.;P Talmud.;J R McEwan.;W J McKenna.;S Humphries.
来源: Circulation. 1997年96卷3期741-7页
The absence (deletion allele [D]) of a 287-base pair marker in the ACE gene is associated with higher ACE levels than its presence (insertion allele [I]). If renin-angiotensin systems regulate left ventricular (LV) growth, then individuals of DD genotype might show a greater hypertrophic response than those of II genotype. We tested this hypothesis by studying exercise-induced LV hypertrophy.
|