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281. Artemether as a modulator of EMT in colorectal cancer: enhancing radiosensitivity and reversing chemo-radiation resistance.
作者: Lv Ge.;Shan Liu.;Shenglan Yu.;Ming Li.;Wanni Zhang.;Chunmao Xie.;Zhuo Gao.;Sijia Tang.;Minqi Xiao.;Tao Zou.;Yongxin Jiang.;Hu Lu.
来源: BMC Gastroenterol. 2026年26卷1期
The efficacy of conventional chemoradiotherapy for colorectal cancer is often limited by resistance, with epithelial-mesenchymal transition being a key mechanism. Although the artemisinin derivative artemether (ARE) has shown antitumor potential, it remains unclear whether it can enhance radiosensitivity and reverse chemo-radiation resistance in colorectal cancer by regulating EMT. This study aimed to investigate the radiosensitizing and resistance-reversing effects of ARE on human colorectal cancer xenografts in nude mice and to elucidate the underlying mechanism related to EMT regulation.
282. Automatic processing of gastrointestinal endoscopy referrals and patient instructions using large language models.
作者: Yuri Gorelik.;Eyas Awawdeh.;Shiri Fistel.;Ariel Gralnek.;Amir Klein.
来源: BMC Gastroenterol. 2026年26卷1期
Open-access endoscopy relies on referrals that are manually vetted, which is a resource consuming process, with potential biases. While Large Language Models (LLMs) have demonstrated potential in medical utilities, their ability to autonomously manage complex referral logistics remains understudied. We assessed whether LLMs can provide accurate recommendations on gastrointestinal endoscopy referrals.
283. Knowledge on modes of hepatitis B transmission and the practice of family screening and vaccination among patients with chronic hepatitis B infection at a tertiary center in Ethiopia.
作者: Sewale Anagaw.;Hailemichael Desalegn.;Arsema Goytom.;Henok Fisseha.;Kinfe Woldu.;Bizatu Mengistie.
来源: BMC Gastroenterol. 2026年26卷1期
Hepatitis B infection remains an important global public health problem. Screening and vaccination of family contacts are among the key interventions to control hepatitis B. The objective of this study was to assess the knowledge on modes of transmission of hepatitis B and the practice of family screening and vaccination among patients with chronic hepatitis B infection who had follow-ups at a tertiary center in Ethiopia.
284. Risk factors for significant hepatic fibrosis in alcoholic liver disease and construction of a nomogram prediction model.
Significant fibrosis represents a critical stage in the progression of Alcoholic Liver Disease (ALD) to cirrhosis. Early identification of significant hepatic fibrosis is crucial for treatment and prognosis. This study aims to investigate risk factors for significant hepatic fibrosis in ALD patients via clinical data analysis and establish a nomogram for risk prediction.
285. Endoscopic ultrasound-guided gastroenterostomy: an emerging modality for the treatment of malignant gastrointestinal obstruction.
作者: Muaaz Masood.;Nihaal Karnik.;Shayan Irani.;Rajesh Krishnamoorthi.
来源: Minerva Gastroenterol (Torino). 2026年72卷1期119-122页 286. Recompensation following first decompensation in patients with alcohol-related cirrhosis.
作者: Ji Yoon Kwak.;Hankyu Jeon.;Hyeon Uk Kwon.;Jae Eun Kim.;Ji Hee Han.;Jung Woo Choi.;Ra Ri Cha.;Jae Min Lee.;Sang Soo Lee.
来源: BMC Gastroenterol. 2026年26卷1期
The Baveno VII consensus recently introduced the term “recompensated cirrhosis,” but its prognostic relevance in alcohol-related cirrhosis remains unclear. This study aims to analyze the frequency and associated factors of recompensation in patients with alcohol-related cirrhosis following the first decompensation and evaluate the prognosis based on recompensation status.
287. Adolescent Risk Factors for the Presence and Persistence of Irritable Bowel Syndrome in Young Adulthood-Findings From a Prospective Birth Cohort.
作者: Jessica Sjölund.;Jóhann P Hreinsson.;Anna Bergström.;Hans Törnblom.;Magnus Simrén.;Ola Olén.
来源: Gastroenterology. 2026年 288. Forecasting the Incidence and Prevalence of Inflammatory Bowel Disease Across Nine Epidemiologic Stage 3 Nations.
作者: Stephanie Coward.;Eduard Brunet-Mash.;Johan Burisch.;Peter L Lakatos.;Edward V Loftus.;Gilaad G Kaplan.; .
来源: Gastroenterology. 2026年 289. The impact of gastroesophageal reflux disease in East Asia and China between 1990 and 2021: insights from the 2021 global burden of disease research.
作者: Chengying Zhu.;Zeming Le.;Zhanjun Lu.;Zihao Guo.;Guo Yu.;Zhiyuan Cheng.;Changjie Zhao.;Rong Wan.;Weiliang Jiang.;Wenqin Xiao.
来源: BMC Gastroenterol. 2026年26卷1期
Gastroesophageal reflux disease (GERD) is a common chronic digestive disorder with a growing epidemiological footprint worldwide. However, the specific characteristics and burden of GERD in East Asia, particularly in China, remain insufficiently documented.
290. The mediating role of resilience in the relationship between cognitive flexibility and psychological well-being in patients with irritable bowel syndrome: a cross-sectional study.
作者: Mohammad Reza Tamannaeifar.;Zahra Shirani.;Mahboobe Esmikhani.;Zeinab Zaremohzzabieh.
来源: BMC Gastroenterol. 2026年26卷1期
Irritable bowel syndrome (IBS) is one of the most common brain-gut interaction disorders, characterized by chronic abdominal pain, altered bowel habits, and heightened stress responses that significantly affect patients' psychological functioning and quality of life. Given that chronic stress plays a central role in the onset and maintenance of IBS symptoms, identifying psychological resources that promote adaptation and well-being is crucial. The present study aimed to examine the mediating role of resilience in the relationship between cognitive flexibility and psychological well-being among patients with IBS.
291. Multicenter Prospective Cohort Study on Clinical Outcomes and Fibrosis Patterns in Biopsy-Proven Steatotic Liver Disease Subtypes.
作者: Gi-Ae Kim.;Heejoon Jang.;Moon Young Kim.;Jeong Hwan Park.;Jung Gil Park.;Eun-Young Cho.;Jae Yoon Jeong.;Seogsong Jeong.;Seul Ki Han.;Heesu Kwon.;Youngae Jung.;Geum-Sook Hwang.;Yu Rim Lee.;Soo Young Park.;Sang Gyune Kim.;Won Kim.
来源: Gastroenterology. 2026年
Clinical outcomes and histologic characteristics of biopsy-proven steatotic liver disease (SLD) subtypes remain understudied. We investigated clinical outcomes and fibrosis patterns in metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-related liver disease (MetALD), and alcohol-associated liver disease (ALD).
292. Vonoprazan-Tetracycline Dual Regimen as Rescue Therapy for Helicobacter pylori Infection: Randomized Controlled Trial.
作者: Wen Gao.;Jingwen Li.;Guibin Yang.;Shiyu Du.;Tingsheng Ling.;Xuezhi Zhang.;Hui Ye.;Yihong Xiong.;Yuling Tian.;Jianxiang Liu.;Binbin Liu.;Chi Wang.;Hong Cheng.
来源: Gastroenterology. 2026年
Treatment of Helicobacter pylori infection after previous eradication failure remains challenging. This study evaluated the efficacy and safety of a vonoprazan-tetracycline (VT) dual regimen as a potential rescue therapy.
293. Transanal Endoscopic Microsurgery or Endoscopic Submucosal Dissection in Early Rectal Tumors: A Clinical and Cost-Effectiveness Analysis: The MUCEM Study.
作者: Laura Beyer-Berjot.;Coralie Delettrez.;Jérémie Jacques.;Philippe Rouanet.;Stanislas Chaussade.;Jérémie H Lefèvre.;Edouard Chabrun.;Stéphane Koch.;Jean-Jacques Tuech.;Valérie Bridoux.;Eric Rullier.;Quentin Denost.;Yves Panis.;Léon Maggiori.;Stéphane Benoist.;Antoine Brouquet.;Marc Barthet.;Jean-Michel Gonzalez.;Eddy Cotte.;Justine Arquillière.;Mehrdad Jafari.;Guillaume Meurette.;Laurent Poincloux.;Philippe Zerbib.;Jean-Marc Regimbeau.;Charles Sabbagh.;Michel Prudhomme.;Romain Legros.;Stéphane Berdah.;Benoît Dervaux.;Mohamed Boucekine.;Fanette Denies.;Jérôme Rivory.;Karine Baumstarck.;Mathieu Pioche.;Vincent Lepilliez.
来源: Gastroenterology. 2026年
For the local excision of early rectal tumors (ERTs), the relative effectiveness of endoscopic submucosal dissection (ESD) vs transanal endoscopic microsurgery (TEM) is subject to debate. The comparisons are limited to retrospective, single-center studies lacking a health economic assessment.
298. Serum aberrant expression of miR-331-3p and its diagnostic value in severe pancreatitis.
Severe acute pancreatitis (SAP) is characterized by persistent organ failure and a high mortality rate, early diagnosis and disease assessment are crucial for improving patient prognosis.
299. Transjugular liver biopsy in patients with unexplained liver dysfunction and bleeding tendency: a safety and efficacy analysis.
作者: Zhiyuan Zheng.;Minjie Yang.;Lili Ma.;Jingqin Ma.;Zihan Zhang.;Jian Wang.;Yuan Ji.;Shiyao Chen.;Jianjun Luo.;Zhiping Yan.;Xiaolin Wang.;Wen Zhang.
来源: BMC Gastroenterol. 2026年26卷1期
Transjugular liver biopsy (TJLB) enables histopathological diagnosis of liver disease and simultaneous assessment of the hepatic venous pressure gradient (HVPG).
300. Evaluation of efficacy of a polyglycolic acid sheet in laparoscopic gastrectomy for gastric cancer: a single-center retrospective study.
作者: Senichiro Yanagawa.;Yuji Yamamoto.;Tetsushi Nakagawa.;Mizuki Yamaguchi.;Shohei Shiozaki.;Kazuaki Tanabe.;Masahiro Nakahara.;Toshio Noriyuki.
来源: BMC Gastroenterol. 2026年26卷1期
Gastric cancer (GC) is one of the most common causes of cancer-related deaths worldwide. Gastrectomy with lymph node dissection is the standard treatment for GC worldwide. Due to advancements in surgical techniques, the use of laparoscopic gastrectomy (LG) has broadened. However, the incidence of post-operative pancreatic fistula (POPF) after LG is higher than that after open surgery, and the definition and measurement of POPF in gastrectomy have not yet been established. We introduced polyglycolic acid (PGA) sheet to prevent POPF after LG and retrospectively evaluated its effectiveness.
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