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281. Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A.
作者: Alok Srivastava.;Aby Abraham.;Fouzia Aboobacker.;Gurbind Singh.;Tulasi Geevar.;Uday Kulkarni.;Sushil Selvarajan.;Anu Korula.;Rutvi Gautam Dave.;Mohana Shankar.;Abraham S Singh.;Anbu Jeba.;Navien Kumaar.;Christopher Benjamin.;Kavitha M Lakshmi.;Vivi Miriam Srivastava.;Ramachandran V Shaji.;Sukesh C Nair.;Harrison C Brown.;Gabriela Denning.;Pete Lollar.;Christopher B Doering.;Trent Spencer.
来源: N Engl J Med. 2025年392卷5期450-457页
Severe hemophilia A is managed with factor VIII replacement or hemostatic products that stop or prevent bleeding. Data on gene therapy with hematopoietic stem-cell (HSC)-based expression of factor VIII for the treatment of severe hemophilia A are lacking.
282. Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage.
作者: Shane W English.;Anthony Delaney.;Dean A Fergusson.;Michaël Chassé.;Alexis F Turgeon.;François Lauzier.;Angie Tuttle.;Ofer Sadan.;Donald E Griesdale.;Gary Redekop.;Martin Chapman.;Mathew Hannouche.;Andreas Kramer.;Ian Seppelt.;Andrew Udy.;Demetrios J Kutsogiannis.;Ryan Zarychanski.;Frédérick D'Aragon.;J Gordon Boyd.;Gavin Salt.;Judith Bellapart.;Gordon Wood.;Luis Cava.;Gwynedd Pickett.;Lauren Koffman.;Irene Watpool.;Frances Bass.;Naomi Hammond.;Tim Ramsay.;Ranjeeta Mallick.;Damon C Scales.;Christopher R Andersen.;Emily Fitzgerald.;Phil Talbot.;Dar Dowlatshahi.;John Sinclair.;Jason Acker.;Shawn C Marshall.;Lauralyn McIntyre.; .; .
来源: N Engl J Med. 2025年392卷11期1079-1088页
The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear.
283. Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma.
作者: Meletios A Dimopoulos.;Peter M Voorhees.;Fredrik Schjesvold.;Yael C Cohen.;Vania Hungria.;Irwindeep Sandhu.;Jindriska Lindsay.;Ross I Baker.;Kenshi Suzuki.;Hiroshi Kosugi.;Mark-David Levin.;Meral Beksac.;Keith Stockerl-Goldstein.;Albert Oriol.;Gabor Mikala.;Gonzalo Garate.;Koen Theunissen.;Ivan Spicka.;Anne K Mylin.;Sara Bringhen.;Katarina Uttervall.;Bartosz Pula.;Eva Medvedova.;Andrew J Cowan.;Philippe Moreau.;Maria-Victoria Mateos.;Hartmut Goldschmidt.;Tahamtan Ahmadi.;Linlin Sha.;Annelore Cortoos.;Eva G Katz.;Els Rousseau.;Liang Li.;Robyn M Dennis.;Robin Carson.;S Vincent Rajkumar.; .
来源: N Engl J Med. 2025年392卷18期1777-1788页
Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a precursor disease of active multiple myeloma for which no treatments have been approved.
284. Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children.
作者: Sumit Gupta.;Rachel E Rau.;John A Kairalla.;Karen R Rabin.;Cindy Wang.;Anne L Angiolillo.;Sarah Alexander.;Andrew J Carroll.;Susan Conway.;Lia Gore.;Ilan Kirsch.;Holly R Kubaney.;Amanda M Li.;Jennifer L McNeer.;Olga Militano.;Tamara P Miller.;Yvonne Moyer.;Maureen M O'Brien.;Maki Okada.;Shalini C Reshmi.;Mary Shago.;Elizabeth Wagner.;Naomi Winick.;Brent L Wood.;Tara Haworth-Wright.;Faraz Zaman.;Gerhard Zugmaier.;Sue Zupanec.;Meenakshi Devidas.;Stephen P Hunger.;David T Teachey.;Elizabeth A Raetz.;Mignon L Loh.
来源: N Engl J Med. 2025年392卷9期875-891页
B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common childhood cancer. Despite a high overall cure rate, relapsed B-cell ALL remains a leading cause of cancer-related death among children. The addition of the bispecific T-cell engager molecule blinatumomab (an anti-CD19 and anti-CD3 single-chain molecule) to therapy for newly diagnosed standard-risk (as defined by the National Cancer Institute) B-cell ALL in children may improve outcomes.
285. Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia.
作者: Claire Roddie.;Karamjeet S Sandhu.;Eleni Tholouli.;Aaron C Logan.;Paul Shaughnessy.;Pere Barba.;Armin Ghobadi.;Manuel Guerreiro.;Deborah Yallop.;Mehrdad Abedi.;Jeremy M Pantin.;Jean A Yared.;Amer M Beitinjaneh.;Sridhar Chaganti.;Katharine Hodby.;Tobias Menne.;Martha L Arellano.;Ram Malladi.;Bijal D Shah.;Luke Mountjoy.;Kristen M O'Dwyer.;Karl S Peggs.;Pierre Lao-Sirieix.;Yiyun Zhang.;Wolfram Brugger.;Edgar Braendle.;Martin Pule.;Michael R Bishop.;Daniel J DeAngelo.;Jae H Park.;Elias Jabbour.
来源: N Engl J Med. 2024年391卷23期2219-2230页
Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve persistence.
286. Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer.
作者: Thierry Andre.;Elena Elez.;Eric Van Cutsem.;Lars Henrik Jensen.;Jaafar Bennouna.;Guillermo Mendez.;Michael Schenker.;Christelle de la Fouchardiere.;Maria Luisa Limon.;Takayuki Yoshino.;Jin Li.;Heinz-Josef Lenz.;Jose Luis Manzano Mozo.;Giampaolo Tortora.;Rocio Garcia-Carbonero.;Laetitia Dahan.;Myriam Chalabi.;Rohit Joshi.;Eray Goekkurt.;Maria Ignez Braghiroli.;Timucin Cil.;Elvis Cela.;Tian Chen.;Ming Lei.;Matthew Dixon.;Sandzhar Abdullaev.;Sara Lonardi.; .
来源: N Engl J Med. 2024年391卷21期2014-2026页
Patients with microsatellite-instability-high (MSI-H) or mismatch-repair-deficient (dMMR) metastatic colorectal cancer have poor outcomes with standard chemotherapy with or without targeted therapies. Nivolumab plus ipilimumab has shown clinical benefit in nonrandomized studies of MSI-H or dMMR metastatic colorectal cancer.
287. Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam.
作者: Lay-Myint Yoshida.;Michiko Toizumi.;Hien Anh Thi Nguyen.;Billy J Quilty.;Le Thuy Lien.;Le Huy Hoang.;Chihiro Iwasaki.;Mizuki Takegata.;Noriko Kitamura.;Monica L Nation.;Jason Hinds.;Kevin van Zandvoort.;Belinda D Ortika.;Eileen M Dunne.;Catherine Satzke.;Hung Thai Do.;Kim Mulholland.;Stefan Flasche.;Duc-Anh Dang.
来源: N Engl J Med. 2024年391卷21期1992-2002页
After pneumococcal disease and colonization have been controlled through vaccination campaigns, a reduced pneumococcal conjugate vaccine (PCV) schedule may be sufficient to sustain that control at reduced costs.
288. Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons.
作者: Colleen F Kelley.;Maribel Acevedo-Quiñones.;Allison L Agwu.;Anchalee Avihingsanon.;Paul Benson.;Jill Blumenthal.;Cynthia Brinson.;Carlos Brites.;Pedro Cahn.;Valeria D Cantos.;Jesse Clark.;Meredith Clement.;Cathy Creticos.;Gordon Crofoot.;Ricardo S Diaz.;Susanne Doblecki-Lewis.;Jorge A Gallardo-Cartagena.;Aditya Gaur.;Beatriz Grinsztejn.;Shawn Hassler.;Juan Carlos Hinojosa.;Theo Hodge.;Richard Kaplan.;Marcus Lacerda.;Anthony LaMarca.;Marcelo H Losso.;José Valdez Madruga.;Kenneth H Mayer.;Anthony Mills.;Karam Mounzer.;Nkosiphile Ndlovu.;Richard M Novak.;Alma Perez Rios.;Nittaya Phanuphak.;Moti Ramgopal.;Peter J Ruane.;Jorge Sánchez.;Breno Santos.;Patric Schine.;Tanya Schreibman.;LaShonda Y Spencer.;Olivia T Van Gerwen.;Ricardo Vasconcelos.;Jose Gabriel Vasquez.;Zwelethu Zwane.;Stephanie Cox.;Chris Deaton.;Ramin Ebrahimi.;Pamela Wong.;Renu Singh.;Lillian B Brown.;Christoph C Carter.;Moupali Das.;Jared M Baeten.;Onyema Ogbuagu.; .
来源: N Engl J Med. 2025年392卷13期1261-1276页
Twice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of human immunodeficiency virus (HIV) infection in cisgender women. The efficacy of lenacapavir for preexposure prophylaxis (PrEP) in cisgender men, transgender women, transgender men, and gender-nonbinary persons is unclear.
289. Aggressive Lymphoma after CD19 CAR T-Cell Therapy.
作者: Guido Kobbe.;Monika Brüggemann.;Ben-Niklas Baermann.;Laura Wiegand.;Heiko Trautmann.;Schayan Yousefian.;Silvana Libertini.;Hans D Menssen.;Harald J Maier.;Peter Ulrich.;Jingbo Gao.;Peter-Martin Bruch.;Nora Liebers.;Aleksandar Radujkovic.;Marc Seifert.;Christina Schniederjohann.;Nagarajan Paramasivam.;Donnacha Fitzgerald.;Maximilian Seidel.;Irene Esposito.;Ulrich Germing.;Ron-Patrick Cadeddu.;Kathrin Nachtkamp.;Paul Jäger.;Thomas Ulrych.;Johannes C Fischer.;Jutta M Rox.;Frederik Giesel.;Raphael Koch.;Gerald Antoch.;Jörg H W Distler.;Sven G Meuth.;Malte Jacobsen.;Daniel Hübschmann.;Junyan Lu.;Ingram Iaccarino.;Simon Haas.;Frederik Damm.;Sascha Dietrich.
来源: N Engl J Med. 2024年391卷13期1217-1226页
The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months earlier for autologous transplantation. Somatic DNMT3A and TET2 mutations in CD34+ stem cells and their progeny were detected in the PTCL, in the apheresis specimen that was obtained for CAR T-cell production, and in the autotransplant. The PTCL harbored an additional somatic TET2 mutation, which was already detectable in the CAR T-cell apheresis product and the final CAR T-cell product at very low frequencies, providing evidence that clonal hematopoiesis had contributed to lymphomagenesis.
290. Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.
作者: Seth P Lerner.;Catherine Tangen.;Robert S Svatek.;Siamak Daneshmand.;Kamal S Pohar.;Eila Skinner.;Anne Schuckman.;Arthur I Sagalowsky.;Norm D Smith.;Ashish M Kamat.;Wassim Kassouf.;Melissa Plets.;Rick Bangs.;Theresa M Koppie.;Ajjai Alva.;Francisco G La Rosa.;Sumanta K Pal.;Adam S Kibel.;Daniel J Canter.;Ian M Thompson.; .
来源: N Engl J Med. 2024年391卷13期1206-1216页
Whether extended lymphadenectomy is associated with improved disease-free and overall survival, as compared with standard lymphadenectomy, among patients with localized muscle-invasive bladder cancer undergoing radical cystectomy is unclear.
291. Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite.
作者: Olivia A C Lamers.;Blandine M D Franke-Fayard.;Jan Pieter R Koopman.;Geert V T Roozen.;Jacqueline J Janse.;Severine C Chevalley-Maurel.;Fiona J A Geurten.;Helena M de Bes-Roeleveld.;Eva Iliopoulou.;Emil Colstrup.;Els Wessels.;Geert-Jan van Gemert.;Marga van de Vegte-Bolmer.;Wouter Graumans.;Thabitha R Stoter.;Benjamin G Mordmüller.;Emma L Houlder.;Teun Bousema.;Rajagopal Murugan.;Matthew B B McCall.;Chris J Janse.;Meta Roestenberg.
来源: N Engl J Med. 2024年391卷20期1913-1923页
Currently licensed and approved malaria subunit vaccines provide modest, short-lived protection against malaria. Immunization with live-attenuated Plasmodium falciparum malaria parasites is an alternative vaccination strategy that has potential to improve protection.
292. Middle Meningeal Artery Embolization for Nonacute Subdural Hematoma.
作者: Jianmin Liu.;Wei Ni.;Qiao Zuo.;Heng Yang.;Ya Peng.;Zhiqing Lin.;Zhenbao Li.;Jiyue Wang.;Yong Zhen.;Jing Luo.;Yuanxiang Lin.;Jian Chen.;Xuming Hua.;Hua Lu.;Ming Zhong.;Mingfa Liu.;Jianmin Zhang.;Yang Wang.;Jieqing Wan.;Yi Li.;Tianxiao Li.;Guohua Mao.;Wenyuan Zhao.;Liang Gao.;Conghui Li.;E Chen.;Xin Cheng.;Ping Zhang.;Zigao Wang.;Lei Chen.;Yongxin Zhang.;Bing Tian.;Fang Shen.;Yu Lei.;Yina Wu.;Yanjiang Li.;Guoli Duan.;Liquan Xu.;Nan Lv.;Jian Yu.;Xiaolong Xu.;Zhuoying Du.;Hongjian Zhang.;Jin Hu.;Zifu Li.;Qiang Yuan.;Yu Zhou.;Gang Wu.;Lei Zhang.;Chao Gao.;Dongwei Dai.;Xuehai Wu.;Yongwei Zhang.;Hanqiang Jiang.;Rui Zhao.;Jiabin Su.;Yi Xu.;Johanna Maria Ospel.;Charles B L M Majoie.;Mayank Goyal.;Qiang Li.;Pengfei Yang.;Yuxiang Gu.;Ying Mao.; .
来源: N Engl J Med. 2024年391卷20期1901-1912页
The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.
293. Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma.
作者: Jason M Davies.;Jared Knopman.;Maxim Mokin.;Ameer E Hassan.;Robert E Harbaugh.;Alexander Khalessi.;Jens Fiehler.;Bradley A Gross.;Ramesh Grandhi.;Jason Tarpley.;Walavan Sivakumar.;Mark Bain.;R Webster Crowley.;Thomas W Link.;Justin F Fraser.;Michael R Levitt.;Peng Roc Chen.;Ricardo A Hanel.;Joe D Bernard.;Mouhammad Jumaa.;Patrick Youssef.;Marshall C Cress.;Mohammad Imran Chaudry.;Hakeem J Shakir.;Walter S Lesley.;Joshua Billingsley.;Jesse Jones.;Matthew J Koch.;Alexandra R Paul.;William J Mack.;Joshua W Osbun.;Kathleen Dlouhy.;Jonathan A Grossberg.;Christopher P Kellner.;Daniel H Sahlein.;Justin Santarelli.;Clemens M Schirmer.;Justin Singer.;Jesse J Liu.;Aniel Q Majjhoo.;Thomas Wolfe.;Neil V Patel.;Christopher Roark.;Adnan H Siddiqui.; .
来源: N Engl J Med. 2024年391卷20期1890-1900页
Subacute and chronic subdural hematomas are common and frequently recur after surgical evacuation. The effect of adjunctive middle meningeal artery embolization on the risk of reoperation remains unclear.
294. Nationwide, Couple-Based Genetic Carrier Screening.
作者: Edwin P Kirk.;Martin B Delatycki.;Alison D Archibald.;Erin Tutty.;Jade Caruana.;Jane L Halliday.;Sharon Lewis.;Belinda J McClaren.;Ainsley J Newson.;Lisa Dive.;Stephanie Best.;Janet C Long.;Jeffrey Braithwaite.;Martin J Downes.;Paul A Scuffham.;John Massie.;Kristine Barlow-Stewart.;Abhi Kulkarni.;Amy Ruscigno.;Anaita Kanga-Parabia.;Bianca Rodrigues.;Bruce H Bennetts.;Camron Ebzery.;Clare Hunt.;Corrina C Cliffe.;Crystle Lee.;Dimitar Azmanov.;Emily A King.;Evanthia O Madelli.;Futao Zhang.;Gladys Ho.;Isabelle Danos.;Jan Liebelt.;Janice Fletcher.;Jillian Kennedy.;John Beilby.;Jon D Emery.;Julie McGaughran.;Justine E Marum.;Katrina Scarff.;Katrina Fisk.;Katrina Harrison.;Kirsten Boggs.;Lana Giameos.;Lara Fitzgerald.;Lauren Thomas.;Leslie Burnett.;Lucinda Freeman.;Madeleine Harris.;Marina Berbic.;Mark R Davis.;Marta Cifuentes Ochoa.;Mathew Wallis.;Meaghan Wall.;Melissa T M Chow.;Monica M Ferrie.;Nicholas Pachter.;Nila Quayum.;Nitzan Lang.;Praveena Kasi Pandy.;Rachael Casella.;Richard J N Allcock.;Royston Ong.;Samantha Edwards.;Samantha Sundercombe.;Sarah Jelenich.;Sarah Righetti.;Sebastian Lunke.;Sharanbeer Kaur.;Sharyn Stock-Myer.;Stefanie Eggers.;Susan P Walker.;Tahlia Theodorou.;Tara Catchpool.;Tenielle Clinch.;Tony Roscioli.;Tristan Hardy.;Ying Zhu.;Zoe Fehlberg.;Tiffany F Boughtwood.;Nigel G Laing.; .; .
来源: N Engl J Med. 2024年391卷20期1877-1889页
Genomic sequencing technology allows for identification of reproductive couples with an increased chance, as compared with that in the general population, of having a child with an autosomal recessive or X-linked genetic condition.
295. Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma.
作者: David Fiorella.;Stephen J Monteith.;Ricardo Hanel.;Benjamin Atchie.;SoHyun Boo.;Ryan A McTaggart.;Alois Zauner.;Stavropoula Tjoumakaris.;Charlotte Barbier.;Ronald Benitez.;Laurent Spelle.;Laurent Pierot.;Joshua A Hirsch.;Michael Froehler.;Adam S Arthur.; .
来源: N Engl J Med. 2025年392卷9期855-864页
Patients receiving standard treatment for chronic subdural hematoma have a high risk of treatment failure. The effect of adjunctive middle meningeal artery embolization on the risk of treatment failure in this population remains unknown.
296. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.
作者: .;Nick Daneman.;Asgar Rishu.;Ruxandra Pinto.;Benjamin A Rogers.;Yahya Shehabi.;Rachael Parke.;Deborah Cook.;Yaseen Arabi.;John Muscedere.;Steven Reynolds.;Richard Hall.;Dhiraj B Dwivedi.;Colin McArthur.;Shay McGuinness.;Dafna Yahav.;Bryan Coburn.;Anna Geagea.;Pavani Das.;Phillip Shin.;Michael Detsky.;Andrew Morris.;Michael Fralick.;Jeff E Powis.;Christopher Kandel.;Wendy Sligl.;Sean M Bagshaw.;Nishma Singhal.;Emilie Belley-Cote.;Richard Whitlock.;Kosar Khwaja.;Susan Morpeth.;Alex Kazemi.;Anthony Williams.;Derek R MacFadden.;Lauralyn McIntyre.;Jennifer Tsang.;Francois Lamontagne.;Alex Carignan.;John Marshall.;Jan O Friedrich.;Robert Cirone.;Mark Downing.;Christopher Graham.;Joshua Davis.;Erick Duan.;John Neary.;Gerald Evans.;Basem Alraddadi.;Sameera Al Johani.;Claudio Martin.;Sameer Elsayed.;Ian Ball.;Francois Lauzier.;Alexis Turgeon.;Henry T Stelfox.;John Conly.;Emily G McDonald.;Todd C Lee.;Richard Sullivan.;Jennifer Grant.;Ilya Kagan.;Paul Young.;Cassie Lawrence.;Kevin O'Callaghan.;Matthew Eustace.;Keat Choong.;Pierre Aslanian.;Ulrike Buehner.;Tom Havey.;Alexandra Binnie.;Josef Prazak.;Brenda Reeve.;Edward Litton.;Sylvain Lother.;Anand Kumar.;Ryan Zarychanski.;Tomer Hoffman.;David Paterson.;Peter Daley.;Robert J Commons.;Emmanuel Charbonney.;Jean-Francois Naud.;Sally Roberts.;Ravindranath Tiruvoipati.;Sachin Gupta.;Gordon Wood.;Omar Shum.;Spiros Miyakis.;Peter Dodek.;Clement Kwok.;Robert A Fowler.; .
来源: N Engl J Med. 2025年392卷11期1065-1078页
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain.
297. Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease.
作者: Barry Greenberg.;Matthew Taylor.;Eric Adler.;Steven Colan.;David Ricks.;Paul Yarabe.;Pavan Battiprolu.;Gaurav Shah.;Kinnari Patel.;Matthew Coggins.;Susanna Carou-Keenan.;Jonathan D Schwartz.;Joseph W Rossano.
来源: N Engl J Med. 2025年392卷10期972-983页
Danon disease is a rare, X-linked, monogenic cardiomyopathy caused by mutations in the lysosomal-associated membrane 2 gene (LAMP2), which encodes the LAMP2 protein. In male patients, the predominant phenotype is progressive cardiac hypertrophy, cardiac dysfunction, and early death. There are no directed therapies for the disease.
298. CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy.
作者: Marianna Fontana.;Scott D Solomon.;Jessica Kachadourian.;Liron Walsh.;Ricardo Rocha.;David Lebwohl.;Derek Smith.;Jörg Täubel.;Edward J Gane.;Björn Pilebro.;David Adams.;Yousuf Razvi.;Joy Olbertz.;Alexandra Haagensen.;Peijuan Zhu.;Yuanxin Xu.;Adia Leung.;Alison Sonderfan.;David E Gutstein.;Julian D Gillmore.
来源: N Engl J Med. 2024年391卷23期2231-2241页
Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats and associated Cas9 endonuclease) targeting the gene encoding transthyretin (TTR).
299. Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.
作者: Yufang Bi.;Mian Li.;Yan Liu.;Tingzhi Li.;Jieli Lu.;Peng Duan.;Fengmei Xu.;Qijuan Dong.;Ailiang Wang.;Tiange Wang.;Ruizhi Zheng.;Yuhong Chen.;Min Xu.;Xiaohu Wang.;Xinhuan Zhang.;Yanbo Niu.;Zhiqiang Kang.;Chunru Lu.;Jing Wang.;Xinwen Qiu.;An Wang.;Shujing Wu.;Jingya Niu.;Jingya Wang.;Zhiyun Zhao.;Huanfeng Pan.;Xiaohua Yang.;Xiaohong Niu.;Shuguang Pang.;Xiaoliang Zhang.;Yuancheng Dai.;Qin Wan.;Shihong Chen.;Qidong Zheng.;Shaoping Dai.;Juan Deng.;Leshan Liu.;Guixia Wang.;Huiqi Zhu.;Weidong Tang.;Haixia Liu.;Zhenfang Guo.;Guang Ning.;Jiang He.;Yu Xu.;Weiqing Wang.; .
来源: N Engl J Med. 2025年392卷12期1155-1167页
Effective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.
300. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.
作者: Milton Packer.;Michael R Zile.;Christopher M Kramer.;Seth J Baum.;Sheldon E Litwin.;Venu Menon.;Junbo Ge.;Govinda J Weerakkody.;Yang Ou.;Mathijs C Bunck.;Karla C Hurt.;Masahiro Murakami.;Barry A Borlaug.; .
来源: N Engl J Med. 2025年392卷5期427-437页
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, causes considerable weight loss, but data are lacking with respect to its effects on cardiovascular outcomes.
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