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283. A 12,000-Year-Old Case of NPR2-Related Acromesomelic Dysplasia.
作者: Daniel M Fernandes.;Alejandro Llanos-Lizcano.;Florian Brück.;Victoria Oberreiter.;Kadir T Özdoğan.;Olivia Cheronet.;Michaela Lucci.;Albert Beckers.;Patrick Pétrossians.;Alfredo Coppa.;Ron Pinhasi.;Adrian F Daly.
来源: N Engl J Med. 2026年394卷5期513-515页 288. Peripheral Artery Disease in the Legs.
Peripheral artery disease affects approximately 236 million persons worldwide and is diagnosed with an ankle-brachial index of less than 0.90. Among older persons, 3.3% of those without peripheral artery disease, 18.1% with mild disease, and 52.0% with severe disease could not complete a 6-minute walk test without resting. To prevent cardiovascular events in persons with peripheral artery disease, intensive cholesterol-lowering medications (statins), antiplatelet medications or low-dose aspirin with rivaroxaban, blood-pressure lowering to less than 130/80 mm Hg, and semaglutide are recommended, along with sodium-glucose cotransporter 2 inhibitors in patients with diabetes. Supervised walking exercise and structured home-based walking exercise each improve walking ability in persons with peripheral artery disease. Revascularization in the legs should be reserved for those with persistent disease symptoms that do not respond to exercise.
289. Mental Health Outcomes in Children after Parental Firearm Injury.
作者: George Karandinos.;Mia Giuriato.;José R Zubizarreta.;Katherine A Koh.;Peter T Masiakos.;Zirui Song.;Chana A Sacks.
来源: N Engl J Med. 2026年394卷5期475-485页
Every year, approximately 20,000 youths lose a parent to firearm injury in the United States. Many more youths have parents who sustain nonfatal firearm injuries. The effect of parents' firearm injuries on their children's health and health care is poorly understood.
290. Palbociclib for Hormone-Receptor-Positive, HER2-Positive Advanced Breast Cancer.
作者: Otto Metzger.;Sumithra Mandrekar.;Shom Goel.;Joseph Gligorov.;Elgene Lim.;Eva Ciruelos.;Sibylle Loibl.;Travis Dockter.;Xavier Gonzàlez Farré.;Prudence A Francis.;Filipa Lynce.;Jane Lanzillotti.;Carter DuFrane.;Anna Wall.;Carrie Strand.;Ian Krop.;Ines Vaz-Luis.;Debu Tripathy.;Sherene Loi.;Aleix Prat.;Matthew Goetz.;Santiago Escrivá-de-Romaní.;David Porter.;Jennifer Spoenlein.;Daniel G Stover.;Sagar Sardesai.;Pierre Heudel.;Maria Koehler.;Cynthia Huang Bartlett.;Ariadna Holynskyj.;Prashanth Gopalakrishna.;Eric Gauthier.;Suzette Delaloge.;Kathy Miller.;Eric P Winer.;Luca Gianni.;Ann H Partridge.;Angela DeMichele.;Lisa A Carey.
来源: N Engl J Med. 2026年394卷5期451-462页
Dual anti-human epidermal growth factor receptor 2 (HER2) therapy plus chemotherapy followed by maintenance treatment with HER2-targeted and endocrine therapies is standard first-line treatment for hormone-receptor-positive, HER2-positive metastatic breast cancer. On the basis of preclinical and clinical data, the addition of palbociclib (a selective inhibitor of cyclin-dependent kinases 4 and 6) may overcome resistance to both endocrine and HER2-directed therapies.
291. A Randomized Trial of Tenecteplase in Acute Central Retinal Artery Occlusion.
作者: Stephen J Ryan.;Øystein Kalsnes Jørstad.;Mona Skjelland.;Maiju Pesonen.;Claus Z Simonsen.;Toke Bek.;Rolf Ankerlund Blauenfeldt.;Petra Ijäs.;Arja Laitinen.;Andrej Khanevski.;Jørgen Krohn.;Eyvind Rødahl.;Robin Lemmens.;Jelle Demeestere.;Catherine Cassiman.;Ingvild Nakstad.;Kristin Evensen.;Tiril Sandell.;Steffen Hamann.;Thomas C Truelsen.;Louisa M Christensen.;Sverre Rosenbaum.;Vaidas Matijošaitis.;Reda Žemaitienė.;Hanne Ellekjær.;Erlend Almaas.;Dordi Austeng.;Michael V Mazya.;Frank Traïsk.;Pauli Ylikotila.;Ulpu Salmi.;Kristian N Jenssen.;Håvard Lisether.;Cathrine Breivik.;Kristina Devik.;Lasse-Marius Elden Honningsvåg.;Jurgita Valaikienė.;Andrius Cimbalas.;Vetle Nilsen Malmberg.;Espen Anderson.;Ansar Roy.;Thor Håkon Skattør.;Kristian Lundsgaard Kraglund.;Christina Kefaloykos.;Inge Christoffer Olsen.;Peter Vanacker.;Daniel Strbian.;Morten C Moe.;Anne Hege Aamodt.; .
来源: N Engl J Med. 2026年394卷5期442-450页
Central retinal artery occlusion can result in permanent vision loss. Effective treatment is lacking.
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