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281. Non-vitamin K oral anticoagulants and aspirin do not differ for major bleeding and intracranial hemorrhage at a mean 20 mo.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Hematology: [Formula: see text].
282. Guideline recommends antiviral prophylaxis for patients at high risk for HBV reactivation.
GIM/FP/GP: [Formula: see text] Gastroenterology: [Formula: see text] Infectious Disease: [Formula: see text] Public Health: [Formula: see text].
284. In ischemic stroke, IV thrombolysis >4.5 h after symptom onset vs. standard medical care improves 90-d functional outcomes.
Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Neurology: [Formula: see text].
286. In early postmenopausal women, zoledronate vs. placebo at baseline and 5 y reduced morphometric vertebral fractures at 10 y.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].
288. In nonsevere influenza, antiviral drugs do not reduce mortality or hospital admissions; some shorten symptom duration.
Emergency Med: [Formula: see text] GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Public Health: [Formula: see text].
289. Sins of Omission: Model-Based Estimates of the Health Effects of Excluding Pregnant Participants From Randomized Controlled Trials.
More than 90 million women in the United States have given birth. Randomized controlled trials (RCTs) of medications almost always exclude pregnant participants.
290. Empowering Physicians Through Collective Action: A Position Paper From the American College of Physicians.
Physicians are increasingly frustrated with the nation's health care system. The erosion of the patient-physician relationship, diminished clinical independence, the mounting burden of administrative tasks, and the growing influence of nonclinicians in the health care system have left many physicians disempowered, demoralized, and burned out. As a result, physicians, most of whom are employed by hospitals, health systems, and other organizations, are exploring collective action to enhance their ability to deliver high-quality care to patients, regain control of their profession, and improve their well-being. In this position paper, the American College of Physicians offers recommendations on how physicians can become effective advocates for their patients and their profession through advocacy, the organized medical staff, responsible collective bargaining, and other means.
291. Impact of the COVID-19 Pandemic on Antibiotic Resistant Infection Burden in U.S. Hospitals : Retrospective Cohort Study of Trends and Risk Factors.
作者: Christina Yek.;Alex G Mancera.;Guoqing Diao.;Morgan Walker.;Maniraj Neupane.;Emad A Chishti.;Roxana Amirahmadi.;Mary E Richert.;Chanu Rhee.;Michael Klompas.;Bruce Swihart.;Sarah R Warner.;Sameer S Kadri.; .
来源: Ann Intern Med. 2025年178卷6期796-807页
In 2022, the U.S. Centers for Disease Control and Prevention reported increases in antimicrobial resistance (AMR) across U.S. hospitals during the COVID-19 pandemic. The key drivers and lasting effects of this phenomenon remain unexplored.
292. Sexual Trauma, Suicide, and Overdose in a National Cohort of Older Veterans.
作者: Anita S Hargrave.;Beth E Cohen.;Carolyn J Gibson.;Salomeh Keyhani.;Yixia Li.;W John Boscardin.;Amy L Byers.
来源: Ann Intern Med. 2025年178卷6期775-787页
Little is known about the association between military sexual trauma (MST) and risk for suicide-related outcomes later in life.
293. High Frequency of Chronic Urticaria Following an Investigational HIV-1 BG505 MD39.3 Trimer mRNA Vaccine in a Phase 1, Randomized, Open-Label Clinical Trial (HVTN 302).
作者: Sharon A Riddler.;Zoe Moodie.;Jesse Clark.;Catherine Yen.;Mary Allen.;Briana D Furch.;Huiyin Lu.;Shannon Grant.;Kajari Mondal.;Maija Anderson.;Janine Maenza.;Maria P Lemos.;Amanda S Woodward Davis.;Stephen R Walsh.;Magdalena E Sobieszczyk.;Ian Frank.;Paul Goepfert.;Kathryn E Stephenson.;Lindsey R Baden.;Hong-Van Tieu.;Michael C Keefer.;M Juliana McElrath.;James G Kublin.;Lawrence Corey.
来源: Ann Intern Med. 2025年178卷7期963-974页
The mRNA platform is under investigation for many vaccines, including HIV-1 vaccines.
294. Availability of Cardioprotective Medications for Type 2 Diabetes in the Medicaid Program.
作者: Anil N Makam.;Logan Bailey.;Nigel Anderson.;Kathy Bellitti.;Sasha Skinner.;Oanh Kieu Nguyen.
来源: Ann Intern Med. 2025年178卷6期808-818页
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are the only type 2 diabetes medications that reduce cardiovascular disease and death, yet their availability in Medicaid is unclear.
295. Risk for Stroke After Newly Diagnosed Atrial Fibrillation During Hospitalization for Other Primary Diagnoses : A Retrospective Cohort Study.
作者: Husam Abdel-Qadir.;Madison Gunn.;Jiming Fang.;Tomi Odugbemi.;Irene Jeong.;Peter C Austin.;Paul Dorian.;Cynthia A Jackevicius.;Douglas S Lee.;Sheldon M Singh.;Karen Tu.;Dennis T Ko.
来源: Ann Intern Med. 2025年178卷6期765-774页
Atrial fibrillation (AF) that is first diagnosed during hospitalization for other causes can subside with resolution of the inciting stressor.
296. Prophylactic Weekly Efanesoctocog Alfa Versus Standard-Care Factor VIII in People Living With Severe Hemophilia A : A Cost-Effectiveness Analysis.
作者: Satoko Ito.;Kunal C Potnis.;Jessica Preston Harvey.;Manraj Sra.;Jan Phillipp Bewersdorf.;Robert D Bona.;Harlan M Krumholz.;Adam Cuker.;Ankur Pandya.;George Goshua.
来源: Ann Intern Med. 2025年178卷6期819-828页
Prophylaxis goals for patients with severe hemophilia A encompass advancement toward the hemophilia-free mind (freedom from bleeding, pain, arthropathy, and treatment burden). Efanesoctocog alfa, the first ultra-long half-life factor VIII agent that enables once-weekly prophylaxis, shows a 77% improvement in annualized bleeding rate compared with standard-care factor VIII prophylaxis.
297. Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023.
作者: Adam Rowh.;Marissa Zwald.;Steven Sumner.;Nisha George.;Michael Sheppard.;Kristin Holland.
来源: Ann Intern Med. 2025年178卷5期663-670页
Monitoring temporal trends in firearm injury-related emergency department (ED) visits is challenging because traditional surveillance systems lack detailed temporal information.
298. Trends in Utilization of Glucose- and Weight-Lowering Medications After Tirzepatide Approval in the United States : A Population-Based Cohort Study.
作者: John W Ostrominski.;Janinne Ortega-Montiel.;Helen Tesfaye.;Caroline Alix.;Elyse DiCesare.;Sara J Cromer.;Deborah J Wexler.;Julie M Paik.;Elisabetta Patorno.
来源: Ann Intern Med. 2025年178卷5期620-633页
Recent trends in use of tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide receptor agonist (RA), versus other glucose-lowering medications (GLMs) and weight-lowering medications (WLMs) remain unexplored.
299. Impacts of Communication Type and Quality on Patient Safety Incidents : A Systematic Review.
作者: Leila Keshtkar.;Amber Bennett-Weston.;Ahmad S Khan.;Shaan Mohan.;Max Jones.;Keith Nockels.;Sarah Gunn.;Natalie Armstrong.;Jennifer Bostock.;Jeremy Howick.
来源: Ann Intern Med. 2025年178卷5期687-700页
Poor communication in health care increases the risk for patient safety incidents. However, there is no up-to-date synthesis of these data.
300. Epilepsy.
Epilepsy is a common neurologic condition characterized by at least 1 unprovoked seizure and a high risk for recurrent seizures. Distinguishing epilepsy from conditions that can mimic seizures is important for accurate diagnosis and effective treatment. This article reviews the evaluation of patients suspected of having epilepsy and discusses behavioral strategies and pharmacologic and surgical therapies that can help reduce morbidity associated with recurrent seizures.
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