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281. Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.
作者: Silje Watterdal Syversen.;Guro Løvik Goll.;Kristin Kaasen Jørgensen.;Øystein Sandanger.;Joseph Sexton.;Inge Christoffer Olsen.;Johanna Elin Gehin.;David John Warren.;Marthe Kirkesæther Brun.;Rolf Anton Klaasen.;Lars Normann Karlsen.;Geir Noraberg.;Camilla Zettel.;Maud Kristine Aga Ljoså.;Anne Julsrud Haugen.;Rune Johan Njålla.;Trude Jannecke Bruun.;Kathrine Aglen Seeberg.;Brigitte Michelsen.;Eldri Kveine Strand.;Svanaug Skorpe.;Ingrid Marianne Blomgren.;Yngvill Hovde Bragnes.;Christian Kvikne Dotterud.;Turid Thune.;Carl Magnus Ystrøm.;Roald Torp.;Pawel Mielnik.;Cato Mørk.;Tore K Kvien.;Jørgen Jahnsen.;Nils Bolstad.;Espen A Haavardsholm.
来源: JAMA. 2021年325卷17期1744-1754页
Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on scheduled monitoring of serum drug levels, has been proposed as an alternative to standard therapy to maximize efficacy and safety of infliximab and other biological drugs. However, whether proactive TDM improves clinical outcomes when implemented at the time of drug initiation, compared with standard therapy, remains unclear.
282. Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial.
作者: Siri Lillegraven.;Nina Paulshus Sundlisæter.;Anna-Birgitte Aga.;Joseph Sexton.;Inge C Olsen.;Hallvard Fremstad.;Cristina Spada.;Tor Magne Madland.;Christian A Høili.;Gunnstein Bakland.;Åse Lexberg.;Inger Johanne Widding Hansen.;Inger Myrnes Hansen.;Hilde Haukeland.;Maud-Kristine Aga Ljoså.;Ellen Moholt.;Till Uhlig.;Daniel H Solomon.;Désirée van der Heijde.;Tore K Kvien.;Espen A Haavardsholm.
来源: JAMA. 2021年325卷17期1755-1764页
Sustained remission has become an achievable goal for patients with rheumatoid arthritis (RA) receiving conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), but how to best treat patients in clinical remission remains unclear.
283. Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.
作者: James F Casella.;Bruce A Barton.;Julie Kanter.;L Vandy Black.;Suvankar Majumdar.;Adlette Inati.;Yasser Wali.;Richard A Drachtman.;Miguel R Abboud.;Yurdanur Kilinc.;Beng R Fuh.;Murtadha K Al-Khabori.;Clifford M Takemoto.;Emad Salman.;Sharada A Sarnaik.;Nirmish Shah.;Claudia R Morris.;Jennifer Keates-Baleeiro.;Ashok Raj.;Ofelia A Alvarez.;Lewis L Hsu.;Alexis A Thompson.;India Y Sisler.;Betty S Pace.;Suzie A Noronha.;Joseph L Lasky.;Elena Cela de Julian.;Kamar Godder.;Courtney Dawn Thornburg.;Natalie L Kamberos.;Rachelle Nuss.;Anne M Marsh.;William C Owen.;Anne Schaefer.;Cameron K Tebbi.;Christophe F Chantrain.;Debra E Cohen.;Zeynep Karakas.;Connie M Piccone.;Alex George.;Jason M Fixler.;Tammuella C Singleton.;Thomas Moulton.;Charles T Quinn.;Clarisse Lopes de Castro Lobo.;Abdulkareem M Almomen.;Meenakshi Goyal-Khemka.;Philip Maes.;Marty Emanuele.;Rebecca T Gorney.;Claire S Padgett.;Ed Parsley.;Shari S Kronsberg.;Gregory J Kato.;Mark T Gladwin.
来源: JAMA. 2021年325卷15期1513-1523页
Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there are no disease-modifying therapies for ongoing painful vaso-occlusive episodes; treatment remains supportive. A previous phase 3 trial of poloxamer 188 reported shortened duration of painful vaso-occlusive episodes in SCD, particularly in children and participants treated with hydroxyurea.
284. Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial.
作者: Jeffrey A Meyerhardt.;Qian Shi.;Charles S Fuchs.;Jeffrey Meyer.;Donna Niedzwiecki.;Tyler Zemla.;Priya Kumthekar.;Katherine A Guthrie.;Felix Couture.;Philip Kuebler.;Johanna C Bendell.;Pankaj Kumar.;Dequincy Lewis.;Benjamin Tan.;Monica Bertagnolli.;Axel Grothey.;Howard S Hochster.;Richard M Goldberg.;Alan Venook.;Charles Blanke.;Eileen M O'Reilly.;Anthony F Shields.
来源: JAMA. 2021年325卷13期1277-1286页
Aspirin and cyclooxygenase 2 (COX-2) inhibitors have been associated with a reduced risk of colorectal polyps and cancer in observational and randomized studies. The effect of celecoxib, a COX-2 inhibitor, as treatment for nonmetastatic colon cancer is unknown.
285. Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial.
作者: Mary M McDermott.;Bonnie Spring.;Lu Tian.;Diane Treat-Jacobson.;Luigi Ferrucci.;Donald Lloyd-Jones.;Lihui Zhao.;Tamar Polonsky.;Melina R Kibbe.;Lydia Bazzano.;Jack M Guralnik.;Daniel E Forman.;Al Rego.;Dongxue Zhang.;Kathryn Domanchuk.;Christiaan Leeuwenburgh.;Robert Sufit.;Brittany Smith.;Todd Manini.;Michael H Criqui.;W Jack Rejeski.
来源: JAMA. 2021年325卷13期1266-1276页
Supervised high-intensity walking exercise that induces ischemic leg symptoms is the first-line therapy for people with lower-extremity peripheral artery disease (PAD), but adherence is poor.
286. Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial.
作者: Domenico Luca Grieco.;Luca S Menga.;Melania Cesarano.;Tommaso Rosà.;Savino Spadaro.;Maria Maddalena Bitondo.;Jonathan Montomoli.;Giulia Falò.;Tommaso Tonetti.;Salvatore L Cutuli.;Gabriele Pintaudi.;Eloisa S Tanzarella.;Edoardo Piervincenzi.;Filippo Bongiovanni.;Antonio M Dell'Anna.;Luca Delle Cese.;Cecilia Berardi.;Simone Carelli.;Maria Grazia Bocci.;Luca Montini.;Giuseppe Bello.;Daniele Natalini.;Gennaro De Pascale.;Matteo Velardo.;Carlo Alberto Volta.;V Marco Ranieri.;Giorgio Conti.;Salvatore Maurizio Maggiore.;Massimo Antonelli.; .
来源: JAMA. 2021年325卷17期1731-1743页
High-flow nasal oxygen is recommended as initial treatment for acute hypoxemic respiratory failure and is widely applied in patients with COVID-19.
287. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial.
作者: Domenica Rubino.;Niclas Abrahamsson.;Melanie Davies.;Dan Hesse.;Frank L Greenway.;Camilla Jensen.;Ildiko Lingvay.;Ofri Mosenzon.;Julio Rosenstock.;Miguel A Rubio.;Gottfried Rudofsky.;Sayeh Tadayon.;Thomas A Wadden.;Dror Dicker.; .
来源: JAMA. 2021年325卷14期1414-1425页
The effect of continuing vs withdrawing treatment with semaglutide, a glucagon-like peptide 1 receptor agonist, on weight loss maintenance in people with overweight or obesity is unknown.
288. Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial.
作者: .;Parham Sadeghipour.;Azita H Talasaz.;Farid Rashidi.;Babak Sharif-Kashani.;Mohammad Taghi Beigmohammadi.;Mohsen Farrokhpour.;Seyed Hashem Sezavar.;Pooya Payandemehr.;Ali Dabbagh.;Keivan Gohari Moghadam.;Sepehr Jamalkhani.;Hossein Khalili.;Mahdi Yadollahzadeh.;Taghi Riahi.;Parisa Rezaeifar.;Ouria Tahamtan.;Samira Matin.;Atefeh Abedini.;Somayeh Lookzadeh.;Hamid Rahmani.;Elnaz Zoghi.;Keyhan Mohammadi.;Pardis Sadeghipour.;Homa Abri.;Sanaz Tabrizi.;Seyed Masoud Mousavian.;Shaghayegh Shahmirzaei.;Hooman Bakhshandeh.;Ahmad Amin.;Farnaz Rafiee.;Elahe Baghizadeh.;Bahram Mohebbi.;Seyed Ehsan Parhizgar.;Rasoul Aliannejad.;Vahid Eslami.;Alireza Kashefizadeh.;Hessam Kakavand.;Seyed Hossein Hosseini.;Shadi Shafaghi.;Samrand Fattah Ghazi.;Atabak Najafi.;David Jimenez.;Aakriti Gupta.;Mahesh V Madhavan.;Sanjum S Sethi.;Sahil A Parikh.;Manuel Monreal.;Naser Hadavand.;Alireza Hajighasemi.;Majid Maleki.;Saeed Sadeghian.;Gregory Piazza.;Ajay J Kirtane.;Benjamin W Van Tassell.;Paul P Dobesh.;Gregg W Stone.;Gregory Y H Lip.;Harlan M Krumholz.;Samuel Z Goldhaber.;Behnood Bikdeli.
来源: JAMA. 2021年325卷16期1620-1630页
Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.
289. Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial.
作者: Christine M Albert.;Nancy R Cook.;Julie Pester.;M Vinayaga Moorthy.;Claire Ridge.;Jacqueline S Danik.;Baris Gencer.;Hasan K Siddiqi.;Chee Ng.;Heike Gibson.;Samia Mora.;Julie E Buring.;JoAnn E Manson.
来源: JAMA. 2021年325卷11期1061-1073页
Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to have both benefits and risks with respect to incident AF, but large-scale, long-term randomized trial data are lacking.
290. Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19.
作者: Kathryn E Stephenson.;Mathieu Le Gars.;Jerald Sadoff.;Anne Marit de Groot.;Dirk Heerwegh.;Carla Truyers.;Caroline Atyeo.;Carolin Loos.;Abishek Chandrashekar.;Katherine McMahan.;Lisa H Tostanoski.;Jingyou Yu.;Makda S Gebre.;Catherine Jacob-Dolan.;Zhenfeng Li.;Shivani Patel.;Lauren Peter.;Jinyan Liu.;Erica N Borducchi.;Joseph P Nkolola.;Morgana Souza.;Chen Sabrina Tan.;Rebecca Zash.;Boris Julg.;Ruvandhi R Nathavitharana.;Roger L Shapiro.;Ahmed Abdul Azim.;Carolyn D Alonso.;Kate Jaegle.;Jessica L Ansel.;Diane G Kanjilal.;Caitlin J Guiney.;Connor Bradshaw.;Anna Tyler.;Tatenda Makoni.;Katherine E Yanosick.;Michael S Seaman.;Douglas A Lauffenburger.;Galit Alter.;Frank Struyf.;Macaya Douoguih.;Johan Van Hoof.;Hanneke Schuitemaker.;Dan H Barouch.
来源: JAMA. 2021年325卷15期1535-1544页
Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines.
291. Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial.
作者: Zoher Ghogawala.;Norma Terrin.;Melissa R Dunbar.;Janis L Breeze.;Karen M Freund.;Adam S Kanter.;Praveen V Mummaneni.;Erica F Bisson.;Fred G Barker.;J Sanford Schwartz.;James S Harrop.;Subu N Magge.;Robert F Heary.;Michael G Fehlings.;Todd J Albert.;Paul M Arnold.;K Daniel Riew.;Michael P Steinmetz.;Marjorie C Wang.;Robert G Whitmore.;John G Heller.;Edward C Benzel.
来源: JAMA. 2021年325卷10期942-951页
Cervical spondylotic myelopathy is the most common cause of spinal cord dysfunction worldwide. It remains unknown whether a ventral or dorsal surgical approach provides the best results.
292. Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.
作者: Eduardo López-Medina.;Pío López.;Isabel C Hurtado.;Diana M Dávalos.;Oscar Ramirez.;Ernesto Martínez.;Jesus A Díazgranados.;José M Oñate.;Hector Chavarriaga.;Sócrates Herrera.;Beatriz Parra.;Gerardo Libreros.;Roberto Jaramillo.;Ana C Avendaño.;Dilian F Toro.;Miyerlandi Torres.;Maria C Lesmes.;Carlos A Rios.;Isabella Caicedo.
来源: JAMA. 2021年325卷14期1426-1435页
Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit.
293. Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
作者: Franco Locatelli.;Gerhard Zugmaier.;Carmelo Rizzari.;Joan D Morris.;Bernd Gruhn.;Thomas Klingebiel.;Rosanna Parasole.;Christin Linderkamp.;Christian Flotho.;Arnaud Petit.;Concetta Micalizzi.;Noemi Mergen.;Abeera Mohammad.;William N Kormany.;Cornelia Eckert.;Anja Möricke.;Mary Sartor.;Ondrej Hrusak.;Christina Peters.;Vaskar Saha.;Luciana Vinti.;Arend von Stackelberg.
来源: JAMA. 2021年325卷9期843-854页
Blinatumomab is a CD3/CD19-directed bispecific T-cell engager molecule with efficacy in children with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).
294. Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
作者: Patrick A Brown.;Lingyun Ji.;Xinxin Xu.;Meenakshi Devidas.;Laura E Hogan.;Michael J Borowitz.;Elizabeth A Raetz.;Gerhard Zugmaier.;Elad Sharon.;Melanie B Bernhardt.;Stephanie A Terezakis.;Lia Gore.;James A Whitlock.;Michael A Pulsipher.;Stephen P Hunger.;Mignon L Loh.
来源: JAMA. 2021年325卷9期833-842页
Standard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and young adults is associated with high rates of severe toxicities, subsequent relapse, and death, especially for patients with early relapse (high risk) or late relapse with residual disease after reinduction chemotherapy (intermediate risk). Blinatumomab, a bispecific CD3 to CD19 T cell-engaging antibody construct, is efficacious in relapsed/refractory B-ALL and has a favorable toxicity profile.
295. Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial.
作者: Thomas A Wadden.;Timothy S Bailey.;Liana K Billings.;Melanie Davies.;Juan P Frias.;Anna Koroleva.;Ildiko Lingvay.;Patrick M O'Neil.;Domenica M Rubino.;Dorthe Skovgaard.;Signe O R Wallenstein.;W Timothy Garvey.; .
来源: JAMA. 2021年325卷14期1403-1413页
Weight loss improves cardiometabolic risk factors in people with overweight or obesity. Intensive lifestyle intervention and pharmacotherapy are the most effective noninvasive weight loss approaches.
296. Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial.
作者: Mickael Vourc'h.;Charlotte Garret.;Arnaud Gacouin.;Jean-Claude Lacherade.;Maud Jonas.;Kada Klouche.;Martine Ferrandiere.;Samir Jaber.;Laurent Flet.;Eric Dailly.;Caroline Pouplet.;Adel Maamar.;Jean Reignier.;Antoine Roquilly.;Fanny Feuillet.;Pierre-Joachim Mahe.;Karim Asehnoune.; .
来源: JAMA. 2021年325卷8期732-741页
Unhealthy alcohol use can lead to agitation in the intensive care unit (ICU).
297. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
作者: Jonathan E Sevransky.;Richard E Rothman.;David N Hager.;Gordon R Bernard.;Samuel M Brown.;Timothy G Buchman.;Laurence W Busse.;Craig M Coopersmith.;Christine DeWilde.;E Wesley Ely.;Lindsay M Eyzaguirre.;Alpha A Fowler.;David F Gaieski.;Michelle N Gong.;Alex Hall.;Jeremiah S Hinson.;Michael H Hooper.;Gabor D Kelen.;Akram Khan.;Mark A Levine.;Roger J Lewis.;Chris J Lindsell.;Jessica S Marlin.;Anna McGlothlin.;Brooks L Moore.;Katherine L Nugent.;Samuel Nwosu.;Carmen C Polito.;Todd W Rice.;Erin P Ricketts.;Caroline C Rudolph.;Fred Sanfilippo.;Kert Viele.;Greg S Martin.;David W Wright.; .
来源: JAMA. 2021年325卷8期742-750页
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.
298. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.
作者: Igor H Murai.;Alan L Fernandes.;Lucas P Sales.;Ana J Pinto.;Karla F Goessler.;Camila S C Duran.;Carla B R Silva.;André S Franco.;Marina B Macedo.;Henrique H H Dalmolin.;Janaina Baggio.;Guilherme G M Balbi.;Bruna Z Reis.;Leila Antonangelo.;Valeria F Caparbo.;Bruno Gualano.;Rosa M R Pereira.
来源: JAMA. 2021年325卷11期1053-1060页
The efficacy of vitamin D3 supplementation in coronavirus disease 2019 (COVID-19) remains unclear.
299. Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial.
作者: Stephen P Messier.;Shannon L Mihalko.;Daniel P Beavers.;Barbara J Nicklas.;Paul DeVita.;J Jeffery Carr.;David J Hunter.;Mary Lyles.;Ali Guermazi.;Kim L Bennell.;Richard F Loeser.
来源: JAMA. 2021年325卷7期646-657页
Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms.
300. Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial.
作者: Gregory Ducrocq.;Jose R Gonzalez-Juanatey.;Etienne Puymirat.;Gilles Lemesle.;Marine Cachanado.;Isabelle Durand-Zaleski.;Joan Albert Arnaiz.;Manuel Martínez-Sellés.;Johanne Silvain.;Albert Ariza-Solé.;Emile Ferrari.;Gonzalo Calvo.;Nicolas Danchin.;Cristina Avendaño-Solá.;Jerome Frenkiel.;Alexandra Rousseau.;Eric Vicaut.;Tabassome Simon.;Philippe Gabriel Steg.; .
来源: JAMA. 2021年325卷6期552-560页
The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear.
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