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2921. Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS).
作者: Peter J Mason.;JoAnn E Manson.;Howard D Sesso.;Christine M Albert.;Marilyn J Chown.;Nancy R Cook.;Philip Greenland.;Paul M Ridker.;Robert J Glynn.
来源: Circulation. 2004年109卷13期1623-9页
In apparently healthy people, the relation between blood pressure and risk of subsequent cardiovascular disease (CVD) is linear. In persons with CVD, the relation is uncertain.
2922. Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes.
作者: John V Mitsios.;Athanasios I Papathanasiou.;Foteini I Rodis.;Moses Elisaf.;John A Goudevenos.;Alexandros D Tselepis.
来源: Circulation. 2004年109卷11期1335-8页
The antiplatelet effect of clopidogrel may be attenuated by short-term coadministration of lipophilic statins. We investigated whether the coadministration of atorvastatin for 5 weeks in patients with acute coronary syndromes (ACS) could affect the antiplatelet potency of clopidogrel.
2923. Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL).
作者: Douglas L Mann.;John J V McMurray.;Milton Packer.;Karl Swedberg.;Jeffrey S Borer.;Wilson S Colucci.;Jacques Djian.;Helmut Drexler.;Arthur Feldman.;Lars Kober.;Henry Krum.;Peter Liu.;Markku Nieminen.;Luigi Tavazzi.;Dirk Jan van Veldhuisen.;Anders Waldenstrom.;Marshelle Warren.;Arne Westheim.;Faiez Zannad.;Thomas Fleming.
来源: Circulation. 2004年109卷13期1594-602页
Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure.
2924. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial.
作者: Rainer Hambrecht.;Claudia Walther.;Sven Möbius-Winkler.;Stephan Gielen.;Axel Linke.;Katrin Conradi.;Sandra Erbs.;Regine Kluge.;Kai Kendziorra.;Osama Sabri.;Peter Sick.;Gerhard Schuler.
来源: Circulation. 2004年109卷11期1371-8页
Regular exercise in patients with stable coronary artery disease has been shown to improve myocardial perfusion and to retard disease progression. We therefore conducted a randomized study to compare the effects of exercise training versus standard percutaneous coronary intervention (PCI) with stenting on clinical symptoms, angina-free exercise capacity, myocardial perfusion, cost-effectiveness, and frequency of a combined clinical end point (death of cardiac cause, stroke, CABG, angioplasty, acute myocardial infarction, and worsening angina with objective evidence resulting in hospitalization).
2925. Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia.
作者: Yukihito Higashi.;Masashi Kimura.;Keiko Hara.;Kensuke Noma.;Daisuke Jitsuiki.;Keigo Nakagawa.;Tetsuya Oshima.;Kazuaki Chayama.;Taijiro Sueda.;Chikara Goto.;Hiroaki Matsubara.;Toyoaki Murohara.;Masao Yoshizumi.
来源: Circulation. 2004年109卷10期1215-8页
Patients with limb ischemia were associated with endothelial dysfunction. The purpose of this study was to determine whether autologous bone-marrow mononuclear cell (BM-MNC) implantation improves endothelial dysfunction in patients with limb ischemia.
2926. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.
作者: Scott D Corley.;Andrew E Epstein.;John P DiMarco.;Michael J Domanski.;Nancy Geller.;H Leon Greene.;Richard A Josephson.;Joyce C Kellen.;Richard C Klein.;Andrew D Krahn.;Mary Mickel.;L Brent Mitchell.;Joy Dalquist Nelson.;Yves Rosenberg.;Eleanor Schron.;Lynn Shemanski.;Albert L Waldo.;D George Wyse.; .
来源: Circulation. 2004年109卷12期1509-13页
The AFFIRM Study showed that treatment of patients with atrial fibrillation and a high risk for stroke or death with a rhythm-control strategy offered no survival advantage over a rate-control strategy in an intention-to-treat analysis. This article reports an "on-treatment" analysis of the relationship of survival to cardiac rhythm and treatment as they changed over time.
2927. Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy.
作者: David A Payne.;Chris I Jones.;Paul D Hayes.;Matthew M Thompson.;Nicholas J London.;Peter R Bell.;Alison H Goodall.;A Ross Naylor.
来源: Circulation. 2004年109卷12期1476-81页
Postoperative thromboembolic stroke affects 2% to 3% of patients undergoing carotid endarterectomy (CEA) and is preceded by 1 to 2 hours of increasing cerebral embolization. Previous work has demonstrated that high rates of postoperative embolization are associated with increased platelet reactivity to adenosine 5'-diphosphate (ADP). Our hypothesis was that preoperative administration of the platelet ADP antagonist clopidogrel could reduce postoperative embolization.
2928. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events.
作者: Harold L Lazar.;Stuart R Chipkin.;Carmel A Fitzgerald.;Yusheng Bao.;Howard Cabral.;Carl S Apstein.
来源: Circulation. 2004年109卷12期1497-502页
This study sought to determine whether tight glycemic control with a modified glucose-insulin-potassium (GIK) solution in diabetic coronary artery bypass graft (CABG) patients would improve perioperative outcomes.
2929. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block.
作者: Angelo Auricchio.;Cecilia Fantoni.;Francois Regoli.;Corrado Carbucicchio.;Andreas Goette.;Christoph Geller.;Michael Kloss.;Helmut Klein.
来源: Circulation. 2004年109卷9期1133-9页
Conventional activation mapping in the dilated human left ventricle (LV) with left bundle-branch block (LBBB) morphology is incomplete given the limited number of recording sites that may be collected in a reasonable time and given the lack of precision in marking specific anatomic locations.
2930. Three-year outcome after coronary stenting versus bypass surgery for the treatment of multivessel disease.
作者: Victor M G Legrand.;Patrick W Serruys.;Felix Unger.;Ben A van Hout.;Mathias C M Vrolix.;Geert M P Fransen.;Torsten Toftegaard Nielsen.;Peter Kildeberg Paulsen.;Ricardo Seabra Gomes.;João M G de Queiroz e Melo.;José P Marques dos Santos Neves.;Wietze Lindeboom.;Bianca Backx.; .
来源: Circulation. 2004年109卷9期1114-20页
The primary results of Arterial Revascularization Therapy Study reported a greater need for repeated revascularization after percutaneous coronary intervention with stenting (PCI). However, PCI was less expensive than coronary artery bypass grafting (CABG) and offered the same degree of protection against death, stroke, and myocardial infarction.
2931. Contribution of stent underexpansion to recurrence after sirolimus-eluting stent implantation for in-stent restenosis.
作者: Kenichi Fujii.;Gary S Mintz.;Yoshio Kobayashi.;Stéphane G Carlier.;Hideo Takebayashi.;Takenori Yasuda.;Issam Moussa.;George Dangas.;Roxana Mehran.;Alexandra J Lansky.;Arlene Reyes.;Edward Kreps.;Michael Collins.;Antonio Colombo.;Gregg W Stone.;Paul S Teirstein.;Martin B Leon.;Jeffrey W Moses.
来源: Circulation. 2004年109卷9期1085-8页
We used intravascular ultrasound (IVUS) to evaluate recurrence after sirolimus-eluting stent (SES) implantation treatment of in-stent restenosis (ISR).
2932. Time dependence of mortality risk and defibrillator benefit after myocardial infarction.
作者: David J Wilber.;Wojciech Zareba.;W Jackson Hall.;Mary W Brown.;Albert C Lin.;Mark L Andrews.;Martin Burke.;Arthur J Moss.
来源: Circulation. 2004年109卷9期1082-4页
Prophylactic implantable defibrillators (ICDs) improve survival in patients with impaired ventricular function after myocardial infarction (MI), but it is uncertain whether mortality risk and survival benefit depend on the elapsed time from MI.
2933. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion.
作者: Lazaros A Nikolaidis.;Sunil Mankad.;George G Sokos.;Glen Miske.;Ankur Shah.;Dariush Elahi.;Richard P Shannon.
来源: Circulation. 2004年109卷8期962-5页
Glucose-insulin-potassium infusions are beneficial in uncomplicated patients with acute myocardial infarction (AMI) but are of unproven efficacy in AMI with left ventricular (LV) dysfunction because of volume requirements associated with glucose infusion. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties that stimulate glucose uptake without the requirements for concomitant glucose infusion.
2934. Effect of CO2 insufflation on the number and behavior of air microemboli in open-heart surgery: a randomized clinical trial.
The risks that the presence of air microemboli implies in open-heart surgery have recently been emphasized by reports that their number is correlated with the degree of postoperative neuropsychological disorder. Therefore, we studied the effect of CO2 insufflation into the cardiothoracic wound on the incidence and behavior of microemboli in the heart and ascending aorta.
2935. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade.
作者: Jane Goddard.;Neil R Johnston.;Malcolm F Hand.;Allan D Cumming.;Ton J Rabelink.;Andrew J Rankin.;David J Webb.
来源: Circulation. 2004年109卷9期1186-93页
Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade.
2936. Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions.
作者: Antonio Colombo.;Jeffrey W Moses.;Marie Claude Morice.;Josef Ludwig.;David R Holmes.;Vassilis Spanos.;Yves Louvard.;Benny Desmedt.;Carlo Di Mario.;Martin B Leon.
来源: Circulation. 2004年109卷10期1244-9页
A sirolimus-eluting stent (Cypher, Cordis Corp) has been reported to markedly decrease restenosis in selected lesions; higher-risk lesions, including coronary bifurcations, have not been studied.
2937. Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions.
作者: Maria Siebes.;Bart-Jan Verhoeff.;Martijn Meuwissen.;Robbert J de Winter.;Jos A E Spaan.;Jan J Piek.
来源: Circulation. 2004年109卷6期756-62页
Lack of high-fidelity simultaneous measurements of pressure and flow velocity distal to a coronary artery stenosis has hampered the study of stenosis pressure drop-velocity (DeltaP-v) relationships in patients.
2938. Therapy of ischemic cardiomyopathy with the immunomodulating agent pentoxifylline: results of a randomized study.
作者: Karen Sliwa.;Angela Woodiwiss.;Veuvette N Kone.;Geoffrey Candy.;Danelle Badenhorst.;Gavin Norton.;Chris Zambakides.;Ferande Peters.;Rafique Essop.
来源: Circulation. 2004年109卷6期750-5页
Inflammatory immune activation commonly occurs in heart failure and may perpetuate this syndrome. We sought to determine whether the immunomodulating agent pentoxifylline enhances left ventricular function in patients with ischemic cardiomyopathy. We also investigated the effect of therapy on levels of brain natriuretic peptide (NT-pro BNP), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and the marker of apoptosis, Fas/Apo-1.
2939. Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification.
作者: A John Camm.;Craig M Pratt.;Peter J Schwartz.;Hussein R Al-Khalidi.;Maria J Spyt.;Michael J Holroyde.;Roger Karam.;Edmund H Sonnenblick.;Jose M G Brum.; .
来源: Circulation. 2004年109卷8期990-6页
Depressed left ventricular function (LVF) and low heart rate variability (HRV) identify patients at risk of increased mortality after myocardial infarction (MI). Azimilide, a novel class III antiarrhythmic drug, was investigated for its effects on mortality in patients with depressed LVF after recent MI and in a subpopulation of patients with low HRV.
2940. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction.
作者: Leonardo Bolognese.;Nazario Carrabba.;Guido Parodi.;Giovanni M Santoro.;Piergiovanni Buonamici.;Giampaolo Cerisano.;David Antoniucci.
来源: Circulation. 2004年109卷9期1121-6页
We hypothesized that preserved microvascular integrity in the area at risk would favorably influence left ventricular (LV) remodeling and long-term outcome after acute myocardial infarction.
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