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2821. Noninducibility of atrial fibrillation as an end point of left atrial circumferential ablation for paroxysmal atrial fibrillation: a randomized study.
作者: Hakan Oral.;Aman Chugh.;Kristina Lemola.;Peter Cheung.;Burr Hall.;Eric Good.;Jihn Han.;Kamala Tamirisa.;Frank Bogun.;Frank Pelosi.;Fred Morady.
来源: Circulation. 2004年110卷18期2797-801页
An anatomic approach of left atrial radiofrequency circumferential ablation (LACA) to encircle the pulmonary veins is often effective in eliminating paroxysmal atrial fibrillation (AF). However, no electrophysiological end points other than voltage abatement and/or conduction slowing or block across ablation lines have been used. It has been unclear whether noninducibility of AF is a clinically useful end point.
2822. Effects of fosinopril and pravastatin on cardiovascular events in subjects with microalbuminuria.
作者: Folkert W Asselbergs.;Gilles F H Diercks.;Hans L Hillege.;Ad J van Boven.;Wilbert M T Janssen.;Adriaan A Voors.;Dick de Zeeuw.;Paul E de Jong.;Dirk J van Veldhuisen.;Wiek H van Gilst.; .
来源: Circulation. 2004年110卷18期2809-16页
Microalbuminuria is associated with increased risk of cardiovascular events. We assessed whether therapeutic intervention aimed at lowering urinary albumin excretion would reduce cardiovascular events in microalbuminuric subjects (15 to 300 mg/24 hours).
2823. Diagnosis of sleep-related breathing disorders by visual analysis of transthoracic impedance signals in pacemakers.
作者: Christoph Scharf.;Yong K Cho.;Konrad E Bloch.;Corinna Brunckhorst.;Firat Duru.;Kryzstof Balaban.;Nancy Foldvary.;Lynn Liu.;Richard C Burgess.;Reto Candinas.;Bruce L Wilkoff.
来源: Circulation. 2004年110卷17期2562-7页
Minute ventilation sensors of cardiac pacemakers measure ventilation by means of transthoracic impedance changes between the pacemaker case and the electrode tip. We investigated whether this technique might detect sleep-related breathing disorders.
2824. Abnormalities of neurohormonal and cardiac autonomic nervous activities relate poorly to functional status in fontan patients.
作者: Hideo Ohuchi.;Hisashi Takasugi.;Hiroyuki Ohashi.;Osamu Yamada.;Ken Watanabe.;Toshikatsu Yagihara.;Shigeyuki Echigo.
来源: Circulation. 2004年110卷17期2601-8页
Impaired cardiac autonomic nervous activities and increased neurohumoral activities (CANA, NHA) characterize Fontan patients. However, the clinical significance of these changes is not clearly understood. Our purpose was to clarify the clinical significance of the CANA and NHA in stable Fontan patients.
2825. Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: Pacing Fast Ventricular Tachycardia Reduces Shock Therapies (PainFREE Rx II) trial results.
作者: Mark S Wathen.;Paul J DeGroot.;Michael O Sweeney.;Alice J Stark.;Mary F Otterness.;Wayne O Adkisson.;Robert C Canby.;Koroush Khalighi.;Christian Machado.;Donald S Rubenstein.;Kent J Volosin.; .
来源: Circulation. 2004年110卷17期2591-6页
Successful antitachycardia pacing (ATP) terminates ventricular tachycardia (VT) up to 250 bpm without the need for painful shocks in implantable cardioverter-defibrillator (ICD) patients. Fast VT (FVT) >200 bpm is often treated by shock because of safety concerns, however. This prospective, randomized, multicenter trial compares the safety and utility of empirical ATP with shocks for FVT in a broad ICD population.
2826. Unfavorable effects of resistance training on central arterial compliance: a randomized intervention study.
作者: Motohiko Miyachi.;Hiroshi Kawano.;Jun Sugawara.;Kouki Takahashi.;Kouichiro Hayashi.;Ken Yamazaki.;Izumi Tabata.;Hirofumi Tanaka.
来源: Circulation. 2004年110卷18期2858-63页
Reductions in the compliance of central arteries exert a number of adverse effects on cardiovascular function and disease risk. Endurance training is efficacious in increasing arterial compliance in healthy adults. We determined the effects of resistance training on carotid arterial compliance using the intervention study design.
2827. Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention.
作者: Konstantinos Spargias.;Elias Alexopoulos.;Stamatis Kyrzopoulos.;Panayiotis Iokovis.;Darren C Greenwood.;Athanassios Manginas.;Vassilis Voudris.;Gregory Pavlides.;Christopher E Buller.;Dimitrios Kremastinos.;Dennis V Cokkinos.
来源: Circulation. 2004年110卷18期2837-42页
Contrast agents can cause a reduction in renal function that may be due to the generation of reactive oxygen species. Conflicting evidence suggests that administration of the antioxidant acetylcysteine prevents this renal impairment. The action of other antioxidant agents has not been investigated.
2828. Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials.
作者: James B Young.;Mark E Dunlap.;Marc A Pfeffer.;Jeffrey L Probstfield.;Alain Cohen-Solal.;Rainer Dietz.;Christopher B Granger.;Jaromir Hradec.;Jerzy Kuch.;Robert S McKelvie.;John J V McMurray.;Eric L Michelson.;Bertil Olofsson.;Jan Ostergren.;Peter Held.;Scott D Solomon.;Salim Yusuf.;Karl Swedberg.; .
来源: Circulation. 2004年110卷17期2618-26页
Patients with symptomatic chronic heart failure (CHF) and reduced left ventricular ejection fraction (LVEF) have a high risk of death and hospitalization for CHF deterioration despite therapies with angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, and even an aldosterone antagonist. To determine whether the angiotensin-receptor blocker (ARB) candesartan decreases cardiovascular mortality, morbidity, and all-cause mortality in patients with CHF and depressed LVEF, a prespecified analysis of the combined Candesartan in Heart Failure Assessment of Reduction in Mortality and morbidity (CHARM) low LVEF trials was performed. CHARM is a randomized, double-blind, placebo-controlled, multicenter, international trial program.
2829. There is no evidence for an increase in acute coronary syndromes after short-term abrupt discontinuation of statins in stable cardiac patients.
For a variety of reasons, many patients abruptly discontinue statin therapy. The present analysis was conducted to determine whether the risk of cardiovascular outcomes increases after withdrawal of statin therapy in a stable cardiac population.
2830. Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy.
作者: João A C Lima.;Milind Y Desai.;Henning Steen.;William P Warren.;Sandeep Gautam.;Shenghan Lai.
来源: Circulation. 2004年110卷16期2336-41页
Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Magnetic resonance imaging (MRI) noninvasively detects atherosclerotic plaque (AP) reduction. We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect.
2831. Effect of candesartan on cause-specific mortality in heart failure patients: the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program.
作者: Scott D Solomon.;Duolao Wang.;Peter Finn.;Hicham Skali.;Leonardo Zornoff.;John J V McMurray.;Karl Swedberg.;Salim Yusuf.;Christopher B Granger.;Eric L Michelson.;Stuart Pocock.;Marc A Pfeffer.
来源: Circulation. 2004年110卷15期2180-3页
Patients with heart failure are at increased risk of sudden death and death attributed to progressive pump failure. We assessed the effect of candesartan on cause-specific mortality in patients enrolled in the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM) program.
2832. Heparin and air filters reduce embolic events caused by intra-arterial cerebral angiography: a prospective, randomized trial.
作者: Martin Bendszus.;Martin Koltzenburg.;Andreas J Bartsch.;Roland Goldbrunner.;Thomas Günthner-Lengsfeld.;Franz X Weilbach.;Klaus Roosen.;Klaus V Toyka.;László Solymosi.
来源: Circulation. 2004年110卷15期2210-5页
Intra-arterial cerebral angiography is associated with a low risk for neurological complications, but clinically silent ischemic events after angiography have been seen in a substantial number of patients.
2833. Differential effects of theophylline on sympathetic excitation, hemodynamics, and breathing in congestive heart failure.
作者: Stefan Andreas.;Hartwig Reiter.;Lars Lüthje.;André Delekat.;Rolf W Grunewald.;Gerd Hasenfuss.;Virend K Somers.
来源: Circulation. 2004年110卷15期2157-62页
Patients with heart failure have high levels of central sympathetic outflow and also have a high prevalence of sleep-related breathing disorders, predominantly central sleep apnea. The options for treating central sleep apnea in heart failure are limited and include theophylline. Whether theophylline alters sympathetic activity in heart failure patients is not known.
2834. Medical costs and quality of life 10 to 12 years after randomization to angioplasty or bypass surgery for multivessel coronary artery disease.
作者: Mark A Hlatky.;Derek B Boothroyd.;Kathryn A Melsop.;Maria M Brooks.;Daniel B Mark.;Bertram Pitt.;Guy S Reeder.;William J Rogers.;Thomas J Ryan.;Patrick L Whitlow.;Robert D Wiens.
来源: Circulation. 2004年110卷14期1960-6页
Coronary bypass surgery (CABG) and angioplasty (PTCA) have been compared in several randomized trials, but data about long-term economic and quality-of-life outcomes are limited.
2835. Role of coronary collaterals in off-pump and on-pump coronary bypass surgery.
作者: Hendrik M Nathoe.;Erik Buskens.;Erik W L Jansen.;Willem J L Suyker.;Pieter R Stella.;Jaap R Lahpor.;Wim-Jan van Boven.;Diederik van Dijk.;Jan C Diephuis.;Cornelius Borst.;Karel G M Moons.;Diederick E Grobbee.;Peter P T de Jaegere.
来源: Circulation. 2004年110卷13期1738-42页
Collaterals limit infarct size, preserve viability, and reduce mortality in patients with acute myocardial infarction. In patients with stable coronary disease, collaterals are associated with less angina and ischemia during angioplasty and fewer ischemic events during follow-up. The role of collaterals has not been studied in patients undergoing off-pump or on-pump bypass surgery.
2836. Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I.
作者: Padma Kaul.;Paul W Armstrong.;Wei-Ching Chang.;C David Naylor.;Christopher B Granger.;Kerry L Lee.;Eric D Peterson.;Robert M Califf.;Eric J Topol.;Daniel B Mark.
来源: Circulation. 2004年110卷13期1754-60页
In a previous substudy of the GUSTO-I trial, we observed better functional and quality-of-life outcomes among patients in the United States (US patients) compared with patients in Canada. Rates of invasive therapy were significantly higher in the United States and were associated with a small mortality benefit (0.4%, adjusted P=0.02). We sought to determine whether Canadian-US differences in practice patterns in GUSTO-I had an impact on 5-year mortality.
2837. Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial.
作者: Franz Hartmann.;Milton Packer.;Andrew J S Coats.;Michael B Fowler.;Henry Krum.;Paul Mohacsi.;Jean L Rouleau.;Michal Tendera.;Alain Castaigne.;Stefan D Anker.;Ildiko Amann-Zalan.;Silke Hoersch.;Hugo A Katus.
来源: Circulation. 2004年110卷13期1780-6页
The utility of N-terminal proBNP (NT-proBNP) to predict the occurrence of death and hospitalization was prospectively evaluated in the COPERNICUS study, which enrolled patients with an ejection fraction <25% and symptoms of chronic congestive heart failure at rest or on minimal exertion.
2838. Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass.
作者: Harold L Lazar.;Paula M Bokesch.;Frederick van Lenta.;Carmel Fitzgerald.;Constance Emmett.;Henry C Marsh.;Una Ryan.; .
来源: Circulation. 2004年110卷11 Suppl 1期II274-9页
This study was undertaken to determine whether soluble human complement receptor type 1 (TP10), a potent inhibitor of complement activation, would reduce morbidity and mortality in high-risk patients undergoing cardiac surgery on cardiopulmonary bypass (CPB).
2839. Selective antegrade cerebral perfusion attenuates brain metabolic deficit in aortic arch surgery: a prospective randomized trial.
作者: D K Harrington.;A S Walker.;H Kaukuntla.;R M Bracewell.;T H Clutton-Brock.;M Faroqui.;D Pagano.;R S Bonser.
来源: Circulation. 2004年110卷11 Suppl 1期II231-6页
Aortic arch surgery has a high incidence of brain injury. This may in part be caused by a cerebral metabolic deficit observed after hypothermic circulatory arrest (HCA). We hypothesized that selective antegrade cerebral perfusion (SACP) would attenuate this phenomenon.
2840. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy.
作者: Emerson C Perin.;Hans F R Dohmann.;Radovan Borojevic.;Suzana A Silva.;Andre L S Sousa.;Guilherme V Silva.;Claudio T Mesquita.;Luciano Belém.;William K Vaughn.;Fernando O D Rangel.;Joao A R Assad.;Antonio C Carvalho.;Rodrigo V C Branco.;Maria I D Rossi.;Hans J F Dohmann.;James T Willerson.
来源: Circulation. 2004年110卷11 Suppl 1期II213-8页
We recently reported the safety and feasibility of autologous bone marrow mononuclear cell (ABMMNC) injection into areas of ischemic myocardium in patients with end-stage ischemic cardiomyopathy. The present study evaluated the safety and efficacy of this therapy at 6- and 12-month follow-up.
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