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2781. Effect of mibefradil, a T-type calcium channel blocker, on morbidity and mortality in moderate to severe congestive heart failure: the MACH-1 study. Mortality Assessment in Congestive Heart Failure Trial.
作者: T B Levine.;P J Bernink.;A Caspi.;U Elkayam.;E M Geltman.;B Greenberg.;W J McKenna.;J K Ghali.;T D Giles.;A Marmor.;L H Reisin.;S Ammon.;E Lindberg.
来源: Circulation. 2000年101卷7期758-64页
Calcium antagonists have proved disappointing in long-term congestive heart failure (CHF) studies. Mibefradil, a new calcium antagonist that selectively blocks T-type calcium channels, has been shown to be an effective antihypertensive, antianginal, and anti-ischemic agent, and because of its different mechanism of action, it may be beneficial as adjunct therapy in CHF patients.
2782. Early percutaneous coronary intervention, platelet inhibition with eptifibatide, and clinical outcomes in patients with acute coronary syndromes. PURSUIT Investigators.
作者: N S Kleiman.;A M Lincoff.;G C Flaker.;K S Pieper.;R G Wilcox.;L G Berdan.;T J Lorenz.;D V Cokkinos.;M L Simoons.;E Boersma.;E J Topol.;R M Califf.;R A Harrington.
来源: Circulation. 2000年101卷7期751-7页
Platelet glycoprotein (GP) IIb/IIIa antagonists prevent the composite end point of death or myocardial infarction (MI) in patients with acute coronary syndromes. There is uncertainty about whether this effect is confined to patients who have percutaneous coronary interventions (PCIs) and whether PCIs further prevent death or MI in patients already treated with GP IIb/IIIa antagonists.
2783. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome.
作者: A J Moss.;W Zareba.;W J Hall.;P J Schwartz.;R S Crampton.;J Benhorin.;G M Vincent.;E H Locati.;S G Priori.;C Napolitano.;A Medina.;L Zhang.;J L Robinson.;K Timothy.;J A Towbin.;M L Andrews.
来源: Circulation. 2000年101卷6期616-23页
beta-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of beta-blockers in this disorder have not been evaluated.
2784. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure.
The RALES study showed that spironolactone, added to conventional therapy for chronic heart failure, dramatically reduced mortality. We tested the hypothesis that this benefit was partially due to improvement in endothelial function and/or to amplified suppression of the vascular renin-angiotensin axis.
2785. A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary-artery stents.
The introduction of an effective antiplatelet therapy with aspirin and ticlopidine after the placement of coronary-artery stents has decreased the risk of thrombotic stent occlusions (TSO) and hemorrhagic complications. However, the use of ticlopidine is limited by hematological and gastrointestinal adverse effects. The safety and efficacy of clopidogrel after stenting remains to be established.
2786. Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).
作者: A M Gotto.;E Whitney.;E A Stein.;D R Shapiro.;M Clearfield.;S Weis.;J Y Jou.;A Langendörfer.;P A Beere.;D J Watson.;J R Downs.;J S de Cani.
来源: Circulation. 2000年101卷5期477-84页
The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) is the first primary-prevention study in a cohort with average total cholesterol (TC) and LDL cholesterol (LDL-C) and below-average HDL cholesterol (HDL-C). Treatment with lovastatin (20 to 40 mg/d) resulted in a 25% reduction in LDL-C and a 6% increase in HDL-C, as well as a 37% reduction in risk for first acute major coronary event (AMCE), defined as fatal or nonfatal myocardial infarction, unstable angina, or sudden cardiac death. This article describes the relation between baseline and on-treatment lipid and apolipoprotein (apo) parameters and subsequent risk for AMCEs.
2787. Alcohol potentiates orthostatic hypotension : implications for alcohol-related syncope.
Alcohol consumption may be linked to syncopal events. The mechanisms by which alcohol may induce syncope are unknown. Impairment of the response to orthostatic stress may be involved. Using a double-blind, randomized, placebo-controlled study, we tested the hypothesis that short-term alcohol intake causes orthostatic hypotension because of an impairment in the vasoconstrictor response to orthostatic stress.
2788. Effects of metoprolol CR in patients with ischemic and dilated cardiomyopathy : the randomized evaluation of strategies for left ventricular dysfunction pilot study.
来源: Circulation. 2000年101卷4期378-84页
Metoprolol provides clinical benefits in patients with congestive heart failure (CHF). In this study, we investigated the effects of controlled-release metoprolol (metoprolol CR) on clinical status, on left ventricular (LV) volumes and function, and on neurohumoral activation in a large number of patients with CHF of mixed causes.
2789. Cost-effectiveness of platelet glycoprotein IIb/IIIa inhibition with eptifibatide in patients with non-ST-elevation acute coronary syndromes.
作者: D B Mark.;R A Harrington.;A M Lincoff.;R M Califf.;C L Nelson.;A A Tsiatis.;H Buell.;K W Mahaffey.;L Davidson-Ray.;E J Topol.
来源: Circulation. 2000年101卷4期366-71页
In the PURSUIT trial, eptifibatide significantly reduced the 30-day incidence of death and myocardial infarction relative to placebo in 9461 patients with an acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction).
2790. Three-year clinical and angiographic follow-up after intracoronary radiation : results of a randomized clinical trial.
作者: P S Teirstein.;V Massullo.;S Jani.;J J Popma.;R J Russo.;R A Schatz.;E M Guarneri.;S Steuterman.;K Sirkin.;D A Cloutier.;M B Leon.;P Tripuraneni.
来源: Circulation. 2000年101卷4期360-5页
Although several early trials indicate treatment of restenosis with radiation therapy is safe and effective, the long-term impact of this new technology has been questioned. The objective of this report is to document angiographic and clinical outcome 3 years after treatment of restenotic stented coronary arteries with catheter-based (192)Ir.
2791. Cost-effectiveness of catheter ablation in patients with ventricular tachycardia.
作者: H Calkins.;J T Bigger.;S J Ackerman.;S B Duff.;D Wilber.;R A Kerr.;M Bar-Din.;K M Beusterien.;M J Strauss.
来源: Circulation. 2000年101卷3期280-8页
This study evaluated the cost-effectiveness of catheter ablation therapy versus amiodarone for treating ventricular tachycardia (VT) in patients with structural heart disease. The analysis used a societal perspective for a hypothetical cohort of VT patients with implantable cardioverter-defibrillators, who were experiencing frequent shocks.
2792. Infections, inflammation, and the risk of coronary heart disease.
作者: M Roivainen.;M Viik-Kajander.;T Palosuo.;P Toivanen.;M Leinonen.;P Saikku.;L Tenkanen.;V Manninen.;T Hovi.;M Mänttäri.
来源: Circulation. 2000年101卷3期252-7页
The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk.
2793. Endothelium-derived nitric oxide contributes to the regulation of venous tone in humans.
作者: D J Blackman.;J A Morris-Thurgood.;J J Atherton.;G R Ellis.;R A Anderson.;J R Cockcroft.;M P Frenneaux.
来源: Circulation. 2000年101卷2期165-70页
Although nitric oxide (NO) is known to play an important part in the regulation of arterial tone, little is known about its role in veins. The aim of this study was to investigate the role of basal and stimulated NO activity in the regulation of tone of the human venous capacitance bed.
2794. Influence of a nonionic, iso-osmolar contrast medium (iodixanol) versus an ionic, low-osmolar contrast medium (ioxaglate) on major adverse cardiac events in patients undergoing percutaneous transluminal coronary angioplasty: A multicenter, randomized, double-blind study. Visipaque in Percutaneous Transluminal Coronary Angioplasty [VIP] Trial Investigators.
The potential merits and disadvantages of the use of ionic or nonionic contrast media in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) have been the subjects of controversy. The present study was designed to evaluate the possible influence of both types of contrast media on major adverse cardiac events (MACE) in patients undergoing PTCA.
2796. Sympathetic activation by sildenafil.
作者: B G Phillips.;M Kato.;C A Pesek.;M Winnicki.;K Narkiewicz.;D Davison.;V K Somers.
来源: Circulation. 2000年102卷25期3068-73页
Sildenafil citrate is an effective and widely prescribed therapy for erectile dysfunction. Little is known about the effects of sildenafil on neural control of the circulation or about the effects of sildenafil on neurocirculatory stress responses.
2797. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators.
作者: P Théroux.;B R Chaitman.;N Danchin.;L Erhardt.;T Meinertz.;J S Schroeder.;G Tognoni.;H D White.;J T Willerson.;A Jessel.
来源: Circulation. 2000年102卷25期3032-8页
The transmembrane sodium/hydrogen exchanger maintains myocardial cell pH integrity during myocardial ischemia but paradoxically may precipitate cell necrosis. The development of cariporide, a potent and specific inhibitor of the exchanger, prompted this investigation of the potential of the drug to prevent myocardial cell necrosis.
2798. Enhanced efficacy of eptifibatide administration in patients with acute coronary syndrome requiring in-hospital coronary artery bypass grafting. PURSUIT Investigators.
作者: S P Marso.;D L Bhatt.;M T Roe.;P L Houghtaling.;M Labinaz.;N S Kleiman.;C Dyke.;M L Simmoons.;R M Califf.;R A Harrington.;E J Topol.
来源: Circulation. 2000年102卷24期2952-8页
Patients with a recent episode of non-ST-segment elevation acute coronary syndrome before CABG have higher rates of operative morbidity and mortality than patients with stable coronary syndromes. The efficacy of administering eptifibatide to these patients undergoing in-hospital CABG is unknown.
2799. Randomized comparison of elective stent implantation and coronary balloon angioplasty guided by online quantitative angiography and intracoronary Doppler. DESTINI Study Group (Doppler Endpoint STenting INternational Investigation).
作者: C Di Mario.;J W Moses.;T J Anderson.;R Bonan.;T Muramatsu.;A C Jain.;J Suarez de Lezo.;S Y Cho.;M Kern.;I T Meredith.;D Cohen.;I Moussa.;A Colombo.
来源: Circulation. 2000年102卷24期2938-44页
The purpose of this study was to compare long-term outcomes of coronary stenting in all lesions (elective stenting) or only in lesions with inadequate morphological and functional results after balloon angioplasty (guided PTCA).
2800. Randomized comparison of primary stenting and provisional balloon angioplasty guided by flow velocity measurement. Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) II Study Group.
作者: P W Serruys.;B de Bruyne.;S Carlier.;J E Sousa.;J Piek.;T Muramatsu.;C Vrints.;P Probst.;R Seabra-Gomes.;I Simpson.;V Voudris.;O Gurné.;N Pijls.;J Belardi.;G A van Es.;E Boersma.;M A Morel.;B van Hout.
来源: Circulation. 2000年102卷24期2930-7页
Coronary stenting improves outcomes compared with balloon angioplasty, but it is costly and may have other disadvantages. Limiting stent use to patients with a suboptimal result after angioplasty (provisional angioplasty) may be as effective and less expensive.
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