Radiotherapy remains a valuable yet limited option for select colon cancer cases, with radioresistance representing a major clinical challenge. Lipidomics screening identified autotaxin (ATX), also known as ENPP2, as a key mediator of radiation-induced metabolic reprogramming. Radiation exposure upregulated ATX expression and its product lysophosphatidic acid (LPA), which activated the LPAR2-AKT signaling axis to support tumor cell survival. Pharmacological ATX inhibition with HA130 or genetic ATX knockdown enhanced radiosensitivity in vitro by suppressing proliferation and promoting apoptosis. In mouse models, both HA130 treatment and ATX knockdown significantly suppressed tumor growth and improved radiotherapy efficacy, as shown by reduced tumor volume, weight, and Ki67-positive cell counts. Clinically, elevated ATX-LPA pathway activity was associated with poor patient prognosis. These findings establish ATX as a promising therapeutic target for overcoming radioresistance in colon cancer, supporting the combination of ATX inhibition with radiotherapy to improve treatment outcomes.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases. We aimed to conduct a pilot study to evaluate the potential utility of ChatGPT in early diagnosis of MAFLD.

Inflammatory–immune blood indices such as the systemic immune‑inflammation index (SII) relate to outcomes in hepatocellular carcinoma (HCC). Visit‑to‑visit variability (VVV) may capture instability of host inflammatory homeostasis that is not reflected by average levels. We examined whether early VVV of these indices predicts overall survival (OS) and adds discriminatory value beyond standard prognostic factors and mean levels.

This research aimed to assess the relationship between creatinine-to-albumin ratio (CAR) and clinical outcomes among individuals with upper gastrointestinal bleeding (UGIB), with a particular focus on the association between CAR and 30-day and 90-day all-cause mortality (ACM).

Pancreatic cancer (PC) is the third most common cause of cancer-related deaths worldwide, with the 5-year survival rate for patients with PC in developed countries being only 9-10%. Gastroesophageal reflux disease (GERD) is known to be a high-risk factor for several cancers. However, the relationship between GERD and PC remains controversial. Therefore, this study aimed to investigate the causal association between GERD and the risk of PC. Additionally, we sought to validate the role of omega-6/omega-3 polyunsaturated fatty acids (n-6/n-3 PUFA) as mediators in this pathway by calculating their mediating effect.

The role of low-grade-inflammation in Irritable Bowel Syndrome (IBS) a common disorder of gut-brain interaction is unclear. Association with symptom severity, as well as effects of first line treatments are understudied. In a large cohort of primary care IBS patients (DOMINO trial), a FODMAP-lowering diet application was superior in improving symptoms compared to standard medical therapy (otilonium bromide, OB). We investigated the level of pro-inflammatory markers in this IBS cohort and its changes by the DOMINO application and OB.

The diagnosis and treatment rates for hepatitis C virus (HCV) remain below target levels. This study aims to define and analyze the HCV care cascade for surgical patients in a high-prevalence region, evaluate the impact of a hospital-wide elimination program, and identify barriers and facilitators to completing the diagnostic pathway.

Few studies describe gut microbiome signatures in treatment-naïve new-onset inflammatory bowel disease (IBD). We present a novel secondary bioinformatic reanalysis of sequence outputs mapped to the latest microbial taxonomy.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic disease that provokes dysregulation of the coagulation system. Patients exhibit significantly elevated circulating levels of blood clotting protein fibrin(ogen). Extravascular fibrin deposits contribute to the complex tumor microenvironment in PDAC.

Alcohol is a key driver of liver-related mortality, and phosphatidylethanol (PEth) is a direct biomarker of alcohol intake. We investigated the prognostic performance of PEth with noninvasive liver fibrosis tests (NITs) for predicting hepatic decompensation in an alcohol-related liver disease (ALD) at-risk population.

A significant proportion of patients with colorectal cancer present to the emergency department. For patients at this stage, the options of emergency resection and stent placement are still being discussed in terms of perioperative, postoperative and survival outcomes. Our study aims to determine which method provides the best survival results for patients who present to the emergency department with colorectal cancer-related obstruction in the first three years.

Endoscopic submucosal dissection (ESD) and submucosal tunneling endoscopic resection (STER) have become the safe and effective techniques for early-stage esophageal cancer and small-diameter submucosal tumors of the esophagus. Yet, there remains insufficient research on the appropriate fasting period following ESD or STER in patients with early esophageal neoplasms. This study aims to assess the impact of different fasting durations-long versus short-on postoperative complication rates and hospital stay durations.

Upper gastrointestinal (GI) disorders represent a major cause of morbidity worldwide, and esophagogastroduodenoscopy (EGD) remains the gold standard for both diagnosis and therapeutic guidance. In resource-limited settings such as the Gaza Strip, the utilization of EGD provides critical insights into disease burden, patient characteristics, and clinical outcomes. This study aimed to evaluate the demographic characteristics, clinical indications, endoscopic findings, and management outcomes of patients undergoing EGD at the Gaza Strip Hospitals.

While diet is a modifiable risk factor for digestive cancers, existing dietary scores are not optimized for site-specific risk assessment. We aimed to develop and evaluate cancer-specific dietary scores for improved risk stratification.

Acute cholangitis (AC) is an emergency disease with a high risk of mortality. Red cell distribution width (RDW) has been proven to correlate with the adverse outcomes of several clinical conditions. The present study aims to investigate the association between RDW and 30-day mortality in critical AC.

We aimed to compare upper endoscopy (UE) with histopathology (biopsy) for detecting reflux-related findings at 1 and 3 years following one-anastomosis gastric bypass (OAGB).

Liver cirrhosis not only leads to high mortality but also imposes significant economic burdens and health losses. Aspirin is a drug with potential indications for liver disease, but its benefits in cirrhosis have primarily been demonstrated in outpatient settings. This study aimed to determine whether aspirin therapy confers protective effects on the prognosis of critically ill cirrhosis patients.

Constipation and diarrhea are prevalent gastrointestinal health issues that significantly impact productivity and daily life, often leading to psychological problems and exacerbating public health burdens. Alcohol is a commonly consumed beverage worldwide, and previous studies suggest that it may exert certain effects on the gastrointestinal tract. Investigating the relationship between patterns of alcohol consumption and the presence of gastrointestinal symptoms such as constipation or diarrhea can aid in the formulation of public health strategies and improve management plans for alcohol use and gastrointestinal health.

Inadequate bowel preparation (BP) compromises colonoscopy quality, efficiency, and patient outcomes. We evaluated whether a resource-light multimodal educational package improves BP adequacy compared with standard instructions.

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease. This research investigates the role of miR-199b-5p in NAFLD development.