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261. Prognostic Significance of Noninvasive Simultaneous Renal and Cardiac Perfusion: Interrogating Mechanisms of Cardiovascular-Kidney Interactions.
作者: Omolabake O Alabi.;Zhou Lan.;Daniel M Huck.;Marie Foley Kijewski.;Mi-Ae Park.;Jon Hainer.;Sylvain L Carre.;Anna Perillo.;Laurel Martell.;Leanne Barrett.;Brittany N Weber.;Sanjay Divakaran.;Diana M Lopez.;Ron Blankstein.;Sharmila Dorbala.;Piotr J Slomka.;Marcelo F Di Carli.;Jenifer M Brown.
来源: Circ Cardiovasc Imaging. 2026年19卷3期e018979页
Physiologic interaction between the cardiovascular and renal systems is pivotal in the understanding of disease and as a target for therapeutic interventions, as highlighted in the cardiovascular-kidney-metabolic syndrome. This study explores the association of renal blood flow, derived noninvasively from cardiac positron emission tomography-computed tomography, with cardiovascular and renal outcomes.
262. Multicenter Evaluation of Myocardial Flow Reserve as a Prognostic Marker for Mortality in 13N-Ammonia PET Myocardial Perfusion Imaging.
作者: Giselle Ramirez.;Valerie Builoff.;Robert J H Miller.;Mark Lemley.;Isabel Carvajal-Juarez.;Erick Alexanderson.;Thomas L Rosamond.;Na Song.;Mark I Travin.;Leandro Slipczuk.;Andrew J Einstein.;Samuel Wopperer.;Marcelo Di Carli.;Panithaya Chareonthaitawee.;Piotr Slomka.
来源: Circ Cardiovasc Imaging. 2026年e018729页
Myocardial flow reserve (MFR), measured by positron emission tomography (PET) myocardial perfusion imaging, provides valuable information on epicardial coronary disease, diffuse atherosclerosis, and microvascular function. Despite its routine use, the prognostic efficacy of 13N-ammonia PET MFR remains unconfirmed in larger multicenter cohorts of patients with suspected or known coronary artery disease.
263. Wearable-Derived Training Load and Coronary Atherosclerosis in Middle-Aged and Older Athletes and Physically Active Controls: A New Perspective From the Master@Heart Study.
作者: Rik Pauwels.;Christophe Dausin.;Sergio Ruiz-Carmona.;Ruben De Bosscher.;Jarne De Paepe.;Youri Bekhuis.;Boris Delpire.;Peter Sinnaeve.;Steven Dymarkowski.;Olivier Ghekiere.;Liesbeth Bruckers.;Tatiana Kuznetsova.;Caroline M Van De Heyning.;Paul L Van Herck.;Thijs M H Eijsvogels.;Lieven Herbots.;Tomas Robyns.;André La Gerche.;Hein Heidbuchel.;Rik Willems.;Guido Claessen.
来源: Circulation. 2026年
Middle-aged and older endurance athletes have increased prevalence of coronary artery disease (CAD) on coronary CT angiography (CCTA) compared to healthy controls, despite similarly low cardiovascular risk. Prior studies relied on self-reported data to quantify training load (TL), which poorly correlates with objective wearable-derived TL and may bias outcomes. The impact of objective TL on CAD risk remains unknown.
264. Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in ARVC.
作者: Corrado De Marco.;Babken Asatryan.;Anneline S J M Te Riele.;Andrea Di Marco.;Alessio Gasperetti.;Antoine Delinière.;Jason D Roberts.;Henrik K Jensen.;Brianna Davies.;Andrew D Krahn.;Rafik Tadros.;Anneli Svensson.;Silvia Castelletti.;Lia Crotti.;Pyotr G Platonov.;Karolina Borowiec.;Elżbieta K Biernacka.;Elena Arbelo.;Louis-Philippe David.;Ardan M Saguner.;Jeff S Healey.;Corinna Brunckhorst.;Chiara Cappelletto.;Davide Stolfo.;Marco Merlo.;Christine Rootwelt-Norberg.;Kristina H Haugaa.;Firat Duru.;J Peter van Tintelen.;Birgitta K Velthuis.;Hugh Calkins.;Stefan L Zimmerman.;Cynthia A James.;Laurens P Bosman.;Julia Cadrin-Tourigny.
来源: Circ Arrhythm Electrophysiol. 2026年19卷2期e014265页
The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populations meeting 2010 Task Force Criteria. However, the calculator includes no measure of left ventricular (LV) structure and function, while late gadolinium enhancement (LGE) on cardiac magnetic resonance shows promise in arrhythmic risk prediction. This study aims to evaluate whether LV LGE on cardiac magnetic resonance can further refine ARVC VA risk stratification.
266. Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection.
作者: Maddalena Ardissino.;Alec P Morley.;Buu Truong.;Art Schuermans.;Rohin K Reddy.;Martina Milani.;Alice Sacco.;James S Ware.;Stephen Burgess.;Brian P Halliday.;Thong Huy Cao.;Paulene A Quinn.;Leong L Ng.;Ania A Baranowska-Clarke.;Pradeep Natarajan.;Adam S Butterworth.;Michael C Honigberg.;Kypros Nicolaides.;Thomas Webb.;David Adlam.;Antonio de Marvao.
来源: Circ Genom Precis Med. 2026年19卷1期e005330页
Spontaneous coronary artery dissection (SCAD) is an uncommon cause of myocardial infarction that disproportionately affects women, particularly during pregnancy and the peripartum period. Limited understanding of its underlying pathophysiology hinders the development of effective preventive and therapeutic strategies.
267. Finerenone, Liver Biomarkers, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: An Analysis of FINEARTS-HF.
作者: Jawad H Butt.;Alasdair D Henderson.;Pardeep S Jhund.;Brian L Claggett.;Akshay S Desai.;Maria Borentain.;Katja Rohwedder.;Rania Dayoub.;Yoriko De Sanctis.;Carolyn S P Lam.;Michele Senni.;Sanjiv J Shah.;Adriaan A Voors.;Johann Bauersachs.;Cândida Fonseca.;Gerard C M Linssen.;Mark C Petrie.;Morten Schou.;Subodh Verma.;Faiez Zannad.;Bertram Pitt.;Muthiah Vaduganathan.;Scott D Solomon.;John J V McMurray.
来源: Circ Heart Fail. 2026年19卷2期e013201页
The prevalence and prognostic significance of liver biomarkers in heart failure (HF) with mildly reduced or preserved ejection fraction are uncertain, with both potential hemodynamic and metabolic contributions to liver dysfunction in these patients. We evaluated the prevalence and prognostic value of liver biomarkers and assessed the effects of the nonsteroidal mineralocorticoid receptor antagonist finerenone on these biomarkers and clinical outcomes in FINEARTS-HF (Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With Heart Failure).
268. Can TAVR Be Safely Performed in Patients With Bicuspid Aortic Valve Morphology?
作者: Chloe Kharsa.;Min-Fang Chao.;Gal Sella.;Mangesh Kritya.;Sahar Samimi.;Su Min Chang.;Michael J Reardon.;Joe Aoun.;Neal S Kleiman.;Sachin S Goel.
来源: Circ Cardiovasc Interv. 2026年19卷3期e015967页 269. Pre-TAVI CT Angiography for Coronary Artery Disease Assessment: A Systematic Review and Meta-Analysis of Clinical Outcomes.
作者: Soheil Rahmati.;Amir Nasrollahizadeh.;Dhaval Kolte.;Omar K Khalique.;Tor Biering-Sørensen.;Kaveh Hosseini.
来源: Circ Cardiovasc Interv. 2026年19卷3期e016074页 270. Dynamic Change of Coronary Artery Geometry After Bioadaptor Implantation: A Single-blind Randomized Controlled Trial.
作者: Cheng-Hsuan Tsai.;Han-Hsuan Chu.;Ching-Chang Huang.;Chih-Fan Yeh.;Ying-Hsien Chen.;Mao-Shin Lin.;Tsung-Yu Ko.;Chun-Kai Chen.;Yu-Cheng Huang.;Pin-Yi Chiang.;Wen-Jeng Lee.;Hsien-Li Kao.
来源: Circ Cardiovasc Interv. 2026年19卷2期e016191页
The DynamX bioadaptor, a novel coronary implant, is designed to restore vessel function when the thin polymer coating covering the helical strands resorbs 6 months post-percutaneous coronary intervention. We aimed to evaluate vessel conformability 1 year after percutaneous coronary intervention with the bioadaptor, compared with conventional drug-eluting stents (DESs).
271. Stress Perfusion CMR Imaging-Guided Management and Prognosis in Patients With Suspected Coronary Heart Disease.
作者: Antonin Trimaille.;Philippe Garot.;Solenn Toupin.;Francesca Sanguineti.;Thomas Hovasse.;Suzanne Duhamel.;Stéphane Champagne.;Thierry Unterseeh.;Mariama Akodad.;Antoinette Neylon.;Lounis Hamzi.;Trecy Gonçalves.;Andreea Sorina Afana.;Alexandre Unger.;Jeremy Florence.;Emmanuel Gall.;Paul-Jun Martial.;Alexandre Pfeffer.;Elena Sofia Canuti.;Aicha Kante.;Manveer Singh.;Jean Guillaume Dillinger.;Patrick Henry.;Olivier Morel.;Valérie Bousson.;Jérôme Garot.;Théo Pezel.
来源: Circ Cardiovasc Interv. 2026年19卷3期e015765页
Identifying patients with chronic coronary syndrome who will benefit most from a coronary revascularization strategy is essential. Data on the performance of stress cardiac magnetic resonance (CMR) to guide revascularization are limited. To assess the long-term prognostic impact of stress CMR-guided revascularization strategy to predict all-cause death.
272. Unbiased Characterization of Atrial Fibrillation Phenotypic Architecture Provides Insight Into Genetic Liability and Clinically Relevant Outcomes.
作者: Giovanni Davogustto.;Shilin Zhao.;Yajing Li.;Eric Farber-Eger.;Brandon D Lowery.;Lauren Lee Shaffer.;Jonathan D Mosley.;M Benjamin Shoemaker.;Yaomin Xu.;Dan M Roden.;Quinn S Wells.
来源: Circ Genom Precis Med. 2026年19卷1期e004853页
Atrial fibrillation (AF) is a common and clinically heterogeneous arrhythmia. Machine learning algorithms can define data-driven disease subtypes in an unbiased fashion, but whether these AF subgroups align with underlying mechanisms, such as polygenic liability to AF or inflammation, and associate with clinical outcomes is unclear.
273. Genetic Architecture of N-Terminal Pro-B-Type Natriuretic Peptide in a Multiancestry Study Population.
作者: Naman S Shetty.;Akhil Pampana.;Mokshad Gaonkar.;Amrita Nayak.;Harshvir S Bal.;Nirav Patel.;Nehal Vekariya.;J Gustav Smith.;Alanna C Morrison.;Bing Yu.;Bruce M Psaty.;Eric Boerwinkle.;James S Floyd.;Jerome I Rotter.;Kent D Taylor.;Leslie A Lange.;Marguerite R Irvin.;Mary Cushman.;Stephen S Rich.;Ramachandran S Vasan.;Thomas J Wang.;Xiuqing Guo.;Peng Li.;Garima Arora.;Pankaj Arora.
来源: Circ Genom Precis Med. 2026年19卷1期e005130页
NPs (natriuretic peptides) are bioactive hormones crucial for regulating blood pressure, glucose homeostasis, and lipid metabolism. Despite the high heritability of circulating NP levels, the genetic determinants of NP regulation, particularly across ancestries and sexes, remain poorly understood. The objective of the current study was to identify genetic variants associated with NT-proBNP (N-terminal pro-B-type NP) levels in a multiancestry study population.
274. Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension.
作者: Victoria Toro.;Manon Mougin.;Coline Brossat.;Clement Jambon-Barbara.;Alex Hlavaty.;Charles Antoine Guay.;Reem El Kabbout.;Coralie Bilodeau.;Yann Grobs.;Sandra Martineau.;Sandra Breuils-Bonnet.;Antonella Abi-Sleimen.;Gregoire Ruffenach.;Olivier Boucherat.;Malik Bisserier.;Steeve Provencher.;Sebastien Bonnet.;David Montani.;Charles Khouri.;François Potus.
来源: Circulation. 2026年153卷7期516-533页
Pulmonary arterial hypertension (PAH) and breast cancer disproportionately affect women. BMPR2 (bone morphogenetic protein receptor type 2) mutations, the most common genetic cause of heritable PAH, also exert tumor-suppressive functions, but their role in linking these diseases remains unclear.
275. Race and Ethnic-Specific Burden of Aortic Valve Calcium and Its Association With Long-Term Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis.
作者: Jelani K Grant.;Kunal Jha.;Natalie Marrero.;Alexander C Razavi.;Ellen Boakye.;Khalil Anchouche.;Omar Dzaye.;Matthew J Budoff.;Sanjiv J Shah.;Matthew J Czarny.;Jerome I Rotter.;Xiuqing Guo.;Jie Yao.;George Thanassoulis.;Wendy S Post.;Michael J Blaha.;Seamus P Whelton.
来源: Circ Cardiovasc Imaging. 2026年19卷2期e018916页
Racial and ethnic differences have been reported for aortic valve calcium (AVC) and long-term aortic stenosis (AS). Whether these differences are due to differing risk factor profiles or the burden of AVC is unknown.
276. MEK Inhibition Improves Clinical Outcome in Premature Infants With Multisystemic RASA1 Disease.
作者: Elizabeth K Baker.;Pavalan Selvam.;Ryan Monsberger.;Laura S Peterson.;John Erickson.;Vanina Taliercio.;Jessica Hass Alfonso.;Lonnie J Miner.;David Viskochil.;K Nicole Weaver.
来源: Circ Genom Precis Med. 2026年19卷1期e005578页 277. Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure.
作者: Mahesh K Vidula.;Leon J Schurgers.;Lei Zhao.;Marie-Joe Dib.;Manyun Zhao.;Zhaoqing Wang.;Christina Ebert.;Oday Salman.;Joe D Azzo.;Payman Zamani.;Vanessa van Empel.;A Mark Richards.;Rob Doughty.;Ali Javaheri.;Douglas L Mann.;Ernst Rietzschell.;Karl Kammerhoff.;Peter Schafer.;Dietmar A Seiffert.;Francisco Ramirez-Valle.;Thomas P Cappola.;Julio A Chirinos.
来源: Circ Heart Fail. 2026年19卷2期e012734页
MGP (matrix Gla-protein), a known inhibitor of vascular calcification, becomes biologically active by vitamin K-dependent carboxylation. Circulating levels of dpucMGP (dephospho-uncarboxylated matrix Gla-protein), the inactive form of MGP, have been associated with large artery stiffening and reduced skeletal muscle mass in heart failure (HF). Whether dpucMGP is related to adverse outcomes in patients with HF is unknown.
278. Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy.
作者: Ying Wu.;Xiaojing Sun.;Ru-Xing Wang.;Joseph S Reddy.;Hon-Chi Lee.;Nadine Norton.;Tong Lu.
来源: Circ Genom Precis Med. 2026年19卷1期e005334页
TRPC6 (transient receptor potential canonical 6) channels, encoded by the TRPC6 gene, are widely expressed in cardiomyocytes and play a critical role in maintaining intracellular Ca2+ homeostasis. Variants in TRPC6 are associated with chemotherapy-related cardiomyopathy. Specifically, the TRPC6 A404V polymorphism, with a minor (404 V) allele frequency of 12% in the general population, has been identified in patients undergoing anthracycline therapy. However, the underlying mechanisms remain largely unexplored.
279. Population Modeling Approach for Human Cardiac Arrhythmia Risk Prediction.
作者: Zhen Song.;Fengze Sui.;Xiaodong Huang.;Michael B Liu.;Wen Gao.;James N Weiss.;Zhilin Qu.
来源: Circ Arrhythm Electrophysiol. 2026年19卷2期e014249页
Cardiovascular disease is the number 1 killer in industrialized countries, with sudden cardiac death due to ventricular arrhythmias representing a major component. To reduce sudden cardiac death, accurate risk prediction and development of effective preventive treatments remain major challenges. In this study, we explored the possibility of using a population-based computational modeling approach to perform virtual clinical trials for antiarrhythmic drug discovery and drug safety testing.
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