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261. Impact of Dyspnea on Adults With Respiratory Symptoms Without a Defined Diagnosis.
作者: Jared Bierbrier.;Emily Gerstein.;George A Whitmore.;Katherine L Vandemheen.;Celine Bergeron.;Louis-Philippe Boulet.;Andreanne Cote.;Stephen K Field.;Erika Penz.;R Andrew McIvor.;Catherine Lemière.;Samir Gupta.;Paul Hernandez.;Irvin Mayers.;Mohit Bhutani.;M Diane Lougheed.;Christopher J Licskai.;Tanweer Azher.;Nicole Ezer.;Martha Ainslie.;Gonzalo G Alvarez.;Sunita Mulpuru.;Shawn D Aaron.
来源: Chest. 2024年166卷6期1296-1308页
We investigated dyspnea; its associated risk factors; and its impact on health care utilization, quality of life, and work productivity in adults with undiagnosed respiratory symptoms.
262. Risk Factors, Morbidity, and Mortality in Association With Preserved Ratio Impaired Spirometry and Restrictive Spirometric Pattern: Clinical Relevance of Preserved Ratio Impaired Spirometry and Restrictive Spirometric Pattern.
作者: Lucia Cestelli.;Ane Johannessen.;Amund Gulsvik.;Knut Stavem.;Rune Nielsen.
来源: Chest. 2025年167卷2期548-560页
Preserved ratio impaired spirometry (PRISm) and restrictive spirometric pattern (RSP) are often considered interchangeable in identifying restrictive impairment in spirometry.
263. Breathlessness, Frailty, and Sarcopenia in Older Adults.
作者: Tai Joon An.;Jihye Lim.;Heayon Lee.;Sunghwan Ji.;Hee-Won Jung.;Ji Yeon Baek.;Eunju Lee.;Il-Young Jang.
来源: Chest. 2024年166卷6期1476-1486页
Breathlessness shares aging mechanisms with frailty and sarcopenia.
264. "My Mom Is a Fighter": A Qualitative Analysis of the Use of Combat Metaphors in ICU Clinician Notes.
作者: Shannen Kim.;Hunter Mills.;Teva Brender.;Samuel McGowan.;Eric Widera.;Allyson C Chapman.;Krista L Harrison.;Sei Lee.;Alex K Smith.;David Bamman.;Oksana Gologorskaya.;Julien Cobert.
来源: Chest. 2024年166卷5期1162-1172页
A metaphor conceptualizes one, typically abstract, experience in terms of another, more concrete, experience with the goal of making it easier to understand. Although combat metaphors have been well described in some health contexts, they have not been well characterized in the setting of critical illness.
265. Upper Airway and Translaryngeal Resistance During Mechanical Insufflation-Exsufflation.
作者: Tiina M Andersen.;Anne Kristine Brekka.;Zoe Fretheim-Kelly.;Manel Lujan.;John-Helge Heimdal.;Hege H Clemm.;Thomas Halvorsen.;Ove Fondenes.;Roy M Nilsen.;Ola D Røksund.;Maria Vollsæter.
来源: Chest. 2025年167卷1期188-201页
Mechanical insufflation-exsufflation (MI-E) uses positive and negative pressures to assist weak cough and to help clear airway secretions. Laryngeal visualization during MI-E has revealed that inappropriate upper airway responses can impede its efficacy. However, the dynamics of pressure transmission in the upper airways during MI-E are unclear, as are the relationships among anatomic structure, pressure, and airflow.
266. Effect of Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine on Exacerbation Rate and Risk in Patients With Moderate to Severe COPD.
作者: Frank C Sciurba.;Stephanie A Christenson.;Tara Rheault.;Thomas Bengtsson.;Kathleen Rickard.;Igor Z Barjaktarevic.
来源: Chest. 2025年167卷2期425-435页
Exacerbations in COPD can be life-threatening and can lead to irreversible declines in lung function and quality of life. Medications that reduce exacerbation burden are an unmet need, because exacerbations put patients at risk of more exacerbations and decrease quality of life. Ensifentrine is a first-in-class selective dual inhibitor of phosphodiesterase 3 and 4 with demonstrated nonsteroidal antiinflammatory activity and bronchodilatory effects.
267. Differences in Health Care and Palliative Care Use at the End of Life: A Comparison Study Among Lung Cancer, COPD, and Idiopathic Pulmonary Fibrosis.
作者: Angela O Suen.;Kara Bischoff.;Anand S Iyer.;Keerthana Radhakrishnan.;Cynthia Fenton.;Jonathan P Singer.;Rebecca L Sudore.;Ashwin Kotwal.;Erica Farrand.
来源: Chest. 2024年166卷6期1487-1496页
Patients with lung cancer, idiopathic pulmonary fibrosis (IPF), and COPD have high symptom burden, poor quality of life, and high health care use at the end of life. Although proactive integration of palliative care in lung cancer can improve outcomes, it is unclear whether similar practices have been adopted in COPD and IPF care.
268. Association of Phosphodiesterase-5 Inhibitor Treatment With Improved Survival in Pulmonary Hypertension Associated With COPD in the Pulmonary Vascular Research Institute GoDeep Meta-Registry.
作者: Khodr Tello.;Athiththan Yogeswaran.;Raphael W Majeed.;David G Kiely.;Allan Lawrie.;Evan Brittain.;Jeffrey S Annis.;Horst Olschewski.;Gabor Kovacs.;Paul M Hassoun.;Aparna Balasubramanian.;Ziad Konswa.;Andrew J Sweatt.;Roham T Zamanian.;Martin R Wilkins.;Luke Howard.;Alexandra Arvanitaki.;George Giannakoulas.;Hector R Cajigas.;Robert Frantz.;Paul G Williams.;Marlize Frauendorf.;Kurt Marquardt.;Tobiah Antoine.;Meike Fuenderich.;Manuel Richter.;Friedrich Grimminger.;Hossein-Ardeschir Ghofrani.;Jochen Wilhelm.;Werner Seeger.; .
来源: Chest. 2025年167卷1期224-240页
Patients with COPD frequently demonstrate pulmonary hypertension (PH). Severe PH in patients with COPD, identified by pulmonary vascular resistance (PVR) of > 5 Wood units (WU), is closely linked to impaired transplant-free survival. The impact of PH-targeting pharmacotherapy in this context remains unclear.
269. Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study.
作者: Audrey De Jong.;Mathieu Capdevila.;Yassir Aarab.;Matthieu Cros.;Joris Pensier.;Ines Lakbar.;Clément Monet.;Hervé Quintard.;Raphael Cinotti.;Karim Asehnoune.;Jean-Michel Arnal.;Christophe Guitton.;Catherine Paugam-Burtz.;Paer Abback.;Armand Mekontso-Dessap.;Karim Lakhal.;Sigismond Lasocki.;Gaetan Plantefeve.;Bernard Claud.;Julien Pottecher.;Philippe Corne.;Carole Ichai.;Nicolas Molinari.;Gerald Chanques.;Laurent Papazian.;Elie Azoulay.;Samir Jaber.; .
来源: Chest. 2025年167卷1期139-151页
To our knowledge, no large observational study has compared the incidence and risk factors for extubation failure within 48 h and during ICU stay in the same cohort of unselected critically ill patients with and without obesity.
270. Association of Cardiopulmonary Hemodynamics and Outcomes in Pulmonary Hypertension Following Kidney Transplantation: A Multicenter Retrospective Cohort Study.
作者: Arun Jose.;Sathish S Kumar.;Leonid Gorelik.;Samuel H Friedman.;Antolin S Flores.;Denise Sese.;Michael Vinzani.;Nicholas J Douville.;Akshar Patel.;Rahul G Argula.;Courtney Jones.;Nicole M Bhave.;Jean M Elwing.
来源: Chest. 2024年166卷6期1499-1510页
Pulmonary hypertension (PH) frequently complicates the evaluation of kidney transplantation (KT) candidates, and is associated with increased adverse outcomes (mortality, delayed graft function [DGF], and major adverse cardiovascular event) following KT.
271. BAL Fluid Cellular Analysis and Radiologic Patterns in Patients With Fibrotic Interstitial Lung Disease.
作者: Amanda Grant-Orser.;Michael Asmussen.;Daniel-Costin Marinescu.;Cameron J Hague.;Nestor L Muller.;Darra T Murphy.;Andrew Churg.;Joanne L Wright.;Amna Al-Arnawoot.;Ana-Maria Bilawich.;Patrick Bourgouin.;Gerard Cox.;Celine Durand.;Tracy Elliot.;Jennifer Ellis.;Jolene H Fisher.;Derek Fladeland.;Gillian C Goobie.;Zachary Guenther.;Ehsan Haider.;Nathan Hambly.;James Huynh.;Geoffrey Karjala.;Nasreen Khalil.;Martin Kolb.;Jonathon Leipsic.;Stacey Lok.;Sarah MacIsaac.;Micheal McInnis.;Helene Manganas.;Veronica Marcoux.;John Mayo.;Julie Morisset.;Ciaran Scallan.;Tony Sedlic.;Shane Shapera.;Kelly Sun.;Victoria Tan.;Alyson W Wong.;Boyang Zheng.;Christopher J Ryerson.;Kerri A Johannson.
来源: Chest. 2025年167卷1期172-182页
BAL cellular analysis is often recommended during the initial diagnostic evaluation of fibrotic interstitial lung disease (ILD). Despite recommendation for its use, between-center heterogeneity exists and supportive data concerning the clinical utility and correlation of BAL findings with radiologic features or patterns remain sparse.
272. The Responsiveness of Exercise Tests in COPD: A Randomized Controlled Trial.
作者: Theresa C Harvey-Dunstan.;Molly M Baldwin.;Ruth Tal-Singer.;Matthew Allinder.;Michael I Polkey.;Alan Hamilton.;Matthew Richardson.;Sarah A Edwards.;Michael C Steiner.;Mike D Morgan.;Sally J Singh.; .
来源: Chest. 2025年167卷1期98-111页
COPD is characterized by reduced exercise tolerance, and improving physical performance is an important therapeutic goal. A variety of exercise tests are commonly used to assess exercise tolerance, including laboratory and field-based tests. The responsiveness of these various tests to common COPD interventions is yet to be compared, but the results may inform test selection in clinical and research settings.
273. Diffuse Cystic Lung Disease: A Clinical Guide to Recognition and Management.
作者: Alessandro N Franciosi.;Nishant Gupta.;David J Murphy.;Kathryn A Wikenheiser-Brokamp.;Cormac McCarthy.
来源: Chest. 2025年167卷2期529-547页
Diffuse cystic lung diseases (DCLDs) represent a group of pathophysiologically heterogeneous entities that share a common radiologic phenotype of multiple thin-walled pulmonary cysts. DCLDs differ from the typical fibroinflammatory interstitial lung diseases in their epidemiology, clinical presentation, molecular pathogenesis, and therapeutic approaches, making them worthy of a distinct classification. The importance of timely and accurate identification of DCLDs is heightened by the impact on patient management including recent discoveries of targeted therapeutic approaches for some disorders.
274. Extracellular Vesicle-Encapsulated microRNAs and Respiratory Health Among American Indian Participants in the Strong Heart Study.
作者: Christina M Eckhardt.;Haotian Wu.;Gabriela Jackson.;Marisa H Sobel.;Tessa Bloomquist.;Adnan Divjan.;Hadler da Silva.;Lyle G Best.;Shelley Cole.;Jason Umans.;Ying Zhang.;Peter de Hoff.;Louise C Laurent.;Matthew S Perzanowski.;Ke Cheng.;Andrea A Baccarelli.;Tiffany R Sanchez.
来源: Chest. 2025年167卷1期87-97页
American Indian populations have experienced marked disparities in respiratory disease burden. Extracellular vesicle-encapsulated microRNAs (EV-miRNAs) are a novel class of biomarkers that may improve recognition of lung damage in indigenous populations in the United States.
275. Quantitative Imaging Methods in Combined Pulmonary Fibrosis and Emphysema.
作者: Jennifer M Wang.;Tetsuro Araki.;Vincent Cottin.;MeiLan K Han.;Justin M Oldham.
来源: Chest. 2024年166卷6期1463-1472页
Combined pulmonary fibrosis and emphysema (CPFE) is an underdiagnosed syndrome in which individuals have variable degrees of pulmonary fibrosis and emphysema. Patients with CPFE have high morbidity, including poor exercise tolerance and increased development of comorbidities. CPFE mortality also seems to outpace that of lone emphysema and pulmonary fibrosis. A major limitation to rigorous, large-scale studies of CPFE has been the lack of a precise definition for this syndrome. A 2022 American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association research statement called attention to fundamental gaps in our understanding of CPFE and highlighted the potential use of quantitative imaging techniques to better define CPFE.
276. Evaluating US Multiple Listing Practices in Lung Transplantation: Unveiling Hidden Disparities.
作者: Adora N Moneme.;Mallory Hunt.;Jacqueline Friskey.;Madeline McCurry.;Dun Jin.;Joshua M Diamond.;Michaela R Anderson.;Emily S Clausen.;Aya Saleh.;Allie Raevsky.;Jason D Christie.;Douglas Schaubel.;Jesse Hsu.;A Russell Localio.;Robert Gallop.;Edward Cantu.
来源: Chest. 2024年166卷6期1442-1454页
Multiple listing (ML) is a practice used to increase the potential for transplant but is controversial due to concerns that it disproportionately benefits patients with greater access to health care resources.
277. Equivalency of Multiple Biomarkers to Clinical Pulmonary Arterial Hypertension Survival Risk Models.
作者: Megan Griffiths.;Catherine E Simpson.;Jun Yang.;Dhananjay Vaidya.;Melanie K Nies.;Stephanie Brandal.;Rachel Damico.;Paul Hassoun.;Dunbar D Ivy.;Eric D Austin.;Michael W Pauciulo.;Katie A Lutz.;Lisa J Martin.;Erika B Rosenzweig.;Raymond L Benza.;William C Nichols.;Cedric Manlhiot.;Allen D Everett.
来源: Chest. 2024年166卷6期1511-1531页
Risk assessment in pulmonary arterial hypertension (PAH) is fundamental to guiding treatment and improved outcomes. Clinical models are excellent at identifying high-risk patients, but leave uncertainty amongst moderate-risk patients.
278. Occupational Exposure to Charcoal Smoke and Dust, a Major Risk Factor for COPD: A Multiregional Cross-Sectional Study in the Democratic Republic of Congo.
作者: Pierre Olenga Vuvu Lofuta.;Malgorzata Klass.;Nathalie Pauwen.;Augustin Mboko Kipula.;Philippe van de Borne.;Alain Van Muylem.;Silvia Perez-Bogerd.;Gaël Deboeck.
来源: Chest. 2024年166卷6期1334-1346页
Occupational exposure to charcoal smoke and dust is a threat to workers' respiratory systems.
279. Identifying Risk of Postoperative Cardiorespiratory Complications in OSA.
作者: Maree Azzopardi.;Richard Parsons.;Gemma Cadby.;Stuart King.;Nigel McArdle.;Bhajan Singh.;David R Hillman.
来源: Chest. 2024年166卷5期1197-1208页
Patients with OSA are at increased risk of postoperative cardiorespiratory complications and death. Attempts to stratify this risk have been inadequate, and predictors from large, well-characterized cohort studies are needed.
280. Decídetexto: Mobile Cessation Support for Latino Adults Who Smoke: A Randomized Clinical Trial.
作者: Francisco Cartujano-Barrera.;Lisa Sanderson Cox.;Delwyn Catley.;Xueya Cai.;Francisco J Diaz.;Evelyn Arana-Chicas.;Arlette Chávez-Iñiguez.;Chinwe Ogedegbe.;Kristi D Graves.;M Patricia Rivera.;Arturo Ponce.;Edward F Ellerbeck.;Ana Paula Cupertino.
来源: Chest. 2025年167卷2期619-629页
Latino adults experience multiple barriers to health care access and treatment that result in tobacco-related disparities. Mobile interventions have the potential to deliver smoking cessation treatment among Latino adults, who show the highest use rates of mobile technologies.
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