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263. CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
作者: Cheng Hu.;Rong Zhang.;Weihui Yu.;Jie Wang.;Congrong Wang.;Can Pang.;Xiaojing Ma.;Yuqian Bao.;Kunsan Xiang.;Weiping Jia.
来源: Diabetes. 2011年60卷11期3085-9页
Diabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients. A recent genome-wide association study in type 1 diabetic patients of European descent identified four loci to be associated with diabetic nephropathy. The aim of this study was to test the effects of single nucleotide polymorphisms (SNPs) from these four loci on diabetic nephropathy and retinopathy in Chinese type 2 diabetic patients.
264. Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.
作者: Anna Syreeni.;Assam El-Osta.;Carol Forsblom.;Niina Sandholm.;Maikki Parkkonen.;Lise Tarnow.;Hans-Henrik Parving.;Amy J McKnight.;Alexander P Maxwell.;Mark E Cooper.;Per-Henrik Groop.; .
来源: Diabetes. 2011年60卷11期3073-80页
Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications often persist and progress despite improved glucose control, possibly as a result of prior episodes of hyperglycemia. Epigenetic modifications mediated by histone methyltransferases are associated with gene-activating events that promote enhanced expression of key proinflammatory molecules implicated in vascular injury. In this study, we investigated genetic polymorphisms of the SETD7, SUV39H1, and SUV39H2 methyltransferases as predictors of risk for micro- and macrovascular complications in type 1 diabetes.
265. Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.
作者: Stavroula Kanoni.;Jennifer A Nettleton.;Marie-France Hivert.;Zheng Ye.;Frank J A van Rooij.;Dmitry Shungin.;Emily Sonestedt.;Julius S Ngwa.;Mary K Wojczynski.;Rozenn N Lemaitre.;Stefan Gustafsson.;Jennifer S Anderson.;Toshiko Tanaka.;George Hindy.;Georgia Saylor.;Frida Renstrom.;Amanda J Bennett.;Cornelia M van Duijn.;Jose C Florez.;Caroline S Fox.;Albert Hofman.;Ron C Hoogeveen.;Denise K Houston.;Frank B Hu.;Paul F Jacques.;Ingegerd Johansson.;Lars Lind.;Yongmei Liu.;Nicola McKeown.;Jose Ordovas.;James S Pankow.;Eric J G Sijbrands.;Ann-Christine Syvänen.;André G Uitterlinden.;Mary Yannakoulia.;M Carola Zillikens.; .;Nick J Wareham.;Inga Prokopenko.;Stefania Bandinelli.;Nita G Forouhi.;L Adrienne Cupples.;Ruth J Loos.;Goran Hallmans.;Josée Dupuis.;Claudia Langenberg.;Luigi Ferrucci.;Stephen B Kritchevsky.;Mark I McCarthy.;Erik Ingelsson.;Ingrid B Borecki.;Jacqueline C M Witteman.;Marju Orho-Melander.;David S Siscovick.;James B Meigs.;Paul W Franks.;George V Dedoussis.
来源: Diabetes. 2011年60卷9期2407-16页
Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants.
267. Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.
作者: Adam Barker.;Stephen J Sharp.;Nicholas J Timpson.;Nabila Bouatia-Naji.;Nicole M Warrington.;Stavroula Kanoni.;Lawrence J Beilin.;Soren Brage.;Panos Deloukas.;David M Evans.;Anders Grontved.;Neelam Hassanali.;Deborah A Lawlor.;Cecile Lecoeur.;Ruth J F Loos.;Stephen J Lye.;Mark I McCarthy.;Trevor A Mori.;Ndeye Coumba Ndiaye.;John P Newnham.;Ioanna Ntalla.;Craig E Pennell.;Beate St Pourcain.;Inga Prokopenko.;Susan M Ring.;Naveed Sattar.;Sophie Visvikis-Siest.;George V Dedoussis.;Lyle J Palmer.;Philippe Froguel.;George Davey Smith.;Ulf Ekelund.;Nicholas J Wareham.;Claudia Langenberg.
来源: Diabetes. 2011年60卷6期1805-12页
To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents.
268. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies.
作者: Jens K Hertel.;Stefan Johansson.;Emily Sonestedt.;Anna Jonsson.;Rolv T Lie.;Carl G P Platou.;Peter M Nilsson.;Gull Rukh.;Kristian Midthjell.;Kristian Hveem.;Olle Melander.;Leif Groop.;Valeriya Lyssenko.;Anders Molven.;Marju Orho-Melander.;Pål R Njølstad.
来源: Diabetes. 2011年60卷5期1637-44页
FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span.
274. Islet transplantation a decade later and strategies for filling a half-full glass.
Alloislet transplantation for the treatment of type 1 diabetes enjoyed highly favorable status in the first half of the last decade but declined in favor during the second half. In this Perspective, I will briefly review the literature published in this area from 2000 to 2010 for the purposes of extracting lessons we have learned, considering whether the procedure should be deemed a partial success or a partial failure, and offering several strategies to improve alloislet transplantation outcomes in the future. In the end, I hope to strike a positive note about where this procedure is going, and how it will be applied to establish insulin independence in patients with type 1 diabetes.
280. SIRT1 genetic variation is related to BMI and risk of obesity.
作者: M Carola Zillikens.;Joyce B J van Meurs.;Fernando Rivadeneira.;Najaf Amin.;Albert Hofman.;Ben A Oostra.;Eric J G Sijbrands.;Jacqueline C M Witteman.;Huibert A P Pols.;Cornelia M van Duijn.;André G Uitterlinden.
来源: Diabetes. 2009年58卷12期2828-34页
SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity.
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