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261. Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial.
作者: Lori-Ann Linkins.;Shannon M Bates.;Eddy Lang.;Susan R Kahn.;James D Douketis.;Jim Julian.;Sameer Parpia.;Peter Gross.;Jeffrey I Weitz.;Frederick A Spencer.;Agnes Y Y Lee.;Martin J O'Donnell.;Mark A Crowther.;Howard H Chan.;Wendy Lim.;Sam Schulman.;Jeffrey S Ginsberg.;Clive Kearon.
来源: Ann Intern Med. 2013年158卷2期93-100页
D-Dimer testing is sensitive but not specific for diagnosing deep venous thrombosis (DVT). Changing the use of testing and the threshold level for a positive test result on the basis of risk for DVT might improve the tradeoff between sensitivity and specificity and reduce the need for testing.
262. Improved immunogenicity with high-dose seasonal influenza vaccine in HIV-infected persons: a single-center, parallel, randomized trial.
作者: Noah McKittrick.;Ian Frank.;Jeffrey M Jacobson.;C Jo White.;Deborah Kim.;Rosemarie Kappes.;Carol DiGiorgio.;Thomas Kenney.;Jean Boyer.;Pablo Tebas.
来源: Ann Intern Med. 2013年158卷1期19-26页
HIV-infected persons have less robust antibody responses to influenza vaccines.
263. Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trial.
作者: Alexa B Kimball.;Francisco Kerdel.;David Adams.;Ulrich Mrowietz.;Joel M Gelfand.;Robert Gniadecki.;Errol P Prens.;Joel Schlessinger.;Christos C Zouboulis.;Hessel H van der Zee.;Marie Rosenfeld.;Parvez Mulani.;Yihua Gu.;Susan Paulson.;Martin Okun.;Gregor B E Jemec.
来源: Ann Intern Med. 2012年157卷12期846-55页
Hidradenitis suppurativa (HS) is a chronic, painful skin disease characterized by abscesses, nodules, and draining fistulas in the axilla and groin of young adults.
264. Efficacy of a clinical decision-support system in an HIV practice: a randomized trial.
作者: Gregory K Robbins.;William Lester.;Kristin L Johnson.;Yuchiao Chang.;Gregory Estey.;Dominic Surrao.;Kimon Zachary.;Sara M Lammert.;Henry C Chueh.;James B Meigs.;Kenneth A Freedberg.
来源: Ann Intern Med. 2012年157卷11期757-66页
Data to support improved patient outcomes from clinical decision-support systems (CDSSs) are lacking in HIV care.
265. Effects of an intervention to increase bed alarm use to prevent falls in hospitalized patients: a cluster randomized trial.
作者: Ronald I Shorr.;A Michelle Chandler.;Lorraine C Mion.;Teresa M Waters.;Minzhao Liu.;Michael J Daniels.;Lori A Kessler.;Stephen T Miller.
来源: Ann Intern Med. 2012年157卷10期692-9页
Bed alarm systems intended to prevent hospital falls have not been formally evaluated.
266. Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: a parallel, randomized trial.
作者: Matthew Spitzer.;Shehzad Basaria.;Thomas G Travison.;Maithili N Davda.;Amanda Paley.;Beth Cohen.;Norman A Mazer.;Philip E Knapp.;Samson Hanka.;Kishore M Lakshman.;Jagadish Ulloor.;Anqi Zhang.;Katie Orwoll.;Richard Eder.;Lauren Collins.;Nurahmed Mohammed.;Raymond C Rosen.;Leonard DeRogatis.;Shalender Bhasin.
来源: Ann Intern Med. 2012年157卷10期681-91页
Erectile dysfunction and low testosterone levels frequently occur together.
267. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.
作者: Josiane L Broussard.;David A Ehrmann.;Eve Van Cauter.;Esra Tasali.;Matthew J Brady.
来源: Ann Intern Med. 2012年157卷8期549-57页
Insufficient sleep increases the risk for insulin resistance, type 2 diabetes, and obesity, suggesting that sleep restriction may impair peripheral metabolic pathways. Yet, a direct link between sleep restriction and alterations in molecular metabolic pathways in any peripheral human tissue has not been shown.
268. Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial.
作者: Philip J Hashkes.;Steven J Spalding.;Edward H Giannini.;Bin Huang.;Anne Johnson.;Grace Park.;Karyl S Barron.;Michael H Weisman.;Noune Pashinian.;Andreas O Reiff.;Jonathan Samuels.;Dowain A Wright.;Daniel L Kastner.;Daniel J Lovell.
来源: Ann Intern Med. 2012年157卷8期533-41页
Currently, there is no proven alternative therapy for patients with familial Mediterranean fever (FMF) that is resistant to or intolerant of colchicine. Interleukin-1 is a key proinflammatory cytokine in FMF.
269. Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial.
作者: Maureen R Horton.;Victoria Santopietro.;Leena Mathew.;Karen M Horton.;Albert J Polito.;Mark C Liu.;Sonye K Danoff.;Noah Lechtzin.
来源: Ann Intern Med. 2012年157卷6期398-406页
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder of unknown cause with no effective treatment. Cough affects up to 80% of patients with IPF, is frequently disabling, and lacks effective therapy.
270. The immune reconstitution inflammatory syndrome after antiretroviral therapy initiation in patients with tuberculosis: findings from the SAPiT trial.
作者: Kogieleum Naidoo.;Nonhlanhla Yende-Zuma.;Nesri Padayatchi.;Kasavan Naidoo.;Niraksha Jithoo.;Gonasagrie Nair.;Sheila Bamber.;Santhana Gengiah.;Wafaa M El-Sadr.;Gerald Friedland.;Salim Abdool Karim.
来源: Ann Intern Med. 2012年157卷5期313-24页
Concerns about the immune reconstitution inflammatory syndrome (IRIS) remain a barrier to antiretroviral therapy (ART) initiation during antituberculosis treatment in co-infected patients.
271. Escitalopram for the prevention of peginterferon-α2a-associated depression in hepatitis C virus-infected patients without previous psychiatric disease: a randomized trial.
作者: Martin Schaefer.;Rahul Sarkar.;Viola Knop.;Susanne Effenberger.;Astrid Friebe.;Loni Heinze.;Ulrich Spengler.;Thomas Schlaepfer.;Jens Reimer.;Peter Buggisch.;Johann Ockenga.;Ralph Link.;Michael Rentrop.;Hans Weidenbach.;Gwendolyn Fromm.;Klaus Lieb.;Thomas F Baumert.;Andreas Heinz.;Thomas Discher.;Konrad Neumann.;Stefan Zeuzem.;Thomas Berg.
来源: Ann Intern Med. 2012年157卷2期94-103页
Depression is a major complication during treatment of chronic hepatitis C virus (HCV) infection with interferon-α (IFN-α). It is unclear whether antidepressants can prevent IFN-induced depression in patients without psychiatric risk factors.
272. Improving the efficiency of advanced life support training: a randomized, controlled trial.
作者: Gavin D Perkins.;Peter K Kimani.;Ian Bullock.;Tom Clutton-Brock.;Robin P Davies.;Mike Gale.;Jenny Lam.;Andrew Lockey.;Nigel Stallard.; .
来源: Ann Intern Med. 2012年157卷1期19-28页
Each year, more than 1.5 million health care professionals receive advanced life support (ALS) training.
273. Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial.
作者: Sunil Kripalani.;Christianne L Roumie.;Anuj K Dalal.;Courtney Cawthon.;Alexandra Businger.;Svetlana K Eden.;Ayumi Shintani.;Kelly Cunningham Sponsler.;L Jeff Harris.;Cecelia Theobald.;Robert L Huang.;Danielle Scheurer.;Susan Hunt.;Terry A Jacobson.;Kimberly J Rask.;Viola Vaccarino.;Tejal K Gandhi.;David W Bates.;Mark V Williams.;Jeffrey L Schnipper.; .
来源: Ann Intern Med. 2012年157卷1期1-10页
Clinically important medication errors are common after hospital discharge. They include preventable or ameliorable adverse drug events (ADEs), as well as medication discrepancies or nonadherence with high potential for future harm (potential ADEs).
274. A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations: a randomized, controlled trial.
作者: Vincent S Fan.;J Michael Gaziano.;Robert Lew.;Jean Bourbeau.;Sandra G Adams.;Sarah Leatherman.;Soe Soe Thwin.;Grant D Huang.;Richard Robbins.;Peruvemba S Sriram.;Amir Sharafkhaneh.;M Jeffery Mador.;George Sarosi.;Ralph J Panos.;Padmashri Rastogi.;Todd H Wagner.;Steven A Mazzuca.;Colleen Shannon.;Cindy Colling.;Matthew H Liang.;James K Stoller.;Louis Fiore.;Dennis E Niewoehner.
来源: Ann Intern Med. 2012年156卷10期673-83页
Improving a patient's ability to self-monitor and manage changes in chronic obstructive pulmonary disease (COPD) symptoms may improve outcomes.
275. Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial.
作者: Steven P Cohen.;Ronald L White.;Connie Kurihara.;Thomas M Larkin.;Audrey Chang.;Scott R Griffith.;Christopher Gilligan.;Ralph Larkin.;Benny Morlando.;Paul F Pasquina.;Tony L Yaksh.;Conner Nguyen.
来源: Ann Intern Med. 2012年156卷8期551-9页
Perineural inhibitors of tumor necrosis factor have recently generated intense interest as an alternative to epidural steroid injections for lumbosacral radiculopathy.
276. Effect of an iPod video intervention on consent to donate organs: a randomized trial.
作者: J Daryl Thornton.;Marilyn Alejandro-Rodriguez.;Janeen B León.;Jeffrey M Albert.;Evelyn L Baldeon.;Liza M De Jesus.;Ana Gallardo.;Sabina Hossain.;Elba Adriana Perez.;Jovana Y Martin.;Susan Lasalvia.;Kristine A Wong.;Margaret D Allen.;Mark Robinson.;Charles Heald.;Gordon Bowen.;Ashwini R Sehgal.
来源: Ann Intern Med. 2012年156卷7期483-90页
The gap between the supply of organs available for transplantation and demand is growing, especially among ethnic groups.
277. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial.
作者: J Christopher Gallagher.;Adarsh Sai.;Thomas Templin.;Lynette Smith.
来源: Ann Intern Med. 2012年156卷6期425-37页
Serum 25-hydroxyvitamin D (25-[OH]D) is considered the best biomarker of clinical vitamin D status.
278. Peer mentoring and financial incentives to improve glucose control in African American veterans: a randomized trial.
作者: Judith A Long.;Erica C Jahnle.;Diane M Richardson.;George Loewenstein.;Kevin G Volpp.
来源: Ann Intern Med. 2012年156卷6期416-24页
Compared with white persons, African Americans have a greater incidence of diabetes, decreased control, and higher rates of microvascular complications. A peer mentorship model could be a scalable approach to improving control in this population and reducing disparities in diabetic outcomes.
279. Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial.
作者: John P H Wilding.;Vincent Woo.;Norman G Soler.;Andrea Pahor.;Jennifer Sugg.;Katja Rohwedder.;Shamik Parikh.; .
来源: Ann Intern Med. 2012年156卷6期405-15页
Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2, may improve glycemic control with a lower dose of insulin and attenuate the associated weight gain in patients with inadequate control despite high doses of insulin.
280. Do physicians understand cancer screening statistics? A national survey of primary care physicians in the United States.
作者: Odette Wegwarth.;Lisa M Schwartz.;Steven Woloshin.;Wolfgang Gaissmaier.;Gerd Gigerenzer.
来源: Ann Intern Med. 2012年156卷5期340-9页
Unlike reduced mortality rates, improved survival rates and increased early detection do not prove that cancer screening tests save lives. Nevertheless, these 2 statistics are often used to promote screening.
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