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2761. Appropriate and inappropriate ventricular therapies, quality of life, and mortality among primary and secondary prevention implantable cardioverter defibrillator patients: results from the Pacing Fast VT REduces Shock ThErapies (PainFREE Rx II) trial.
作者: Michael O Sweeney.;Mark S Wathen.;Kent Volosin.;Ismaile Abdalla.;Paul J DeGroot.;Mary F Otterness.;Alice J Stark.
来源: Circulation. 2005年111卷22期2898-905页
Implantable cardioverter defibrillators (ICDs) reduce mortality in primary and secondary prevention. Quality of life, mortality, appropriate therapies for specific ventricular rhythms, and inappropriate therapies for supraventricular tachycardia (SVT) were compared among 582 patients (primary prevention=248; secondary prevention=334) in PainFREE Rx II, a 634-patient prospective, randomized study of antitachycardia pacing or shocks for fast ventricular tachycardia (FVT).
2762. Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome.
作者: Satish R Raj.;Bonnie K Black.;Italo Biaggioni.;Paul A Harris.;David Robertson.
来源: Circulation. 2005年111卷21期2734-40页
Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance notable for an excessive increase in heart rate that occurs on standing. Many current therapeutic strategies focus on sympatholysis, but the alternative strategy of enhancing cardiovagal tone has not been studied. The objective of this study was to test the hypothesis that acetylcholinesterase inhibitors will attenuate the tachycardia and improve symptom burden in patients with POTS.
2763. Delayed preconditioning-mimetic actions of nitroglycerin in patients undergoing exercise tolerance tests.
作者: Hani Jneid.;Mukul Chandra.;Motaz Alshaher.;Carlton A Hornung.;Xian-Liang Tang.;Massoud Leesar.;Roberto Bolli.
来源: Circulation. 2005年111卷20期2565-71页
Nitroglycerin (NTG) induces delayed preconditioning (PC)-mimetic effects in animal models and in humans during coronary angioplasty. We tested the hypothesis that NTG mitigates ischemia and enhances functional capacity during an exercise tolerance test (ETT) in patients with coronary artery disease.
2764. Pioglitazone decreases carotid intima-media thickness independently of glycemic control in patients with type 2 diabetes mellitus: results from a controlled randomized study.
作者: M R Langenfeld.;T Forst.;C Hohberg.;P Kann.;G Lübben.;T Konrad.;S D Füllert.;C Sachara.;A Pfützner.
来源: Circulation. 2005年111卷19期2525-31页
Patients with type 2 diabetes mellitus are at high risk of cardiovascular disease. Carotid intima-media thickness (IMT) is a strong predictor of myocardial infarction and stroke.
2765. Randomized comparison of a titanium-nitride-oxide-coated stent with a stainless steel stent for coronary revascularization: the TiNOX trial.
作者: Stephan Windecker.;Rüdiger Simon.;Markus Lins.;Volker Klauss.;Franz R Eberli.;Marco Roffi.;Giovanni Pedrazzini.;Tiziano Moccetti.;Peter Wenaweser.;Mario Togni.;David Tüller.;Rainer Zbinden.;Christian Seiler.;Julinda Mehilli.;Adnan Kastrati.;Bernhard Meier.;Otto M Hess.
来源: Circulation. 2005年111卷20期2617-22页
Stent coating with titanium-nitride-oxide has been shown to reduce neointimal hyperplasia in the porcine restenosis model. We designed a prospective, randomized, clinical study to investigate the safety and efficacy of titanium-nitride-oxide-coated stents compared with stainless steel stents.
2766. Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial.
作者: Debra A Schaumberg.;Robert J Glynn.;Alicia J Jenkins.;Timothy J Lyons.;Nader Rifai.;JoAnn E Manson.;Paul M Ridker.;David M Nathan.
来源: Circulation. 2005年111卷19期2446-53页
Type 1 diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) that is not fully explained by conventional risk factors. The Diabetes Control and Complications Trial (DCCT) showed that intensive diabetes therapy reduced levels of LDL cholesterol and triglycerides but increased the risk of major weight gain, which might adversely affect CVD risk. The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD.
2767. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study.
作者: Liviu Klein.;Christopher M O'Connor.;Jeffrey D Leimberger.;Wendy Gattis-Stough.;Ileana L Piña.;G Michael Felker.;Kirkwood F Adams.;Robert M Califf.;Mihai Gheorghiade.; .
来源: Circulation. 2005年111卷19期2454-60页
The prognostic value of serum sodium in patients hospitalized for worsening heart failure has not been well defined.
2768. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans.
作者: Ulf Landmesser.;Ferdinand Bahlmann.;Maja Mueller.;Stephan Spiekermann.;Nina Kirchhoff.;Svenja Schulz.;Costantina Manes.;Dieter Fischer.;Kirsten de Groot.;Danilo Fliser.;Günter Fauler.;Winfried März.;Helmut Drexler.
来源: Circulation. 2005年111卷18期2356-63页
Statins may exert important pleiotropic effects, ie, improve endothelial function, independently of their impact on LDL cholesterol. In humans, however, pleiotropic effects of statins have never been unequivocally demonstrated because prolonged statin treatment always results in reduced LDL cholesterol levels. We therefore tested the hypothesis that similar reductions in LDL cholesterol with simvastatin and ezetimibe, a novel cholesterol absorption inhibitor, result in different effects on endothelial function.
2769. Association of prolonged QRS duration with death in a clinical trial of pacemaker therapy for sinus node dysfunction.
作者: Michael O Sweeney.;Anne S Hellkamp.;Kerry L Lee.;Gervasio A Lamas.; .
来源: Circulation. 2005年111卷19期2418-23页
Prolonged QRS duration (QRSd) is an important prognostic indicator for death and heart failure hospitalization in patients with systolic heart failure. The relationship of baseline QRSd to death and heart failure hospitalization in patients with sinus node dysfunction who require pacemaker therapy is unknown.
2770. Early onset and progression of left ventricular remodeling after alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
作者: Willem G van Dockum.;Aernout M Beek.;Folkert J ten Cate.;Jurrien M ten Berg.;Olga Bondarenko.;Marco J W Götte.;Jos W R Twisk.;Mark B M Hofman.;Cees A Visser.;Albert C van Rossum.
来源: Circulation. 2005年111卷19期2503-8页
Alcohol septal ablation (ASA) reduces left ventricular outflow tract (LVOT) pressure gradient in patients with hypertrophic obstructive cardiomyopathy (HOCM), which leads to left ventricular remodeling. We sought to describe the early to midterm changes and modulating factors of the remodeling process using cardiac MRI (CMR).
2771. Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients.
作者: Antonio Ceriello.;Roberta Assaloni.;Roberto Da Ros.;Amabile Maier.;Ludovica Piconi.;Lisa Quagliaro.;Katherine Esposito.;Dario Giugliano.
来源: Circulation. 2005年111卷19期2518-24页
Postprandial hypertriglyceridemia and hyperglycemia are considered risk factors for cardiovascular disease. Evidence suggests that postprandial hypertriglyceridemia and hyperglycemia induce endothelial dysfunction and inflammation through oxidative stress. Statins and angiotensin type 1 receptor blockers have been shown to reduce oxidative stress and inflammation, improving endothelial function.
2772. Effectiveness and safety of sirolimus-eluting stents in the treatment of restenosis after coronary stent placement.
作者: Franz-Josef Neumann.;Walter Desmet.;Eberhard Grube.;Johannes Brachmann.;Patrizia Presbitero.;Paolo Rubartelli.;Andreas Mügge.;Francesco Di Pede.;Diana Füllgraf.;Wim Aengevaeren.;Leonardo Spedicato.;Jeffrey J Popma.
来源: Circulation. 2005年111卷16期2107-11页
In-stent restenosis is notoriously difficult to treat by repeat catheter intervention because of its propensity for aggressive recurrent neointimal formation. This study sought to assess the effectiveness and safety of the sirolimus-eluting stent in the treatment of in-stent restenosis.
2773. Effects of high thoracic epidural analgesia on myocardial blood flow in patients with ischemic heart disease.
作者: Eigil Nygård.;Klaus F Kofoed.;Jacob Freiberg.;Søren Holm.;Jan Aldershvile.;Kirsten Eliasen.;Henning Kelbaek.
来源: Circulation. 2005年111卷17期2165-70页
In patients with ischemic heart disease, high thoracic epidural analgesia (TEA) has been proposed to improve abnormalities of coronary function by inhibiting cardiac sympathetic tone. We evaluated the effect of TEA on myocardial blood flow in patients with ischemic heart disease.
2774. Four-year angiographic and intravascular ultrasound follow-up of patients treated with sirolimus-eluting stents.
作者: J Eduardo Sousa.;Marco A Costa.;Alexandre Abizaid.;Fausto Feres.;Ana C Seixas.;Luiz F Tanajura.;Luiz A Mattos.;Robert Falotico.;Judith Jaeger.;Jeffrey J Popma.;Patrick W Serruys.;Amanda G M R Sousa.
来源: Circulation. 2005年111卷18期2326-9页
Despite the proven superiority of sirolimus-eluting stents (SESs) compared with bare stents in the first year after implantation, long-term outcomes of patients treated with these novel devices remain unknown. Our goal was to evaluate the clinical, angiographic, and intravascular ultrasound (IVUS) outcomes of patients treated with SESs 4 years after implantation.
2775. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
作者: Hugh S Markus.;Dirk W Droste.;Manfred Kaps.;Vincent Larrue.;Kennedy R Lees.;Mario Siebler.;E Bernd Ringelstein.
来源: Circulation. 2005年111卷17期2233-40页
Evidence for efficacy of dual antiplatelet therapy in stroke is limited. Symptomatic carotid stenosis patients are at high risk of early recurrent stroke. In this group, asymptomatic microembolic signals (MES), detected by transcranial Doppler ultrasound (TCD), are markers of future stroke and transient ischemic attack (TIA) risk. They offer a surrogate marker to evaluate antiplatelet therapy, but no multicenter study has evaluated the feasibility of this approach.
2776. Monitoring of bone marrow cell homing into the infarcted human myocardium.
作者: Michael Hofmann.;Kai C Wollert.;Gerd P Meyer.;Alix Menke.;Lubomir Arseniev.;Bernd Hertenstein.;Arnold Ganser.;Wolfram H Knapp.;Helmut Drexler.
来源: Circulation. 2005年111卷17期2198-202页
Intracoronary transfer of autologous bone marrow cells (BMCs) promotes recovery of left ventricular systolic function in patients with acute myocardial infarction. Although the mechanisms of this effect remain to be established, homing of BMCs into the infarcted myocardium is probably a critical early event.
2777. Body build and risk of cardiovascular events in hypertension and left ventricular hypertrophy: the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study.
作者: Giovanni de Simone.;Kristian Wachtell.;Vittorio Palmieri.;Darcy A Hille.;Gareth Beevers.;Björn Dahlöf.;Ulf de Faire.;Frej Fyhrquist.;Hans Ibsen.;Stevo Julius.;Sverre E Kjeldsen.;Ole Lederballe-Pedersen.;Lars H Lindholm.;Markku S Nieminen.;Per Omvik.;Suzanne Oparil.;Richard B Devereux.
来源: Circulation. 2005年111卷15期1924-31页
Obesity may independently increase the risk of adverse events in hypertension with target-organ damage. We investigated whether body build was independently associated with higher cardiovascular risk and whether treatment with losartan relative to atenolol influenced the impact of body build on the primary composite end point of cardiovascular death, stroke, and myocardial infarction and on cardiovascular death in patients with hypertension and left ventricular hypertrophy in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study.
2778. Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children.
作者: Maurício M Ribeiro.;Alexandre G Silva.;Nelson S Santos.;Isabel Guazzelle.;Luciana N J Matos.;Ivani C Trombetta.;Alfredo Halpern.;Carlos E Negrão.;Sandra M F Villares.
来源: Circulation. 2005年111卷15期1915-23页
The effects of diet and diet plus exercise training on muscle vasodilatation during physiological maneuvers in obese children are unknown. We tested the hypothesis that (1) blood pressure (BP) and forearm vascular conductance (FVC) responses during handgrip exercise and mental stress would be altered in obese children and (2) diet plus exercise training would restore BP and FVC responses during exercise and mental stress in obese children.
2779. Simvastatin blunts endotoxin-induced tissue factor in vivo.
作者: Sabine Steiner.;Walter S Speidl.;Johannes Pleiner.;Daniela Seidinger.;Gerlinde Zorn.;Christoph Kaun.;Johann Wojta.;Kurt Huber.;Erich Minar.;Michael Wolzt.;Christoph W Kopp.
来源: Circulation. 2005年111卷14期1841-6页
Beyond lipid lowering, various antiinflammatory properties have been ascribed to statins. Moreover, in vitro studies have suggested the presence of anticoagulant effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, as lipopolysaccharide (LPS)-induced monocyte tissue factor (TF) was suppressed. In this study, we examined the role of statins in experimental endotoxemia on inflammatory and procoagulant responses in vivo.
2780. Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial.
作者: Alexandra J Lansky.;Cody Pietras.;Ricardo A Costa.;Yoshihiro Tsuchiya.;Bruce R Brodie.;David A Cox.;Eve D Aymong.;Thomas D Stuckey.;Eulogio Garcia.;James E Tcheng.;Roxana Mehran.;Manuela Negoita.;Martin Fahy.;Ecaterina Cristea.;Mark Turco.;Martin B Leon.;Cindy L Grines.;Gregg W Stone.
来源: Circulation. 2005年111卷13期1611-8页
Women with acute myocardial infarction (AMI) undergoing primary angioplasty have higher rates of morbidity and mortality than do men. Whether contemporary interventional treatment strategies have improved outcomes for women compared with men is unknown.
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