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2741. Serum surfactant protein-A is a strong predictor of early mortality in idiopathic pulmonary fibrosis.
作者: Brent W Kinder.;Kevin K Brown.;Francis X McCormack.;Joachim H Ix.;Alma Kervitsky.;Marvin I Schwarz.;Talmadge E King.
来源: Chest. 2009年135卷6期1557-1563页
Serum surfactant protein (SP) A and SP-D had prognostic value for mortality in patients with idiopathic pulmonary fibrosis (IPF) in prior studies before the reclassification of the idiopathic interstitial pneumonias. We hypothesized that baseline serum SP-A and SP-D concentrations would be independently associated with mortality among patients with biopsy-proven IPF and would improve a prediction model for mortality.
2742. Association of circulating adhesion molecules with lung function. The CARDIA study.
作者: Bharat Thyagarajan.;Lewis J Smith.;R Graham Barr.;Myron D Gross.;Akshay Sood.;Ravi Kalhan.;David R Jacobs.
来源: Chest. 2009年135卷6期1481-1487页
Systemic inflammation has been associated with reduced lung function. Adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and P-selectin, figure importantly in initiating the inflammatory response. We studied the association between ICAM-1 and P-selectin concentrations and lung function in the Coronary Artery Risk Development in Young Adults study.
2743. "Real-world" effectiveness of reactive telephone counseling for smoking cessation: a randomized controlled trial.
作者: Akshay Sood.;Jennifer Andoh.;Steven Verhulst.;Mathany Ganesh.;Billie Edson.;Patricia Hopkins-Price.
来源: Chest. 2009年136卷5期1229-1236页
Reactive telephone helplines for smoking cessation (where all calls to counselors are smoker initiated) are increasingly used in the United States. However, limited data from randomized controlled trials are available on their effectiveness. The study objective was to evaluate the real-world effectiveness of reactive telephone counseling for smoking cessation using a randomized controlled trial study design.
2744. Obstructive sleep apnea in children: relative contributions of body mass index and adenotonsillar hypertrophy.
作者: Ehab Dayyat.;Leila Kheirandish-Gozal.;Oscar Sans Capdevila.;Muna M A Maarafeya.;David Gozal.
来源: Chest. 2009年136卷1期137-144页
The obesity epidemic has prompted remarkable changes in the proportion of obese children who are referred for habitual snoring. However, the contribution of obesity to adenotonsillar hypertrophy remains undefined.
2745. A pilot study to examine the effects of smoking cessation on serum markers of inflammation in women at risk for cardiovascular disease.
作者: Virginia Reichert.;Xiangying Xue.;Diane Bartscherer.;Daniel Jacobsen.;Christine Fardellone.;Patricia Folan.;Nina Kohn.;Arunabh Talwar.;Christine N Metz.
来源: Chest. 2009年136卷1期212-219页
The links among smoking, inflammation, and cardiovascular disease (CVD) are well established. Several studies have demonstrated that quitting smoking reverses the risk of coronary heart disease within 5 to 10 years. However, the immediate effects of quitting smoking on inflammatory biomarkers associated with CVD risk have not been well described.
2746. Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury.
作者: Jonathan A Kropski.;Richard D Fremont.;Carolyn S Calfee.;Lorraine B Ware.
来源: Chest. 2009年135卷6期1440-1447页
Acute lung injury (ALI) and ARDS are common clinical syndromes that are underdiagnosed. Clara cell secretory protein (CC16) is an antiinflammatory protein secreted by the Clara cells of the distal respiratory epithelium that has been proposed as a biomarker of lung epithelial injury. We tested the diagnostic and prognostic utility of CC16 in patients with non-trauma-related ALI/ARDS compared to a control group of patients with acute cardiogenic pulmonary edema (CPE).
2747. Cigarette smoking induces overexpression of a fat-depleting gene AZGP1 in the human.
作者: Holly Vanni.;Angeliki Kazeros.;Rui Wang.;Ben-Gary Harvey.;Barbara Ferris.;Bishnu P De.;Brendan J Carolan.;Ralf-Harto Hübner.;Timothy P O'Connor.;Ronald G Crystal.
来源: Chest. 2009年135卷5期1197-1208页
Smokers weigh less and have less body fat than nonsmokers. Increased body fat and weight gain are observed following smoking cessation. To assess a possible molecular mechanism underlying the inverse association between smoking and body weight, we hypothesized that smoking may induce the expression of a fat-depleting gene in the airway epithelium, the cell population that takes the brunt of the stress of cigarette smoke.
2748. Association of the metabolic syndrome with pulmonary venous hypertension.
作者: Ivan M Robbins.;John H Newman.;Roger F Johnson.;Anna R Hemnes.;Richard D Fremont.;Robert N Piana.;David X Zhao.;Daniel W Byrne.
来源: Chest. 2009年136卷1期31-36页
Pulmonary venous hypertension (PVH) is a well-described cause of pulmonary hypertension (PH) in patients with left heart disease associated with elevated left heart filling pressure. PVH results from a number of processes, including left-sided valvular disease, constrictive pericardial disease, restrictive cardiomyopathies, and left ventricular (LV) systolic dysfunction. PVH in patients with normal LV systolic function, commonly referred to as diastolic dysfunction, is not well characterized. We observed that many patients with PH due to PVH have obesity, hypertension, diabetes mellitus, and hypercholesterolemia, which are clinical features of the metabolic syndrome (MS), a previously identified cause for systemic vascular disease.
2749. Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure.
作者: Joseph E Levitt.;Harmeet Bedi.;Carolyn S Calfee.;Michael K Gould.;Michael A Matthay.
来源: Chest. 2009年135卷4期936-943页
Despite being a focus of intensive investigation, acute lung injury (ALI) remains a major cause of morbidity and mortality. However, the current consensus definition impedes identification of patients with ALI before they require mechanical ventilation. To establish a definition of early ALI (EALI), we carried out a prospective cohort study to identify clinical predictors of progression to ALI.
2750. Serotonin transporter polymorphisms in patients with portopulmonary hypertension.
作者: Kari E Roberts.;Michael B Fallon.;Michael J Krowka.;Raymond L Benza.;James A Knowles.;David B Badesch.;Robert S Brown.;Darren B Taichman.;James Trotter.;Steven Zacks.;Evelyn M Horn.;Steven M Kawut.; .
来源: Chest. 2009年135卷6期1470-1475页
The long allele of a functional promoter polymorphism in the serotonin transporter (SERT) is associated with an increased risk of some forms of pulmonary arterial hypertension. We hypothesized that the long allele or other polymorphisms in SERT would be associated with an increased risk of portopulmonary hypertension (PPHTN) in patients with advanced liver disease.
2751. Imprecision in automated volume measurements of pulmonary nodules and its effect on the level of uncertainty in volume doubling time estimation.
作者: Paul J Nietert.;James G Ravenel.;William M Leue.;James V Miller.;Katherine K Taylor.;Elizabeth S Garrett-Mayer.;Gerard A Silvestri.
来源: Chest. 2009年135卷6期1580-1587页
Detection of small indeterminate pulmonary nodules (4 to 10 mm in diameter) in clinical practice is increasing, largely because of increased utilization and improved imaging technology. Although there currently exists software for CT scan machines that automate nodule volume estimation, the imprecision associated with volume estimates is particularly poor for nodules < or = 6 mm in diameter, with greater imprecision associated with increasing CT scan slice thickness. This study examined the effects of the volume estimation error associated with four CT scan slice thicknesses (0.625, 1.25, 2.50, and 5.00 mm) on estimates of volume doubling time (VDT) for solid nodules of various sizes.
2753. Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea.
作者: Ehab Dayyat.;Laura D Serpero.;Leila Kheirandish-Gozal.;Julie L Goldman.;Ayelet Snow.;Rakesh Bhattacharjee.;David Gozal.
来源: Chest. 2009年135卷5期1142-1149页
The abundant expression of leukotrienes (LTs) and their receptors in adenotonsillar tissues of children with obstructive sleep apnea (OSA) suggest that LT antagonists could be useful in treating OSA.
2754. Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience.
作者: Christopher F Barnett.;Eric J Bonura.;Steven D Nathan.;Shahzad Ahmad.;Oksana A Shlobin.;Kwabena Osei.;Ari L Zaiman.;Paul M Hassoun.;David R Moller.;Scott D Barnett.;Reda E Girgis.
来源: Chest. 2009年135卷6期1455-1461页
Pulmonary hypertension (PH) is a common complication of sarcoidosis that is associated with increased mortality. The pathogenesis of PH in sarcoidosis is uncertain, and the role of pulmonary arterial hypertension (PAH)-specific therapies remains to be determined.
2755. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
作者: Danny J Eckert.;Atul Malhotra.;Yu L Lo.;David P White.;Amy S Jordan.
来源: Chest. 2009年135卷4期957-964页
The mechanisms contributing to worsening of obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep have been minimally studied. Reduced upper-airway muscle tone may be an important contributor. Because respiratory events and the associated blood gas changes can influence genioglossus (GG) activity, we compared GG activity between OSA patients and control subjects during REM sleep using continuous positive airway pressure (CPAP) to minimize the influences of upper-airway resistance (RUA) and blood gas disturbances on GG activity.
2756. Oxidative damage to nucleic acids in severe emphysema.
作者: Gaetan Deslee.;Jason C Woods.;Carla Moore.;Susan H Conradi.;David S Gierada.;Jeffrey J Atkinson.;John T Battaile.;Lucy Liu.;G Alexander Patterson.;Tracy L Adair-Kirk.;Michael J Holtzman.;Richard A Pierce.
来源: Chest. 2009年135卷4期965-974页
Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to investigate oxidative damage to nucleic acids in severe emphysematous lungs.
2757. Depressive symptoms as predictors of mortality in patients with COPD.
作者: Jacob N de Voogd.;Johan B Wempe.;Gerard H Koëter.;Klaas Postema.;Eric van Sonderen.;Adelita V Ranchor.;James C Coyne.;Robbert Sanderman.
来源: Chest. 2009年135卷3期619-625页
Prognostic studies of mortality in patients with COPD have mostly focused on physiologic variables, with little attention to depressive symptoms. This stands in sharp contrast to the attention that depressive symptoms have been given in the outcomes of patients with other chronic health conditions. The present study investigated the independent association of depressive symptoms in stable patients with COPD with all-cause mortality.
2758. Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease.
作者: Teresa Pitts.;Donald Bolser.;John Rosenbek.;Michelle Troche.;Michael S Okun.;Christine Sapienza.
来源: Chest. 2009年135卷5期1301-1308页
Cough provides high expiratory airflows to aerosolize and remove material that cannot be adequately removed by ciliary action. Cough is particularly important for clearing foreign particles from the airway in those with dysphagia who may be at risk for penetration/aspiration (P/A). Expiratory muscle strength training (EMST) was tested to improve cough and swallow function.
2759. Diagnosis and outcome of early pleural space infection following lung transplantation.
作者: Momen M Wahidi.;Daniel A Willner.;Laurie D Snyder.;Jeremy L Hardison.;Jessica Y Chia.;Scott M Palmer.
来源: Chest. 2009年135卷2期484-491页
Despite the frequent occurrence of pleural effusions in lung transplant recipients, little is known about early posttransplant pleural space infections. We sought to determine the predictors and clinical significance of pleural infection in this population.
2760. Outcomes Associated With Delirium in Older Patients in Surgical ICUs.
作者: Michele C Balas.;Mary Beth Happ.;Wei Yang.;Lakshmipathi Chelluri.;Therese Richmond.
来源: Chest. 2009年135卷1期18-25页
We previously noted that older adults admitted to surgical ICUs (SICUs) are at high risk for delirium. In the current study, we describe the association between the presence of delirium and complications in older SICU patients, and describe the association between delirium occurring in the SICU and functional ability and discharge placement for older patients.
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