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2681. Intravenous amiodarone for incessant tachyarrhythmias in children: a randomized, double-blind, antiarrhythmic drug trial.
作者: J Philip Saul.;William A Scott.;Stephen Brown.;Pablo Marantz.;Valeria Acevedo.;Susan P Etheridge.;James C Perry.;John K Triedman.;Susan W Burriss.;Paul Cargo.;Jay Graepel.;Eeva-Kaarina Koskelo.;Rebecca Wang.; .
来源: Circulation. 2005年112卷22期3470-7页
Intravenous (IV) amiodarone has proven efficacy in adults. However, its use in children is based on limited retrospective data.
2682. Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: a 5-year follow-up.
作者: Holger Thiele.;Stefan Oettel.;Stephan Jacobs.;Rainer Hambrecht.;Peter Sick.;Jan F Gummert.;Friedrich W Mohr.;Gerhard Schuler.;Volkmar Falk.
来源: Circulation. 2005年112卷22期3445-50页
Randomized trials comparing stenting with minimally invasive direct coronary artery bypass surgery in patients with isolated proximal left anterior descending lesions have shown a significantly higher reintervention rate for stenting and similar results for mortality and reinfarction at short-term follow-up. Long-term follow-up data are sparse.
2683. Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment.
作者: Leong Lee.;Ross Campbell.;Michaela Scheuermann-Freestone.;Rachel Taylor.;Prasad Gunaruwan.;Lynne Williams.;Houman Ashrafian.;John Horowitz.;Alan G Fraser.;Kieran Clarke.;Michael Frenneaux.
来源: Circulation. 2005年112卷21期3280-8页
Chronic heart failure (CHF) is a major cause of morbidity and mortality that requires a novel approach to therapy. Perhexiline is an antianginal drug that augments glucose metabolism by blocking muscle mitochondrial free fatty acid uptake, thereby increasing metabolic efficiency. We assessed the effects of perhexiline treatment in CHF patients.
2684. Cardiac magnetic resonance imaging after stage I Norwood operation for hypoplastic left heart syndrome.
作者: Vivek Muthurangu.;Andrew M Taylor.;Sanjeet R Hegde.;Robert Johnson.;Robert Tulloh.;John M Simpson.;Shakeel Qureshi.;Eric Rosenthal.;Edward Baker.;David Anderson.;Reza Razavi.
来源: Circulation. 2005年112卷21期3256-63页
After the Norwood operation, a patient's suitability for proceeding to a bidirectional cavopulmonary connection (BCPC) is assessed by a combination of echocardiography and diagnostic cardiac catheterization. In this study, we describe the results of 37 patients who underwent cardiovascular magnetic resonance (MR) assessment before BCPC.
2685. Mortality and morbidity remain high despite captopril and/or Valsartan therapy in elderly patients with left ventricular systolic dysfunction, heart failure, or both after acute myocardial infarction: results from the Valsartan in Acute Myocardial Infarction Trial (VALIANT).
作者: Harvey D White.;Philip E G Aylward.;Zhen Huang.;Anthony J Dalby.;W Douglas Weaver.;Ståle Barvik.;José Antonio Marin-Neto.;Jan Murin.;Rolf O Nordlander.;Wiek H van Gilst.;Faiez Zannad.;John J V McMurray.;Robert M Califf.;Marc A Pfeffer.; .
来源: Circulation. 2005年112卷22期3391-9页
The elderly constitute an increasing proportion of acute myocardial infarction patients and have disproportionately high mortality and morbidity. Those with heart failure or impaired left ventricular left ventricular function after acute myocardial infarction have high complication and mortality rates. Little is known about outcomes with contemporary therapies in these patients.
2686. Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study.
作者: Lars Gullestad.;Thor Ueland.;Jan G Fjeld.;Even Holt.;Torstein Gundersen.;Kjell Breivik.;Magne Følling.;Anders Hodt.;Rita Skårdal.;John Kjekshus.;Arne Andreassen.;Elin Kjekshus.;Ragnhild Wergeland.;Arne Yndestad.;Stig S Frøland.;Anne Grete Semb.;Pål Aukrust.
来源: Circulation. 2005年112卷22期3408-14页
Inflammation and matrix degradation may play a pathogenic role in chronic heart failure (CHF), and therefore, we examined whether thalidomide, a drug with potential immunomodulating and matrix-stabilizing properties, could improve left ventricular (LV) function in patients with CHF secondary to idiopathic dilated cardiomyopathy (IDCM) or coronary artery disease (CAD).
2687. Angiographic and clinical outcomes in patients receiving low-molecular-weight heparin versus unfractionated heparin in ST-elevation myocardial infarction treated with fibrinolytics in the CLARITY-TIMI 28 Trial.
作者: Marc S Sabatine.;David A Morrow.;Gilles Montalescot.;Mikael Dellborg.;Jose L Leiva-Pons.;Matyas Keltai.;Sabina A Murphy.;Carolyn H McCabe.;C Michael Gibson.;Christopher P Cannon.;Elliott M Antman.;Eugene Braunwald.; .
来源: Circulation. 2005年112卷25期3846-54页
Low-molecular-weight heparin (LMWH) offers pharmacological and practical advantages over unfractionated heparin (UFH). Whether these advantages translate into greater infarct-related artery patency and fewer adverse clinical events in patients with ST-elevation myocardial infarction (STEMI) receiving fibrinolytic therapy remains under study.
2688. Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial.
作者: Kristel C M C Koeijvoets.;Jessica Rodenburg.;Barbara A Hutten.;Albert Wiegman.;John J P Kastelein.;Eric J G Sijbrands.
来源: Circulation. 2005年112卷20期3168-73页
The lipid-lowering effects of statin therapy show considerable interindividual variation in patients with familial hypercholesterolemia (FH). Whether the type of LDL receptor mutation predicts the response to statin treatment is not yet established. We analyzed the relationship between LDL receptor genotype and response to pravastatin treatment in children with FH using carotid intima-media thickness (IMT) to measure efficacy.
2689. Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study.
作者: Ignatios Ikonomidis.;George Athanassopoulos.;John Lekakis.;Kyriaki Venetsanou.;Margarita Marinou.;Kimon Stamatelopoulos.;Dennis V Cokkinos.;Petros Nihoyannopoulos.
来源: Circulation. 2005年112卷21期3272-9页
Interleukin-6 (IL-6) and macrophage colony stimulating factor plasma levels are elevated in acute coronary syndromes. IL-6 has an inherent negative inotropic action and, with tissue factor (TF), mediates the ischemia-reperfusion myocardial injury. We hypothesized that inducible ischemia leads to cytokine production, TF expression, and consequently persistent left ventricular dysfunction after dobutamine stress echocardiography (DSE) in coronary artery disease patients.
2690. Resting myocardial blood flow is impaired in hibernating myocardium: a magnetic resonance study of quantitative perfusion assessment.
作者: Joseph B Selvanayagam.;Michael Jerosch-Herold.;Italo Porto.;David Sheridan.;Adrian S H Cheng.;Steffen E Petersen.;Nick Searle.;Keith M Channon.;Adrian P Banning.;Stefan Neubauer.
来源: Circulation. 2005年112卷21期3289-96页
Although impairment in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy as to whether resting myocardial blood flow (MBF) is reduced in such circumstances. Quantitative first-pass cardiovascular magnetic resonance (CMR) perfusion imaging allows absolute quantification of MBF. We hypothesized that MBF assessed at rest by quantitative CMR perfusion imaging is reduced in hibernating myocardium.
2691. Clinical efficacy of polymer-based paclitaxel-eluting stents in the treatment of complex, long coronary artery lesions from a multicenter, randomized trial: support for the use of drug-eluting stents in contemporary clinical practice.
作者: Keith D Dawkins.;Eberhard Grube.;Giulio Guagliumi.;Adrian P Banning.;Krzysztof Zmudka.;Antonio Colombo.;Leif Thuesen.;Karl Hauptman.;Jean Marco.;William Wijns.;Jeffrey J Popma.;Joerg Koglin.;Mary E Russell.; .
来源: Circulation. 2005年112卷21期3306-13页
Intracoronary polymer-based stent delivery of paclitaxel has been shown to be effective in reducing restenosis in simple coronary lesions, but the evidence base for contemporary use in longer, more complex coronary stenoses is lacking.
2692. Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy.
作者: Roland Fries.;Kaveh Shariat.;Hubertus von Wilmowsky.;Michael Böhm.
来源: Circulation. 2005年112卷19期2980-5页
Vasodilatory therapy of Raynaud's phenomenon represents a difficult clinical problem because treatment often remains inefficient and may be not tolerated because of side effects.
2693. Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study.
作者: Hideo Izawa.;Toyoaki Murohara.;Kohzo Nagata.;Satoshi Isobe.;Hiroyuki Asano.;Tetsuya Amano.;Sahoko Ichihara.;Tomoko Kato.;Satoru Ohshima.;Yosuke Murase.;Shigeo Iino.;Koji Obata.;Akiko Noda.;Kenji Okumura.;Mitsuhiro Yokota.
来源: Circulation. 2005年112卷19期2940-5页
Mineralocorticoid receptor antagonism reduces mortality associated with heart failure by mechanisms that remain unclear. The effects of the mineralocorticoid receptor antagonist spironolactone on left ventricular (LV) function and chamber stiffness associated with myocardial fibrosis were investigated in mildly symptomatic patients with idiopathic dilated cardiomyopathy (DCM).
2694. A noninvasive method for assessing impaired diastolic suction in patients with dilated cardiomyopathy.
作者: Raquel Yotti.;Javier Bermejo.;J Carlos Antoranz.;M Mar Desco.;Cristina Cortina.;José Luis Rojo-Alvarez.;Carmen Allué.;Laura Martín.;Mar Moreno.;José A Serrano.;Roberto Muñoz.;Miguel A García-Fernández.
来源: Circulation. 2005年112卷19期2921-9页
Diastolic suction is a major determinant of early left ventricular filling in animal experiments. However, suction remains incompletely characterized in the clinical setting.
2696. Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
作者: Chris J Packard.;Ian Ford.;Michele Robertson.;James Shepherd.;Gerard J Blauw.;Michael B Murphy.;Edward L E M Bollen.;Brendan M Buckley.;Stuart M Cobbe.;Allan Gaw.;Michael Hyland.;J Wouter Jukema.;Adriaan M Kamper.;Peter W Macfarlane.;Ivan J Perry.;David J Stott.;Brian J Sweeney.;Cillian Twomey.;Rudi G J Westendorp.; .
来源: Circulation. 2005年112卷20期3058-65页
Statins are important in vascular disease prevention in the elderly. However, the best method of selecting older patients for treatment is uncertain. We assessed the role of plasma lipoproteins as predictors of risk and of treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
2697. Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI).
作者: Hüseyin Ince.;Michael Petzsch.;Hans Dieter Kleine.;Heike Schmidt.;Tim Rehders.;Thomas Körber.;Carl Schümichen.;Mathias Freund.;Christoph A Nienaber.
来源: Circulation. 2005年112卷20期3097-106页
Considering experimental evidence that stem cells enhance myocardial regeneration and granulocyte colony-stimulating factor (G-CSF) mediates mobilization of CD34+ mononuclear blood stem cells (MNCCD34+), we tested the impact of G-CSF integrated into primary percutaneous coronary intervention (PCI) management of acute myocardial infarction in man.
2698. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake.
作者: Alexander Leaf.;Christine M Albert.;Mark Josephson.;David Steinhaus.;Jeffrey Kluger.;Jing X Kang.;Benjamin Cox.;Hui Zhang.;David Schoenfeld.; .
来源: Circulation. 2005年112卷18期2762-8页
The long-chain n-3 fatty acids in fish have been demonstrated to have antiarrhythmic properties in experimental models and to prevent sudden cardiac death in a randomized trial of post-myocardial infarction patients. Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients.
2699. Ghrelin improves endothelial function in patients with metabolic syndrome.
作者: Manfredi Tesauro.;Francesca Schinzari.;Micaela Iantorno.;Stefano Rizza.;Domenico Melina.;Davide Lauro.;Carmine Cardillo.
来源: Circulation. 2005年112卷19期2986-92页
Metabolic syndrome importantly accelerates the atherosclerotic process, the earliest event of which is endothelial dysfunction. Ghrelin, a gastric peptide with cardiovascular actions, has been shown to inhibit proatherogenic changes in experimental models. This study therefore investigated whether ghrelin administration might beneficially affect endothelial function in metabolic syndrome.
2700. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial.
作者: Nicolas von Beckerath.;Dirk Taubert.;Gisela Pogatsa-Murray.;Edgar Schömig.;Adnan Kastrati.;Albert Schömig.
来源: Circulation. 2005年112卷19期2946-50页
For patients undergoing percutaneous coronary intervention, the administration of a clopidogrel loading dose ranging from 300 to 600 mg is currently recommended. It is unknown, though, whether loading doses higher than 600 mg exert additional suppression of platelet function.
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