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2641. Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial.
作者: Paul Schoenhagen.;E Murat Tuzcu.;Carolyn Apperson-Hansen.;Chaohui Wang.;Kathy Wolski.;Songhua Lin.;Ilke Sipahi.;Stephen J Nicholls.;William A Magyar.;Aaron Loyd.;Tammy Churchill.;Tim Crowe.;Steven E Nissen.
来源: Circulation. 2006年113卷24期2826-34页
Coronary plaque progression and instability are associated with expansive remodeling of the arterial wall. However, the remodeling response during plaque-stabilizing therapy and its relationship to markers of lipid metabolism and inflammation are incompletely understood.
2642. Cognitive outcomes in elderly high-risk patients after off-pump versus conventional coronary artery bypass grafting: a randomized trial.
作者: Birte Ostergaard Jensen.;Pia Hughes.;Lars S Rasmussen.;Preben U Pedersen.;Daniel A Steinbrüchel.
来源: Circulation. 2006年113卷24期2790-5页
It has been suggested that the risk of cerebral dysfunction is less with off-pump coronary artery bypass grafting (OPCAB) than with conventional coronary artery bypass grafting (CCAB). However, evidence for this statement is preliminary, and additional insight is needed.
2643. Dual-chamber versus single-chamber detection enhancements for implantable defibrillator rhythm diagnosis: the detect supraventricular tachycardia study.
作者: Paul A Friedman.;Robyn L McClelland.;William R Bamlet.;Helbert Acosta.;David Kessler.;Thomas M Munger.;Neal G Kavesh.;Mark Wood.;Emile Daoud.;Ali Massumi.;Claudio Schuger.;Stephen Shorofsky.;Bruce Wilkoff.;Michael Glikson.
来源: Circulation. 2006年113卷25期2871-9页
Delivery of inappropriate shocks caused by misdetection of supraventricular tachycardia (SVT) remains a substantial complication of implanted cardioverter/defibrillator (ICD) therapy. Whether use of optimally programmed dual-chamber ICDs lowers this risk compared with that in single-chamber ICDs is not clear.
2644. Effects of conjugated equine estrogen on stroke in the Women's Health Initiative.
作者: Susan L Hendrix.;Sylvia Wassertheil-Smoller.;Karen C Johnson.;Barbara V Howard.;Charles Kooperberg.;Jacques E Rossouw.;Maurizio Trevisan.;Aaron Aragaki.;Alison E Baird.;Paul F Bray.;Julie E Buring.;Michael H Criqui.;David Herrington.;John K Lynch.;Stephen R Rapp.;James Torner.; .
来源: Circulation. 2006年113卷20期2425-34页
The Women's Health Initiative (WHI) Estrogen Alone trial assessed the balance of benefits and risks of hormone use in healthy postmenopausal women. The trial was stopped prematurely because there was no benefit for coronary heart disease and an increased risk of stroke. This report provides a thorough analysis of the stroke finding using the final results from the completed trial database.
2645. Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
作者: Barry R Davis.;Linda B Piller.;Jeffrey A Cutler.;Curt Furberg.;Kay Dunn.;Stanley Franklin.;David Goff.;Frans Leenen.;Syed Mohiuddin.;Vasilios Papademetriou.;Michael Proschan.;Allan Ellsworth.;John Golden.;Pedro Colon.;Richard Crow.; .
来源: Circulation. 2006年113卷18期2201-10页
Hypertension is a major cause of heart failure (HF) and is antecedent in 91% of cases. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) stipulated assessment of the relative effect of chlorthalidone, lisinopril, and amlodipine in preventing HF.
2646. Heart failure during cardiac pacing.
Right ventricular apical (RVA) pacing creates abnormal left ventricular contraction, hypertrophy, and reduced pump function. The adverse effects of ventricular desynchronization may explain the association of RVA pacing with an increased risk of heart failure hospitalization (HFH) in clinical trials.
2647. A tailored approach to catheter ablation of paroxysmal atrial fibrillation.
作者: Hakan Oral.;Aman Chugh.;Eric Good.;Sundar Sankaran.;Stephen S Reich.;Petar Igic.;Darryl Elmouchi.;David Tschopp.;Thomas Crawford.;Sujoya Dey.;Alan Wimmer.;Kristina Lemola.;Krit Jongnarangsin.;Frank Bogun.;Frank Pelosi.;Fred Morady.
来源: Circulation. 2006年113卷15期1824-31页
Because the genesis of atrial fibrillation (AF) is multifactorial and variable, an ablation strategy that involves pulmonary vein isolation and/or a particular set of ablation lines may not be equally effective or efficient in all patients with AF. A tailored strategy that targets initiators and drivers of AF is a possible alternative to a standardized lesion set.
2648. Relationship between homocysteine and mortality in chronic kidney disease.
作者: Vandana Menon.;Mark J Sarnak.;Tom Greene.;Xuelei Wang.;Arema A Pereira.;Gerald J Beck.;John W Kusek.;Jacob Selhub.;Allan J Collins.;Andrew S Levey.;Michael G Shlipak.
来源: Circulation. 2006年113卷12期1572-7页
The relationship between total homocysteine (tHcy) and outcomes has not been investigated in patients with chronic kidney disease stages 3 to 4.
2649. Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) trial.
作者: Michelle O'Donoghue.;David A Morrow.;Marc S Sabatine.;Sabina A Murphy.;Carolyn H McCabe.;Christopher P Cannon.;Eugene Braunwald.
来源: Circulation. 2006年113卷14期1745-52页
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with the risk of cardiovascular (CV) events in population-based studies. The prognostic value of Lp-PLA2 in patients with acute coronary syndromes (ACS) has not been established.
2650. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial.
作者: James D Otvos.;Dorothea Collins.;David S Freedman.;Irina Shalaurova.;Ernst J Schaefer.;Judith R McNamara.;Hanna E Bloomfield.;Sander J Robins.
来源: Circulation. 2006年113卷12期1556-63页
Changes in conventional lipid risk factors with gemfibrozil treatment only partially explain the reductions in coronary heart disease (CHD) events experienced by men in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). We examined whether measurement of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle subclasses provides additional information relative to CHD risk reduction.
2651. Impact of diabetes mellitus on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcome during antihypertensive therapy: the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study.
作者: Peter M Okin.;Richard B Devereux.;Eva Gerdts.;Steven M Snapinn.;Katherine E Harris.;Sverker Jern.;Sverre E Kjeldsen.;Stevo Julius.;Jonathan M Edelman.;Lars H Lindholm.;Björn Dahlöf.; .
来源: Circulation. 2006年113卷12期1588-96页
Diabetes mellitus is associated with increased cardiovascular (CV) morbidity and mortality and with greater ECG left ventricular hypertrophy (LVH); however, it is unclear whether diabetes attenuates regression of hypertensive LVH and whether regression of ECG LVH has similar prognostic value in diabetic and nondiabetic hypertensive individuals.
2652. Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial.
作者: Rasmus Sejersten Ripa.;Erik Jørgensen.;Yongzhong Wang.;Jens Jakob Thune.;Jens Christian Nilsson.;Lars Søndergaard.;Hans Erik Johnsen.;Lars Køber.;Peer Grande.;Jens Kastrup.
来源: Circulation. 2006年113卷16期1983-92页
Phase 1 clinical trials of granulocyte-colony stimulating factor (G-CSF) treatment after myocardial infarction have indicated that G-CSF treatment is safe and may improve left ventricular function. This randomized, double-blind, placebo-controlled trial aimed to assess the efficacy of subcutaneous G-CSF injections on left ventricular function in patients with ST-elevation myocardial infarction.
2653. Hemodynamic effects of long-term cardiac resynchronization therapy: analysis by pressure-volume loops.
作者: Paul Steendijk.;Sven A Tulner.;Jeroen J Bax.;Pranobe V Oemrawsingh.;Gabe B Bleeker.;Lieselot van Erven.;Hein Putter.;Harriette F Verwey.;Ernst E van der Wall.;Martin J Schalij.
来源: Circulation. 2006年113卷10期1295-304页
Acute hemodynamic effects of cardiac resynchronization therapy (CRT) were reported previously, but detailed invasive studies showing hemodynamic consequences of long-term CRT are not available.
2654. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial.
作者: Gerd P Meyer.;Kai C Wollert.;Joachim Lotz.;Jan Steffens.;Peter Lippolt.;Stephanie Fichtner.;Hartmut Hecker.;Arnd Schaefer.;Lubomir Arseniev.;Bernd Hertenstein.;Arnold Ganser.;Helmut Drexler.
来源: Circulation. 2006年113卷10期1287-94页
Intracoronary transfer of autologous bone marrow cells (BMCs) may enhance recovery of left ventricular (LV) function in patients after acute myocardial infarction (AMI). However, clinical studies addressing the effects of BMCs after AMI have covered only limited time frames ranging from 3 to 6 months. The critical question of whether BMC transfer can have a sustained impact on LV function remains unanswered.
2655. Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope.
作者: Robert Sheldon.;Stuart Connolly.;Sarah Rose.;Thomas Klingenheben.;Andrew Krahn.;Carlos Morillo.;Mario Talajic.;Teresa Ku.;Fetnat Fouad-Tarazi.;Debbie Ritchie.;Mary-Lou Koshman.; .
来源: Circulation. 2006年113卷9期1164-70页
Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope.
2656. Reduced cardiocirculatory complications with unrestrictive visiting policy in an intensive care unit: results from a pilot, randomized trial.
作者: Stefano Fumagalli.;Lorenzo Boncinelli.;Antonella Lo Nostro.;Paolo Valoti.;Giorgio Baldereschi.;Mauro Di Bari.;Andrea Ungar.;Samuele Baldasseroni.;Pierangelo Geppetti.;Giulio Masotti.;Riccardo Pini.;Niccolò Marchionni.
来源: Circulation. 2006年113卷7期946-52页
Observational studies suggest that open visiting policies are preferred by most patients and visitors in intensive care units (ICUs), but no randomized trial has compared the safety and health outcomes of unrestrictive (UVP) and restrictive (RVP) visiting policies. The aim of this pilot, randomized trial was to compare the complications associated with UVP (single visitor with frequency and duration chosen by patient) and RVP (single visitor for 30 minutes twice a day).
2657. Magnetic resonance imaging-guided balloon angioplasty of coarctation of the aorta: a pilot study.
作者: Julia J Krueger.;Peter Ewert.;Sevim Yilmaz.;Dinah Gelernter.;Björn Peters.;Klaus Pietzner.;Axel Bornstedt.;Bernhard Schnackenburg.;Hashim Abdul-Khaliq.;Eckart Fleck.;Eike Nagel.;Felix Berger.;Titus Kuehne.
来源: Circulation. 2006年113卷8期1093-100页
MRI guidance of percutaneous transluminal balloon angioplasty (PTA) of aortic coarctation (CoA) would be desirable for continuous visualization of anatomy and to eliminate x-ray exposure. The aim of this study was (1) to determine the suitability of MRI-controlled PTA using the iron oxide-based contrast medium Resovist (ferucarbotran) for catheter visualization and (2) to subsequently apply this technique in a pilot study with patients with CoA.
2658. Introduction of metoprolol increases plasma B-type cardiac natriuretic peptides in mild, stable heart failure.
作者: Mark E Davis.;A Mark Richards.;M Gary Nicholls.;Timothy G Yandle.;Christopher M Frampton.;Richard W Troughton.
来源: Circulation. 2006年113卷7期977-85页
The effect of beta-blockade on the cardiac natriuretic peptides is poorly understood but could contribute to their beneficial treatment effect and may be relevant to clinical use of plasma brain natriuretic peptide (BNP)/N-terminal pro brain natriuretic peptide (NTproBNP) measurements in risk stratification and in titration of anti-heart failure therapy.
2659. Biventricular pacing improves the blunted force-frequency relation present during univentricular pacing in patients with heart failure and conduction delay.
作者: Dirk Vollmann.;Lars Lüthje.;Peter Schott.;Gerd Hasenfuss.;Christina Unterberg-Buchwald.
来源: Circulation. 2006年113卷7期953-9页
In patients with chronic heart failure (CHF) and conduction delay, biventricular (BiV) and left ventricular (LV) pacing similarly improve systolic function at resting heart rates. We hypothesized that BiV and univentricular pacing differentially affect contractile function at increasing heart rates.
2660. Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm.
作者: Stavros P Loukogeorgakis.;Anna T Panagiotidou.;Derek M Yellon.;John E Deanfield.;Raymond J MacAllister.
来源: Circulation. 2006年113卷7期1015-9页
Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury. Brief periods of ischemia applied at the onset of reperfusion have been shown to reduce ischemia-reperfusion (IR) injury, a phenomenon called postconditioning. The aim of this study was to determine whether postconditioning protects against endothelial IR injury in humans, in vivo.
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