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2621. Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial.
作者: David A Morrow.;James A de Lemos.;Marc S Sabatine.;Stephen D Wiviott.;Michael A Blazing.;Amy Shui.;Nader Rifai.;Robert M Califf.;Eugene Braunwald.
来源: Circulation. 2006年114卷4期281-8页
Elevated levels of high-sensitivity C-reactive protein (hsCRP) are associated with higher risk of adverse outcomes in patients at risk for or with established coronary artery disease. Retrospective analyses suggest that this risk may be modified with statin therapy. However, a role for hsCRP in monitoring the success of therapy remains uncertain.
2622. Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study.
作者: Stefan Blankenberg.;Matthew J McQueen.;Marek Smieja.;Janice Pogue.;Cynthia Balion.;Eva Lonn.;Hans J Rupprecht.;Christoph Bickel.;Laurence Tiret.;Francois Cambien.;Hertzel Gerstein.;Thomas Münzel.;Salim Yusuf.; .
来源: Circulation. 2006年114卷3期201-8页
Individual markers of inflammation may add incremental predictive value in the context of conventionally available risk factors. We evaluated the ability of 9 inflammatory biomarkers, microalbuminuria, and N-terminal pro-brain natriuretic peptide (Nt-proBNP) to improve cardiovascular risk prediction beyond that obtained from traditional risk factors in a secondary-prevention population.
2623. Mitral valve repair with Carpentier-McCarthy-Adams IMR ETlogix annuloplasty ring for ischemic mitral regurgitation: early echocardiographic results from a multi-center study.
作者: Masao Daimon.;Shota Fukuda.;David H Adams.;Patrick M McCarthy.;A Marc Gillinov.;Alain Carpentier.;Farzan Filsoufi.;Vivian M Abascal.;Vera H Rigolin.;Sacha Salzberg.;Anna Huskin.;Michelle Langenfeld.;Takahiro Shiota.
来源: Circulation. 2006年114卷1 Suppl期I588-93页
Ischemic mitral regurgitation (IMR) is associated with asymmetric changes in annular and ventricular geometry. Surgical repair with standard symmetric annuloplasty rings results in a high incidence of residual or recurrent mitral regurgitation (MR). The Carpentier-McCarthy-Adams (CMA) IMR ETlogix annuloplasty ring is the first remodeling ring specifically designed to treat asymmetric leaflet tethering and annular dilatation. We used quantitative 2-dimensional echo to examine early results of mitral valve (MV) repair with the CMA IMR ETlogix annuloplasty ring in patients with IMR.
2624. Are stentless valves superior to modern stented valves? A prospective randomized trial.
作者: Ayyaz Ali.;James C Halstead.;Fay Cafferty.;Linda Sharples.;Fiona Rose.;Richard Coulden.;Evelyn Lee.;John Dunning.;Vincenzo Argano.;Steven Tsui.
来源: Circulation. 2006年114卷1 Suppl期I535-40页
It is presumed that stentless aortic bioprostheses are hemodynamically superior to stented bioprostheses. A prospective randomized controlled trial was undertaken to compare stentless versus modern stented valves.
2625. Mitral valve repair versus revascularization alone in the treatment of ischemic mitral regurgitation.
作者: Duk-Hyun Kang.;Mi-Jeong Kim.;Soo-Jin Kang.;Jong-Min Song.;Hyun Song.;Myeong-Ki Hong.;Kee-Joon Choi.;Jae-Kwan Song.;Jae-Won Lee.
来源: Circulation. 2006年114卷1 Suppl期I499-503页
For patients with ischemic mitral regurgitation (MR), it is not clear whether adjunctive mitral valve (MV) repair at the time of coronary artery bypass graft surgery (CABG) is beneficial. We sought to test the hypothesis that MV repair with CABG is superior to CABG alone in improving MR without increasing operative or long-term mortality.
2626. Coronary revascularization (surgical or percutaneous) decreases mortality after the first year in diabetic subjects but not in nondiabetic subjects with multivessel disease: an analysis from the Medicine, Angioplasty, or Surgery Study (MASS II).
作者: Paulo R Soares.;Whady A Hueb.;Pedro A Lemos.;Neuza Lopes.;Eulógio E Martinez.;Luis A M Cesar.;Sergio A Oliveira.;Jose A F Ramires.
来源: Circulation. 2006年114卷1 Suppl期I420-4页
It is currently unknown whether revascularization procedures are associated with an improvement in mortality among diabetic subjects, as compared with a more conservative medical treatment.
2627. Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress: the EPAS trial.
作者: Henning Morawietz.;Sandra Erbs.;Jürgen Holtz.;Andreas Schubert.;Michael Krekler.;Winfried Goettsch.;Oliver Kuss.;Volker Adams.;Karsten Lenk.;Friedrich W Mohr.;Gerhard Schuler.;Rainer Hambrecht.
来源: Circulation. 2006年114卷1 Suppl期I296-301页
Statins and angiotensin type 1 (AT1) receptor blockers reduce cardiovascular mortality and morbidity. In the Endothelial Protection, AT1 blockade and Cholesterol-Dependent Oxidative Stress (EPAS) trial, impact of independent or combined statin and AT1 receptor blocker therapy on endothelial expression of anti-atherosclerotic and proatherosclerotic genes and endothelial function in arteries of patients with coronary artery disease were tested.
2628. Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting.
作者: Aaron M Ranasinghe.;David W Quinn.;Domenico Pagano.;Nicola Edwards.;Muzzafar Faroqui.;Timothy R Graham.;Bruce E Keogh.;Jorge Mascaro.;David W Riddington.;Stephen J Rooney.;John N Townend.;Ian C Wilson.;Robert S Bonser.
来源: Circulation. 2006年114卷1 Suppl期I245-50页
Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown.
2629. Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC Cell-3-DES randomized, controlled trial.
作者: Hyun-Jae Kang.;Hae-Young Lee.;Sang-Hoon Na.;Sung-A Chang.;Kyung-Woo Park.;Hyung-Kwan Kim.;Song-Yi Kim.;Ho-Joon Chang.;Whal Lee.;Won Jun Kang.;Bon-Kwon Koo.;Yong-Jin Kim.;Dong Soo Lee.;Dae-Won Sohn.;Kyou-Sup Han.;Byung-Hee Oh.;Young-Bae Park.;Hyo-Soo Kim.
来源: Circulation. 2006年114卷1 Suppl期I145-51页
The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation.
2630. Clinical application of tissue engineered human heart valves using autologous progenitor cells.
作者: Serghei Cebotari.;Artur Lichtenberg.;Igor Tudorache.;Andres Hilfiker.;Heike Mertsching.;Rainer Leyh.;Thomas Breymann.;Klaus Kallenbach.;Liviu Maniuc.;Aurel Batrinac.;Oleg Repin.;Oxana Maliga.;Anatol Ciubotaru.;Axel Haverich.
来源: Circulation. 2006年114卷1 Suppl期I132-7页
Tissue engineering (TE) of heart valves reseeded with autologous cells has been successfully performed in vitro. Here, we report our first clinical implantation of pulmonary heart valves (PV) engineered with autologous endothelial progenitor cells (EPCs) and the results of 3.5 years of follow-up.
2631. The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction.
作者: Yasushi Numaguchi.;Takahito Sone.;Kenji Okumura.;Masakazu Ishii.;Yasuhiro Morita.;Ryuji Kubota.;Kazuhiko Yokouchi.;Hajime Imai.;Mitsunori Harada.;Hiroyuki Osanai.;Takahisa Kondo.;Toyoaki Murohara.
来源: Circulation. 2006年114卷1 Suppl期I114-9页
Circulating endothelial progenitor cells (EPCs) are known to be involved in vasculogenesis and mobilized after acute myocardial infarction (AMI). To test the hypothesis that the angiogenic function of EPCs affects post-myocardial infarction (MI) myocardial salvage, we evaluated the number and potential differentiation of EPCs and compared these data with clinical parameters 6 months after MI.
2632. Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients.
作者: Albert A Hagège.;Jean-Pierre Marolleau.;Jean-Thomas Vilquin.;Armelle Alhéritière.;Séverine Peyrard.;Denis Duboc.;Eric Abergel.;Emmanuel Messas.;Elie Mousseaux.;Ketty Schwartz.;Michel Desnos.;Philippe Menasché.
来源: Circulation. 2006年114卷1 Suppl期I108-13页
Skeletal myoblast (SM) transplantation (Tx) in a post-myocardial infarction (MI) scar experimentally improves left ventricular (LV) ejection fraction (EF). Short-term follow-up (FU) studies have suggested that a similar benefit could clinically occur despite an increased risk of LV arrhythmias.
2633. Recovery of regional but not global contractile function by the direct intramyocardial autologous bone marrow transplantation: results from a randomized controlled clinical trial.
作者: Marc Hendrikx.;Karen Hensen.;Christel Clijsters.;Hanne Jongen.;Remco Koninckx.;Eric Bijnens.;Michel Ingels.;Axel Jacobs.;Robert Geukens.;Paul Dendale.;Johan Vijgen.;Dagmara Dilling.;Paul Steels.;Urbain Mees.;Jean-Luc Rummens.
来源: Circulation. 2006年114卷1 Suppl期I101-7页
Recent trials have shown that intracoronary infusion of bone marrow cells (BMCs) improves functional recovery after acute myocardial infarction. However, whether this treatment is effective in heart failure as a consequence of remodeling after organized infarcts remains unclear. In this randomized trial, we assessed the hypothesis that direct intramyocardial injection of autologous mononuclear bone marrow cells during coronary artery bypass graft (CABG) could improve global and regional left ventricular ejection fraction (LVEF) at 4-month follow-up.
2634. Intravenous administration of metoprolol is more effective than oral administration in the prevention of atrial fibrillation after cardiac surgery.
作者: Jari Halonen.;Tapio Hakala.;Tommi Auvinen.;Jari Karjalainen.;Anu Turpeinen.;Ari Uusaro.;Pirjo Halonen.;Juha Hartikainen.;Mikko Hippeläinen.
来源: Circulation. 2006年114卷1 Suppl期I1-4页
Atrial fibrillation (AF) is the most common arrhythmia to occur after cardiac surgery, with an incidence of 20% to 40%. AF is associated with postoperative complications, including increased risk of stroke and need of additional treatment, as well as prolonged hospital stay and increased costs. It has been shown that prophylactic oral administration of beta-blocker therapy reduces the incidence of postoperative AF after cardiac surgery. However, it is possible that absorption of drugs is impaired after cardiopulmonary perfusion associated with cardiac surgery. The purpose of this prospective, controlled, randomized trial was to study compare intravenous and per oral metoprolol administration in the prevention of AF after cardiac surgery.
2635. Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
作者: Stefan H Hohnloser.;Paul Dorian.;Robin Roberts.;Michael Gent.;Carsten W Israel.;Eric Fain.;Jean Champagne.;Stuart J Connolly.
来源: Circulation. 2006年114卷2期104-9页
Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial.
2636. Renal function and effectiveness of angiotensin-converting enzyme inhibitor therapy in patients with chronic stable coronary disease in the Prevention of Events with ACE inhibition (PEACE) trial.
作者: Scott D Solomon.;Madeline M Rice.;Kathleen A Jablonski.;Powell Jose.;Michael Domanski.;Marc Sabatine.;Bernard J Gersh.;Jean Rouleau.;Marc A Pfeffer.;Eugene Braunwald.; .
来源: Circulation. 2006年114卷1期26-31页
Patients with reduced renal function are at increased risk for adverse cardiovascular outcomes. In the post-myocardial infarction setting, angiotensin-converting enzyme (ACE) inhibitors have been shown to be as effective in patients with impaired renal function as in those with preserved renal function.
2637. Routine thrombectomy in percutaneous coronary intervention for acute ST-segment-elevation myocardial infarction: a randomized, controlled trial.
作者: Anne Kaltoft.;Morten Bøttcher.;Søren Steen Nielsen.;Hans-Henrik Tilsted Hansen.;Christian Terkelsen.;Michael Maeng.;Jens Kristensen.;Leif Thuesen.;Lars Romer Krusell.;Steen Dalby Kristensen.;Henning Rud Andersen.;Jens Flensted Lassen.;Klaus Rasmussen.;Michael Rehling.;Torsten Toftegaard Nielsen.;Hans Erik Bøtker.
来源: Circulation. 2006年114卷1期40-7页
Distal embolization during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction may result in reduced myocardial perfusion, infarct extension, and impaired prognosis.
2638. Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failure.
作者: Uta C Hoppe.;Jaime M Casares.;Hans Eiskjaer.;Arne Hagemann.;John G F Cleland.;Nick Freemantle.;Erland Erdmann.
来源: Circulation. 2006年114卷1期18-25页
Atrial fibrillation/flutter (AF) and heart failure often coexist; however, the effect of cardiac resynchronization therapy (CRT) on the incidence of AF and on the outcome of patients with new-onset AF remains undefined.
2639. Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study.
作者: Nazzareno Galiè.;Maurice Beghetti.;Michael A Gatzoulis.;John Granton.;Rolf M F Berger.;Andrea Lauer.;Eleonora Chiossi.;Michael Landzberg.; .
来源: Circulation. 2006年114卷1期48-54页
Eisenmenger syndrome is characterized by the development of pulmonary arterial hypertension with consequent intracardiac right-to-left shunt and hypoxemia in patients with preexisting congenital heart disease. Because Eisenmenger syndrome is associated with increased endothelin expression, patients may benefit from endothelin receptor antagonism. Theoretically, interventions that have some effect on the systemic vascular bed could worsen the shunt and increase hypoxemia.
2640. Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II.
作者: Ilan Goldenberg.;Arthur J Moss.;W Jackson Hall.;Scott McNitt.;Wojciech Zareba.;Mark L Andrews.;David S Cannom.; .
来源: Circulation. 2006年113卷24期2810-7页
Implantable cardioverter-defibrillator (ICD) therapy may be associated with an increased risk for heart failure (HF). The present study evaluated the frequency, causes, and consequences of HF after ICD implantation.
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