250. Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study.
作者: Alexandre Kalimouttou.;Jason N Kennedy.;Jean Feng.;Harvineet Singh.;Suchi Saria.;Derek C Angus.;Christopher W Seymour.;Romain Pirracchio.
来源: JAMA. 2025年333卷19期1688-98页
Norepinephrine is the first-line vasopressor for patients with septic shock. When and whether a second agent, such as vasopressin, should be added is unknown.
251. Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial.
作者: Matthieu Jabaudon.;Jean-Pierre Quenot.;Julio Badie.;Jules Audard.;Samir Jaber.;Benjamin Rieu.;Caroline Varillon.;Antoine Monsel.;François Thouy.;Julien Lorber.;Joël Cousson.;Stéphanie Bulyez.;Jérémy Bourenne.;Ghada Sboui.;Claire Lhommet.;Virginie Lemiale.;Belaïd Bouhemad.;Clément Brault.;Sigismond Lasocki.;François Legay.;Thomas Lebouvier.;Arthur Durand.;Julien Pottecher.;Alexandre Conia.;Delphine Brégeaud.;Lionel Velly.;Arnaud W Thille.;Fabien Lambiotte.;Erwan L'Her.;Mehran Monchi.;Antoine Roquilly.;Aziz Berrouba.;Franck Verdonk.;Russell Chabanne.;Thomas Godet.;Marc Garnier.;Raiko Blondonnet.;Jérémy Vernhes.;Vincent Sapin.;Lucile Borao.;Emmanuel Futier.;Bruno Pereira.;Jean-Michel Constantin.; .
来源: JAMA. 2025年333卷18期1608-1617页
Whether the use of inhaled or intravenous sedation affects outcomes differentially in mechanically ventilated adults with acute respiratory distress syndrome (ARDS) is unknown.
256. Chronic Myeloid Leukemia: A Review.
Chronic myeloid leukemia (CML) has an annual incidence of 2 cases per 100 000 people and is newly diagnosed in approximately 9300 individuals per year in the US. Approximately 150 000 people in the US and 5 million worldwide have CML.
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