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241. Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials.
作者: Monica R Shah.;Vic Hasselblad.;Lynne W Stevenson.;Cynthia Binanay.;Christopher M O'Connor.;George Sopko.;Robert M Califf.
来源: JAMA. 2005年294卷13期1664-70页
Randomized clinical trials (RCTs) evaluating the pulmonary artery catheter (PAC) have been limited by small sample size. Some nonrandomized studies suggest that PAC use is associated with increased morbidity and mortality.
242. Sirolimus-eluting stents vs paclitaxel-eluting stents in patients with coronary artery disease: meta-analysis of randomized trials.
作者: Adnan Kastrati.;Alban Dibra.;Sonja Eberle.;Julinda Mehilli.;José Suárez de Lezo.;Jean-Jacque Goy.;Kurt Ulm.;Albert Schömig.
来源: JAMA. 2005年294卷7期819-25页
Placement of sirolimus-eluting stents or paclitaxel-eluting stents has emerged as the predominant percutaneous treatment strategy in patients with coronary artery disease (CAD). Whether there are any differences in efficacy and safety between these 2 drug-eluting stents is unclear.
243. Duration of anticoagulation following venous thromboembolism: a meta-analysis.
作者: David Ost.;Josh Tepper.;Hanako Mihara.;Owen Lander.;Raphael Heinzer.;Alan Fein.
来源: JAMA. 2005年294卷6期706-15页
Patients with venous thromboembolism (VTE) are susceptible to recurrent events, but whether prolonging anticoagulation is warranted in patients with VTE remains controversial.
244. Predisplacement and postdisplacement factors associated with mental health of refugees and internally displaced persons: a meta-analysis.
The global refugee crisis requires that researchers, policymakers, and clinicians comprehend the magnitude of the psychological consequences of forced displacement and the factors that moderate them. To date, no empirical synthesis of research on these issues has been undertaken.
245. Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials.
In the United States, an estimated 2 million persons have neuropathic pain that is often resistant to therapy. The use of opioids for neuropathic pain remains controversial, in part because studies have been small, have yielded equivocal results, and have not established the long-term risk-benefit ratio of this treatment.
246. Routine vs selective invasive strategies in patients with acute coronary syndromes: a collaborative meta-analysis of randomized trials.
作者: Shamir R Mehta.;Christopher P Cannon.;Keith A A Fox.;Lars Wallentin.;William E Boden.;Rudolf Spacek.;Petr Widimsky.;Peter A McCullough.;David Hunt.;Eugene Braunwald.;Salim Yusuf.
来源: JAMA. 2005年293卷23期2908-17页
Patients with unstable angina or non-ST-segment elevation myocardial infarction (NSTEMI) can be cared for with a routine invasive strategy involving coronary angiography and revascularization or more conservatively with a selective invasive strategy in which only those with recurrent or inducible ischemia are referred for acute intervention.
247. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials.
Although Chlamydia pneumoniae infection has been associated with the initiation and progression of atherosclerosis, results of clinical trials investigating antichlamydial antibiotics as adjuncts to standard therapy in patients with coronary artery disease (CAD) have been inconsistent.
248. Personal use of hair dyes and risk of cancer: a meta-analysis.
Use of hair dyes has been suggested recently as a risk factor for several types of cancer in epidemiologic studies. This alarming news and controversial declarations by scientific organizations and general media have made necessary a systematic evaluation of the epidemiologic evidence.
249. Behavior problems and mental health referrals of international adoptees: a meta-analysis.
International adoption involves more than 40,000 children a year moving among more than 100 countries. Before adoption, international adoptees often experience insufficient medical care, malnutrition, maternal separation, and neglect and abuse in orphanages.
250. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
作者: Heike A Bischoff-Ferrari.;Walter C Willett.;John B Wong.;Edward Giovannucci.;Thomas Dietrich.;Bess Dawson-Hughes.
来源: JAMA. 2005年293卷18期2257-64页
The role and dose of oral vitamin D supplementation in nonvertebral fracture prevention have not been well established.
251. Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic review.
作者: Rene Quiroz.;Nils Kucher.;Kelly H Zou.;Florian Kipfmueller.;Philip Costello.;Samuel Z Goldhaber.;U Joseph Schoepf.
来源: JAMA. 2005年293卷16期2012-7页
The clinical validity of using computed tomography (CT) to diagnose peripheral pulmonary embolism is uncertain. Insufficient sensitivity for peripheral pulmonary embolism is considered the principal limitation of CT.
252. Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials.
作者: Jonathan D Sackner-Bernstein.;Marcin Kowalski.;Marshal Fox.;Keith Aaronson.
来源: JAMA. 2005年293卷15期1900-5页
Nesiritide improves symptoms in patients with acutely decompensated heart failure compared with placebo and appears to be safer than dobutamine. Its short-term safety relative to standard diuretic and vasodilator therapies is less clear.
253. Abciximab as adjunctive therapy to reperfusion in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized trials.
作者: Giuseppe De Luca.;Harry Suryapranata.;Gregg W Stone.;David Antoniucci.;James E Tcheng.;Franz-Josef Neumann.;Frans Van de Werf.;Elliott M Antman.;Eric J Topol.
来源: JAMA. 2005年293卷14期1759-65页
The benefits of abciximab in patients with ST-segment elevation myocardial infarction (STEMI) are still a matter of debate.
254. Association between compensation status and outcome after surgery: a meta-analysis.
作者: Ian Harris.;Jonathan Mulford.;Michael Solomon.;James M van Gelder.;Jane Young.
来源: JAMA. 2005年293卷13期1644-52页
Compensation, whether through workers' compensation or through litigation, has been associated with poor outcome after surgery; however, this association has not been examined by meta-analysis.
255. Evaluation of new treatments in radiation oncology: are they better than standard treatments?
作者: Heloisa P Soares.;Ambuj Kumar.;Stephanie Daniels.;Suzanne Swann.;Alan Cantor.;Iztok Hozo.;Mike Clark.;Fadila Serdarevic.;Clement Gwede.;Andy Trotti.;Benjamin Djulbegovic.
来源: JAMA. 2005年293卷8期970-8页
The superiority of innovative over standard treatments is not known. To describe accurately the outcomes of innovations that are tested in randomized controlled trials (RCTs) 3 factors have to be considered: publication rate, quality of trials, and the choice of the adequate comparator intervention.
256. Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials.
作者: Akshay S Desai.;James C Fang.;William H Maisel.;Kenneth L Baughman.
来源: JAMA. 2004年292卷23期2874-9页
Implantable cardioverter defibrillator (ICD) therapy is effective in primary and secondary prevention of sudden cardiac death among patients with prior myocardial infarction and depressed ejection fraction. However, conclusive evidence of survival benefit in patients with nonischemic cardiomyopathy (NICM) is still lacking.
257. Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials.
作者: Thomas G Roberts.;Bernardo H Goulart.;Lee Squitieri.;Sarah C Stallings.;Elkan F Halpern.;Bruce A Chabner.;G Scott Gazelle.;Stan N Finkelstein.;Jeffrey W Clark.
来源: JAMA. 2004年292卷17期2130-40页
In the past, cancer patients entering phase 1 studies confronted the prospects of high risk and unlikely benefit. Over the last decade, cancer drugs under development have become more targeted, and the clinical research environment has become more scrutinized. The impact of these changes on the risks and benefits to patients who participate in phase 1 cancer trials is unknown.
258. Bariatric surgery: a systematic review and meta-analysis.
作者: Henry Buchwald.;Yoav Avidor.;Eugene Braunwald.;Michael D Jensen.;Walter Pories.;Kyle Fahrbach.;Karen Schoelles.
来源: JAMA. 2004年292卷14期1724-37页
About 5% of the US population is morbidly obese. This disease remains largely refractory to diet and drug therapy, but generally responds well to bariatric surgery.
259. Benefits of adding a drug to a single-agent or a 2-agent chemotherapy regimen in advanced non-small-cell lung cancer: a meta-analysis.
作者: Catherine Delbaldo.;Stefan Michiels.;Nathalie Syz.;Jean-Charles Soria.;Thierry Le Chevalier.;Jean-Pierre Pignon.
来源: JAMA. 2004年292卷4期470-84页
Randomized trials have demonstrated that adding a drug to a single-agent or to a 2-agent regimen increased the tumor response rate in patients with advanced non-small-cell lung cancer (NSCLC), although its impact on survival remains controversial.
260. Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis.
Over the last 2 decades, many new pharmacological agents have been introduced to reduce the growing morbidity associated with asthma, but the long-term effects of these agents on exacerbations are unclear.
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