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2541. Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure?
作者: K Bennett-Richards.;M Kattenhorn.;A Donald.;G Oakley.;Z Varghese.;L Rees.;J E Deanfield.
来源: Circulation. 2002年105卷15期1810-5页
Accelerated vascular disease is common in chronic renal failure (CRF) and accounts for significant mortality and morbidity. Elevated homocysteine levels may contribute by an effect on endothelial function.
2542. Effects of sustained-release moxonidine, an imidazoline agonist, on plasma norepinephrine in patients with chronic heart failure.
作者: Karl Swedberg.;Michael R Bristow.;Jay N Cohn.;Henry Dargie.;Matthias Straub.;Curtis Wiltse.;Theressa J Wright.; .
来源: Circulation. 2002年105卷15期1797-803页
In chronic heart failure, sympathetic activation is increased. Moxonidine acts on central nervous system receptors to decrease sympathetic activation. We investigated the dose-response relationship of a new sustained-release (SR) preparation of moxonidine and the plasma concentration of norepinephrine in patients with chronic heart failure.
2543. Plasma homocysteine concentration, statin therapy, and the risk of first acute coronary events.
作者: Paul M Ridker.;Jessie Shih.;Thomas J Cook.;Michael Clearfield.;John R Downs.;Aruna D Pradhan.;Stephan E Weis.;Antonio M Gotto.; .
来源: Circulation. 2002年105卷15期1776-9页
Elevated homocysteine levels are associated with increased coronary risk, and it has been suggested that homocysteine screening may provide a method to identify high-risk patients for aggressive primary prevention.
2544. Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial infarction: results of the ENTIRE-Thrombolysis in Myocardial Infarction (TIMI) 23 Trial.
作者: Elliott M Antman.;Hans W Louwerenburg.;Hubert F Baars.;Jan C L Wesdorp.;Bas Hamer.;Jean-Pierre Bassand.;Frederique Bigonzi.;Ghislaine Pisapia.;C Michael Gibson.;Hein Heidbuchel.;Eugene Braunwald.;Frans Van de Werf.
来源: Circulation. 2002年105卷14期1642-9页
ENTIRE-TIMI 23 evaluated enoxaparin with full-dose tenecteplase (TNK) and half-dose TNK plus abciximab.
2545. Metoprolol CR/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF).
作者: Jalal K Ghali.;Ileana L Piña.;Stephen S Gottlieb.;Prakash C Deedwania.;John C Wikstrand.; .
来源: Circulation. 2002年105卷13期1585-91页
Underrepresentation of women in heart failure clinical trials has limited conclusions regarding the effect of various management strategies on survival in women with heart failure and decreased left ventricular ejection fraction (LVEF).
2546. Effect of 3 months of antimicrobial treatment with clarithromycin in acute non-q-wave coronary syndrome.
作者: Juha Sinisalo.;Kimmo Mattila.;Ville Valtonen.;Olli Anttonen.;Jukka Juvonen.;John Melin.;Helena Vuorinen-Markkola.;Markku S Nieminen.; .
来源: Circulation. 2002年105卷13期1555-60页
Coronary artery disease, an inflammatory disease, may be caused by infection. We investigated whether the antibiotic clarithromycin would reduce morbidity and mortality in patients with acute non-Q-wave coronary syndrome.
2547. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults.
作者: Robert D Brook.;Jeffrey R Brook.;Bruce Urch.;Renaud Vincent.;Sanjay Rajagopalan.;Frances Silverman.
来源: Circulation. 2002年105卷13期1534-6页
Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function.
2548. Statin attenuates increase in C-reactive protein during estrogen replacement therapy in postmenopausal women.
作者: Kwang Kon Koh.;William H Schenke.;Myron A Waclawiw.;Gyorgy Csako.;Richard O Cannon.
来源: Circulation. 2002年105卷13期1531-3页
HMG-CoA reductase inhibitor (statin) therapy reduces cardiovascular risk, mechanisms of which may include diminished arterial inflammation, as suggested by reduction in levels of C-reactive protein (CRP). Because oral estrogens increase CRP in postmenopausal women, with potential inflammatory and thrombotic consequences that could compromise any benefit to cardiovascular risk, we determined whether the coadministration of a statin might modify the estrogenic effect on CRP.
2549. Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione.
Current antiplatelet regimens fail to prevent the majority of recurrent strokes. Asymptomatic circulating emboli can be detected by transcranial Doppler ultrasound, are frequent in patients with symptomatic carotid stenosis, and predict recurrent stroke risk. S-nitrosoglutathione (GSNO) is a nitric oxide donor that appears to have relative platelet specificity. We evaluated its effectiveness in reducing embolization in patients with symptomatic carotid stenosis who already were taking aspirin.
2550. Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT).
作者: Dietmar Bänsch.;Matthias Antz.;Sigrid Boczor.;Marius Volkmer.;Jürgen Tebbenjohanns.;Karlheinz Seidl.;Michael Block.;Frank Gietzen.;Jürgen Berger.;Karl Heinz Kuck.
来源: Circulation. 2002年105卷12期1453-8页
Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly.
2551. Coronary heart disease in patients with low LDL-cholesterol: benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors.
作者: Frank M Sacks.;Andrew M Tonkin.;Timothy Craven.;Marc A Pfeffer.;James Shepherd.;Anthony Keech.;Curt D Furberg.;Eugene Braunwald.
来源: Circulation. 2002年105卷12期1424-8页
In two large secondary prevention trials of pravastatin, risk reduction was not significant in participants who had low baseline LDL-C concentrations (that is, <125 mg/dL). We conducted exploratory analyses of participant characteristics, lipid risk factors, and risk reduction in this group.
2552. High-dose intravascular beta-radiation after de novo stent implantation induces coronary artery spasm.
作者: D Scheinert.;V Strnad.;R Müller.;R Burckhard.;S Ropers.;R Sauer.;W G Daniel.;R Bonan.;J Ludwig.
来源: Circulation. 2002年105卷12期1420-3页
Intracoronary brachytherapy is effective in preventing restenosis after coronary interventions. However, in vitro and animal studies have shown that irradiation produces immediate and sustained endothelial dysfunction. This study assesses the clinical relevance of impaired vasomotoric function induced by brachytherapy.
2553. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy.
作者: Stephen S Gottlieb.;D Craig Brater.;Ignatius Thomas.;Edward Havranek.;Robert Bourge.;Steven Goldman.;Farere Dyer.;Miguel Gomez.;Donald Bennett.;Barry Ticho.;Evan Beckman.;William T Abraham.
来源: Circulation. 2002年105卷11期1348-53页
Adenosine may adversely affect renal function via its effects on renal arterioles and tubuloglomerular feedback, but effects of adenosine blockade in humans receiving furosemide and ACE inhibitors is unknown.
2554. Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling.
作者: Leslie A Saxon.;Teresa De Marco.;Jill Schafer.;Kanu Chatterjee.;Uday N Kumar.;Elyse Foster.; .
来源: Circulation. 2002年105卷11期1304-10页
Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated.
2555. Effect of azithromycin treatment on endothelial function in patients with coronary artery disease and evidence of Chlamydia pneumoniae infection.
作者: Nikhil Parchure.;Emmanouil G Zouridakis.;Juan Carlos Kaski.
来源: Circulation. 2002年105卷11期1298-303页
It has been suggested that infection with Chlamydia pneumoniae(CPn) can trigger inflammatory mechanisms that may in turn impair vascular endothelial function. The aim of the present study was to assess whether treatment with the macrolide antibiotic azithromycin improves endothelial function in patients with coronary artery disease and antibodies positive to CPn.
2556. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris.
作者: Cindy L Grines.;Matthew W Watkins.;Greg Helmer.;William Penny.;Jeffrey Brinker.;Jonathan D Marmur.;Andrew West.;Jeffery J Rade.;Pran Marrott.;H Kirk Hammond.;Robert L Engler.
来源: Circulation. 2002年105卷11期1291-7页
The angiogenic response to myocardial ischemia can be augmented in animal models by gene transfer with the use of a replication defective adenovirus (Ad) containing a human fibroblast growth factor (FGF) gene.
2557. Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts.
作者: Donald S Baim.;Dennis Wahr.;Barry George.;Martin B Leon.;Joel Greenberg.;Donald E Cutlip.;Unsal Kaya.;Jeffrey J Popma.;Kalon K L Ho.;Richard E Kuntz.; .
来源: Circulation. 2002年105卷11期1285-90页
Stents provide effective treatment for stenotic saphenous venous aorto-coronary bypass grafts, but their placement carries a 20% incidence of procedure-related complications, which potentially are related to the distal embolization of atherosclerotic debris. We report the first multicenter randomized trial to evaluate use of a distal embolic protection device during stenting of such lesions.
2558. Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF).
作者: Stephen S Gottlieb.;Michael L Fisher.;John Kjekshus.;Prakash Deedwania.;Lars Gullestad.;Jiri Vitovec.;John Wikstrand.; .
来源: Circulation. 2002年105卷10期1182-8页
beta-Blockade improves survival when administered over a long period of time to patients with heart failure. However, the time course of any possible deterioration during the titration phase has not been reported.
2559. Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment.
作者: Eberhard Schulz.;Nikolaus Tsilimingas.;Ruth Rinze.;Beate Reiter.;Maria Wendt.;Mathias Oelze.;Silke Woelken-Weckmüller.;Ulrich Walter.;Hermann Reichenspurner.;Thomas Meinertz.;Thomas Münzel.
来源: Circulation. 2002年105卷10期1170-5页
In experimental animal models, long-term in vivo treatment with nitroglycerin (NTG) induces both endothelial dysfunction and tolerance to nitrates. However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO.
2560. Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma.
作者: Masahiko Tsuchiya.;Akira Asada.;Emiko Kasahara.;Eisuke F Sato.;Mitsuo Shindo.;Masayasu Inoue.
来源: Circulation. 2002年105卷10期1155-7页
Cigarette smoking is a well-known risk factor for the development of cardiovascular disease, yet the mechanism of action involved is not completely understood. Because cigarette smoke contains superoxide and other reactive oxygen species, it has been hypothesized that some of the adverse effects of smoking may result from oxidative damage to endothelial cells, which results in nitric oxide (NO) shortage. However, little information is available regarding the acute effects of smoking on plasma concentrations of NO and antioxidants. We measured the changes in the combined plasma concentrations of nitrate and nitrite as an index of NO concentration, as well as changes in concentrations of major serum antioxidants (ascorbic acid, cysteine, methionine, and uric acid) in smokers after smoking a single cigarette.
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