当前位置: 首页 >> 检索结果
2461. Meta-analysis of the efficacy of amifostine in the prevention of cisplatin ototoxicity.
The effectiveness of amifostine in the prevention of cisplatin ototoxicity remains controversial. The objective of this meta-analysis was to determine whether amifostine is successful in preventing ototoxicity secondary to cisplatin chemotherapy.
2462. Association between KRAS codon 13 mutations and clinical response to anti-EGFR treatment in patients with metastatic colorectal cancer: results from a meta-analysis.
To comparatively evaluate whether metastatic colorectal cancer (mCRC) patients with KRAS codon 13 mutations (codon 13 muts) can benefit from anti-EGFR treatment.
2463. Systematic review of β-elemene injection as adjunctive treatment for lung cancer.
作者: Bin Wang.;Xiao-Xia Peng.;Rao Sun.;Jie Li.;Xiao-Ri Zhan.;Li-Juan Wu.;Shu-Ling Wang.;Tian Xie.
来源: Chin J Integr Med. 2012年18卷11期813-23页
To evaluate the effectiveness and safety of β-elemene Injection as an adjunctive treatment for lung cancer by systematic review.
2464. Primary prophylactic colony-stimulating factors for the prevention of chemotherapy-induced febrile neutropenia in breast cancer patients.
作者: Peter Renner.;Stefania Milazzo.;Jian Ping Liu.;Marcel Zwahlen.;Josef Birkmann.;Markus Horneber.
来源: Cochrane Database Syst Rev. 2012年10卷10期CD007913页
High-dose or dose-intensive cytotoxic chemotherapy often causes myelosuppression and severe neutropenia among cancer patients. Severe neutropenia accompanied by fever, named febrile neutropenia (FN), is the most serious manifestation of neutropenia usually requiring hospitalization and intravenous antibiotics. FN and neutropenia can lead to chemotherapy treatment delays or dose reductions, which potentially compromises the effectiveness of cancer treatment and prospects for a cure. Granulocyte-macrophage (GM) and granulocyte colony-stimulating factors (G-CSFs) are administered during chemotherapy in order to prevent or reduce the incidence or the duration of FN and neutropenia.
2465. Chemotherapy for metastatic and recurrent cervical cancer.
作者: Kate Scatchard.;Jennifer L Forrest.;Maxine Flubacher.;Paul Cornes.;Chris Williams.
来源: Cochrane Database Syst Rev. 2012年10卷10期CD006469页
Cervical cancer is the second most common cancer among women up to 65 years of age and is the most frequent cause of death from gynaecological cancers worldwide. A woman's risk of developing cervical cancer by 65 years of age ranges from 0.69% in developed countries to 1.38% in developing countries. Although screening by Pap smear should mean early detection at a curable stage for most women, many still present with advanced or metastatic disease with a worse prognosis. The addition of platinum-based chemotherapy to radiotherapy has improved outcome compared to radiotherapy alone; however, 30% to 50% fail to respond to treatment or develop recurrent disease. There are no standard treatment options for these patients, although platinum-based chemotherapy is frequently used and trials are on-going.
2466. Pharmacokinetic-pharmacodynamic relationship of bosutinib in patients with chronic phase chronic myeloid leukemia.
作者: Poe-Hirr Hsyu.;Diane R Mould.;Richard N Upton.;Michael Amantea.
来源: Cancer Chemother Pharmacol. 2013年71卷1期209-18页
Bosutinib is an orally active, dual Src/Abl tyrosine kinase inhibitor that has demonstrated manageable safety and high response rates in patients with chronic phase (CP) chronic myeloid leukemia (CML). The current analysis evaluated potential bosutinib pharmacokinetic-pharmacodynamic relationships.
2467. Meta analysis of gene expression changes upon treatment of A549 cells with anti-cancer drugs to identify universal responses.
A meta-analysis of publicly available gene expression changes in A549 cells upon treatment with anti-cancer drugs is reported. To reduce false positives, both fold-change and significance level cutoffs were used. Simulated datasets and permutation analysis were used to guide choice of ratio cutoff. Of the genes identified, FDXR is the only gene differentially expressed in six of the seven drug treatments. Though FDXR has been reported to be differentially expressed upon treatment with 5-fluorouracil and its expression correlated to long term disease survival, to our knowledge this is a first study implicating a wide effect of anti-cancer drug treatment on FDXR expression. The other genes identified which are differentially expressed in four out of the seven drug treatments are CDKN1A and PARVB which are upregulated and MYC, HBP1, LDLR, SIM2, ALX1 and GPHN which are downregulated.
2468. Sorafenib in treatment of patients with advanced hepatocellular carcinoma: a systematic review.
作者: Xin Zhang.;Xin-Rong Yang.;Xiao-Wu Huang.;Wei-Min Wang.;Ruo-Yu Shi.;Yang Xu.;Zheng Wang.;Shuang-Jian Qiu.;Jia Fan.;Jian Zhou.
来源: Hepatobiliary Pancreat Dis Int. 2012年11卷5期458-66页
Sorafenib has become the standard first-line treatment for patients with advanced hepatocellular carcinoma (HCC). This study aimed to assess the efficacy and safety of sorafenib in advanced HCC patients and explore its true value for specific subgroups.
2469. Fixed-dose rate infusion and standard rate infusion of gemcitabine in patients with advanced non-small-cell lung cancer: a meta-analysis of six trials.
作者: Man-Tang Qiu.;Xiang-Xiang Ding.;Jing-Wen Hu.;Hong-Ya Tian.;Rong Yin.;Lin Xu.
来源: Cancer Chemother Pharmacol. 2012年70卷6期861-73页
To compare the response, survival, hematological and non-hematological toxicities of gemcitabine administrated at fixed-dose rate infusion (10 mg/m(2)/min, FDR) and standard 30 min infusion in patients with advanced non-small-cell lung cancer (NSCLC).
2470. A meta-analysis of tea consumption and the risk of bladder cancer.
作者: Xiao Wang.;Yi-Wei Lin.;Shuai Wang.;Jian Wu.;Qi-Qi Mao.;Xiang-Yi Zheng.;Li-Ping Xie.
来源: Urol Int. 2013年90卷1期10-6页
Previous studies on the association between tea consumption and bladder cancer risk have only illustrated contradictory results. The role of tea in bladder carcinogenesis still remains conflicting. In order to illustrate the potential relationship between tea consumption and bladder cancer, a meta-analysis of case-control and cohort studies was conducted.
2471. P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer.
作者: Min-Bin Chen.;Xiao-Yang Wu.;Rong Yu.;Chen Li.;Li-Qiang Wang.;Wei Shen.;Pei-Hua Lu.
来源: PLoS One. 2012年7卷9期e45388页
Numerous studies have yielded inconsistent results regarding the relationship between p53 status and the response to neoadjuvant radiation-based therapy in patients with rectal cancer. We conducted a meta-analysis to clarify the relationship between p53 status and response to radiation-based therapy in rectal cancer.
2472. Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?
作者: Chen Sun.;Daniel Ansari.;Roland Andersson.;De-Quan Wu.
来源: World J Gastroenterol. 2012年18卷35期4944-58页
To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment alone.
2473. Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis.
This systematic review has two purposes: to consolidate the current knowledge about clinical effectiveness of electrochemotherapy, a highly effective local therapy for cutaneous and subcutaneous tumors; and to investigate the differences in effectiveness of electrochemotherapy with respect to tumor type, chemotherapeutic drug, and route of drug administration.
2474. Interventions for mycosis fungoides.
作者: Tobias Weberschock.;Reinhard Strametz.;Maria Lorenz.;Christoph Röllig.;Charles Bunch.;Andrea Bauer.;Jochen Schmitt.
来源: Cochrane Database Syst Rev. 2012年9期CD008946页
Mycosis fungoides is the most common type of cutaneous T-cell lymphoma, a malignant, chronic disease initially affecting the skin. Several therapies are available, which may induce clinical remission for a time.
2475. The association of Raynaud's syndrome with cisplatin-based chemotherapy - a meta-analysis.
Vasospastic disorders of the digital circulation such as the Raynaud's syndrome (RS) are known side-effects of treatment of cisplatin-based chemotherapy. The prevalence of RS in patients during treatment with cisplatin-based chemotherapy is not well-defined.
2476. Single-agent maintenance therapy in non-small cell lung cancer: a systematic review and meta-analysis.
作者: Dong-Mei Yuan.;Shu-Zhen Wei.;Yan-Ling Lü.;Yan Zhang.;Xiao-Hui Miao.;Ping Zhan.;Li-Ke Yu.;Yi Shi.;Yong Song.
来源: Chin Med J (Engl). 2012年125卷17期3143-9页
Can single-agent maintenance therapy be considered as an ideal strategy for non-small cell lung cancer (NSCLC) treatment to achieve prolonged survival and tolerated toxicity? A systematic review and meta-analysis was performed to elucidate this issue.
2477. Systematic review and meta-analysis of Endostar (rh-endostatin) combined with chemotherapy versus chemotherapy alone for treating advanced non-small cell lung cancer.
作者: Biaoxue Rong.;Shuanying Yang.;Wei Li.;Wei Zhang.;Zongjuan Ming.
来源: World J Surg Oncol. 2012年10卷170页
Many studies have investigated the efficacy of Endostar combined with platinum-based doublet chemotherapy (PBDC) versus PBDC alone for treating advanced non-small cell lung cancer (NSCLC). This study is a meta-analysis of available evidence.
2478. Incidence and risk of pulmonary toxicity in patients treated with mTOR inhibitors for malignancy. A meta-analysis of published trials.
作者: Roberto Iacovelli.;Antonella Palazzo.;Silvia Mezi.;Federica Morano.;Giuseppe Naso.;Enrico Cortesi.
来源: Acta Oncol. 2012年51卷7期873-9页
mTOR inhibitors are currently used in the treatment of solid malignancies. Since their approval, several cases of pulmonary toxicity (PT) have been described. This analysis aims to report the incidence and the risk of PT in published randomized controlled trials.
2479. Denosumab for treatment of bone metastases secondary to solid tumours: systematic review and network meta-analysis.
作者: John A Ford.;Rob Jones.;Andrew Elders.;Clive Mulatero.;Pamela Royle.;Pawana Sharma.;Fiona Stewart.;Radha Todd.;Graham Mowatt.
来源: Eur J Cancer. 2013年49卷2期416-30页
To evaluate the evidence for denosumab for the treatment of bone metastases secondary to solid tumours and, using a network meta-analysis, indirectly compare denosumab with bisphosphonates and best supportive care.
2480. Ca/Mg infusions for the prevention of oxaliplatin-related neurotoxicity in patients with colorectal cancer: a meta-analysis.
作者: F Wen.;Y Zhou.;W Wang.;Q C Hu.;Y T Liu.;P F Zhang.;Z D Du.;J Dai.;Q Li.
来源: Ann Oncol. 2013年24卷1期171-8页
Oxaliplatin-related neurotoxicity is the main limitation for its continuation in adjuvant and palliative chemotherapy for patients with colorectal cancer. The purpose of this meta-analysis was to determine the efficacy of calcium and magnesium (Ca/Mg) infusions in oxaliplatin-induced neurotoxicity.
|