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2381. Comparative effects of carvedilol and metoprolol on regional vascular responses to adrenergic stimuli in normal subjects and patients with chronic heart failure.
作者: Katarzyna Hryniewicz.;Ana Silvia Androne.;Alhakam Hudaihed.;Stuart D Katz.
来源: Circulation. 2003年108卷8期971-6页
Adrenergic receptor blockers used in the treatment of heart failure have distinct receptor affinity profiles. We hypothesized that alpha-adrenergic-blocking effects of carvedilol would limit vasoconstriction in response to adrenergic stimuli when compared with metoprolol.
2382. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy.
作者: Victor L Serebruany.;Alexander H Glassman.;Alex I Malinin.;Charles B Nemeroff.;Dominique L Musselman.;Louis T van Zyl.;Mitchell S Finkel.;K Ranga R Krishnan.;Michael Gaffney.;Wilma Harrison.;Robert M Califf.;Christopher M O'Connor.; .
来源: Circulation. 2003年108卷8期939-44页
Depression after acute coronary syndromes (ACSs) has been identified as an independent risk factor for subsequent cardiac death. Enhanced platelet activation has been hypothesized to represent 1 of the mechanisms underlying this association. Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit platelet activity. Whether treatment of depressed post-ACS patients with SSRIs alters platelet function was not known. Accordingly, we serially assessed the release of established platelet/endothelial biomarkers in patients treated with sertraline vs placebo in the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART).
2383. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial.
作者: Marguerite M Engler.;Mary B Engler.;Mary J Malloy.;Elisa Y Chiu.;Monique C Schloetter.;Steven M Paul.;Markus Stuehlinger.;Ken Y Lin.;John P Cooke.;Jason D Morrow.;Paul M Ridker.;Nader Rifai.;Elizabeth Miller.;Joseph L Witztum.;Michele Mietus-Snyder.
来源: Circulation. 2003年108卷9期1059-63页
Hyperlipidemia is associated with endothelial dysfunction, an early event in atherosclerosis and predictor of risk for future coronary artery disease. Epidemiological studies suggest that increased dietary intake of antioxidants reduces the risk of coronary artery disease. The purpose of this study was to determine whether antioxidant vitamin therapy improves endothelial function and affects surrogate biomarkers for oxidative stress and inflammation in hyperlipidemic children.
2384. Effect of lower dose of oral conjugated equine estrogen on size and oxidative susceptibility of low-density lipoprotein particles in postmenopausal women.
作者: Akihiko Wakatsuki.;Yuji Okatani.;Nobuo Ikenoue.;Koichi Shinohara.;Kazushi Watanabe.;Takao Fukaya.
来源: Circulation. 2003年108卷7期808-13页
Estrogen replacement therapy (ERT) has an antioxidant effect that opposes the oxidation of LDL. Oral ERT-induced increases in plasma triglyceride, however, are associated with decreased LDL size, which may counteract this antioxidant effect. Because lower doses of oral estrogen do not affect plasma triglyceride concentrations, LDL size might not change, and the antioxidant effect of estrogen might be preserved. We investigated whether a lower dose of oral estrogen could eliminate the adverse effects of high-dose oral ERT on the size and oxidative susceptibility of LDL in postmenopausal women.
2385. Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions.
作者: Antonio Colombo.;Janusz Drzewiecki.;Adrian Banning.;Eberhard Grube.;Karl Hauptmann.;Sigmund Silber.;Dariusz Dudek.;Stephen Fort.;Francois Schiele.;Krysztof Zmudka.;Giulio Guagliumi.;Mary E Russell.; .
来源: Circulation. 2003年108卷7期788-94页
Early clinical studies demonstrated the feasibility of local paclitaxel delivery in reducing restenosis after treatment of de novo coronary lesions in small patient populations.
2386. Effect of 7-year infancy-onset dietary intervention on serum lipoproteins and lipoprotein subclasses in healthy children in the prospective, randomized Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study.
作者: Tuuli Kaitosaari.;Tapani Rönnemaa.;Olli Raitakari.;Sanna Talvia.;Katariina Kallio.;Iina Volanen.;Aila Leino.;Eero Jokinen.;Ilkka Välimäki.;Jorma Viikari.;Olli Simell.
来源: Circulation. 2003年108卷6期672-7页
We previously showed that low-saturated-fat dietary intervention from infancy until 5 years of age safely and effectively reduced serum cholesterol concentration. We now report how such intervention influenced serum lipids, LDL particle size, and HDL subfractions in children when they reached the age of 7 years.
2387. Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention for Endpoint reduction in Hypertension (LIFE) Study.
作者: Peter M Okin.;Richard B Devereux.;Sverker Jern.;Sverre E Kjeldsen.;Stevo Julius.;Markku S Nieminen.;Steven Snapinn.;Katherine E Harris.;Peter Aurup.;Jonathan M Edelman.;Bjorn Dahlof.; .
来源: Circulation. 2003年108卷6期684-90页
Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular morbidity and mortality, and regression of ECG LVH may predict improved prognosis in hypertensive patients. However, uncertainty persists as to how best to regress ECG LVH.
2388. Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
作者: Koichi Node.;Masashi Fujita.;Masafumi Kitakaze.;Masatsugu Hori.;James K Liao.
来源: Circulation. 2003年108卷7期839-43页
Chronic heart failure is associated with inflammation and neurohormonal imbalance. The 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, exert anti-inflammatory and vascular protective effects. We hypothesized that short-term statin therapy may have beneficial effects in patients with nonischemic heart failure.
2389. Randomized comparison of distal protection with a filter-based catheter and a balloon occlusion and aspiration system during percutaneous intervention of diseased saphenous vein aorto-coronary bypass grafts.
作者: Gregg W Stone.;Campbell Rogers.;James Hermiller.;Robert Feldman.;Patrick Hall.;Robert Haber.;A Masud.;Patrick Cambier.;Ron P Caputo.;Mark Turco.;Richard Kovach.;Bruce Brodie.;Howard C Herrmann.;Richard E Kuntz.;Jeffrey J Popma.;Steve Ramee.;David A Cox.; .
来源: Circulation. 2003年108卷5期548-53页
The high rate of periprocedural complications resulting from atherothrombotic embolization after percutaneous intervention in diseased saphenous vein grafts is reduced by distal microcirculatory protection using a balloon occlusion and aspiration system. Whether filter-based catheters, which offer the inherent advantages of maintained perfusion and ease of use, are as effective for this purpose has not been established.
2390. Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease.
作者: Eric J Topol.;Donald Easton.;Robert A Harrington.;Pierre Amarenco.;Robert M Califf.;Carmen Graffagnino.;Stephen Davis.;Hans-Christophe Diener.;James Ferguson.;Desmond Fitzgerald.;Jeffrey Granett.;Ashfaq Shuaib.;Peter J Koudstaal.;Pierre Theroux.;Frans Van de Werf.;Kristina Sigmon.;Karen Pieper.;Marc Vallee.;James T Willerson.; .
来源: Circulation. 2003年108卷4期399-406页
This is the primary report of the large-scale evaluation of lotrafiban, an orally administered IIb/IIIa receptor antagonist, a unique trial with respect to the platelet antagonist, protocol design, and inclusion of cerebrovascular disease in a significant proportion of patients.
2391. Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) Trial.
作者: Pantaleo Giannuzzi.;Pier Luigi Temporelli.;Ugo Corrà.;Luigi Tavazzi.; .
来源: Circulation. 2003年108卷5期554-9页
The effects of exercise training (ET) on left ventricular (LV) remodeling in chronic heart failure are not definitively established, and the safety of ET in these patients is still debated.
2392. Cardiac resynchronization therapy improves heart rate variability in patients with symptomatic heart failure.
作者: Philip B Adamson.;Karen J Kleckner.;Warren L VanHout.;Sriram Srinivasan.;William T Abraham.
来源: Circulation. 2003年108卷3期266-9页
Cardiac resynchronization therapy (CRT) using biventricular pacing improves symptoms and functional capacity in patients with moderate to severe heart failure. The present study examined whether an improvement in ventricular performance from resynchronization therapy changes the autonomic control of heart rate.
2393. Efficacy and safety of tenecteplase in combination with the low-molecular-weight heparin enoxaparin or unfractionated heparin in the prehospital setting: the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 PLUS randomized trial in acute myocardial infarction.
作者: L Wallentin.;P Goldstein.;P W Armstrong.;C B Granger.;A A J Adgey.;H R Arntz.;K Bogaerts.;T Danays.;B Lindahl.;M Mäkijärvi.;F Verheugt.;F Van de Werf.
来源: Circulation. 2003年108卷2期135-42页
The combination of a single-bolus fibrinolytic and a low-molecular-weight heparin may facilitate prehospital reperfusion and further improve clinical outcome in patients with ST-elevation myocardial infarction.
2394. Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial.
作者: Thomas P Erlinger.;Edgar R Miller.;Jeanne Charleston.;Lawrence J Appel.
来源: Circulation. 2003年108卷2期150-4页
Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet.
2395. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy.
作者: Stefan K James.;Bertil Lindahl.;Agneta Siegbahn.;Mats Stridsberg.;Per Venge.;Paul Armstrong.;Elliot S Barnathan.;Robert Califf.;Eric J Topol.;Maarten L Simoons.;Lars Wallentin.
来源: Circulation. 2003年108卷3期275-81页
Biochemical markers are useful for prediction of cardiac events in patients with non-ST-segment-elevation acute coronary syndrome (ACS). The associations between N-terminal pro-brain natriuretic peptide (NT-proBNP) and other biochemical and clinical risk indicators, as well as their prognostic value concerning the individual end points of death and myocardial infarction (MI), were elucidated in a large cohort of ACS patients.
2396. Proarrhythmic effect of pacemaker stimulation in patients with implanted cardioverter-defibrillators.
作者: Ewald Himmrich.;Oliver Przibille.;Christian Zellerhoff.;Andreas Liebrich.;Stefan Rosocha.;Klaus Andreas.;Dirk Nebeling.;Babatunde Omogbehin.;Jürgen Meyer.
来源: Circulation. 2003年108卷2期192-7页
We sought to determine the potential of right ventricular VVI backup pacing to induce ventricular tachyarrhythmias in patients with implanted cardioverter-defibrillators.
2397. Timing of antioxidant vitamin ingestion alters postprandial proatherogenic serum markers.
This study was designed to determine the optimal timing of vitamins E and C to prevent oxidative stress induced by a high-fat evening meal in type 2 diabetes.
2398. Racial differences in outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT): a comparison of whites versus blacks.
作者: Andrea M Russo.;Gail E Hafley.;Kerry L Lee.;Nicholas J Stamato.;Michael H Lehmann.;Richard L Page.;Teresa Kus.;Alfred E Buxton.; .
来源: Circulation. 2003年108卷1期67-72页
The Multicenter UnSustained Tachycardia Trial (MUSTT) demonstrated the benefit of implantable cardioverter-defibrillators (ICDs) in patients with coronary disease, asymptomatic nonsustained ventricular tachycardia, and reduced left ventricular function. Previous studies have shown racial differences in risk of sudden death in patients with ischemic heart disease.
2399. Randomized evaluation of polytetrafluoroethylene-covered stent in saphenous vein grafts: the Randomized Evaluation of polytetrafluoroethylene COVERed stent in Saphenous vein grafts (RECOVERS) Trial.
作者: Goran Stankovic.;Antonio Colombo.;Patrizia Presbitero.;Frank van den Branden.;Luigi Inglese.;Carmelo Cernigliaro.;Luigi Niccoli.;Antonio L Bartorelli.;Paolo Rubartelli.;Nicholaus Reifart.;Guy R Heyndrickx.;Kari Saunamäki.;Marie Claude Morice.;Fabio A Sgura.;Carlo Di Mario.; .
来源: Circulation. 2003年108卷1期37-42页
Treatment of lesions located in saphenous vein grafts (SVGs) is associated with increased procedural risk and a high rate of restenosis.
2400. Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition.
作者: Jens Tank.;Christoph Schroeder.;Andre Diedrich.;Elke Szczech.;Sebastian Haertter.;Arya M Sharma.;Friedrich C Luft.;Jens Jordan.
来源: Circulation. 2003年107卷23期2949-54页
Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone.
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