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201. The Michael Mason prize: development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine.
作者: Laurna Bullock.;Natasha Tyler.;Jane Fleming.;Emma M Clark.;Simon Thomas.;Christopher Gidlow.;Cynthia P Iglesias-Urrutia.;Robert Horne.;Ida Bentley.;Ashley Hawarden.;Nicola Peel.;Celia L Gregson.;Stuart H Ralston.;Joanne Protheroe.;Janet Lefroy.;Sarah Ryan.;Terence W O'Neill.;Christian Mallen.;Clare Jinks.;Zoe Paskins.
来源: Rheumatology (Oxford). 2026年65卷1期
Only 12% of people recommended fracture prevention medicines remain on treatment 1 year post fracture. The 'improving uptake of Fracture Prevention treatments' (iFraP) intervention aims to improve shared decision-making (SDM) about, and uptake of, osteoporosis medicines in Fracture Liaison Services (FLS). This paper details development and feasibility.
202. Achieving inactive disease state in men and women with axial spondyloarthritis: results from a multi-country prospective observational study.
作者: Denis Poddubnyy.;Joachim Sieper.;Servet Akar.;Santiago Muñoz-Fernández.;Hildrun Haibel.;Mikhail Protopopov.;Elisabeth Altmaier.;Fabiana Ganz.;Robert D Inman.
来源: Rheumatology (Oxford). 2025年64卷12期6337-6344页
To assess the probability of achieving low disease activity (LDA) and inactive disease (ID) in men vs women with recently diagnosed axial spondyloarthritis (axSpA).
203. Clinical characteristics and outcomes of anti-MDA5 dermatomyositis: a retrospective study.
作者: Tulaton Sodsri.;Tananchai Petnak.;Thitiporn Suwatanapongched.;Chayanin Nitiwarangkul.;Nantakarn Pongtarakulpanit.;Pintip Ngamjanyaporn.
来源: BMC Rheumatol. 2025年9卷1期102页
Anti-MDA5 dermatomyositis (anti-MDA5 DM) is a rare but severe subtype of dermatomyositis associated with high mortality. This study aimed to describe clinical characteristics and identify variables associated with rapidly progressive interstitial lung disease (RP-ILD) and mortality among affected patients.
204. Impaired humoral and T helper cell responses to toxic shock syndrome toxin-1 (TSST-1) in granulomatosis with polyangiitis.
作者: Hang Liao.;Abraham Rutgers.;Minke G Huitema.;Caroline Roozendaal.;Peter Heeringa.;Wayel H Abdulahad.
来源: Rheumatology (Oxford). 2025年64卷12期6309-6318页
Nasal carriage of toxic shock syndrome toxin-1 (TSST-1)-positive Staphylococcus aureus (SA) is associated with a high relapse rate in granulomatosis with polyangiitis (GPA), suggesting TSST-1's role in disease progression. This study investigated the immune response to S. aureus-derived TSST-1 and characterized TSST-1-specific Th cells in GPA patients.
205. Aquaporin-4 downregulation in dysphagic patients with idiopathic inflammatory myopathies: myofiber vulnerability and inflammation drivers.
作者: Marco Fornaro.;Margherita Giannini.;Dario D'Abbicco.;Maria L Fiorella.;Mariella Errede.;Daniela Virgintino.;Onofrio Valente.;Antonio Frigeri.;Florenzo Iannone.;Francesco Girolamo.
来源: Rheumatology (Oxford). 2025年64卷12期6378-6386页
To evaluate whether the impairment of aquaporin-4 (AQP4), a water channel protein important for muscle function, may be associated with dysphagia in idiopathic inflammatory myopathies (IIMs). Swallowing muscle inflammation in IIM has been documented in case reports, but direct correlations with limb muscles impairment are lacking.
206. A screening tool to detect interstitial lung disease in systemic sclerosis: the ILD-RISC score.
作者: Cosimo Bruni.;Lorenzo Tofani.;Håvard Fretheim.;Sophie I E Liem.;Arthiha Velauthapillai.;Hilde Bjørkekjær.;Imon Barua.;Ilaria Galetti.;Alexandru Garaiman.;Mike O Becker.;Anna-Maria Hoffmann-Vold.;Jeska de Vries-Bouwstra.;Madelon C Vonk.;Jörg H W Distler.;Marco Matucci-Cerinic.;Oliver Distler.
来源: Rheumatology (Oxford). 2025年64卷12期6285-6293页
As a screening tool for the presence of systemic sclerosis-associated interstitial lung disease (SSc-ILD) on high-resolution computed tomography (HRCT) is missing, we aimed to develop the ILD-RISC score, a risk algorithm to guide physicians in ordering HRCTs, with specific focus on follow-up visits.
207. Identification of a novel TGFB1 variant in a patient with Camurati-Engelmann disease responsive to alendronate.
作者: Neelam Hassan.;Celia L Gregson.;Michael Oldridge.;Tracy Lester.;Emma L Duncan.;Jonathan H Tobias.
来源: Rheumatology (Oxford). 2025年64卷12期6427-6429页 208. High ischemic deficit in computed tomography perfusion is a risk factor for cerebral vascular ischemic events in Takayasu arteritis: a prospective observational study.
Patients suffering from Takayasu arteritis (TA) with stenosis or occlusion of supra-aortic trunks carry a high risk of cerebral vascular ischemic events (CVIEs). We explored the relationship between cerebral blood perfusion and CVIEs in TA.
209. Patient characteristics and adverse effects of allogeneic blood transfusion following lower extremity joint replacement in rheumatoid arthritis: a nationwide inpatient sample database study.
作者: Wenyan Geng.;Lulu Ye.;Xuegao Yu.;Qinfeng Yang.;Linlin Wang.;Xiaodan Li.;Qing Xiao.;Jian Wang.
来源: BMC Rheumatol. 2025年9卷1期101页
Allogeneic blood transfusion is a common therapeutic intervention for patients with rheumatoid arthritis (RA) undergoing lower extremity joint replacement (LEJR). Despite the potential for adverse outcomes associated with blood transfusion, the risks related to this procedure in RA patients remain underexplored, particularly within the framework of a large-scale national dataset.
211. Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence.
作者: Andy Nolan.;Daniel M Foulkes.;Emma E Fairweather.;Michele Fresneda Alarcon.;Christina Linford.;Andrew Sellin.;Zoe McLaren.;Patrick A Eyers.;Helen L Wright.
来源: Rheumatology (Oxford). 2025年64卷12期6409-6414页
Activation of neutrophils and release of neutrophil extracellular traps (NETs), proteases and reactive oxygen species (ROS) is pathogenic in immune-mediated inflammatory diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), driving inflammation and damaging host tissues. The aim of this research was to identify small molecule inhibitors of NET production using a highly curated panel of narrow-spectrum small molecule kinase inhibitors termed the kinase chemogenomic set (KCGS).
212. Anxiety symptoms and associated factors in the Scleroderma Patient-centered Intervention Network (SPIN) cohort: a cross-sectional study.
作者: Sabrina Provencher.;Marie-Eve Carrier.;Gabrielle Virgili-Gervais.;Meira Golberg.;Richard S Henry.;Linda Kwakkenbos.;Catherine Fortuné.;Amy Gietzen.;Karen Gottesman.;Geneviève Guillot.;Amanda Lawrie-Jones.;Maureen Sauvé.;Susan J Bartlett.;Laura K Hummers.;Vanessa Malcarne.;Maureen D Mayes.;Michelle Richard.;James Stempel.;Robyn K Wojeck.;Luc Mouthon.;Andrea Benedetti.;Brett D Thombs.; .
来源: Rheumatology (Oxford). 2025年64卷12期6268-6277页
We (1) compared anxiety symptom levels in a multinational SSc cohort to a general population normative sample and (2) evaluated sociodemographic, lifestyle and SSc disease factors associated with symptoms.
213. Eye-openers for advanced management of elderly-onset rheumatoid arthritis.
作者: Hamit Harun Dag.;Selinde V J Snoeck Henkemans.;Agnes E M Looijen.;Judith W Heutz.;Radboud J E M Dolhain.;Pascal H P de Jong.
来源: Rheumatology (Oxford). 2025年64卷12期6241-6249页
To investigate whether clinical outcomes and patient-reported outcomes (PROs) differ over 2 years based on the age of onset of RA.
214. Exploration of health-related quality of life, anxiety and depression in antineutrophil cytoplasmic antibody-associated vasculitis.
作者: Annika Granath.;Sara Brolin.;Karuna Dahlberg.;Iva Gunnarsson.;Elisabet Welin.;Susanne Pettersson.
来源: Rheumatology (Oxford). 2025年64卷12期6233-6240页
To explore health-related quality of life (HRQoL), anxiety, depression and fatigue among persons with ANCA-associated vasculitis (AAV).
215. Risk of venous thromboembolism in people with RA: a population-based study in the UK.
作者: Mark D Russell.;Katie Bechman.;Mark Gibson.;Victoria Basey.;Michael Mclean.;Saqib Rana.;Anna Barkaway.;Simon de Lusignan.;Maya H Buch.;James B Galloway.
来源: Rheumatology (Oxford). 2025年64卷12期6224-6232页
To evaluate the absolute and relative risk of venous thromboembolism (VTE) in individuals with RA, with relation to age, sex, BMI, disease duration and exposure to exogenous oestrogens.
216. Self-reported cognitive dysfunction and memory impairment in Systemic Autoimmune Rheumatic Diseases (SARDs): a mixed methods analysis of the INSPIRE cohort.
作者: Avni Varshney.;Thomas A Pollak.;Arjoon Arunasalam.;Efthalia Massou.;Felix Naughton.;James A Bourgeois.;Lucy Calderwood.;Guy Leschziner.;Alessandra Bortoluzzi.;Alice Tunks.;Ellie Dalby.;Martha Piper.;Laura Andreoli.;Xiaofeng Yan.;Sharmilee Gnanapavan.;Arvind Kaul.;David D'Cruz.;Melanie Sloan.
来源: Rheumatology (Oxford). 2025年64卷12期6213-6223页
To explore self-reported cognitive dysfunction, including memory impairment, across systemic autoimmune rheumatic diseases (SARDs) and examine its impact and associations with demographic, clinical and psychosocial factors.
217. Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis.
作者: Shuang Xu.;William F Jiemy.;Anqi Zhang.;Fokke Walinga.;Miranda Nijenhuis.;Elien Hensema.;Wayel Abdulahad.;Kornelis Sm van der Geest.;Peter Heeringa.;Annemieke Boots.;Elisabeth Brouwer.;Maria Sandovici.
来源: Rheumatology (Oxford). 2026年65卷3期
Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodelling. Macrophages and fibroblasts are abundantly present in arteries affected by GCA, but their crosstalk in GCA pathogenesis is largely unknown. Here we investigated the interaction between macrophages and fibroblasts in GCA-affected arteries and in vitro.
218. Anti-Mi2 autoantibodies target PHD fingers of SP140L and TIF1γ, while anti-TIF1γ autoantibodies primarily bind TIF1γ outside the PHD region.
作者: Iago Pinal-Fernandez.;Jon Musai.;Maria Casal-Dominguez.;Katherine Pak.;Mariana Kaplan.;Blake M Warner.;Lisa G Rider.;Rohit Aggarwal.;Chester V Oddis.;Siamak Moghadam-Kia.;Gloria Garrabou.;Albert Selva-O'Callaghan.;Jose C Milisenda.;John A Chiorini.;Andrew L Mammen.;Peter D Burbelo.
来源: Rheumatology (Oxford). 2025年64卷12期6371-6377页
Plant homeodomain (PHD) fingers are present in many chromatin-binding proteins. We recently discovered that anti-Mi2 autoantibodies recognize PHD fingers in Mi2 and AIRE. The purpose of this study was to characterize anti-Mi2 autoantibody recognition of PHD fingers in SP140L and TIF1γ as well as to explore recognition of TIF1γ by both anti-TIF1γ and anti-Mi2 autoantibodies.
219. Prevalence and functional characterization of anti-interferon autoantibodies in inflammatory myopathies.
作者: Iago Pinal-Fernandez.;Lindsey B Rosen.;Jose Luis Gomez-Vazquez.;Maria Casal-Dominguez.;Serena Lee.;Jose C Milisenda.;Katherine Pak.;Xavier Solanich.;Steven M Holland.;Albert Selva-O'Callaghan.;Andrew L Mammen.
来源: Rheumatology (Oxford). 2025年64卷12期6404-6408页
Functional autoantibodies targeting IFNs can lead to immunodeficiency and have been implicated in various autoimmune diseases. Despite the critical role of interferons in myositis pathogenesis, the significance of anti-IFN autoantibodies in inflammatory myopathies remains poorly understood. This study aimed to investigate the prevalence and functional impact of anti-IFN autoantibodies in patients with myositis.
220. Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews.
作者: Tim Pickles.;Rhiannon Phillips.;Mike Horton.;David Gillespie.;Janice Davies.;Susan Campbell.;Ernest Choy.
来源: Rheumatology (Oxford). 2025年64卷12期6176-6183页
Using Rasch measurement theory, an item pool of 12 questions has been identified, covering tenderness and swelling, disease activity, pain, physical functioning and stiffness for assessing the construct of RA disease activity. This study aimed to assess the content validity of this item pool using cognitive interviews.
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