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201. CNM-Au8 in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.
作者: .;James D Berry.;Nicholas J Maragakis.;Eric A Macklin.;Lori B Chibnik.;Melanie Quintana.;Benjamin R Saville.;Michelle A Detry.;Matteo Vestrucci.;Joseph Marion.;Anna McGlothlin.;Elijah W Stommel.;Marianne Chase.;Lindsay Pothier.;Brittney A Harkey.;Hong Yu.;Alex Sherman.;Jeremy Shefner.;Meghan Hall.;Gale Kittle.;Suma Babu.;Jinsy Andrews.;Derek D'Agostino.;Eric Tustison.;Erica Scirocco.;Elisa Giacomelli.;Gustavo Alameda.;Eduardo Locatelli.;Doreen Ho.;Adam Quick.;Senda Ajroud-Driss.;Jonathan Katz.;Daragh Heitzman.;Stanley H Appel.;Sheetal Shroff.;Kevin J Felice.;Zachary Simmons.;Timothy Miller.;Nicholas Olney.;Michael D Weiss.;Stephen A Goutman.;Joseph Americo Fernandes.;Omar Jawdat.;Margaret Ayo Owegi.;Laura Foster.;Tuan Vu.;Hristelina Ilieva.;Daniel S Newman.;Ximena Arcila-Londono.;Carlayne Jackson.;Shafeeq Ladha.;Terry Heiman-Patterson.;James Caress.;Andrea Swenson.;Amanda Peltier.;Richard Lewis.;Dominic Fee.;Matthew Elliott.;Richard Bedlack.;Edward J Kasarskis.;Lauren Elman.;Jeffrey Rosenfeld.;David Walk.;Courtney E McIlduff.;Paul Twydell.;Eufrosina Young.;Kristin Johnson.;Kourosh Rezania.;Namita A Goyal.;Jeffrey A Cohen.;Michael Benatar.;Vovanti Jones.;Jonathan Glass.;Jaimin Shah.;Said R Beydoun.;James P Wymer.;Lindsay Zilliox.;Shakti Nayar.;Gary L Pattee.;Jennifer Martinez-Thompson.;Austin Rynders.;Jacob Evan.;Jeremy Evan.;Alan Hartford.;Marjan Sepassi.;Karen S Ho.;Robert Glanzman.;Benjamin Greenberg.;Michael T Hotchkin.;Sabrina Paganoni.;Merit E Cudkowicz.; .
来源: JAMA. 2025年333卷13期1138-49页
Bioenergetic failure has been proposed as a driver of amyotrophic lateral sclerosis (ALS). CNM-Au8 is a suspension of gold nanocrystals that catalyzes the conversion of nicotinamide adenine dinucleotide hydride into NAD+, resulting in an increase of cellular adenosine triphosphate production.
202. Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.
作者: .;Jeremy M Shefner.;Björn Oskarsson.;Eric A Macklin.;Lori B Chibnik.;Melanie Quintana.;Benjamin R Saville.;Michelle A Detry.;Matteo Vestrucci.;Joe Marion.;Anna McGlothlin.;Terry Heiman-Patterson.;Marianne Chase.;Lindsay Pothier.;Brittney A Harkey.;Hong Yu.;Alexander V Sherman.;Meghan Hall.;Gale Kittle.;James D Berry.;Suma Babu.;Jinsy Andrews.;Derek D'Agostino.;Eric Tustison.;Erica Scirocco.;Elisa Giacomelli.;Gustavo Alameda.;Eduardo Locatelli.;Doreen Ho.;Adam Quick.;Senda Ajroud-Driss.;Jonathan Katz.;Daragh Heitzman.;Stanley H Appel.;Sheetal Shroff.;Kevin Felice.;Nicholas J Maragakis.;Zachary Simmons.;Timothy M Miller.;Nicholas Olney.;Michael D Weiss.;Stephen A Goutman.;Joseph Americo Fernandes.;Omar Jawdat.;Margaret Ayo Owegi.;Laura A Foster.;Tuan Vu.;Hristelina Ilieva.;Daniel S Newman.;Ximena Arcila-Londono.;Carlayne E Jackson.;Shafeeq Ladha.;James B Caress.;Andrea Swenson.;Amanda Peltier.;Richard A Lewis.;Dominic Fee.;Matthew Elliott.;Richard Bedlack.;Edward J Kasarskis.;Lauren Elman.;Jeffrey Rosenfeld.;David Walk.;Courtney McIlduff.;Paul Twydell.;Eufrosina Young.;Kristin Johnson.;Kourosh Rezania.;Namita A Goyal.;Jeffrey A Cohen.;Michael Benatar.;Vovanti Jones.;Jaimin Shah.;Said R Beydoun.;James P Wymer.;Lindsay Zilliox.;Shakti Nayar.;Gary L Pattee.;Jennifer Martinez-Thompson.;Melanie L Leitner.;Kelly Chen.;Y Paul Goldberg.;Yael Cohen.;Michal Geva.;Michael R Hayden.;Sabrina Paganoni.;Merit E Cudkowicz.; .
来源: JAMA. 2025年333卷13期1128-37页
Amyotrophic lateral sclerosis (ALS) is a fatal disease. The sigma-1 (σ1) receptor emerged as a target for intervention.
203. Preventive Services for Food Insecurity: Evidence Report and Systematic Review for the US Preventive Services Task Force.
作者: Elizabeth A O'Connor.;Elizabeth M Webber.;Allea M Martin.;Michelle L Henninger.;Michelle L Eder.;Jennifer S Lin.
来源: JAMA. 2025年333卷15期1340-1351页
An estimated 12.8% of US households experienced food insecurity in 2022.
204. High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial.
作者: Eric Thouvenot.;David Laplaud.;Christine Lebrun-Frenay.;Nathalie Derache.;Emmanuelle Le Page.;Elisabeth Maillart.;Caroline Froment-Tilikete.;Giovanni Castelnovo.;Olivier Casez.;Marc Coustans.;Anne-Marie Guennoc.;Olivier Heinzlef.;Laurent Magy.;Chantal Nifle.;Xavier Ayrignac.;Agnès Fromont.;Nicolas Gaillard.;Nathalie Caucheteux.;Ivania Patry.;Jérôme De Sèze.;Romain Deschamps.;Pierre Clavelou.;Damien Biotti.;Gilles Edan.;William Camu.;Hanane Agherbi.;Dimitri Renard.;Christophe Demattei.;Pascale Fabbro-Peray.;Thibault Mura.;Manon Rival.; .
来源: JAMA. 2025年333卷16期1413-1422页
Vitamin D deficiency is a risk factor for multiple sclerosis (MS) and is associated with the risk of disease activity, but data on the benefits of supplementation are conflicting.
206. HIV Viral Suppression With Use of Long-Acting Antiretroviral Therapy in People With and Without Initial Viremia.
作者: Matthew A Spinelli.;Megan J Heise.;Nathanial Gistand.;Chesa Cox.;Janet Grochowski.;Jon Oskarsson.;David V Glidden.;Monica Gandhi.
来源: JAMA. 2025年333卷16期1451-1453页 208. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
作者: Nitesh Nerlekar.;Sheran A Vasanthakumar.;Kristyn Whitmore.;Cheng Hwee Soh.;Jasmine Chan.;Vinay Goel.;Jacqueline Ryan.;Catherine Jones.;Tony Stanton.;Geoffrey Mitchell.;Andrew Tonkin.;Gerald F Watts.;Stephen J Nicholls.;Thomas H Marwick.; .
来源: JAMA. 2025年333卷16期1403-1412页
Coronary artery calcium (CAC) scoring provides prognostic information, especially in patients at intermediate risk for coronary artery disease (CAD). However, the benefit of combining CAC score with a primary prevention strategy has not been tested in a randomized trial.
209. Population-Scale Studies of Protein S Abnormalities and Thrombosis.
作者: Sharjeel A Chaudhry.;Amelia K Haj.;Justine Ryu.;Sean J Jurgens.;Alfonso Rodriguez Espada.;Xin Wang.;Seung Hoan Choi.;Simone Sanna-Cherchi.;Steven P Grover.;Kenneth A Bauer.;Patrick T Ellinor.;Pavan K Bendapudi.
来源: JAMA. 2025年333卷16期1423-1432页
Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.
211. Medicaid Spending and Health-Related Social Needs in the North Carolina Healthy Opportunities Pilots Program.
作者: Seth A Berkowitz.;Jessica Archibald.;Zhitong Yu.;Myklynn LaPoint.;Salma Ali.;Maihan B Vu.;Gaurav Dave.;Kori B Flower.;Marisa Elena Domino.
来源: JAMA. 2025年333卷12期1041-50页
Health-related social needs are drivers of worse health and high health care spending. In North Carolina Medicaid's 1115 waiver, the Healthy Opportunities Pilots (HOP) program allows for nonmedical services to address health-related social needs, such as healthy food boxes and housing navigation, financed by Medicaid, in 3 regions of North Carolina.
212. Unintentional Fentanyl Use Detected in Hair of People With HIV Risk Using Methamphetamine.
作者: Ayesha Appa.;Matthew A Spinelli.;Marjan Javanbakht.;M J Heise.;Hideaki Okochi.;Alexander R Bazazi.;Phillip Coffin.;Pamina M Gorbach.;Monica Gandhi.
来源: JAMA. 2025年333卷14期1257-9页 213. First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer: The GEMSTONE-303 Randomized Clinical Trial.
作者: Xiaotian Zhang.;Jufeng Wang.;Gang Wang.;Yanqiao Zhang.;Qingxia Fan.;Chuangxin Lu.;Changlu Hu.;Meili Sun.;Yiye Wan.;Sanyuan Sun.;Junye Wang.;Li Zhang.;Yongqian Shu.;Jie Luo.;Dan Zhu.;Zhenwei Shen.;Sheng Yao.;Qingmei Shi.;Jason Yang.;Lin Shen.; .
来源: JAMA. 2025年333卷15期1305-1314页
Gastric cancer, including gastroesophageal junction cancer, is one of the most commonly diagnosed cancers worldwide, with high mortality. Sugemalimab is a fully human anti-programmed death-ligand 1 (PD-L1) antibody. The combination of sugemalimab and chemotherapy showed promising antitumor activity and safety in a phase 1b study among patients with treatment-naive, unresectable, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma. This combination was further evaluated in the GEMSTONE-303 phase 3 trial.
219. Out-of-Hospital Cardiac Arrest in Apparently Healthy, Young Adults.
Out-of-hospital cardiac arrest incidence in apparently healthy adults younger than 40 years ranges from 4 to 14 per 100 000 person-years worldwide. Of an estimated 350 000 to 450 000 total annual out-of-hospital cardiac arrests in the US, approximately 10% survive.
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