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206. Safety Assessment of Pulsed Field Ablation Near the Sinus Node and His Bundle.
作者: Ryosuke Kato.;Masateru Takigawa.;Iwanari Kawamura.;Megumi Toda.;Masaki Honda.;Miho Negishi.;Ryo Tateishi.;Hidehiro Iwakawa.;Kazuya Yamao.;Kentaro Goto.;Takuro Nishimura.;Susumu Tao.;Shinsuke Miyazaki.;Hiroyuki Watanabe.;Tetsuo Sasano.
来源: Circ Arrhythm Electrophysiol. 2026年19卷7期e014823页 207. Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat Model.
作者: Beatrice Vahle.;Sven Weidner.;André Tomalka.;Antje Schauer.;Antje Augstein.;Anita Männel.;Peggy Barthel.;Janet Friedrich.;Grietje Beck.;Siegfried Labeit.;T Scott Bowen.;Tobias Siebert.;Axel Linke.;Volker Adams.
来源: Circ Heart Fail. 2026年e014397页
Exercise intolerance, promoted by skeletal muscle- and mitochondrial dysfunction, has been identified as a therapeutic target in heart failure with preserved ejection fraction (HFpEF). In the context of mitochondrial dysfunction, altered cardiolipin integrity has been reported in the myocardium of HFpEF, suggesting Elamipretide, a cardiolipin stabilizing agent, as potential therapeutic approach. The present study investigated cardiolipin dysregulation in the skeletal muscle of HFpEF rats and analyzed the effect of Elamipretide treatment.
209. Influence of Cooling Agents on the Arrhythmogenic and Autonomic Effects of Electronic Cigarettes in an in vivo Model.
作者: Cory Kucera.;Anand R Ramalingam.;Sean M Raph.;Romith Paily.;Shweta Srivastava.;Pawel K Lorkiewicz.;Aruni Bhatnagar.;Matthew A Nystoriak.;Alex P Carll.
来源: Circ Arrhythm Electrophysiol. 2026年19卷6期e014253页
Despite the growing popularity of electronic cigarettes, evidence is mounting that vaping induces autonomic nervous system imbalance, cardiac arrhythmia, and potentially even cardiac arrest. The ingredients menthol, WS-3, and WS-23 are cooling agents that enhance the appeal of electronic cigarettes (e-cigs) but bear unknown risks when inhaled.
210. Donor-Derived Cell-Free DNA at Diagnosis of Cardiac Allograft Rejection Stratifies Risk of Mortality and Graft Dysfunction.
作者: Zaid N Safiullah.;Han Su.;Hyesik Kong.;Moon Kyoo Jang.;Keyur Shah.;Gerald J Berry.;Palak Shah.;Hannah A Valantine.;Xin Tian.;Sean Agbor-Enoh.
来源: Circ Heart Fail. 2026年19卷7期e013718页
Cardiac acute rejection (AR) is a risk factor for poor outcomes; however, there are limited risk prediction models to stratify these patients for death or prolonged left ventricular (LV) dysfunction. We assessed the prognostic utility of percent donor-derived cell-free DNA (%dd-cfDNA) measured at AR diagnosis for predicting adverse outcomes.
211. Sirolimus-Eluting Balloon With Provisional Stenting Versus Systematic Drug-Eluting Stent Implantation to Treat De Novo Coronary Lesions: A Randomized, Open-Label, Noninferiority Trial.
作者: Christian Spaulding.;Florian Krackhardt.;Kris Bogaerts.;Eltigani Abdelaal.;Fernando Alfonso.;Carlo Briguori.;Leonhard Bruch.;Nicholas Cruden.;Alexander W Den Hartog.;Philippe Garot.;Mathieu Godin.;David Hildick-Smith.;Thomas Johnson.;Andrew Ladwiniec.;Axel Linke.;Clint Anthony Maart.;Kambis Mashayekhi.;Pascal Meier.;Ludovic Meunier.;Kenneth Morgan.;Peter O'Kane.;Etienne Puymirat.;Tuomas T Rissanen.;Manel Sabaté.;Thomas Schmitz.;Gabor G Toth.;Jasper Trevelyan.;Piotr Wanczura.;Marcus Wiemer.;Joanna J Wykrzykowska.;Philip Urban.;Simon Eccleshall.; .
来源: Circulation. 2026年154卷3期185-197页
Implantation of drug eluting stents (DESs) is currently the default approach for percutaneous coronary interventions, but long-term adverse events still exist. An approach with minimal stenting deserves to be assessed in a randomized trial. We studied a novel sirolimus-eluting balloon (SEB) that elutes sirolimus over a 90-day period using a biodegradable polymer microreservoir technology.
212. Galectin-3 Regulates Smooth Muscle Contraction and Blood Pressure by Modulating CaV1.2 Channel Function.
作者: Kelvin Wei Zhern Loh.;Yanruo Zhou.;Cong Liu.;Jing Zhai.;Chaitanya K Jaladanki.;Cheryl Jia Yi Neo.;Dejie Yu.;Mui Cheng Liang.;Mengxia Shen.;Hao Fan.;Ping Liao.;Zhenyu Hu.;Tuck Wah Soong.
来源: Circulation. 2026年
Fine-tuning of CaV1.2 calcium channel activity by binding proteins represents a novel mechanism for regulating smooth muscle contraction and blood pressure (BP). This study aimed to elucidate the role of Gal-3 (galectin-3), a newly identified CaV1.2-binding protein, in the pathogenesis of hypertension.
213. Ablation of Persistent Atrial Fibrillation Using a Dual-Energy Contact Force-sensing Catheter: Topography of Pulsed Field Mediated Symptoms and New Safety Challenges.
作者: Francesco Notaristefano.;Nicolas Johner.;Geoffroy Ditac.;Allan Plant.;Laurens Verhaeghe.;John L Fitzgerald.;Kinan Kneizeh.;Karim Benali.;Konstantinos Vlachos.;Cinzia Monaco.;Marine Arnaud.;Benjamin Sacristan.;Jan Charton.;Léa Benabou.;Marianne Tétreault-Langlois.;Josselin Duchateau.;Frédéric Sacher.;Romain Tixier.;Mélèze Hocini.;Pierre Jaïs.;Michel Haïssaguerre.;Thomas Pambrun.;Nicolas Derval.
来源: Circ Arrhythm Electrophysiol. 2026年19卷7期e014920页 214. Discovery of Novel Magnetocardiography Parameters Predicting Future ICD Therapies: Insights From the Magneto-SCD Study.
作者: Thomas Lachlan.;Hejie He.;Adam Miller.;Nakul Chandan.;Shoaib Siddiqui.;Roger Beadle.;David Wilson.;Sanjiv Petkar.;Peter K Kimani.;G Andre Ng.;Faizel Osman.
来源: Circ Arrhythm Electrophysiol. 2026年19卷7期e014998页 216. Primary Aldosteronism: CXCR4- and FAP-Targeted PET/MR for Adrenal-Cardiac Axis.
作者: Jie Ding.;Kun Wang.;Jun Song.;Jing Huang.;Xinwei Cheng.;Feng Yin.;Xing Chen.;Zengbei Yuan.;Zirong Zhou.;Na Qi.;Haiyan Wang.;Peicheng Li.;Rongbing Li.;Lin Ye.;Bo Feng.;Li Huo.;Jun Zhao.
来源: Circ Cardiovasc Imaging. 2026年19卷7期e019657页
Primary aldosteronism (PA) carries excess cardiovascular risk not fully explained by hemodynamic load. While aldosterone promotes fibroblast activation experimentally, in vivo evidence linking adrenocortical activity with myocardial remodeling remains limited. This study integrated CXCR4 (C-X-C chemokine receptor type 4)-targeted 68Ga-Pentixafor positron emission tomography (PET)/magnetic resonance and FAP (fibroblast activation protein)-targeted 68Ga-FAPI (fibroblast activation protein inhibitor)-04 PET/cardiac magnetic resonance to evaluate the adrenal-cardiac axis in PA.
218. RND3 Enhances Cardiac Glucose Metabolism Through Inhibiting ACAT1-Dependent PDHA1 Acetylation and Protects Against Ischemia-Reperfusion Injury.
作者: Zhenyu Xiong.;Yueyang Li.;Yan Zhang.;Zhengjun Ma.;Meiying Qi.;Huanle Zhang.;Xiaohua Zhang.;Mengyuan Jiang.;Jie Liu.;Erhe Gao.;Congye Li.;Wanrong Man.;Mingming Zhang.;Jianqiang Hu.;Jie Lin.;Zhi Yang.;Li Fan.;Yundai Chen.;Dongdong Sun.
来源: Circulation. 2026年154卷1期37-57页
Metabolic disturbances are key contributors to myocardial ischemia-reperfusion (I/R) injury, yet the underlying molecular mechanisms remain largely unclear. Rho family GTPase 3 (RND3), a cytosolic small guanosine triphosphatase (GTPase) known to antagonize ROCK1 (Rho-associated coiled-coil kinase 1), has been implicated in several cardiovascular disorders. However, its mitochondrial localization and functional role in cardiac energy metabolism and I/R injury remain unknown.
219. Heart Rate and Cardiovascular Outcomes in Post-Myocardial Infarction Patients Treated by β-Blockers: A Secondary Analysis of the ABYSS Trial.
作者: Michel Zeitouni.;Niki Procopi.;Guillaume Cayla.;Emile Ferrari.;Grégoire Rangé.;Etienne Puymirat.;Nicolas Delarche.;Paul Guedeney.;Thomas Cuisset.;Olivier Varenne.;Romain Cador.;Pascal Motreff.;Luc-Philippe Christiaens.;Anne Bellemain-Appaix.;Maxime Fayard.;Gilles Bayet.;Jean-Michel Quédillac.;Pascal Goube.;Marc Goralski.;Simon Elhadad.;Frédéric Heliot.;Christophe Caussin.;Jean-Charles Aisenfarb.;Jean Litalien.;Geoffray Rambaud.;David Attias.;Raphaëlle Dumaine.;Michel S Slama.;Mohamad El Kasty.;Laurent Payot.;Karim Aacha.;Abdourahmane Diallo.;Eric Vicaut.;Gilles Montalescot.;Johanne Silvain.; .
来源: Circulation. 2026年
Heart rate (HR) is a key prognostic factor after myocardial infarction (MI), but its relevance in the modern reperfusion era is uncertain. We aim to evaluate the association between HR and β-blocker interruption on cardiovascular outcomes.
220. Endothelial SHMT2 Drives Pulmonary Vascular Remodeling Through Noncanonical Pathway in Pulmonary Hypertension.
作者: Qianqian Wang.;Jingjing Tian.;Dongdong Liu.;Tengfei Zheng.;Xiaolin Liu.;Yachao Zhao.;Xiao Li.;Hongyu Zhong.;Jichen Pan.;Chong Yuan.;Yuliang Zhao.;Shanshan Wang.;Jian Li.;Wencheng Zhang.;Meng Zhang.;Cheng Zhang.;Fengming Liu.;Mei Zhang.;Shen Dai.
来源: Circulation. 2026年
Pulmonary hypertension (PH) is a progressive, life-threatening disease characterized primarily by pulmonary vascular remodeling in which endothelial dysfunction plays a vital role. However, the molecular factors contributing to this pathological process remain incompletely understood. Through proteomic analysis of hypoxia-treated human pulmonary artery endothelial cells, we identified serine hydroxymethyltransferase 2 (SHMT2) as a potential target in PH, but its role in disease pathogenesis and the underlying mechanisms remain unclear.
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