Core needle biopsy (CNB) is the preferred diagnostic method for suspected soft tissue and bone sarcoma, but nondiagnostic results remain common. To clarify the role of repeat biopsy, we conducted a systematic review of studies reporting repeat CNB after an initial nondiagnostic CNB, searching MEDLINE, EMBASE and PubMed. Nine studies involving nearly 9757 initial CNBs were included. Meta-analysis showed a pooled diagnostic yield of 69% (95% CI: 0.564-0.819) for repeat CNB. Subgroup analyses demonstrated a significantly higher diagnostic yield in bone sarcoma (83.1%) compared with soft tissue sarcoma (48.5%). The repeat CNB rate following a nondiagnostic initial biopsy was 5.48%. This study represents the first systematic review and meta-analysis evaluating repeat CNB in this setting, and it highlights substantial variability in diagnostic yield between sarcoma subtypes. Further research focusing on repeat biopsy across specific sarcoma subgroups is warranted to guide clinical decision-making.

This systematic review and meta-analysis compared fibroblast activation protein inhibitor (FAPI) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) regarding diagnostic efficacy in primary liver cancers, focusing on sensitivity, specificity, and clinical applicability.

Different image-enhanced endoscopy (IEE) methods have shown promise in improving colorectal lesion detection, but direct comparisons remain limited. This network meta-analysis compared the detection and diagnostic performance of various IEE modalities for colorectal lesions.

The aim of this study is to compare the efficacy of the laparoscopic pylorus-preserving gastrectomy (LPPG) and laparoscopic distal gastrectomy (LDG) for gastric cancer (GC) on postoperative complications and nutritional status.

Pancreaticoduodenectomy (PD) is the standard curative option for pancreatic head carcinoma, but R1 resections remain frequent. The superior mesenteric artery (SMA) "artery-first" approach (AFA) may improve oncologic clearance and operative safety. We conducted a systematic review and meta-analysis comparing AFA versus standard PD.

Accurate preoperative localization is essential for successful breast-conserving surgery on non-palpable breast lesions. In recent years, Magseed has emerged as a non-wired localization approach with promising outcomes due to its flexibility and precision. This meta-analysis aimed to evaluate the efficacy and safety of Magseed localization on non-palpable breast lesions.

The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) and tumor-associated neutrophils (TANs) in head and neck squamous cell carcinoma (HNSCC) remains a subject of considerable research interest. This systematic review and meta-analysis aimed to evaluate the relationship between pretreatment NLR and TANs and survival outcomes in patients with HNSCC.

Radiotherapy-induced malignancies are well-documented, but the clinicopathological profile and prognostic factors of radiation-induced oral squamous cell carcinoma (R-OSCC) remain unclear.

Totally laparoscopic distal gastrectomy (TLDG) is a minimally invasive alternative to laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer. While both are widely used, it remains unclear which yields better outcomes. Therefore, this meta-analysis aimed to compare surgical outcomes and postoperative quality of life (QoL) between TLDG and LADG.

The cell surface protein TROP-2 is overexpressed in various solid tumors, making it an attractive therapeutic target. Datopotamab deruxtecan (Dato-DXd) is a novel antibody-drug conjugate (ADC) designed to selectively deliver cytotoxic agents to TROP-2-expressing cancer cells. It has recently been approved for treating unresectable or metastatic hormone receptor-positive, HER2-negative breast cancer. While preclinical and early phase clinical trials have shown promising efficacy, this meta-analysis aims to provide a comprehensive evaluation of the efficacy and safety of Dato-DXd in patients with advanced solid tumors by synthesizing the available clinical evidence.

Lysophosphatidic acid receptor 1 (LPAR1) mediates various biological behaviors in physiological and pathological processes. This study aims to comprehensively evaluate the prognostic value of LPAR1 expression and methylation in LGG, and explore their functional effects on tumor progression and immune regulation.

Gallbladder cancer is the fifth most common gastrointestinal cancer worldwide, often diagnosed incidentally after cholecystectomy for presumed benign disease. Previous studies have reported geographic variations in the incidence of incidental gallbladder cancer (IGBC), but comprehensive pooled estimates examining multiple predictors of IGBC are lacking. The study aims to synthesize the risk factors and clinical predictors associated with IGBC in patients undergoing cholecystectomy for benign gallbladder conditions.

This study aims to systematically examine how minimally invasive thymectomy-covering both video-assisted and robotic-assisted methods-compares with open thymectomy in terms of perioperative safety and effectiveness for treating large thymomas. We thoroughly searched several databases for relevant studies, including randomized controlled trials and cohort studies, published up until October 2025. Data on perioperative factors, including surgical duration, blood loss, length of hospitalization, complications, and recurrence rates, were extracted and analyzed using random-effects models in STATA 18. Seven studies involving 12,880 patients were included. open surgery showed significantly more blood loss (WMD = 110.43, 95% CI 105.83-115.03; P < 0.05), longer hospital stays (WMD = 2.04, 95% CI 1.38-2.7; P < 0.05) compared to MIT. No notable difference in surgical duration was observed. Moreover, minimally invasive thymectomy (MIT) was associated with a reduced rate of recurrence after surgery (OR = 0.54, 95% CI 0.35-0.84; P < 0.05) as well as fewer postoperative complications (OR = 0.27, 95% CI 0.19-0.39; P < 0.05). MIT offers significant advantages over open surgery for large thymomas, including reduced blood loss, shorter hospital stays, and lower rates of complications and recurrence, though operative time was similar. Further large-scale studies are needed to confirm these findings and assess long-term efficacy.

This review aims to explore the potential of Indonesian medicinal plants as therapeutic agents for breast cancer in in vitro studies.

Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide, with a median overall survival of approximately 12 months. The proto-oncogene c-MYC is among the most frequently activated oncogenes, implicated in roughly 20% of all malignancies.

Salivary duct carcinoma is a highly aggressive salivary gland malignancy characterized by rapid progression, early regional and distant metastasis, and poor clinical outcomes. Among the histopathological features associated with its aggressiveness, perineural invasion is of particular significance. Perineural invasion refers to the infiltration of tumor cells within or surrounding the perineural spaces and serves as an important route for tumor dissemination. In salivary duct carcinoma, the presence of perineural invasion has been identified as a negative prognostic indicator, correlating with increased risks of local recurrence, nodal involvement, and distant metastasis. Consequently, evaluation of perineural invasion is crucial in prognostication and treatment planning for patients with salivary duct carcinoma. A systematic review was conducted to evaluate the prevalence of perineural invasion in salivary duct carcinoma and to assess its impact on survival outcomes. Following PRISMA guidelines. PubMed, Scopus, Science direct and Embase were searched up to September, 2025 for studies on salivary duct carcinoma and its prognostic factors. Eligible studies were screened, data extracted, and quality assessed using the QUIPS Scale. Pooled estimates were calculated using a random-effects model. The pooled proportion of perineural invasion among salivary duct carcinoma cases was 0.54 (95 % CI: 0.45-0.63). Meta-analysis using a random-effects model demonstrated that the presence of PNI was significantly associated with poorer survival outcomes (HR = 1.64; 95 % CI: 1.01-2.68). For overall survival, PNI showed a trend towards adverse prognosis (HR = 1.67; 95 % CI: 0.80-3.48), while it emerged as a strong negative predictor for disease-free survival (HR = 3.32; 95 % CI: 1.77-6.23). Similarly, for disease-specific survival (HR = 1.48; 95 % CI: 0.23-9.48), progression-free survival (HR = 2.47), and distant recurrence (HR = 4.56), PNI was consistently associated with unfavorable outcomes, underscoring its role as a significant adverse prognostic factor in salivary duct carcinoma. Its presence is consistently associated with reduced survival and increased recurrence, emphasizing its prognostic importance in patient management.

Boron neutron capture therapy (BNCT) has emerged as a promising radiotherapy option for locally recurrent head and neck cancer (LRHNC). This study aims to evaluate the efficacy and safety of BNCT in patients with LRHNC and explore predictive factors for tumor control and overall survival.

The rapid integration of immune checkpoint inhibitor (ICI) based combination therapies in first-line treatment of metastatic renal cell carcinoma (mRCC) is raising questions about next-line treatments and outcomes of ICI rechallenge.

Osteosarcoma is an aggressive bone cancer primarily affecting children and adolescents, with low survival rates in advanced stages. A systematic review and meta-analysis were conducted following PRISMA guidelines to evaluate the impact of ICIs on survival and toxicity in advanced osteosarcoma. ICIs show potential in treating advanced osteosarcoma but are associated with significant toxicity and uncertain survival benefits. Further research is needed to define their role and identify biomarkers for predicting response. Close monitoring for adverse events is essential.

The heterogeneous efficacy of immunotherapy in hepatocellular carcinoma (HCC) remains unclear. We evaluated efficacy and safety of various immunotherapeutic regimens-including immune checkpoint inhibitor (ICI) monotherapy, dual ICIs, and ICI plus targeted therapy-for unresectable HCC, to identify patient subgroups that benefit most.