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201. Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis.
作者: Mira M Wouters.;Sander Van Wanrooy.;Anh Nguyen.;James Dooley.;Javier Aguilera-Lizarraga.;Winde Van Brabant.;Josselyn E Garcia-Perez.;Lukas Van Oudenhove.;Marc Van Ranst.;Jan Verhaegen.;Adrian Liston.;Guy Boeckxstaens.
来源: Gut. 2016年65卷8期1279-88页
Psychological factors increase the risk to develop postinfectious IBS (PI-IBS), but the mechanisms involved are unclear. As stress affects the immune system, we investigated the potential interaction between psychological factors, the immune response against infectious gastroenteritis (IGE) and the development of IGE and PI-IBS in a large cohort exposed to contaminated drinking water.
202. Monocyte-derived hepatocyte-like cells for causality assessment of idiosyncratic drug-induced liver injury.
Idiosyncratic drug-induced liver injury (iDILI) is a frequent cause of acute liver injury and a serious problem in late stage drug-development. Its diagnosis is one of the most challenging in hepatology, since it is done by exclusion and relies on expert opinion. Until now no reliable in vitro test exists to support the diagnosis of iDILI. In some instances it is impossible to determine the causative drug in polymedicated patients.
203. Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease.
作者: Anna Janina Engstler.;Tobias Aumiller.;Christian Degen.;Marion Dürr.;Eva Weiss.;Ina Barbara Maier.;Jörn Markus Schattenberg.;Cheng Jun Jin.;Cathrin Sellmann.;Ina Bergheim.
来源: Gut. 2016年65卷9期1564-71页
Increased fasting blood ethanol levels, suggested to stem from an increased endogenous ethanol synthesis in the GI tract, are discussed to be critical in the development of non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to further delineate the mechanisms involved in the elevated blood ethanol levels found in patients with NAFLD.
204. A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.
作者: Kai-feng Pan.;Lian Zhang.;Markus Gerhard.;Jun-ling Ma.;Wei-dong Liu.;Kurt Ulm.;Jian-xi Wang.;Lei Zhang.;Yang Zhang.;Monther Bajbouj.;Lan-fu Zhang.;Ming Li.;Michael Vieth.;Rui-yong Liu.;Michael Quante.;Le-hua Wang.;Stepan Suchanek.;Tong Zhou.;Wei-xiang Guan.;Roland Schmid.;Meinhard Classen.;Wei-cheng You.
来源: Gut. 2016年65卷1期9-18页
To clarify the full range of benefits and adverse consequences of Helicobacter pylori eradication as a strategy for gastric cancer prevention, the community-based intervention trial was launched in Linqu County, China.
205. Reliability among central readers in the evaluation of endoscopic findings from patients with Crohn's disease.
作者: Reena Khanna.;Guangyong Zou.;Geert D'Haens.;Paul Rutgeerts.;J W D McDonald.;Marco Daperno.;Brian G Feagan.;William J Sandborn.;Elena Dubcenco.;Larry Stitt.;Margaret K Vandervoort.;Allan Donner.;Allison Luo.;Barrett G Levesque.
来源: Gut. 2016年65卷7期1119-25页
The Crohn's Disease Endoscopic Index of Severity (CDEIS) and Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however, neither instrument has been fully validated. We assessed intra-rater and inter-rater reliability of these indices.
206. Detection of precancerous gastric lesions and gastric cancer through exhaled breath.
作者: Haitham Amal.;Marcis Leja.;Konrads Funka.;Roberts Skapars.;Armands Sivins.;Guntis Ancans.;Inta Liepniece-Karele.;Ilze Kikuste.;Ieva Lasina.;Hossam Haick.
来源: Gut. 2016年65卷3期400-7页
Timely detection of gastric cancer (GC) and the related precancerous lesions could provide a tool for decreasing both cancer mortality and incidence.
207. Tenofovir monotherapy versus tenofovir and entecavir combination therapy in adefovir-resistant chronic hepatitis B patients with multiple drug failure: results of a randomised trial.
作者: Young-Suk Lim.;Byung Chul Yoo.;Kwan Soo Byun.;So Young Kwon.;Yoon Jun Kim.;Jihyun An.;Han Chu Lee.;Yung Sang Lee.
来源: Gut. 2016年65卷6期1042-51页
Little clinical data are available regarding the optimal treatment of patients who harbour adefovir-resistant HBV.
208. A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis.
作者: Stephan Miehlke.;Petr Hruz.;Michael Vieth.;Christian Bussmann.;Ulrike von Arnim.;Monther Bajbouj.;Christoph Schlag.;Ahmed Madisch.;Christiane Fibbe.;Henning Wittenburg.;Hans Dieter Allescher.;Max Reinshagen.;Stefan Schubert.;Jan Tack.;Michaela Müller.;Patrick Krummenerl.;Joris Arts.;Ralph Mueller.;Karin Dilger.;Roland Greinwald.;Alex Straumann.
来源: Gut. 2016年65卷3期390-9页
To investigate the efficacy and safety of two different budesonide formulations (effervescent tablet for orodispersible use (BET) and viscous suspension (BVS)) with different daily dosages for short-term treatment of eosinophilic oesophagitis (EoE).
209. An international randomised trial of celecoxib versus celecoxib plus difluoromethylornithine in patients with familial adenomatous polyposis.
作者: Patrick M Lynch.;Carol A Burke.;Robin Phillips.;Jeffrey S Morris.;Rebecca Slack.;Xuemei Wang.;Jun Liu.;Sherri Patterson.;Frank A Sinicrope.;Miguel A Rodriguez-Bigas.;Elizabeth Half.;Steffen Bulow.;Andrew Latchford.;Sue Clark.;William A Ross.;Bonnie Malone.;Hennie Hasson.;Ellen Richmond.;Ernest Hawk.
来源: Gut. 2016年65卷2期286-95页
Although Non-steroidal anti-inflammatory drugs reduce colorectal adenoma burden in familial adenomatous polyposis (FAP), the utility of combining chemopreventive agents in FAP is not known. We conducted a randomised trial of celecoxib (CXB) versus CXB+diflouromethylornithine (DFMO) to determine the synergistic effect, if any.
210. A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D).
作者: Ching Lam.;Wei Tan.;Matthew Leighton.;Margaret Hastings.;Melanie Lingaya.;Yirga Falcone.;Xiaoying Zhou.;Luting Xu.;Peter Whorwell.;Andrew F Walls.;Abed Zaitoun.;Alan Montgomery.;Robin Spiller.
来源: Gut. 2016年65卷1期91-9页
Immune activation has been reported in the mucosa of IBS patients with diarrhoea (IBS-D), and some small studies have suggested that mesalazine may reduce symptoms. We performed a double-blind, randomised placebo-controlled trial of 2 g mesalazine twice daily versus placebo for 3 months in patients with Rome III criteria IBS-D. Primary outcome was daily average stool frequency during weeks 11-12; secondary outcomes were abdominal pain, stool consistency, urgency and satisfactory relief of IBS symptoms.
211. Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation.
作者: Ugo Grossi.;Emma V Carrington.;Adil E Bharucha.;Emma J Horrocks.;S Mark Scott.;Charles H Knowles.
来源: Gut. 2016年65卷3期447-55页
The diagnostic accuracy of anorectal manometry (AM), which is necessary to diagnose functional defecatory disorders (FDD), is unknown. Using blinded analysis and standardised reporting of diagnostic accuracy, we evaluated whether AM could discriminate between asymptomatic controls and patients with functional constipation (FC).
212. Leadership training to improve adenoma detection rate in screening colonoscopy: a randomised trial.
作者: Michal F Kaminski.;John Anderson.;Roland Valori.;Ewa Kraszewska.;Maciej Rupinski.;Jacek Pachlewski.;Ewa Wronska.;Michael Bretthauer.;Siwan Thomas-Gibson.;Ernst J Kuipers.;Jaroslaw Regula.
来源: Gut. 2016年65卷4期616-24页
Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared the effect of leadership training versus feedback only on colonoscopy quality in a countrywide randomised trial.
213. Tenofovir monotherapy versus tenofovir and entecavir combination therapy in patients with entecavir-resistant chronic hepatitis B with multiple drug failure: results of a randomised trial.
作者: Young-Suk Lim.;Kwan Soo Byun.;Byung Chul Yoo.;So Young Kwon.;Yoon Jun Kim.;Jihyun An.;Han Chu Lee.;Yung Sang Lee.
来源: Gut. 2016年65卷5期852-60页
Little clinical data are available regarding the optimal treatment of patients who harbour entecavir (ETV)-resistant HBV.
214. Baseline quantitative hepatitis B core antibody titre alone strongly predicts HBeAg seroconversion across chronic hepatitis B patients treated with peginterferon or nucleos(t)ide analogues.
作者: Rong Fan.;Jian Sun.;Quan Yuan.;Qing Xie.;Xuefan Bai.;Qin Ning.;Jun Cheng.;Yanyan Yu.;Junqi Niu.;Guangfeng Shi.;Hao Wang.;Deming Tan.;Mobin Wan.;Shijun Chen.;Min Xu.;Xinyue Chen.;Hong Tang.;Jifang Sheng.;Fengmin Lu.;Jidong Jia.;Hui Zhuang.;Ningshao Xia.;Jinlin Hou.; .
来源: Gut. 2016年65卷2期313-20页
The investigation regarding the clinical significance of quantitative hepatitis B core antibody (anti-HBc) during chronic hepatitis B (CHB) treatment is limited. The aim of this study was to determine the performance of anti-HBc as a predictor for hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive CHB patients treated with peginterferon (Peg-IFN) or nucleos(t)ide analogues (NUCs), respectively.
215. Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study.
作者: Walter Reinisch.;Julián Panés.;Sunil Khurana.;Gabor Toth.;Fei Hua.;Gail M Comer.;Michelle Hinz.;Karen Page.;Margot O'Toole.;Tara McDonnell Moorehead.;Hua Zhu.;YanHui Sun.;Fabio Cataldi.
来源: Gut. 2015年64卷6期894-900页
Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody that inhibits human IL-13, was evaluated for the treatment of UC.
216. Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.
作者: R J Haidry.;M A Butt.;J M Dunn.;A Gupta.;G Lipman.;H L Smart.;P Bhandari.;L Smith.;R Willert.;G Fullarton.;M Di Pietro.;C Gordon.;I Penman.;H Barr.;P Patel.;N Kapoor.;J Hoare.;R Narayanasamy.;Y Ang.;A Veitch.;K Ragunath.;M Novelli.;L B Lovat.; .
来源: Gut. 2015年64卷8期1192-9页
Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA) is an alternative to surgery for patients with BE-related neoplasia.
217. Randomised controlled trial of mesalazine in IBS.
作者: Giovanni Barbara.;Cesare Cremon.;Vito Annese.;Guido Basilisco.;Franco Bazzoli.;Massimo Bellini.;Antonio Benedetti.;Luigi Benini.;Fabrizio Bossa.;Paola Buldrini.;Michele Cicala.;Rosario Cuomo.;Bastianello Germanà.;Paola Molteni.;Matteo Neri.;Marcello Rodi.;Alfredo Saggioro.;Maria Lia Scribano.;Maurizio Vecchi.;Giorgio Zoli.;Roberto Corinaldesi.;Vincenzo Stanghellini.
来源: Gut. 2016年65卷1期82-90页
Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS.
218. Effects of bowel cleansing on the intestinal microbiota.
作者: Jonna Jalanka.;Anne Salonen.;Jarkko Salojärvi.;Jarmo Ritari.;Outi Immonen.;Luca Marciani.;Penny Gowland.;Caroline Hoad.;Klara Garsed.;Ching Lam.;Airi Palva.;Robin C Spiller.;Willem M de Vos.
来源: Gut. 2015年64卷10期1562-8页
An adequate bowel cleansing is essential for a successful colonoscopy. Although purgative consumption is safe for the patient, there is little consensus on how the intestinal microbiota is affected by the procedure, especially regarding the potential long-term consequences.
219. Comparison of colonoscopic performance between medical and nurse endoscopists: a non-inferiority randomised controlled study in Asia.
作者: Aric J Hui.;James Y Lau.;Phyllis P Y Lam.;Alman O M Chui.;Alice S H Fan.;Thomas Y T Lam.;Yee-Kit Tse.;Raymond S Y Tang.;Siew C Ng.;Justin C Y Wu.;Jessica Y L Ching.;Martin C S Wong.;Francis K L Chan.;Joseph Sung.
来源: Gut. 2015年64卷7期1058-62页
To test the hypothesis that trained nurse endoscopists are not inferior to medical endoscopists in finding adenomas during colonoscopy.
220. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults.
作者: Edward S Chambers.;Alexander Viardot.;Arianna Psichas.;Douglas J Morrison.;Kevin G Murphy.;Sagen E K Zac-Varghese.;Kenneth MacDougall.;Tom Preston.;Catriona Tedford.;Graham S Finlayson.;John E Blundell.;Jimmy D Bell.;E Louise Thomas.;Shahrul Mt-Isa.;Deborah Ashby.;Glen R Gibson.;Sofia Kolida.;Waljit S Dhillo.;Stephen R Bloom.;Wayne Morley.;Stuart Clegg.;Gary Frost.
来源: Gut. 2015年64卷11期1744-54页
The colonic microbiota ferment dietary fibres, producing short chain fatty acids. Recent evidence suggests that the short chain fatty acid propionate may play an important role in appetite regulation. We hypothesised that colonic delivery of propionate would increase peptide YY (PYY) and glucagon like peptide-1 (GLP-1) secretion in humans, and reduce energy intake and weight gain in overweight adults.
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