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201. Unloading Shoes for Self-management of Knee Osteoarthritis: A Randomized Trial.
作者: Rana S Hinman.;Tim V Wrigley.;Ben R Metcalf.;Penny K Campbell.;Kade L Paterson.;David J Hunter.;Jessica Kasza.;Andrew Forbes.;Kim L Bennell.
来源: Ann Intern Med. 2016年165卷6期381-9页
Appropriate footwear is recommended for self-management of knee osteoarthritis. Shoes that reduce harmful knee loads are available, but symptomatic effects are uncertain.
202. Effectiveness of a Multicomponent Quality Improvement Strategy to Improve Achievement of Diabetes Care Goals: A Randomized, Controlled Trial.
作者: Mohammed K Ali.;Kavita Singh.;Dimple Kondal.;Raji Devarajan.;Shivani A Patel.;Roopa Shivashankar.;Vamadevan S Ajay.;A G Unnikrishnan.;V Usha Menon.;Premlata K Varthakavi.;Vijay Viswanathan.;Mala Dharmalingam.;Ganapati Bantwal.;Rakesh Kumar Sahay.;Muhammad Qamar Masood.;Rajesh Khadgawat.;Ankush Desai.;Bipin Sethi.;Dorairaj Prabhakaran.;K M Venkat Narayan.;Nikhil Tandon.; .
来源: Ann Intern Med. 2016年165卷6期399-408页
Achievement of diabetes care goals is suboptimal globally. Diabetes-focused quality improvement (QI) is effective but remains untested in South Asia.
203. Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus: A Randomized Trial.
作者: Kenneth Cusi.;Beverly Orsak.;Fernando Bril.;Romina Lomonaco.;Joan Hecht.;Carolina Ortiz-Lopez.;Fermin Tio.;Jean Hardies.;Celia Darland.;Nicolas Musi.;Amy Webb.;Paola Portillo-Sanchez.
来源: Ann Intern Med. 2016年165卷5期305-15页
The metabolic defects of nonalcoholic steatohepatitis (NASH) and prediabetes or type 2 diabetes mellitus (T2DM) seem to be specifically targeted by pioglitazone. However, information about its long-term use in this population is limited.
204. Comparative Effectiveness of Tai Chi Versus Physical Therapy for Knee Osteoarthritis: A Randomized Trial.
作者: Chenchen Wang.;Christopher H Schmid.;Maura D Iversen.;William F Harvey.;Roger A Fielding.;Jeffrey B Driban.;Lori Lyn Price.;John B Wong.;Kieran F Reid.;Ramel Rones.;Timothy McAlindon.
来源: Ann Intern Med. 2016年165卷2期77-86页
Few remedies effectively treat long-term pain and disability from knee osteoarthritis. Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared Tai Chi with standard therapies for osteoarthritis.
205. Long-Term Outcomes of Patients With Recent-Onset Rheumatoid Arthritis After 10 Years of Tight Controlled Treatment: A Randomized Trial.
作者: Iris M Markusse.;Gülsah Akdemir.;Linda Dirven.;Yvonne P M Goekoop-Ruiterman.;Johannes H L M van Groenendael.;K Huub Han.;T H Esmeralda Molenaar.;Saskia Le Cessie.;Willem F Lems.;Peter A H M van der Lubbe.;Pit J S M Kerstens.;André J Peeters.;H Karel Ronday.;Peter B J de Sonnaville.;Irene Speyer.;Theo Stijnen.;Saskia Ten Wolde.;Tom W J Huizinga.;Cornelia F Allaart.
来源: Ann Intern Med. 2016年164卷8期523-31页
Treat-to-target therapy is effective for patients with rheumatoid arthritis (RA), but long-term results of continued targeted treatment are lacking.
206. Intervention to Prevent Major Depression in Primary Care: A Cluster Randomized Trial.
作者: Juan Ángel Bellón.;Sonia Conejo-Cerón.;Patricia Moreno-Peral.;Michael King.;Irwin Nazareth.;Carlos Martín-Pérez.;Carmen Fernández-Alonso.;Antonina Rodríguez-Bayón.;Anna Fernández.;José María Aiarzaguena.;Carmen Montón-Franco.;Inmaculada Ibanez-Casas.;Emiliano Rodríguez-Sánchez.;María Isabel Ballesta-Rodríguez.;Antoni Serrano-Blanco.;María Cruz Gómez.;Pilar LaFuente.;María Del Mar Muñoz-García.;Pilar Mínguez-Gonzalo.;Luz Araujo.;Diego Palao.;Paola Bully.;Fernando Zubiaga.;Desirée Navas-Campaña.;Juan Mendive.;Jose Manuel Aranda-Regules.;Alberto Rodriguez-Morejón.;Luis Salvador-Carulla.;Juan de Dios Luna.
来源: Ann Intern Med. 2016年164卷10期656-65页
Not enough is known about universal prevention of depression in adults.
207. Gradual Versus Abrupt Smoking Cessation: A Randomized, Controlled Noninferiority Trial.
作者: Nicola Lindson-Hawley.;Miriam Banting.;Robert West.;Susan Michie.;Bethany Shinkins.;Paul Aveyard.
来源: Ann Intern Med. 2016年164卷9期585-92页
Most smoking cessation guidelines advise quitting abruptly. However, many quit attempts involve gradual cessation. If gradual cessation is as successful, smokers can be advised to quit either way.
208. Oral Prednisolone in the Treatment of Acute Gout: A Pragmatic, Multicenter, Double-Blind, Randomized Trial.
作者: Timothy Hudson Rainer.;Chi Hung Cheng.;Hein J E M Janssens.;Chi Yin Man.;Lai Shan Tam.;Yu Fai Choi.;Wah Hon Yau.;Ka Hing Lee.;Colin Alexander Graham.
来源: Ann Intern Med. 2016年164卷7期464-71页
Two recent double-blind, randomized, controlled trials (RCTs) showed that oral steroids and nonsteroidal anti-inflammatory drugs have similar analgesic effectiveness for management of gout, but the trials had small sample sizes and other methodological limitations.
209. Sex-Specific Differences at Presentation and Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement: A Cohort Study.
作者: Susheel Kodali.;Mathew R Williams.;Darshan Doshi.;Rebecca T Hahn.;Karin H Humphries.;Vuyisile T Nkomo.;David J Cohen.;Pamela S Douglas.;Michael Mack.;Ke Xu.;Lars Svensson.;Vinod H Thourani.;E Murat Tuzcu.;Neil J Weissman.;Martin Leon.;Ajay J Kirtane.
来源: Ann Intern Med. 2016年164卷6期377-84页
Female sex is associated with poorer outcomes after surgical aortic valve replacement (SAVR). Data on sex-specific differences after transcatheter aortic valve replacement (TAVR) are conflicting.
210. Framing Financial Incentives to Increase Physical Activity Among Overweight and Obese Adults: A Randomized, Controlled Trial.
作者: Mitesh S Patel.;David A Asch.;Roy Rosin.;Dylan S Small.;Scarlett L Bellamy.;Jack Heuer.;Susan Sproat.;Chris Hyson.;Nancy Haff.;Samantha M Lee.;Lisa Wesby.;Karen Hoffer.;David Shuttleworth.;Devon H Taylor.;Victoria Hilbert.;Jingsan Zhu.;Lin Yang.;Xingmei Wang.;Kevin G Volpp.
来源: Ann Intern Med. 2016年164卷6期385-94页
Financial incentive designs to increase physical activity have not been well-examined.
211. Mechanical Symptoms and Arthroscopic Partial Meniscectomy in Patients With Degenerative Meniscus Tear: A Secondary Analysis of a Randomized Trial.
作者: Raine Sihvonen.;Martin Englund.;Aleksandra Turkiewicz.;Teppo L N Järvinen.; .
来源: Ann Intern Med. 2016年164卷7期449-55页
Recent evidence shows that arthroscopic partial meniscectomy (APM) offers no benefit over conservative treatment of patients with a degenerative meniscus tear. However, patients who report mechanical symptoms (sensations of knee catching or locking) may benefit from APM.
212. Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention: A Randomized Trial.
作者: Lindsey R Baden.;Etienne Karita.;Gaudensia Mutua.;Linda-Gail Bekker.;Glenda Gray.;Liesl Page-Shipp.;Stephen R Walsh.;Julien Nyombayire.;Omu Anzala.;Surita Roux.;Fatima Laher.;Craig Innes.;Michael S Seaman.;Yehuda Z Cohen.;Lauren Peter.;Nicole Frahm.;M Juliana McElrath.;Peter Hayes.;Edith Swann.;Nicole Grunenberg.;Maria Grazia-Pau.;Mo Weijtens.;Jerry Sadoff.;Len Dally.;Angela Lombardo.;Jill Gilmour.;Josephine Cox.;Raphael Dolin.;Patricia Fast.;Dan H Barouch.;Dagna S Laufer.; .
来源: Ann Intern Med. 2016年164卷5期313-22页
A prophylactic HIV-1 vaccine is a global health priority.
213. Medical Assistant-Based Care Management for High-Risk Patients in Small Primary Care Practices: A Cluster Randomized Clinical Trial.
作者: Tobias Freund.;Frank Peters-Klimm.;Cynthia M Boyd.;Cornelia Mahler.;Jochen Gensichen.;Antje Erler.;Martin Beyer.;Matthias Gondan.;Justine Rochon.;Ferdinand M Gerlach.;Joachim Szecsenyi.
来源: Ann Intern Med. 2016年164卷5期323-30页
Patients with multiple chronic conditions are at high risk for potentially avoidable hospitalizations, which may be reduced by care coordination and self-management support. Medical assistants are an increasingly available resource for patient care in primary care practices.
214. Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.
作者: Kurt D Christensen.;J Scott Roberts.;Peter J Whitehouse.;Charmaine D M Royal.;Thomas O Obisesan.;L Adrienne Cupples.;Jacqueline A Vernarelli.;Deepak L Bhatt.;Erin Linnenbringer.;Melissa B Butson.;Grace-Ann Fasaye.;Wendy R Uhlmann.;Susan Hiraki.;Na Wang.;Robert Cook-Deegan.;Robert C Green.; .
来源: Ann Intern Med. 2016年164卷3期155-63页
Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information.
215. Acupuncture for Menopausal Hot Flashes: A Randomized Trial.
作者: Carolyn Ee.;Charlie Xue.;Patty Chondros.;Stephen P Myers.;Simon D French.;Helena Teede.;Marie Pirotta.
来源: Ann Intern Med. 2016年164卷3期146-54页
Hot flashes (HFs) affect up to 75% of menopausal women and pose a considerable health and financial burden. Evidence of acupuncture efficacy as an HF treatment is conflicting.
216. Laparoscopic Lavage for Perforated Diverticulitis With Purulent Peritonitis: A Randomized Trial.
作者: Anders Thornell.;Eva Angenete.;Thue Bisgaard.;David Bock.;Jakob Burcharth.;Jane Heath.;Hans-Christian Pommergaard.;Jacob Rosenberg.;Nikolaj Stilling.;Stefan Skullman.;Eva Haglind.
来源: Ann Intern Med. 2016年164卷3期137-45页
Perforated diverticulitis with purulent peritonitis has traditionally been treated with open colon resection and stoma formation with risk for reoperations, morbidity, and mortality. Laparoscopic lavage alone has been suggested as definitive treatment.
217. A Combined Patient and Provider Intervention for Management of Osteoarthritis in Veterans: A Randomized Clinical Trial.
作者: Kelli D Allen.;William S Yancy.;Hayden B Bosworth.;Cynthia J Coffman.;Amy S Jeffreys.;Santanu K Datta.;Jennifer McDuffie.;Jennifer L Strauss.;Eugene Z Oddone.
来源: Ann Intern Med. 2016年164卷2期73-83页
Management of osteoarthritis requires both medical and behavioral strategies, but some recommended therapies are underused.
218. HIV Salvage Therapy Does Not Require Nucleoside Reverse Transcriptase Inhibitors: A Randomized, Controlled Trial.
作者: Karen T Tashima.;Laura M Smeaton.;Carl J Fichtenbaum.;Adriana Andrade.;Joseph J Eron.;Rajesh T Gandhi.;Victoria A Johnson.;Karin L Klingman.;Justin Ritz.;Sally Hodder.;Jorge L Santana.;Timothy Wilkin.;Richard H Haubrich.; .
来源: Ann Intern Med. 2015年163卷12期908-17页
Nucleoside reverse transcriptase inhibitors (NRTIs) are often included in antiretroviral regimens in treatment-experienced patients in the absence of data from randomized trials.
219. Four-Week Direct-Acting Antiviral Regimens in Noncirrhotic Patients With Hepatitis C Virus Genotype 1 Infection: An Open-Label, Nonrandomized Trial.
作者: Anita Kohli.;Sarah Kattakuzhy.;Sreetha Sidharthan.;Amy Nelson.;Mary McLaughlin.;Cassie Seamon.;Eleanor Wilson.;Eric G Meissner.;Zayani Sims.;Rachel Silk.;Chloe Gross.;Elizabeth Akoth.;Lydia Tang.;Angie Price.;Tim A Jolley.;Benjamin Emmanuel.;Michael Proschan.;Gebeyehu Teferi.;Jose Chavez.;Stephen Abbott.;Anuoluwapo Osinusi.;Hongmei Mo.;Michael A Polis.;Henry Masur.;Shyam Kottilil.
来源: Ann Intern Med. 2015年163卷12期899-907页
Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) for 6 weeks achieves sustained virologic response (SVR) rates of 95% in some patients. If effective, shorter therapeutic courses could improve adherence and treatment costs.
220. Sofosbuvir Plus Velpatasvir Combination Therapy for Treatment-Experienced Patients With Genotype 1 or 3 Hepatitis C Virus Infection: A Randomized Trial.
作者: Stephen Pianko.;Steven L Flamm.;Mitchell L Shiffman.;Sonal Kumar.;Simone I Strasser.;Gregory J Dore.;John McNally.;Diana M Brainard.;Lingling Han.;Brian Doehle.;Erik Mogalian.;John G McHutchison.;Mordechai Rabinovitz.;William J Towner.;Edward J Gane.;Catherine A M Stedman.;K Rajender Reddy.;Stuart K Roberts.
来源: Ann Intern Med. 2015年163卷11期809-17页
Effective treatment options are needed for patients with genotype 1 or 3 hepatitis C virus (HCV) infection in whom previous therapy has failed.
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