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2121. Comparison of Blood Volume Profiles in Heart Failure With Preserved and Reduced Ejection Fractions: Sex Makes a Difference.
Blood volume (BV) profiles vary markedly in patients with heart failure (HF), but how HF phenotypes and patient sex impact volume profiles remain to be explored. The aim of the study was to differentiate BV, plasma volume, and red blood cell mass profiles by phenotypes of preserved and reduced left ventricular ejection fractions and assess the impact of patient sex on profile heterogeneity.
2122. Iatrogenic Common Iliac Artery AV Fistula After Lumbar Discus Surgery Resulting in Severe High-Output Heart Failure in a Young Patient.
作者: Marie Bayer Elming.;Søren Schmiegelow.;Rudina Balliu Nielsen.;Stephan Bach-Frommer.;Kim Kargaard Bredahl.;Mads Ersbøll.
来源: Circ Heart Fail. 2024年17卷7期e010889页 2123. Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF.
作者: Pooja Dewan.;Li Shen.;João Pedro Ferreira.;Pardeep S Jhund.;Inder S Anand.;Alvin Chandra.;Lu-May Chiang.;Brian Claggett.;Akshay S Desai.;Jianjian Gong.;Carolyn S P Lam.;Martin P Lefkowitz.;Aldo P Maggioni.;Felipe Martinez.;Milton Packer.;Margaret M Redfield.;Jean L Rouleau.;Dirk J van Veldhuisen.;Faiez Zannad.;Michael R Zile.;Scott D Solomon.;John J V McMurray.
来源: Circulation. 2024年150卷4期272-282页
A hypothetical concern has been raised that sacubitril/valsartan might cause cognitive impairment because neprilysin is one of several enzymes degrading amyloid-β peptides in the brain, some of which are neurotoxic and linked to Alzheimer-type dementia. To address this, we examined the effect of sacubitril/valsartan compared with valsartan on cognitive function in patients with heart failure with preserved ejection fraction in a prespecified substudy of PARAGON-HF (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin Receptor Blocker Global Outcomes in Heart Failure With Preserved Ejection Fraction).
2124. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1.
作者: Hengzhi Du.;Yanru Zhao.;Jianpei Wen.;Beibei Dai.;Guo Hu.;Yufei Zhou.;Zhongwei Yin.;Nan Ding.;Huaping Li.;Jiahui Fan.;Xiang Nie.;Feng Wang.;Qian Liu.;Zheng Wen.;Gang Xu.;Dao Wen Wang.;Chen Chen.
来源: Circulation. 2024年150卷13期1030-1049页
Dilated cardiomyopathy is characterized by left ventricular dilation and continuous systolic dysfunction. Mitochondrial impairment is critical in dilated cardiomyopathy; however, the underlying mechanisms remain unclear. Here, we explored the cardioprotective role of a heart-enriched long noncoding RNA, the dilated cardiomyopathy repressive transcript (DCRT), in maintaining mitochondrial function.
2126. Comparing Management Strategies in Patients With Clot-in-Transit.
作者: Robert S Zhang.;Eugene Yuriditsky.;Peter Zhang.;Lindsay Elbaum.;Eric Bailey.;Muhammad H Maqsood.;Radu Postelnicu.;Nancy E Amoroso.;Thomas S Maldonado.;Muhamed Saric.;Carlos L Alviar.;James M Horowitz.;Sripal Bangalore.
来源: Circ Cardiovasc Interv. 2024年17卷8期e014109页
Clot-in-transit is associated with high mortality, but optimal management strategies remain uncertain. The aim of this study was to compare the outcomes of different treatment strategies in patients with clot-in-transit.
2127. Impact of Cerebral Embolic Protection Devices on Disabling Stroke After TAVR: Updated Results From the STS/ACC TVT Registry.
作者: Neel M Butala.;Samir R Kapadia.;Eric A Secemsky.;Dianne Gallup.;Andrzej S Kosinski.;Sreekanth Vemulapalli.;John C Messenger.;Robert W Yeh.;David J Cohen.
来源: Circ Cardiovasc Interv. 2024年17卷9期e013697页
Cerebral embolic protection devices (EPDs) were developed to mitigate the risk of stroke during transcatheter aortic valve replacement (TAVR), but their benefit remains unproven. In the PROTECTED-TAVR trial (Stroke Protection With Sentinel During Transcatheter), EPD use did not reduce periprocedural stroke (primary study outcome) but led to a 62% reduction in the secondary end point of disabling stroke. Given these results, the impact of EPDs during TAVR remains unclear.
2130. Impact of Left Atrial Pressure on Outcomes After Mitral Transcatheter Edge-to-Edge Repair.
作者: Yasser M Sammour.;Rody G Bou Chaaya.;Taha Hatab.;Syed Zaid.;Joe Aoun.;Omar M Makram.;Priscilla Wessly.;Sahar Samimi.;Sherif F Nagueh.;William A Zoghbi.;Marvin D Atkins.;Michael J Reardon.;Nadeen Faza.;Stephen H Little.;Neal S Kleiman.;Sachin S Goel.
来源: Circ Cardiovasc Interv. 2024年17卷9期e014055页
Increased left atrial pressure (LAP) has been associated with adverse outcomes after mitral transcatheter edge-to-edge repair (M-TEER). We sought to evaluate outcomes based on differences in postprocedural LAP measured after the final clip deployment.
2131. Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.
作者: Christine Quast.;Florian Bönner.;Amin Polzin.;Verena Veulemans.;Ramesh Chennupati.;Isabella Gyamfi Poku.;Susanne Pfeiler.;Nicolas Kramser.;Magdalena Nankinova.;Nicole Staub.;Elric Zweck.;Juliane Jokiel.;Fabian Keyser.;Jasmina Hoffe.;Sven Witkowski.;Katrin Becker.;Pia Leuders.;Saif Zako.;Ralf Erkens.;Christian Jung.;Ulrich Flögel.;Tianai Wang.;Michael Neidlin.;Ulrich Steinseifer.;Sven Thomas Niepmann.;Sebastian Zimmer.;Norbert Gerdes.;Miriam M Cortese-Krott.;Martin Feelisch.;Tobias Zeus.;Malte Kelm.
来源: Circulation. 2024年150卷12期952-965页
Whether aortic valve stenosis (AS) can adversely affect systemic endothelial function independently of standard modifiable cardiovascular risk factors is unknown.
2132. Potential Life-Threatening Complication After Transacatheter Aortic Valve Replacement: A Pseudoaneurysm of the Interventricular Septum.
作者: Marialisa Nesta.;Piergiorgio Bruno.;Rosanna Gambardella.;Monica Filice.;Alessandro Olimpieri.;Annalisa Pasquini.;Natalia Pavone.;Federico Cammertoni.;Giovanni Alfonso Chiariello.;Maria Grandinetti.;Francesco Burzotta.;Enrico Romagnoli.;Cristina Aurigemma.;Massimo Muciaccia.;Federico Costa.;Carlo Trani.;Massimo Massetti.
来源: Circ Cardiovasc Imaging. 2024年17卷8期e016193页 2133. Road-Map to Epicardial Approach for Catheter Ablation of Ventricular Tachycardia in Structural Heart Disease: Results From a 10-Year Tertiary-Center Experience.
作者: Caterina Bisceglia.;Luca R Limite.;Francesca Baratto.;Giuseppe D'Angelo.;Manuela Cireddu.;Paolo Della Bella.
来源: Circ Arrhythm Electrophysiol. 2024年17卷7期e012181页
Epicardial approach in ventricular tachycardia (VT) ablation is still regarded as a second-step strategy, due to the risk of complications. We evaluated the frequency that epicardial ablation targets were identified and ablation performed following pericardial access compared with unnecessary pericardial access for different VT causes and potential markers of epicardial VT.
2135. IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.
作者: Chao Li.;Shiqian Li.;Guangyu Zhang.;Qinfeng Li.;Weidan Song.;Xiaoding Wang.;Jane A Cook.;Miesje van der Stoel.;Bradley W Wright.;Francisco Altamirano.;Erica L Niewold.;Jungsoo Han.;Garrett Kimble.;Pengfei Zhang.;Xiang Luo.;Hery Urra.;Herman I May.;Anwarul Ferdous.;Xue-Nan Sun.;Yingfeng Deng.;Elina Ikonen.;Claudio Hetz.;Randal J Kaufman.;Kezhong Zhang.;Thomas G Gillette.;Philipp E Scherer.;Joseph A Hill.;Jin Chen.;Zhao V Wang.
来源: Circulation. 2024年150卷13期1010-1029页
Cardiomyocyte growth is coupled with active protein synthesis, which is one of the basic biological processes in living cells. However, it is unclear whether the unfolded protein response transducers and effectors directly take part in the control of protein synthesis. The connection between critical functions of the unfolded protein response in cellular physiology and requirements of multiple processes for cell growth prompted us to investigate the role of the unfolded protein response in cell growth and underlying molecular mechanisms.
2137. Chronic Thromboembolic Pulmonary Hypertension: When Thrombus Mandates Definite Diagnosis to Occur in the Operating Room.
作者: Irene Martín de Miguel.;María Jesús López-Gude.;Amaya Martínez Meñaca.;Yolanda Revilla Ostolaza.;Fernando Arribas Ynsaurriaga.;Pilar Escribano Subías.
来源: Circ Cardiovasc Imaging. 2024年17卷9期e016543页 2138. Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory From the American Heart Association.
作者: Dhruv S Kazi.;Mitchell S V Elkind.;Anne Deutsch.;William N Dowd.;Paul Heidenreich.;Olga Khavjou.;Daniel Mark.;Michael E Mussolino.;Bruce Ovbiagele.;Sonali S Patel.;Remy Poudel.;Ben Weittenhiller.;Tiffany M Powell-Wiley.;Karen E Joynt Maddox.; .
来源: Circulation. 2024年150卷4期e89-e101页
Quantifying the economic burden of cardiovascular disease and stroke over the coming decades may inform policy, health system, and community-level interventions for prevention and treatment.
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