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2121. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.
To develop and validate a new Simplified Acute Physiology Score, the SAPS II, from a large sample of surgical and medical patients, and to provide a method to convert the score to a probability of hospital mortality.
2122. Breath alcohol values following mouthwash use.
To determine whether breath alcohol values (BrAV) attained following mouthwash use pose a realistic threat to the accuracy of blood alcohol determinations by breath analysis.
2123. A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients.
To assess the effect of deliberate perioperative increase in oxygen delivery on mortality and morbidity in patients who are at high risk of both following surgery.
2124. Mortality following ventricular arrhythmia suppression by encainide, flecainide, and moricizine after myocardial infarction. The original design concept of the Cardiac Arrhythmia Suppression Trial (CAST).
作者: A E Epstein.;A P Hallstrom.;W J Rogers.;P R Liebson.;A A Seals.;J L Anderson.;J D Cohen.;R J Capone.;D G Wyse.
来源: JAMA. 1993年270卷20期2451-5页
To test the hypothesis that in survivors of myocardial infarction, the suppression of ventricular premature depolarizations improves survival free of cardiac arrest and arrhythmic death.
2125. Impact of first-responder defibrillation in an urban emergency medical services system.
作者: A L Kellermann.;B B Hackman.;G Somes.;T K Kreth.;L Nail.;P Dobyns.
来源: JAMA. 1993年270卷14期1708-13页
To evaluate the impact of adding first-responder defibrillation by fire-fighters to an existing advanced life-support emergency medical services system.
2126. Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. An overview of results from randomized controlled trials.
To investigate the effects of prophylactic therapy with antiarrhythmic agents on mortality in patients with myocardial infarction.
2127. Prehospital-initiated vs hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Intervention Trial.
作者: W D Weaver.;M Cerqueira.;A P Hallstrom.;P E Litwin.;J S Martin.;P J Kudenchuk.;M Eisenberg.
来源: JAMA. 1993年270卷10期1211-6页
To determine the effect of prehospital-initiated vs hospital-initiated treatment of myocardial infarction on clinical outcome.
2128. A controlled trial of educational outreach to improve blood transfusion practice.
作者: S B Soumerai.;S Salem-Schatz.;J Avorn.;C S Casteris.;D Ross-Degnan.;M A Popovsky.
来源: JAMA. 1993年270卷8期961-6页
To determine whether brief, face-to-face educational outreach visits can improve the appropriateness of blood product utilization.
2129. Topical anesthesia during circumcision in newborn infants.
To determine the efficacy of topical anesthetic cream, eutectic mixture of local anesthetics (EMLA), in alleviating pain from neonatal circumcision.
2130. Calcium supplementation and bone mineral density in adolescent girls.
作者: T Lloyd.;M B Andon.;N Rollings.;J K Martel.;J R Landis.;L M Demers.;D F Eggli.;K Kieselhorst.;H E Kulin.
来源: JAMA. 1993年270卷7期841-4页
To evaluate the effect of calcium supplementation on bone acquisition in adolescent white girls.
2131. The relationship of treatment adherence to the risk of death after myocardial infarction in women.
To examine the relationship between adherence to a medical regimen and mortality following a myocardial infarction in women.
2132. Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group.
作者: J D Neaton.;R H Grimm.;R J Prineas.;J Stamler.;G A Grandits.;P J Elmer.;J A Cutler.;J M Flack.;J A Schoenberger.;R McDonald.
来源: JAMA. 1993年270卷6期713-24页
To compare six antihypertensive interventions for the treatment of mild hypertension.
2136. A controlled trial of HA-1A in a canine model of gram-negative septic shock.
作者: Z M Quezado.;C Natanson.;D W Alling.;S M Banks.;C A Koev.;R J Elin.;J M Hosseini.;J D Bacher.;R L Danner.;W D Hoffman.
来源: JAMA. 1993年269卷17期2221-7页
To investigate the therapeutic efficacy and microbiological and physiological effects of a human IgM monoclonal antibody (HA-1A) directed against the lipid A component of endotoxin in a canine model of sepsis that simulates the cardiovascular abnormalities of human septic shock.
2137. Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991.
To determine whether over-the-counter cold medications have been shown to be effective in relieving symptoms in children, adolescents, and adults.
2138. Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial.
To determine the incidence of side effects from short-term glucocorticoid therapy prescribed for treatment of optic neuritis in the Optic Neuritis Treatment Trial.
2139. Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients.
To maximize deposition of an aerosolized dose of insulin (mean +/- SD = 0.99 +/- 0.06 U/kg of body weight) in the lungs of subjects with non-insulin-dependent diabetes mellitus (NIDDM), and investigate its efficacy in normalizing plasma glucose levels during the fasting state.
2140. The effects of psychosocial services in substance abuse treatment.
To examine whether the addition of counseling, medical care, and psychosocial services improves the efficacy of methadone hydrochloride therapy in the rehabilitation of opiate-dependent patients.
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