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2091. Safe administration of the measles vaccine to children allergic to eggs.
The safety of administering the combined measles-mumps-rubella (MMR) vaccine to patients who are allergic to eggs has been debated for decades because of concern about potential anaphylaxis, since the live attenuated virus used in the vaccine is grown in cultured chick-embryo fibroblasts.
2094. Discontinuation of antihyperlipidemic drugs--do rates reported in clinical trials reflect rates in primary care settings?
作者: S E Andrade.;A M Walker.;L K Gottlieb.;N K Hollenberg.;M A Testa.;G M Saperia.;R Platt.
来源: N Engl J Med. 1995年332卷17期1125-31页
Discontinuation rates for drugs used to treat chronic conditions may affect the success of therapy. However, the discontinuation rates reported in clinical trials may not reflect those in primary care settings.
2100. Screening for colorectal cancer.
In the past few years, knowledge of the clinical, biologic, and molecular genetic characteristics of colorectal cancer has greatly increased. Although the most cost-effective approach remains to be identified, screening for colorectal cancer can decrease mortality due to this disease by detecting cancers at earlier stages and allowing the removal of adenomas, thus preventing the subsequent development of cancer. Molecular studies that have helped define the genetic basis for this disease hold great promise for the development of better and more powerful methods to identify populations at risk. Individually, these technological, clinical, and basic-science advances are exciting; together, they promise to move us closer to the goal of substantially reducing mortality due to colorectal cancer.
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