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2061. Randomized controlled trial of 3 vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis.
To compare 14-day outcomes and relapse and recurrence rates among patients with acute maxillary sinusitis randomized to 3-day (3D) vs 10-day (10D) treatment with trimethoprim/sulfamethoxazole (TMP/SMX).
2062. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group.
作者: E Abraham.;R Wunderink.;H Silverman.;T M Perl.;S Nasraway.;H Levy.;R Bone.;R P Wenzel.;R Balk.;R Allred.
来源: JAMA. 1995年273卷12期934-41页
To evaluate the efficacy and safety of anti-tumor necrosis factor alpha monoclonal antibody (TNF-alpha MAb) in the treatment of patients with sepsis syndrome.
2063. An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial.
To test the hypothesis that ibuprofen increases the risk of hospitalization for gastrointestinal bleeding, renal failure, or anaphylaxis among febrile children.
2064. Costs and effects of long-term oral anticoagulant treatment after myocardial infarction.
作者: P F van Bergen.;J J Jonker.;B A van Hout.;R T van Domburg.;J W Deckers.;A J Azar.;A Hofman.
来源: JAMA. 1995年273卷12期925-8页
To investigate the costs and effects of long-term oral anticoagulant treatment after myocardial infarction.
2065. Cardiac demands of heavy snow shoveling.
作者: B A Franklin.;P Hogan.;K Bonzheim.;D Bakalyar.;E Terrien.;S Gordon.;G C Timmis.
来源: JAMA. 1995年273卷11期880-2页
To assess the physiologic responses to manual (shoveling) vs automated (electric snow thrower) snow removal in healthy, untrained men.
2066. Interchangeability of conjugated Haemophilus influenzae type b vaccines in infants.
作者: E L Anderson.;M D Decker.;J A Englund.;K M Edwards.;P Anderson.;P McInnes.;R B Belshe.
来源: JAMA. 1995年273卷11期849-53页
To evaluate the safety and immunogenicity of two Haemophilus influenzae type b (Hib) conjugate vaccines when administered in serial combination. These vaccines consisted of Hib capsular polysaccharide polyribosyl-ribitol phosphate (PRP) conjugated to the meningococcal outer membrane protein (OMP) complex (PRP-OMP) and H influenzae oligosaccharide conjugated to a mutant toxin (CRM197) isolated from Corynebacterium diphtheriae (HbOC).
2067. Optic nerve decompression surgery for nonarteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful. The Ischemic Optic Neuropathy Decompression Trial Research Group.
来源: JAMA. 1995年273卷8期625-32页
To assess the safety and efficacy of optic nerve decompression surgery compared with careful follow-up alone in patients with nonarteritic anterior ischemic optic neuropathy (NAION).
2068. Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten-year results.
To improve current adjuvant results in patients with resectable mammary carcinoma and more than three positive axillary lymph nodes.
2069. Medical decision making in situations that offer multiple alternatives.
To determine whether situations involving multiple options can paradoxically influence people to choose an option that would have been declined if fewer options were available.
2070. Health status and function with zidovudine or zalcitabine as initial therapy for AIDS. A randomized controlled trial. Roche 3300/ACTG 114 Study Group.
To evaluate the functional and health status implications of prescribing zalcitabine or zidovudine for initial therapy of acquired immunodeficiency syndrome (AIDS).
2071. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial.
来源: JAMA. 1995年273卷3期199-208页
To assess pairwise differences between placebo, unopposed estrogen, and each of three estrogen/progestin regimens on selected heart disease risk factors in healthy postmenopausal women.
2072. Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women.
To determine the efficacy, safety, and costs associated with four different 3-day regimens for the treatment of acute uncomplicated cystitis in women.
2073. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial.
作者: M E Nelson.;M A Fiatarone.;C M Morganti.;I Trice.;R A Greenberg.;W J Evans.
来源: JAMA. 1994年272卷24期1909-14页
To determine how multiple risk factors for osteoporotic fractures could be modified by high-intensity strength training exercises in postmenopausal women.
2074. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial.
作者: T M Govaert.;C T Thijs.;N Masurel.;M J Sprenger.;G J Dinant.;J A Knottnerus.
来源: JAMA. 1994年272卷21期1661-5页
To determine the efficacy of influenza vaccination in elderly people.
2075. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study.
作者: N R Anthonisen.;J E Connett.;J P Kiley.;M D Altose.;W C Bailey.;A S Buist.;W A Conway.;P L Enright.;R E Kanner.;P O'Hara.
来源: JAMA. 1994年272卷19期1497-505页
To determine whether a program incorporating smoking intervention and use of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 second (FEV1) in smokers aged 35 to 60 years who have mild obstructive pulmonary disease.
2076. Serum carotenoids and coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up Study.
To examine the relationship between total serum carotenoid levels and the risk of subsequent coronary heart disease (CHD) events.
2077. Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome.
作者: J G Weg.;R A Balk.;R S Tharratt.;S G Jenkinson.;J B Shah.;D Zaccardelli.;J Horton.;E N Pattishall.
来源: JAMA. 1994年272卷18期1433-8页
To evaluate the safety and potential efficacy of aerosolized surfactant in intubated patients with adult respiratory distress syndrome (ARDS).
2078. The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis.
To compare the effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in patients with hyperdynamic sepsis.
2079. Early intervention in low-birth-weight premature infants. Results through age 5 years from the Infant Health and Development Program.
作者: J Brooks-Gunn.;C M McCarton.;P H Casey.;M C McCormick.;C R Bauer.;J C Bernbaum.;J Tyson.;M Swanson.;F C Bennett.;D T Scott.
来源: JAMA. 1994年272卷16期1257-62页
To evaluate the persistence of effects on health and development at age 5 years of the Infant Health and Development Program, an early childhood intervention that was provided to low-birth-weight (LBW) premature infants from neonatal discharge through age 3 years.
2080. Reduction of fever and streptococcal bacteremia in granulocytopenic patients with cancer. A trial of oral penicillin V or placebo combined with pefloxacin. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer.
来源: JAMA. 1994年272卷15期1183-9页
To determine the effect of oral penicillin V combined with a fluoroquinolone (pefloxacin) on the occurrence of fever and streptococcal and other gram-positive coccal bacteremic infections in granulocytopenic patients with cancer.
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