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2021. Effect of frequency of prenatal care visits on perinatal outcome among low-risk women. A randomized controlled trial.
In 1989, the Expert Panel on the Content of Prenatal Care established guidelines on the timing and content of prenatal care, including a schedule consisting of fewer prenatal visits than traditionally provided, for women at low risk of adverse perinatal outcomes. We tested the hypothesis that there are no significant increases in adverse perinatal outcomes when low-risk women are seen in a prenatal care visit schedule of fewer visits than routinely advised.
2022. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. GUSTO-I investigators.
作者: W D Weaver.;H D White.;R G Wilcox.;P E Aylward.;D Morris.;A Guerci.;E M Ohman.;G I Barbash.;A Betriu.;Z Sadowski.;E J Topol.;R M Califf.
来源: JAMA. 1996年275卷10期777-82页
To compare baseline characteristics, complications, and treatment-specific outcomes of women and men with acute myocardial infarction treated with thrombolytic therapy.
2023. Outcomes of a field trial to improve children's dietary patterns and physical activity. The Child and Adolescent Trial for Cardiovascular Health. CATCH collaborative group.
作者: R V Luepker.;C L Perry.;S M McKinlay.;P R Nader.;G S Parcel.;E J Stone.;L S Webber.;J P Elder.;H A Feldman.;C C Johnson.
来源: JAMA. 1996年275卷10期768-76页
To assess the outcomes of health behavior interventions, focusing on the elementary school environment, classroom curricula, and home programs, for the primary prevention of cardiovascular disease.
2024. A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression.
To assess the use of desipramine for secondary depression in primary alcohol dependence and its effect on abstinence.
2025. Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation.
作者: E R Greenberg.;J A Baron.;M R Karagas.;T A Stukel.;D W Nierenberg.;M M Stevens.;J S Mandel.;R W Haile.
来源: JAMA. 1996年275卷9期699-703页
To examine the relationship between beta carotene plasma concentration and beta carotene supplementation and risk of death from major disease causes.
2026. Effect of vitamin E and beta carotene on the incidence of angina pectoris. A randomized, double-blind, controlled trial.
作者: J M Rapola.;J Virtamo.;J K Haukka.;O P Heinonen.;D Albanes.;P R Taylor.;J K Huttunen.
来源: JAMA. 1996年275卷9期693-8页
To examine the effect of supplementation with vitamin E (alpha tocopherol), beta carotene, or both on the incidence of angina pectoris in men without known previous coronary heart disease.
2027. Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass graft surgery. A randomized, double-blind, placebo- controlled trial. Duke T3 study group.
作者: E Bennett-Guerrero.;J L Jimenez.;W D White.;E B D'Amico.;B I Baldwin.;D A Schwinn.
来源: JAMA. 1996年275卷9期687-92页
To test the hypothesis that triiodothyronine (T(3)) administration improves hemodynamic variables and decreases inotropic drug requirements in cardiac surgery patients.
2028. Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants.
作者: A Varvarigou.;C L Bardin.;K Beharry.;S Chemtob.;A Papageorgiou.;J V Aranda.
来源: JAMA. 1996年275卷7期539-44页
To test whether early postnatal (0 to 3 hours) intravenous administration of ibuprofen will prevent patent ductus arteriosus (PDA) in preterm neonates.
2029. Initial experience with partial liquid ventilation in adult patients with the acute respiratory distress syndrome.
作者: R B Hirschl.;T Pranikoff.;C Wise.;M C Overbeck.;P Gauger.;R J Schreiner.;R Dechert.;R H Bartlett.
来源: JAMA. 1996年275卷5期383-9页
To evaluate the safety and efficacy of partial liquid ventilation (PLV).
2030. Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial.
来源: JAMA. 1996年275卷5期370-5页
To report the histological findings of the endometrium of postmenopausal women who were randomized to receive placebo, estrogen only, or one of three estrogen plus progestin (E+P) regimens in the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial.
2031. Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza.
作者: F G Hayden.;J J Treanor.;R F Betts.;M Lobo.;J D Esinhart.;E K Hussey.
来源: JAMA. 1996年275卷4期295-9页
The current study evaluated whether intranasal administration of the sialic acid analog 4-guanidino-Neu5Ac2en (GG167), an inhibitor of influenza virus neuraminidase, was effective and safe in either preventing or treating experimental human influenza.
2032. Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia.
作者: R G Bakker-Arkema.;M H Davidson.;R J Goldstein.;J Davignon.;J L Isaacsohn.;S R Weiss.;L M Keilson.;W V Brown.;V T Miller.;L J Shurzinske.;D M Black.
来源: JAMA. 1996年275卷2期128-33页
To assess the lipid-lowering effect of atorvastatin (a new 3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitor) on levels of serum triglycerides and other lipoprotein fractions in patients with primary hypertriglyceridemia, determine if atorvastatin causes a redistribution of triglycerides in various lipoprotein fractions, and assess its safety by reporting adverse events and clinical laboratory measurements.
2033. Effects of weight loss vs aerobic exercise training on risk factors for coronary disease in healthy, obese, middle-aged and older men. A randomized controlled trial.
作者: L I Katzel.;E R Bleecker.;E G Colman.;E M Rogus.;J D Sorkin.;A P Goldberg.
来源: JAMA. 1995年274卷24期1915-21页
To compare the effects of weight loss vs aerobic exercise training on coronary artery disease risk factors in healthy sedentary, obese, middle-aged and older men.
2034. Effects of lowering elevated LDL cholesterol on the cardiovascular risk of lipoprotein(a).
作者: V M Maher.;B G Brown.;S M Marcovina.;L A Hillger.;X Q Zhao.;J J Albers.
来源: JAMA. 1995年274卷22期1771-4页
To determine if lowering elevated low-density lipoprotein cholesterol (LDL-C) levels offsets the adverse effect of raised lipoprotein(a) (Lp[a]) levels on coronary artery disease (CAC) in men.
2035. Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction.
To determine whether the effects of topically administered timolol in an individual would be dependent on the presence or absence in that individual of the P-450 enzyme CYP2D6 and whether the effects of topically administered timolol would be increased and its metabolism decreased by the oral administration of quinidine, a known inhibitor of CYP2D6.
2036. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators.
来源: JAMA. 1995年274卷20期1591-8页
To improve end-of-life decision making and reduce the frequency of a mechanically supported, painful, and prolonged process of dying.
2037. Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet.
作者: E J Schaefer.;A H Lichtenstein.;S Lamon-Fava.;J R McNamara.;M M Schaefer.;H Rasmussen.;J M Ordovas.
来源: JAMA. 1995年274卷18期1450-5页
To assess the effects of a diet restricted in fat, saturated fat, and cholesterol, under weight-maintenance and ad libitum conditions on body weight and plasma lipid levels in hypercholesterolemic subjects.
2038. High-dose nicotine patch therapy. Percentage of replacement and smoking cessation.
作者: L C Dale.;R D Hurt.;K P Offord.;G M Lawson.;I T Croghan.;D R Schroeder.
来源: JAMA. 1995年274卷17期1353-8页
To assess the level of nicotine replacement, evidence of nicotine toxicity, and withdrawal symptom relief with placebo and 11-, 22-, and 44-mg/d doses of transdermal nicotine. A secondary objective was to assess short- and long-term smoking cessation rates.
2039. Varying nicotine patch dose and type of smoking cessation counseling.
作者: D E Jorenby.;S S Smith.;M C Fiore.;R D Hurt.;K P Offord.;I T Croghan.;J T Hays.;S F Lewis.;T B Baker.
来源: JAMA. 1995年274卷17期1347-52页
To compare the efficacy and safety of 22-mg and 44-mg doses of transdermal nicotine therapy when it is paired with minimal, individual, or group counseling to improve smoking cessation rates.
2040. A randomized controlled trial of an HIV sexual risk-reduction intervention for young African-American women.
To evaluate the efficacy of a community-based social skills human immunodeficiency virus (HIV) prevention intervention to enhance consistent condom use.
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