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183. A More Selective vs a Standard Risk-Stratified, Heparin-Based, Obstetric Thromboprophylaxis Protocol.
作者: Macie L Champion.;Christina T Blanchard.;Michelle Y Lu.;Ashley E Shea.;Anna I Lively.;J Morgan Jenkins.;Samantha E Howell.;Grace M Lee.;Brian M Casey.;Ashley N Battarbee.;Akila Subramaniam.
来源: JAMA. 2024年332卷4期310-317页
In 2016, our institution adopted a pregnancy-related venous thromboembolism (VTE) prophylaxis protocol based on American College of Obstetricians and Gynecologists guidelines that recommended postpartum heparin-based chemoprophylaxis (enoxaparin) based on a risk-stratified algorithm. In response to increased wound hematomas without significant reduction in VTE using this protocol, a more selective risk-stratified approach was adopted in 2021.
186. Comparison of No-Test Telehealth and In-Person Medication Abortion.
作者: Lauren J Ralph.;C Finley Baba.;M Antonia Biggs.;Colleen McNicholas.;Amy Hagstrom Miller.;Daniel Grossman.
来源: JAMA. 2024年332卷11期898-905页
In the US, access to medication abortion using history-based (no-test) eligibility assessment, including through telehealth and mailing of mifepristone, has grown rapidly. Additional evidence on the effectiveness and safety of these models is needed.
188. A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome.
作者: Mingke Ni.;Ziv Dadon.;Julian O M Ormerod.;Johan Saenen.;Wiert F Hoeksema.;Pavel Antiperovitch.;Rafik Tadros.;Morten K Christiansen.;Christian Steinberg.;Marine Arnaud.;Shanshan Tian.;Bo Sun.;John Paul Estillore.;Ruiwu Wang.;Habib R Khan.;Thomas M Roston.;Andrea Mazzanti.;John R Giudicessi.;Konstantinos C Siontis.;Aiman Alak.;J Gabriel Acosta.;Syamkumar M Divakara Menon.;Nigel S Tan.;Christian van der Werf.;Babak Nazer.;Hari Vivekanantham.;Tanvi Pandya.;Jennifer Cunningham.;Lorne J Gula.;Jorge A Wong.;Guy Amit.;Melvin M Scheinman.;Andrew D Krahn.;Michael J Ackerman.;Silvia G Priori.;Michael H Gollob.;Jeff S Healey.;Frederic Sacher.;Eyal Nof.;Michael Glikson.;Arthur A M Wilde.;Hugh Watkins.;Henrik K Jensen.;Pieter G Postema.;Bernard Belhassen.;S R Wayne Chen.;Jason D Roberts.
来源: JAMA. 2024年332卷3期204-213页
Sudden death and cardiac arrest frequently occur without explanation, even after a thorough clinical evaluation. Calcium release deficiency syndrome (CRDS), a life-threatening genetic arrhythmia syndrome, is undetectable with standard testing and leads to unexplained cardiac arrest.
191. Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis: A Randomized Clinical Trial.
作者: Andreas F Widmer.;Andrew Atkinson.;Stefan P Kuster.;Aline Wolfensberger.;Steffi Klimke.;Rami Sommerstein.;Friedrich S Eckstein.;Florian Schoenhoff.;Guido Beldi.;Christian A Gutschow.;Jonas Marschall.;Alexander Schweiger.;Philipp Jent.
来源: JAMA. 2024年332卷7期541-549页
Preoperative skin antisepsis is an established procedure to prevent surgical site infections (SSIs). The choice of antiseptic agent, povidone iodine or chlorhexidine gluconate, remains debated.
192. Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction: The DEFENDER Randomized Clinical Trial.
作者: Caio A M Tavares.;Luciano C P Azevedo.;Álvaro Rea-Neto.;Niklas S Campos.;Cristina P Amendola.;Amanda C Kozesinski-Nakatani.;Paula G David-João.;Suzana M Lobo.;Thiago C Filiponi.;Guacyra M B Almeida.;Ricardo R Bergo.;Mário R R Guimarães-Júnior.;Rodrigo C Figueiredo.;Joan R Castro.;Clewer J Schuler.;Glauco A Westphal.;Ana C R Carioca.;Frederico Monfradini.;Josue Nieri.;Flavia M O Neves.;Jaqueline A Paulo.;Camila S N Albuquerque.;Mariana C R Silva.;Mikhail N Kosiborod.;Adriano J Pereira.;Lucas P Damiani.;Thiago D Corrêa.;Ary Serpa-Neto.;Otavio Berwanger.;Fernando G Zampieri.; .
来源: JAMA. 2024年332卷5期401-411页
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve outcomes in patients with type 2 diabetes, heart failure, and chronic kidney disease, but their effect on outcomes of critically ill patients with organ failure is unknown.
193. Germline CDH1 Variants and Lifetime Cancer Risk.
作者: Carrie E Ryan.;Grace-Ann Fasaye.;Amber F Gallanis.;Lauren A Gamble.;Paul H McClelland.;Anna Duemler.;Sarah G Samaranayake.;Andrew M Blakely.;Christine M Drogan.;Kerry Kingham.;Devanshi Patel.;Linda Rodgers-Fouche.;Ava Siegel.;Sonia S Kupfer.;James M Ford.;Daniel C Chung.;James G Dowty.;Joshua Sampson.;Jeremy L Davis.
来源: JAMA. 2024年332卷9期722-729页
Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breast cancer. Previously, the lifetime risk of gastric cancer was estimated to be approximately 25% to 83% and for breast cancer it was estimated to be approximately 39% to 55% in individuals with loss of function CDH1 gene variants.
195. Association Between Cost Sharing and Naloxone Prescription Dispensing.
作者: Kao-Ping Chua.;Rena M Conti.;Pooja Lagisetty.;Amy S Bohnert.;Sijia He.;Thuy D Nguyen.
来源: JAMA. 2024年332卷2期124-132页
Increasing access to naloxone (an opioid antagonist that can reverse overdose) could slow the US opioid epidemic. Prior studies suggest cost sharing may be a barrier to dispensing of naloxone prescriptions, but these studies were limited by their cross-sectional designs and use of databases that do not capture prescriptions that are not filled (abandoned).
198. Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock: A Systematic Review and Meta-Analysis.
作者: Mohd H Abdul-Aziz.;Naomi E Hammond.;Stephen J Brett.;Menino O Cotta.;Jan J De Waele.;Anthony Devaux.;Gian Luca Di Tanna.;Joel M Dulhunty.;Hatem Elkady.;Lars Eriksson.;M Shahnaz Hasan.;Ayesha Bibi Khan.;Jeffrey Lipman.;Xiaoqiu Liu.;Giacomo Monti.;John Myburgh.;Emmanuel Novy.;Shahed Omar.;Dorrilyn Rajbhandari.;Claire Roger.;Fredrik Sjövall.;Irene Zaghi.;Alberto Zangrillo.;Anthony Delaney.;Jason A Roberts.
来源: JAMA. 2024年332卷8期638-648页
There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock.
199. Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial.
作者: Joel M Dulhunty.;Stephen J Brett.;Jan J De Waele.;Dorrilyn Rajbhandari.;Laurent Billot.;Menino O Cotta.;Joshua S Davis.;Simon Finfer.;Naomi E Hammond.;Serena Knowles.;Xiaoqiu Liu.;Shay McGuinness.;Jayanthi Mysore.;David L Paterson.;Sandra Peake.;Andrew Rhodes.;Jason A Roberts.;Claire Roger.;Charudatt Shirwadkar.;Therese Starr.;Colman Taylor.;John A Myburgh.;Jeffrey Lipman.; .
来源: JAMA. 2024年332卷8期629-637页
Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain.
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