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181. Breathlessness, Frailty, and Sarcopenia in Older Adults.
作者: Tai Joon An.;Jihye Lim.;Heayon Lee.;Sunghwan Ji.;Hee-Won Jung.;Ji Yeon Baek.;Eunju Lee.;Il-Young Jang.
来源: Chest. 2024年166卷6期1476-1486页
Breathlessness shares aging mechanisms with frailty and sarcopenia.
182. "My Mom Is a Fighter": A Qualitative Analysis of the Use of Combat Metaphors in ICU Clinician Notes.
作者: Shannen Kim.;Hunter Mills.;Teva Brender.;Samuel McGowan.;Eric Widera.;Allyson C Chapman.;Krista L Harrison.;Sei Lee.;Alex K Smith.;David Bamman.;Oksana Gologorskaya.;Julien Cobert.
来源: Chest. 2024年166卷5期1162-1172页
A metaphor conceptualizes one, typically abstract, experience in terms of another, more concrete, experience with the goal of making it easier to understand. Although combat metaphors have been well described in some health contexts, they have not been well characterized in the setting of critical illness.
183. Upper Airway and Translaryngeal Resistance During Mechanical Insufflation-Exsufflation.
作者: Tiina M Andersen.;Anne Kristine Brekka.;Zoe Fretheim-Kelly.;Manel Lujan.;John-Helge Heimdal.;Hege H Clemm.;Thomas Halvorsen.;Ove Fondenes.;Roy M Nilsen.;Ola D Røksund.;Maria Vollsæter.
来源: Chest. 2025年167卷1期188-201页
Mechanical insufflation-exsufflation (MI-E) uses positive and negative pressures to assist weak cough and to help clear airway secretions. Laryngeal visualization during MI-E has revealed that inappropriate upper airway responses can impede its efficacy. However, the dynamics of pressure transmission in the upper airways during MI-E are unclear, as are the relationships among anatomic structure, pressure, and airflow.
184. Effect of Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine on Exacerbation Rate and Risk in Patients With Moderate to Severe COPD.
作者: Frank C Sciurba.;Stephanie A Christenson.;Tara Rheault.;Thomas Bengtsson.;Kathleen Rickard.;Igor Z Barjaktarevic.
来源: Chest. 2025年167卷2期425-435页
Exacerbations in COPD can be life-threatening and can lead to irreversible declines in lung function and quality of life. Medications that reduce exacerbation burden are an unmet need, because exacerbations put patients at risk of more exacerbations and decrease quality of life. Ensifentrine is a first-in-class selective dual inhibitor of phosphodiesterase 3 and 4 with demonstrated nonsteroidal antiinflammatory activity and bronchodilatory effects.
185. Differences in Health Care and Palliative Care Use at the End of Life: A Comparison Study Among Lung Cancer, COPD, and Idiopathic Pulmonary Fibrosis.
作者: Angela O Suen.;Kara Bischoff.;Anand S Iyer.;Keerthana Radhakrishnan.;Cynthia Fenton.;Jonathan P Singer.;Rebecca L Sudore.;Ashwin Kotwal.;Erica Farrand.
来源: Chest. 2024年166卷6期1487-1496页
Patients with lung cancer, idiopathic pulmonary fibrosis (IPF), and COPD have high symptom burden, poor quality of life, and high health care use at the end of life. Although proactive integration of palliative care in lung cancer can improve outcomes, it is unclear whether similar practices have been adopted in COPD and IPF care.
186. Association of Cardiopulmonary Hemodynamics and Outcomes in Pulmonary Hypertension Following Kidney Transplantation: A Multicenter Retrospective Cohort Study.
作者: Arun Jose.;Sathish S Kumar.;Leonid Gorelik.;Samuel H Friedman.;Antolin S Flores.;Denise Sese.;Michael Vinzani.;Nicholas J Douville.;Akshar Patel.;Rahul G Argula.;Courtney Jones.;Nicole M Bhave.;Jean M Elwing.
来源: Chest. 2024年166卷6期1499-1510页
Pulmonary hypertension (PH) frequently complicates the evaluation of kidney transplantation (KT) candidates, and is associated with increased adverse outcomes (mortality, delayed graft function [DGF], and major adverse cardiovascular event) following KT.
187. The Responsiveness of Exercise Tests in COPD: A Randomized Controlled Trial.
作者: Theresa C Harvey-Dunstan.;Molly M Baldwin.;Ruth Tal-Singer.;Matthew Allinder.;Michael I Polkey.;Alan Hamilton.;Matthew Richardson.;Sarah A Edwards.;Michael C Steiner.;Mike D Morgan.;Sally J Singh.; .
来源: Chest. 2025年167卷1期98-111页
COPD is characterized by reduced exercise tolerance, and improving physical performance is an important therapeutic goal. A variety of exercise tests are commonly used to assess exercise tolerance, including laboratory and field-based tests. The responsiveness of these various tests to common COPD interventions is yet to be compared, but the results may inform test selection in clinical and research settings.
188. Diffuse Cystic Lung Disease: A Clinical Guide to Recognition and Management.
作者: Alessandro N Franciosi.;Nishant Gupta.;David J Murphy.;Kathryn A Wikenheiser-Brokamp.;Cormac McCarthy.
来源: Chest. 2025年167卷2期529-547页
Diffuse cystic lung diseases (DCLDs) represent a group of pathophysiologically heterogeneous entities that share a common radiologic phenotype of multiple thin-walled pulmonary cysts. DCLDs differ from the typical fibroinflammatory interstitial lung diseases in their epidemiology, clinical presentation, molecular pathogenesis, and therapeutic approaches, making them worthy of a distinct classification. The importance of timely and accurate identification of DCLDs is heightened by the impact on patient management including recent discoveries of targeted therapeutic approaches for some disorders.
189. Quantitative Imaging Methods in Combined Pulmonary Fibrosis and Emphysema.
作者: Jennifer M Wang.;Tetsuro Araki.;Vincent Cottin.;MeiLan K Han.;Justin M Oldham.
来源: Chest. 2024年166卷6期1463-1472页
Combined pulmonary fibrosis and emphysema (CPFE) is an underdiagnosed syndrome in which individuals have variable degrees of pulmonary fibrosis and emphysema. Patients with CPFE have high morbidity, including poor exercise tolerance and increased development of comorbidities. CPFE mortality also seems to outpace that of lone emphysema and pulmonary fibrosis. A major limitation to rigorous, large-scale studies of CPFE has been the lack of a precise definition for this syndrome. A 2022 American Thoracic Society/European Respiratory Society/Japanese Respiratory Society/Latin American Thoracic Association research statement called attention to fundamental gaps in our understanding of CPFE and highlighted the potential use of quantitative imaging techniques to better define CPFE.
190. Evaluating US Multiple Listing Practices in Lung Transplantation: Unveiling Hidden Disparities.
作者: Adora N Moneme.;Mallory Hunt.;Jacqueline Friskey.;Madeline McCurry.;Dun Jin.;Joshua M Diamond.;Michaela R Anderson.;Emily S Clausen.;Aya Saleh.;Allie Raevsky.;Jason D Christie.;Douglas Schaubel.;Jesse Hsu.;A Russell Localio.;Robert Gallop.;Edward Cantu.
来源: Chest. 2024年166卷6期1442-1454页
Multiple listing (ML) is a practice used to increase the potential for transplant but is controversial due to concerns that it disproportionately benefits patients with greater access to health care resources.
191. Equivalency of Multiple Biomarkers to Clinical Pulmonary Arterial Hypertension Survival Risk Models.
作者: Megan Griffiths.;Catherine E Simpson.;Jun Yang.;Dhananjay Vaidya.;Melanie K Nies.;Stephanie Brandal.;Rachel Damico.;Paul Hassoun.;Dunbar D Ivy.;Eric D Austin.;Michael W Pauciulo.;Katie A Lutz.;Lisa J Martin.;Erika B Rosenzweig.;Raymond L Benza.;William C Nichols.;Cedric Manlhiot.;Allen D Everett.
来源: Chest. 2024年166卷6期1511-1531页
Risk assessment in pulmonary arterial hypertension (PAH) is fundamental to guiding treatment and improved outcomes. Clinical models are excellent at identifying high-risk patients, but leave uncertainty amongst moderate-risk patients.
192. Occupational Exposure to Charcoal Smoke and Dust, a Major Risk Factor for COPD: A Multiregional Cross-Sectional Study in the Democratic Republic of Congo.
作者: Pierre Olenga Vuvu Lofuta.;Malgorzata Klass.;Nathalie Pauwen.;Augustin Mboko Kipula.;Philippe van de Borne.;Alain Van Muylem.;Silvia Perez-Bogerd.;Gaël Deboeck.
来源: Chest. 2024年166卷6期1334-1346页
Occupational exposure to charcoal smoke and dust is a threat to workers' respiratory systems.
193. Identifying Risk of Postoperative Cardiorespiratory Complications in OSA.
作者: Maree Azzopardi.;Richard Parsons.;Gemma Cadby.;Stuart King.;Nigel McArdle.;Bhajan Singh.;David R Hillman.
来源: Chest. 2024年166卷5期1197-1208页
Patients with OSA are at increased risk of postoperative cardiorespiratory complications and death. Attempts to stratify this risk have been inadequate, and predictors from large, well-characterized cohort studies are needed.
194. Decídetexto: Mobile Cessation Support for Latino Adults Who Smoke: A Randomized Clinical Trial.
作者: Francisco Cartujano-Barrera.;Lisa Sanderson Cox.;Delwyn Catley.;Xueya Cai.;Francisco J Diaz.;Evelyn Arana-Chicas.;Arlette Chávez-Iñiguez.;Chinwe Ogedegbe.;Kristi D Graves.;M Patricia Rivera.;Arturo Ponce.;Edward F Ellerbeck.;Ana Paula Cupertino.
来源: Chest. 2025年167卷2期619-629页
Latino adults experience multiple barriers to health care access and treatment that result in tobacco-related disparities. Mobile interventions have the potential to deliver smoking cessation treatment among Latino adults, who show the highest use rates of mobile technologies.
197. Exacerbation History and Risk of Myocardial Infarction and Pulmonary Embolism in COPD.
作者: Oskar Wallström.;Caroline Stridsman.;Anne Lindberg.;Fredrik Nyberg.;Lowie E G W Vanfleteren.
来源: Chest. 2024年166卷6期1347-1359页
Acute exacerbations (AEs) of COPD are increasingly recognized as episodes of heightened risk of cardiovascular events. It is not known whether exacerbation history is differentially associated with future myocardial infarction (MI) or pulmonary embolism (PE).
199. Role of Exercise Hemodynamics in the Prediction of Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers.
作者: Christian Gerges.;Antoine Beurnier.;Xavier Jaïs.;Philippe Hervé.;Edmund M T Lau.;Barbara Girerd.;Sven Günther.;Amir Bouchachi.;Mitja Jevnikar.;Athénaïs Boucly.;Harm Jan Bogaard.;Gérald Simonneau.;Olivier Sitbon.;Laurent Savale.;Denis Chemla.;Marc Humbert.;David Montani.
来源: Chest. 2024年166卷5期1173-1183页
Exercise hemodynamics are recommended for early detection of pulmonary arterial hypertension (PAH) and have been suggested to be predictive of future development of PAH in high-risk populations such as BMPR2 mutation carriers. However, the optimal exercise hemodynamic screening parameter remains to be determined. Recent data suggest that pulmonary vascular distensibility (α) may serve as a useful parameter for early detection of PAH.
200. Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization: A Multicenter, Retrospective Study.
作者: Yongpo Jiang.;Xiaohan Huang.;Huili Zhou.;Mingqiang Wang.;Shengfeng Wang.;Xindie Ren.;Guojun He.;Jun Xu.;Qianqian Wang.;Muhua Dai.;Yonghui Xiong.;Lin Zhong.;Xuwei He.;Xuntao Deng.;Yujie Pan.;Yinghe Xu.;Hongliu Cai.;Shengwei Jin.;Hongyu Wang.;Lingtong Huang.
来源: Chest. 2025年167卷1期54-66页
For decades, the incidence and clinical characteristics of Pneumocystis jirovecii colonization in patients with severe pneumonia was unclear.
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