191. Group B Streptococcal Disease.
Group B streptococcus commonly colonizes the human gastrointestinal and genitourinary tracts and is the single most common bacterial cause of invasive infection among newborns in the United States. Intrapartum antibiotic prophylaxis is currently used to reduce the risk of group B streptococcal disease among pregnant persons and newborns. No strategies are currently available to prevent disease in later infancy or among nonpregnant adults. Vaccines against group B streptococcal disease that consist of capsular polysaccharides linked to protein antigens are in development and may provide a means of prevention for all at-risk populations.
192. Tecovirimat for the Treatment of Mpox.
作者: Jason Zucker.;William A Fischer.;Lu Zheng.;Caitlyn McCarthy.;Pooja T Saha.;Arzhang Cyrus Javan.;Alex Greninger.;Matthew M Hamill.;Kieron Leslie.;Kristina M Brooks.;Jonathan Berardi.;Davey Smith.;Lara Hosey.;Grace Aldrovandi.;Kathie Ferbas.;Cheryl Day.;Rachel A Bender Ignacio.;Robert Bolan.;Marshall J Glesby.;Raphael J Landovitz.;Anne F Luetkemeyer.;Juan Sierra Madero.;Rajesh T Gandhi.;Sharon Nachman.;Joe Eron.;Judith S Currier.;Timothy Wilkin.; .
来源: N Engl J Med. 2026年394卷9期884-895页
Tecovirimat is approved for smallpox treatment under the Food and Drug Administration Animal Rule on the basis of efficacy in nonhuman primate models of mpox (previously known as monkeypox). However, the clinical efficacy of tecovirimat against human clade II mpox is unclear.
193. Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C-Mutated Tumors.
作者: Ecaterina E Dumbrava.;Geoffrey I Shapiro.;Aparna R Parikh.;Melissa L Johnson.;Anthony W Tolcher.;John A Thompson.;Anthony B El-Khoueiry.;Andrae L Vandross.;Shivaani Kummar.;Dale R Shepard.;Kim LeDuke.;Lisa Sheehan.;Leila Alland.;Arshad Haque.;Deepika Jalota.;Marc Fellous.;Alison M Schram.
来源: N Engl J Med. 2026年394卷9期872-883页
Rezatapopt is an investigational, first-in-class, oral, selective p53 reactivator that specifically binds to Y220C-mutated p53, which stabilizes p53 in its wild-type conformation and restores its functionality.
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