GIM/FP/GP: [Formula: see text] Hematology: [Formula: see text].

GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].

GIM/FP/GP: [Formula: see text].

Internal medicine physicians are frequently responsible for caring for patients with rheumatologic diseases, whether as a primary provider or in collaboration with subspecialists. This article calls attention to 8 studies published in 2024 that shed new light on the management of common rheumatologic conditions that internal medicine physicians are likely to encounter. The first study suggests that the weight loss medication semaglutide can improve pain and function in patients with painful knee osteoarthritis (OA), potentially providing a novel approach to management of this condition. The results of the second study show that methotrexate, a proven therapy for inflammatory arthritis, has promise for improving pain in patients with knee OA. The third study establishes that a trial of resistance training does not provide similar benefits as total joint replacement for patients with hip OA. The fourth study finds that platelet-rich plasma injections are no more effective than exercise in reducing pain for patients with knee OA. The fifth study underscores the importance of screening for lung cancer in patients with rheumatoid arthritis (RA), particularly in those known to have interstitial lung disease. The results of the sixth study emphasize that exercise therapy is safe and effective at improving function in patients with RA and severe activity limitations. The seventh study highlights the increased short-term risk for acute cardiovascular events in patients experiencing a new gout diagnosis. The final study suggests that supplementation with omega-3 fatty acids may provide sustained protection against developing new autoimmune diseases. Familiarity with these new studies will provide internal medicine physicians with valuable insights to enhance their care of patients with rheumatic diseases.

In 2024, infectious disease literature focused on advancements in the treatment of severe infections and prevention of high-burden diseases. Building on prior data, further evidence supports both the use of shorter courses of antibiotics and the earlier transition to oral antibiotics, including for severe infections, such as bacteremia. A new medication has demonstrated significant, high-impact findings in the long-acting category of drugs for the prevention of HIV infection. Antibiotic resistance continues to be a growing threat, and research this year has demonstrated significant advances for new agents helping to combat resistant gram-negative organisms. Research on the long-term sequelae of COVID-19 continues to expand, with a living systematic review providing us a better understanding of symptom management. Novel treatment regimens for Helicobacter pylori infection are being studied, and the evidence is reviewed for these new regimens. Finally, several emerging infections are highlighted to raise awareness of new or concerning outbreaks that may cause significant effects in the coming year.

Over the past 5 decades, substantial advances in oncology have reshaped cancer care, reflecting the dynamic role of internal medicine physicians in patients' journey from screening to diagnosis, treatment, and surveillance. This review highlights 10 landmark studies from 2024 that address emerging therapies and evolving clinical standards. Immunotherapy remains a central focus, with checkpoint inhibitors redefining the management of solid tumors and showing expanded applications across disease sites and earlier stages of disease. Targeted therapies and antibody-drug conjugates, including trastuzumab deruxtecan and enfortumab vedotin, are enhancing precision treatment options in metastatic cancer. Meanwhile, advances in supportive care, such as magnetic resonance imaging-guided prostate cancer screening, ponsegromab for cachexia, and celiac plexus radiosurgery for pain, show enhanced symptom management and quality of life for patients. These innovations highlight the critical role of multidisciplinary approaches, where internal medicine physicians contribute to co-management and toxicity monitoring, ultimately optimizing patient care. By staying current with these developments, internal medicine physicians are positioned to navigate complex oncologic care, ensuring that the benefits of novel therapies are maximized while mitigating their challenges.

Patient navigation is a recommended practice of the Guide to Community Preventive Services; little is known about whether it improves colonoscopy completion for adults who have received an abnormal stool test result.

Black Americans have lower wealth, income, and education and higher mortality rates than White Americans, especially during childhood.