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181. Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial.
作者: Gregory D Lewis.;Adriaan A Voors.;Alain Cohen-Solal.;Marco Metra.;David J Whellan.;Justin A Ezekowitz.;Michael Böhm.;John R Teerlink.;Kieran F Docherty.;Renato D Lopes.;Punag H Divanji.;Stephen B Heitner.;Stuart Kupfer.;Fady I Malik.;Lisa Meng.;Amy Wohltman.;G Michael Felker.
来源: JAMA. 2022年328卷3期259-269页
Exercise limitation is a cardinal manifestation of heart failure with reduced ejection fraction (HFrEF) but is not consistently improved by any of the current guideline-directed medical therapies.
182. Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial.
作者: David W Oslin.;Kevin G Lynch.;Mei-Chiung Shih.;Erin P Ingram.;Laura O Wray.;Sara R Chapman.;Henry R Kranzler.;Joel Gelernter.;Jeffrey M Pyne.;Annjanette Stone.;Scott L DuVall.;Lisa Soleymani Lehmann.;Michael E Thase.; .;Muhammad Aslam.;Steven L Batki.;James M Bjork.;Frederic C Blow.;Lisa A Brenner.;Peijun Chen.;Shivan Desai.;Eric W Dieperink.;Scott C Fears.;Matthew A Fuller.;Courtney S Goodman.;David P Graham.;Gretchen L Haas.;Mark B Hamner.;Amy W Helstrom.;Robin A Hurley.;Michael S Icardi.;George J Jurjus.;Amy M Kilbourne.;Julie Kreyenbuhl.;Daniel J Lache.;Steven P Lieske.;Julie A Lynch.;Laurence J Meyer.;Cristina Montalvo.;Sumitra Muralidhar.;Michael J Ostacher.;Gayla Y Paschall.;Paul N Pfeiffer.;Susana Prieto.;Ronald M Przygodzki.;Mohini Ranganathan.;Mercedes M Rodriguez-Suarez.;Hannah Roggenkamp.;Steven A Schichman.;John S Schneeweis.;Joseph A Simonetti.;Stuart R Steinhauer.;Trisha Suppes.;Maria A Umbert.;Jason L Vassy.;Deepak Voora.;Ilse R Wiechers.;Amanda E Wood.
来源: JAMA. 2022年328卷2期151-161页
Selecting effective antidepressants for the treatment of major depressive disorder (MDD) is an imprecise practice, with remission rates of about 30% at the initial treatment.
183. Effect of an Intensive Nurse Home Visiting Program on Adverse Birth Outcomes in a Medicaid-Eligible Population: A Randomized Clinical Trial.
作者: Margaret A McConnell.;Slawa Rokicki.;Samuel Ayers.;Farah Allouch.;Nicolas Perreault.;Rebecca A Gourevitch.;Michelle W Martin.;R Annetta Zhou.;Chloe Zera.;Michele R Hacker.;Alyna Chien.;Mary Ann Bates.;Katherine Baicker.
来源: JAMA. 2022年328卷1期27-37页
Improving birth outcomes for low-income mothers is a public health priority. Intensive nurse home visiting has been proposed as an intervention to improve these outcomes.
184. Effect of Nitric Oxide via Cardiopulmonary Bypass on Ventilator-Free Days in Young Children Undergoing Congenital Heart Disease Surgery: The NITRIC Randomized Clinical Trial.
作者: Luregn J Schlapbach.;Kristen S Gibbons.;Stephen B Horton.;Kerry Johnson.;Debbie A Long.;David H F Buckley.;Simon Erickson.;Marino Festa.;Yves d'Udekem.;Nelson Alphonso.;David S Winlaw.;Carmel Delzoppo.;Kim van Loon.;Mark Jones.;Paul J Young.;Warwick Butt.;Andreas Schibler.; .
来源: JAMA. 2022年328卷1期38-47页
In children undergoing heart surgery, nitric oxide administered into the gas flow of the cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output syndrome, leading to improved recovery and shorter duration of respiratory support. It remains uncertain whether nitric oxide administered into the cardiopulmonary bypass oxygenator improves ventilator-free days (days alive and free from mechanical ventilation).
185. Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial.
作者: Nassir F Marrouche.;Oussama Wazni.;Christopher McGann.;Tom Greene.;J Michael Dean.;Lilas Dagher.;Eugene Kholmovski.;Moussa Mansour.;Francis Marchlinski.;David Wilber.;Gerhard Hindricks.;Christian Mahnkopf.;Darryl Wells.;Pierre Jais.;Prashanthan Sanders.;Johannes Brachmann.;Jeroen J Bax.;Leonie Morrison-de Boer.;Thomas Deneke.;Hugh Calkins.;Christian Sohns.;Nazem Akoum.; .
来源: JAMA. 2022年327卷23期2296-2305页
Ablation of persistent atrial fibrillation (AF) remains a challenge. Left atrial fibrosis plays an important role in the pathophysiology of AF and has been associated with poor procedural outcomes.
186. Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial.
作者: Padmanabhan Ramnarayan.;Alvin Richards-Belle.;Laura Drikite.;Michelle Saull.;Izabella Orzechowska.;Robert Darnell.;Zia Sadique.;Julie Lester.;Kevin P Morris.;Lyvonne N Tume.;Peter J Davis.;Mark J Peters.;Richard G Feltbower.;Richard Grieve.;Karen Thomas.;Paul R Mouncey.;David A Harrison.;Kathryn M Rowan.; .
来源: JAMA. 2022年328卷2期162-172页
The optimal first-line mode of noninvasive respiratory support for acutely ill children is not known.
187. Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial.
作者: Derek W Russell.;Jonathan D Casey.;Kevin W Gibbs.;Shekhar Ghamande.;James M Dargin.;Derek J Vonderhaar.;Aaron M Joffe.;Akram Khan.;Matthew E Prekker.;Joseph M Brewer.;Simanta Dutta.;Janna S Landsperger.;Heath D White.;Sarah W Robison.;Joanne M Wozniak.;Susan Stempek.;Christopher R Barnes.;Olivia F Krol.;Alejandro C Arroliga.;Tasnim Lat.;Sheetal Gandotra.;Swati Gulati.;Itay Bentov.;Andrew M Walters.;Kevin M Dischert.;Stephanie Nonas.;Brian E Driver.;Li Wang.;Christopher J Lindsell.;Wesley H Self.;Todd W Rice.;David R Janz.;Matthew W Semler.; .
来源: JAMA. 2022年328卷3期270-279页
Hypotension is common during tracheal intubation of critically ill adults and increases the risk of cardiac arrest and death. Whether administering an intravenous fluid bolus to critically ill adults undergoing tracheal intubation prevents severe hypotension, cardiac arrest, or death remains uncertain.
188. Effect of Varenicline Added to Counseling on Smoking Cessation Among African American Daily Smokers: The Kick It at Swope IV Randomized Clinical Trial.
作者: Lisa Sanderson Cox.;Nicole L Nollen.;Matthew S Mayo.;Babalola Faseru.;Allen Greiner.;Edward F Ellerbeck.;Ron Krebill.;Rachel F Tyndale.;Neal L Benowitz.;Jasjit S Ahluwalia.
来源: JAMA. 2022年327卷22期2201-2209页
African American smokers have among the highest rates of tobacco-attributable morbidity and mortality in the US, and effective treatment is needed for all smoking levels.
189. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial.
作者: Melanie Meersch.;Raphael Weiss.;Mira Küllmar.;Lars Bergmann.;Astrid Thompson.;Leonore Griep.;Desiree Kusmierz.;Annika Buchholz.;Alexander Wolf.;Hartmuth Nowak.;Tim Rahmel.;Michael Adamzik.;Jan Gerrit Haaker.;Carina Goettker.;Matthias Gruendel.;Andre Hemping-Bovenkerk.;Ulrich Goebel.;Julius Braumann.;Irawan Wisudanto.;Manuel Wenk.;Darius Flores-Bergmann.;Andreas Böhmer.;Sebastian Cleophas.;Andreas Hohn.;Anne Houben.;Richard K Ellerkmann.;Jan Larmann.;Julia Sander.;Markus A Weigand.;Nicolas Eick.;Sebastian Ziemann.;Eike Bormann.;Joachim Gerß.;Daniel I Sessler.;Carola Wempe.;Christina Massoth.;Alexander Zarbock.
来源: JAMA. 2022年327卷24期2403-2412页
Intraoperative handovers of anesthesia care are common. Handovers might improve care by reducing physician fatigue, but there is also an inherent risk of losing critical information. Large observational analyses report associations between handover of anesthesia care and adverse events, including higher mortality.
190. Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial.
作者: Ethan Basch.;Deborah Schrag.;Sydney Henson.;Jennifer Jansen.;Brenda Ginos.;Angela M Stover.;Philip Carr.;Patricia A Spears.;Mattias Jonsson.;Allison M Deal.;Antonia V Bennett.;Gita Thanarajasingam.;Lauren J Rogak.;Bryce B Reeve.;Claire Snyder.;Deborah Bruner.;David Cella.;Lisa A Kottschade.;Jane Perlmutter.;Cindy Geoghegan.;Cleo A Samuel-Ryals.;Barbara Given.;Gina L Mazza.;Robert Miller.;Jon F Strasser.;Dylan M Zylla.;Anna Weiss.;Victoria S Blinder.;Amylou C Dueck.
来源: JAMA. 2022年327卷24期2413-2422页
Electronic systems that facilitate patient-reported outcome (PRO) surveys for patients with cancer may detect symptoms early and prompt clinicians to intervene.
191. Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial.
作者: Pamela J Goodwin.;Bingshu E Chen.;Karen A Gelmon.;Timothy J Whelan.;Marguerite Ennis.;Julie Lemieux.;Jennifer A Ligibel.;Dawn L Hershman.;Ingrid A Mayer.;Timothy J Hobday.;Judith M Bliss.;Priya Rastogi.;Manuela Rabaglio-Poretti.;Som D Mukherjee.;John R Mackey.;Vandana G Abramson.;Conrad Oja.;Robert Wesolowski.;Alastair M Thompson.;Daniel W Rea.;Paul M Stos.;Lois E Shepherd.;Vuk Stambolic.;Wendy R Parulekar.
来源: JAMA. 2022年327卷20期1963-1973页
Metformin, a biguanide commonly used to treat type 2 diabetes, has been associated with potential beneficial effects across breast cancer subtypes in observational and preclinical studies.
192. Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial.
作者: Jicheng Lv.;Muh Geot Wong.;Michelle A Hladunewich.;Vivekanand Jha.;Lai Seong Hooi.;Helen Monaghan.;Minghui Zhao.;Sean Barbour.;Meg J Jardine.;Heather N Reich.;Daniel Cattran.;Richard Glassock.;Adeera Levin.;David C Wheeler.;Mark Woodward.;Laurent Billot.;Sandrine Stepien.;Kris Rogers.;Tak Mao Chan.;Zhi-Hong Liu.;David W Johnson.;Alan Cass.;John Feehally.;Jürgen Floege.;Giuseppe Remuzzi.;Yangfeng Wu.;Rajiv Agarwal.;Hong Zhang.;Vlado Perkovic.; .
来源: JAMA. 2022年327卷19期1888-1898页
The effect of glucocorticoids on major kidney outcomes and adverse events in IgA nephropathy has been uncertain.
193. Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial.
作者: .;William D Toff.;David Hildick-Smith.;Jan Kovac.;Michael J Mullen.;Olaf Wendler.;Anita Mansouri.;Ines Rombach.;Keith R Abrams.;Simon P Conroy.;Marcus D Flather.;Alastair M Gray.;Philip MacCarthy.;Mark J Monaghan.;Bernard Prendergast.;Simon Ray.;Christopher P Young.;David C Crossman.;John G F Cleland.;Mark A de Belder.;Peter F Ludman.;Stephen Jones.;Cameron G Densem.;Steven Tsui.;Manoj Kuduvalli.;Joseph D Mills.;Adrian P Banning.;Rana Sayeed.;Ragheb Hasan.;Douglas G W Fraser.;Uday Trivedi.;Simon W Davies.;Alison Duncan.;Nick Curzen.;Sunil K Ohri.;Christopher J Malkin.;Pankaj Kaul.;Douglas F Muir.;W Andrew Owens.;Neal G Uren.;Renzo Pessotto.;Simon Kennon.;Wael I Awad.;Saib S Khogali.;Maciej Matuszewski.;Richard J Edwards.;Bandigowdanapalya C Ramesh.;Miles Dalby.;Shahzad G Raja.;Giovanni Mariscalco.;Clinton Lloyd.;Ian D Cox.;Simon R Redwood.;Mark G Gunning.;Paul D Ridley.
来源: JAMA. 2022年327卷19期1875-1887页
Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear.
194. Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial.
作者: Waleed Alhazzani.;Ken Kuljit S Parhar.;Jason Weatherald.;Zainab Al Duhailib.;Mohammed Alshahrani.;Abdulrahman Al-Fares.;Sarah Buabbas.;Sujith V Cherian.;Laveena Munshi.;Eddy Fan.;Fahad Al-Hameed.;Jamal Chalabi.;Amera A Rahmatullah.;Erick Duan.;Jennifer L Y Tsang.;Kimberley Lewis.;François Lauzier.;John Centofanti.;Bram Rochwerg.;Sarah Culgin.;Katlynne Nelson.;Sheryl Ann Abdukahil.;Kirsten M Fiest.;Henry T Stelfox.;Haytham Tlayjeh.;Maureen O Meade.;Dan Perri.;Kevin Solverson.;Daniel J Niven.;Rachel Lim.;Morten Hylander Møller.;Emilie Belley-Cote.;Lehana Thabane.;Hani Tamim.;Deborah J Cook.;Yaseen M Arabi.; .
来源: JAMA. 2022年327卷21期2104-2113页
The efficacy and safety of prone positioning is unclear in nonintubated patients with acute hypoxemia and COVID-19.
195. Effect of Robot-Assisted Radical Cystectomy With Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients With Bladder Cancer: A Randomized Clinical Trial.
作者: James W F Catto.;Pramit Khetrapal.;Federico Ricciardi.;Gareth Ambler.;Norman R Williams.;Tarek Al-Hammouri.;Muhammad Shamim Khan.;Ramesh Thurairaja.;Rajesh Nair.;Andrew Feber.;Simon Dixon.;Senthil Nathan.;Tim Briggs.;Ashwin Sridhar.;Imran Ahmad.;Jaimin Bhatt.;Philip Charlesworth.;Christopher Blick.;Marcus G Cumberbatch.;Syed A Hussain.;Sanjeev Kotwal.;Anthony Koupparis.;John McGrath.;Aidan P Noon.;Edward Rowe.;Nikhil Vasdev.;Vishwanath Hanchanale.;Daryl Hagan.;Chris Brew-Graves.;John D Kelly.; .
来源: JAMA. 2022年327卷21期2092-2103页
Robot-assisted radical cystectomy is being performed with increasing frequency, but it is unclear whether total intracorporeal surgery improves recovery compared with open radical cystectomy for bladder cancer.
196. Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial.
作者: Natalia Pérez de la Ossa.;Sònia Abilleira.;Tudor G Jovin.;Álvaro García-Tornel.;Xavier Jimenez.;Xabier Urra.;Pere Cardona.;Dolores Cocho.;Francisco Purroy.;Joaquin Serena.;Luis San Román Manzanera.;Rosa Maria Vivanco-Hidalgo.;Mercè Salvat-Plana.;Angel Chamorro.;Miquel Gallofré.;Carlos A Molina.;Erik Cobo.;Antoni Davalos.;Marc Ribo.; .
来源: JAMA. 2022年327卷18期1782-1794页
In nonurban areas with limited access to thrombectomy-capable centers, optimal prehospital transport strategies in patients with suspected large-vessel occlusion stroke are unknown.
197. Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial.
作者: Julian Bösel.;Wolf-Dirk Niesen.;Farid Salih.;Nicholas A Morris.;Jeremy T Ragland.;Bryan Gough.;Hauke Schneider.;Jan-Oliver Neumann.;David Y Hwang.;Phani Kantamneni.;Michael L James.;William D Freeman.;Venkatakrishna Rajajee.;Chethan Venkatasubba Rao.;Deepak Nair.;Laura Benner.;Jan Meis.;Christina Klose.;Meinhard Kieser.;José I Suarez.;Silvia Schönenberger.;David B Seder.; .
来源: JAMA. 2022年327卷19期1899-1909页
Many patients with severe stroke have impaired airway protective reflexes, resulting in prolonged invasive mechanical ventilation.
198. Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy: The BUMP 1 Randomized Clinical Trial.
作者: Katherine L Tucker.;Sam Mort.;Ly-Mee Yu.;Helen Campbell.;Oliver Rivero-Arias.;Hannah M Wilson.;Julie Allen.;Rebecca Band.;Alison Chisholm.;Carole Crawford.;Greig Dougall.;Lazarina Engonidou.;Marloes Franssen.;Marcus Green.;Sheila Greenfield.;Lisa Hinton.;James Hodgkinson.;Layla Lavallee.;Paul Leeson.;Christine McCourt.;Lucy Mackillop.;Jane Sandall.;Mauro Santos.;Lionel Tarassenko.;Carmelo Velardo.;Lucy Yardley.;Lucy C Chappell.;Richard J McManus.; .
来源: JAMA. 2022年327卷17期1656-1665页
Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring of BP in the general population has been shown to improve the diagnosis and management of hypertension; however, little is known about its use in pregnancy.
199. Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension: The BUMP 2 Randomized Clinical Trial.
作者: Lucy C Chappell.;Katherine L Tucker.;Ushma Galal.;Ly-Mee Yu.;Helen Campbell.;Oliver Rivero-Arias.;Julie Allen.;Rebecca Band.;Alison Chisholm.;Carole Crawford.;Greig Dougall.;Lazarina Engonidou.;Marloes Franssen.;Marcus Green.;Sheila Greenfield.;Lisa Hinton.;James Hodgkinson.;Layla Lavallee.;Paul Leeson.;Christine McCourt.;Lucy Mackillop.;Jane Sandall.;Mauro Santos.;Lionel Tarassenko.;Carmelo Velardo.;Hannah Wilson.;Lucy Yardley.;Richard J McManus.; .
来源: JAMA. 2022年327卷17期1666-1678页
Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role of blood pressure self-monitoring in pregnancy in improving clinical outcomes for the pregnant individual and infant is unclear.
200. Effect of a Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care on Walking in Adults With Peripheral Artery Disease: The MOSAIC Randomized Clinical Trial.
作者: Lindsay M Bearne.;Brittannia Volkmer.;Janet Peacock.;Mandeep Sekhon.;Graham Fisher.;Melissa N Galea Holmes.;Abdel Douiri.;Aliya Amirova.;Dina Farran.;Sophia Quirke-McFarlane.;Bijan Modarai.;Catherine Sackley.;John Weinman.;Julie Bieles.; .
来源: JAMA. 2022年327卷14期1344-1355页
Home-based walking exercise interventions are recommended for people with peripheral artery disease (PAD), but evidence of their efficacy has been mixed.
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