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1161. [Drug-induced pancreatitis].1162. [Repair of DNA-protein cross-links induced by antineoplastic alkylating agents].
The bifunctional and antitumor alkylating agents embichin and its aromatic derivatives sarcolysin and chlorfenacyl remarkably differ in DNA-protein cross-links induction in Chinese hamster cell cultures in vitro. The differences involve the concentration necessary for cross-linkage, the time of cross-links emergence, and their reparation. Since all three compounds have the same alkylating group, it is obvious that the differences seen in the cross-linkage arise from the structure of aromatic groupings introduced into the molecule.
1163. [Relation between sister chromatid exchange and duration of human cell treatment with ethyleneimine derivatives].
The sister chromatid exchange (SCE) induction by various concentrations of thiophosphamide and dipin was studied depending on the exposure time to mutagens. There is a linear relationship between the number of SCE and the increase in the concentration and exposure time regardless of the chemical structure of mutagens. The dose dependence (the product of the concentration magnitude by exposure) is also depictable by the linear law. A sudden leap of the number of SCE was observed during the transition from control to minimal exposure.
1164. [Cell test system for the preliminary screening of antitumor preparations].
作者: N N Kuznetsova.;S S Nurizhdaniants.;Z P Pan.;F S Mukhamedkhanova.
来源: Vopr Onkol. 1981年27卷12期36-9页
A cell model CaPa (Human Cancer Pancreas) for prescreening of synthetic and plant substances with suggested antitumor activity is offered. The sensitivity of this cell line to 22 clinical drugs of different classes (alkylating compounds, antimetabolites, antibiotics, substances of plant origin, etc.) was studied. The cytotoxic action of drugs was assessed by measuring the level of DNA synthesis on the basis of 3H-thymidine incorporation, total nucleic acids and protein. The results showed that the cell line CaPa is sufficiently sensitive to clinical drugs.
1165. [Use of patient isolation, nonabsorbable antibiotics and intravenous administration of gentamycin for prevention of infectious complications in hemoblastoses during cytostatic therapy].
作者: A E Baranov.;L N Petrosian.;N M Nadezhina.;T V Shishkova.;V I Nesterova.
来源: Ter Arkh. 1981年53卷9期45-50页 1166. [Combination chemotherapy in the adjuvant treatment of disseminated breast cancer].
The results of clinical studies are presented on the combined chemotherapy in spread breast cancer, conducted according to the following three schedules: 1. thiophosphamide, carminomycin, vincristine, ftorafur, prednisolone, 2. diiodobenzoTEPA, carminomycin, vincristine, ftorafur, prednisolone, 3. methotrexate, cyclophosphane, vincristine, ftorafur, prednisolone. The combined chemotherapy in the complex treatment of 91 patients with spread breast cancer was found to be effective in 33-40% of cases. Primary tumors of the mammary gland and metastases in soft tissues, lymph nodes were mostly sensitive to the combined chemotherapy, metastases in bones and visceral organs--less sensitive. Schedules 2 and 3 proved to be the least toxic ones.
1168. [DNA as the principal target for carcinogenic, mutagenic and antineoplastic drugs].1171. [Current trends in the study of immunosuppressive agents].
An analysis has been made of the specificity of the action of immunodepressants with respect to different types of immune responses. The main attention is concentrated on the specificity of the drug action in varied autoimmune diseases. It has been suggested that the general principles of tumor chemotherapy may be applicable to chemotherapy of autoimmune disorders. It is recommended that immunodepressants be studied in experimental autoimmune diseases of man and that optimal regimens of drug administration be developed accordingly.
1172. [Nature of the cell targets of the action of the antitumor preparation methylnitrosourea].1173. [Exogenous toxic polyneuropathies].
作者: K F Kanareĭkin.;S V Babenkova.;L S Manvelov.;M A Eskin.
来源: Zh Nevropatol Psikhiatr Im S S Korsakova. 1981年81卷1期138-50页 1174. [Physicochemical properties and biological activity of an antitumor substance isolated from Bacillus mesentericus culture broth].
作者: D G Zatula.;O A Tanasienko.;O G Khomiak.;V K Sytenko.;T A Siadro.
来源: Mikrobiol Zh (1978). 1980年42卷6期766-8页 1175. [Sequelae and hazards of using highly effective drug agents].1176. [Effect of DNA-tropic substances used jointly with tuberculostatic preparations on the development of drug resistance in Mycobacterium tuberculosis].1177. [Effect of DNA-tropic antineoplastic and antiparasitic agents on DNAase I activity].
Kinetics of DNAase I activity was studied in reaction mixtures containing tightly bound to DNA drugs used for study and treatment of cancer and some other diseases. Distamycin proved to be the strongest inhibitor. The inhibitory activity of the substances studied decreased as follows: distamycin greater than or equal to actinomycin D greater than or equal to ethidium bromide > proflavine > carminomycin > bleomycin. The latter substance did not possess any inhibitory action. The data obtained are discussed in relation to mechanisms of interaction of the substances studied and DNA. High efficiency was typical for substances, which were bound with the DNA molecules on their small curvature.
1178. [Macrophage activation by blastolysin].
作者: I B Sorokina.;E L Khasman.;N P Gor'kova.;I Ia Uchitel'.
来源: Biull Eksp Biol Med. 1980年89卷4期449-52页
Blastolysin consisting largely of glycopeptide fragments of cell walls from Lactobacillus bulgaricus has a significant antineoplastic activity against a number of transplanted and spontaneous animal tumours. Blastolysin exerts a pronounced adjuvant action and activates the cells of the mononuclear phagocytic system. This is shown by stimulation of phagocytosis and digestion as well as by acquired ability of macrophages to elicit a cytotoxic action on allogeneic and syngeneic target cells (labelled with radioactive chromium) with abnormal growth. Administration of blastolysin or BCG was demonstrated to lead to variations in the time course of macrophage acquired cytotoxicity. Macrophage activation induced by blastolysin has a clearly pronounced two-phasic nature. During the first short phase the cytotoxicity is seen 2 hours following blastolysin administration, rapidly disappears and emerges after 2 weeks, remaining unchanged up to the 5th week (experimental period).
1179. [Complications of glomerulonephritis in children].1180. [Self-maintenance and the proliferative activity of hematopoietic stroma precursor cells]. |