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981. [Regulation of immuno- and hematopoiesis with asterin].
It was shown that asterin, a higher plant preparation, had a marked antiblastomic action and a favourable effect on differentiation of the precursor cells and blood cells. It accelerated proliferation, migration of the truncal hemopoietic cells and their transfer from the dormant state into the cellular cycle. It also changed the cell differentiation in the direction of myelopoiesis. The mechanism of the asterin's immunomodulating action was found to be associated with regulation of T-cellular immunity and T-dependent immune response.
982. [The mechanism of the interaction of the pH-dependent cytostatic cauloside C with the membranes of tumor cells and liposomes].
作者: N G Prokof'eva.;G N Likhatskaia.;D L Aminin.;Iu M Gafurov.;V A Sasunkevich.;L I Strigina.;M M Anisimov.
来源: Izv Akad Nauk SSSR Biol. 1990年3期338-42页
The effect of the medium pH on accumulation of [3H]-cauloside C by tumor cells, its intracellular localization, and interaction of the glicoside with membranes of tumor cells and liposomes has been studied. The shift towards weakly acids pH leads to the increase in the amount of cauloside C accumulated by tumor cells and changes the pattern of interaction of cauloside C with the membranes.
983. [Structural effects in membranes after exposure to methyl (embiquin) and metaxylyl derivatives of chloroalkylamines].
作者: O I Lebed'.;V V Zhirnov.;R G Primak.;B S Braver-Chernobul'skaia.
来源: Ukr Biokhim Zh (1978). 1990年62卷3期81-7页
Chloroaklylamine derivatives are studied for their effect on the structural organization of mitochondrion and microsome membranes of the cattle liver. The antitumoural preparation--embiquin is shown to increase microviscosity of hydrophobic zones of a lipid matrix of mitochondrial membranes and to decrease the quantity of immobilized cytochrome C, whereas it has no effect on microsomal membranes. It is established that the replacement of a methyl substituent in the nitrogen atom of chloroalkylamines by the metaxylyl one evokes no qualitative differences in the character of disturbances of the structural properties of mitochondrial membranes, however it induces structural perturbations in the microsomal membranes.
984. [Membrane mechanisms of the effect of alkylating cytostatic agents].
The data bearing witness to realization of the cytostatic activity of alkylating agents by means of interaction with cell membrane receptors was obtained. Alkylating agents block receptors of the polyphosphoinositol system. It is shown that chloralkylamines inhibiting sites coincide with M-++cholinomimetics and alpha-adrenergic receptors, inhibitors of H-histamine receptors, cyclo- and lypoxigenase inhibitors. Such likeness is determined by identical structures of the molecule active part, and quantum-chemical calculations.
985. [Chemistry of galtamycin. Specification of the aglycone structure. Synthesis of the amino analog].
The structure of galtamycin aglycone was elucidated. Synthesis of its amino analog with higher antitumor activity and antibacterial activity is described.
986. [Errors in the treatment of breast cancer].987. [Ability of the lymphocytes in the peripheral blood of oncologic patients to repair DNA].
作者: N A Nikiforova.;I P Moskalenko.;L A Gaĭseniuk.;O N Pozhidaeva.
来源: Med Radiol (Mosk). 1990年35卷3期25-7页
A study was made of the level of reparative capacity of peripheral blood lymphocytes of cancer patients in response to DNA damaging R-radiation testing at a dose of 250 Gy before the next course of cancer chemotherapy. A low capacity of peripheral blood lymphocytes for reparation of DNA or its complete suppression is characteristic for most cancer patients irrespective of a nosological entity and the number of cancer chemotherapy courses in their history. The frequency of cancer patients with the initially suppressed capacity of peripheral blood lymphocytes for DNA reparation has an increasing tendency depending on the spreading of a process. These data can serve as an additional criterion of prognosis of complication during antitumor therapy.
988. [Antimutagenic properties of sea buckthorn oil].
The influence of sea-buckthorn oil on cyclophosphamide, farmorubicin and dioxadet mutagenicity was studied. The oil decreased significantly the cytogenetic action of cyclophosphamide and farmorubicin, but not of dioxadet action. Possible mechanisms of antimutagenic action of the oil are discussed.
989. [Detection of cells with phenotype of multiple drug resistance in myeloproliferative disorders before the treatment].
作者: J Kemnitz.;M Freund.;M Diminis.;T Cohnert.;A Uysal.;A Georgii.
来源: Gematol Transfuziol. 1990年35卷2期15-8页
The expression of the multidrug resistance (MDR) phenotype is connected with the overexpression of P-glycoprotein. By applying the immunocytochemical assay we have demonstrated that in myeloproliferative diseases (AML, ALL, MDS, CGL), in single cases, in smear preparations from the peripheral blood and bone marrow the cells with MDR-positive phenotype can be detected in the material obtained from patients before therapy, and without clinically and anamnestically known exposure to cytotoxic or immunosuppressive drugs. This finding has demonstrated the presence of subpopulations of MDR-positive cells in leukemias and myelodysplastic syndromes already before therapy, and, furthermore, has evidenced that a positive MDR phenotype is not necessarily associated with a malignant phenotype of a malignant cell transformation.
990. [Results of the studies of ethyleneiminotriazines].
作者: B A Ivin.;B O Kraĭz.;M V Korsakov.;A N Stukov.;V P Sheĭman.;V A Filov.
来源: Vopr Onkol. 1990年36卷1期6-12页 991. [Ways to overcome the contradictions between the experimental and clinical chemotherapy of tumors].992. [Sensitivity of bone marrow cells damaged by antitumor drugs to cytotoxic action of effectors of a normal spleen].
作者: M Iu Klimova.;I V Bogdashin.;V V Novitskiĭ.;E D Gol'dberg.
来源: Biull Eksp Biol Med. 1990年109卷1期60-2页
Different cytogenetic effects in bone marrow cells induced by antitumor drugs with different mechanisms of action was studied. The treatment of adriablastine causes the appearance of chromatid deletion, vinblastine-polyploid cells, cyclophosphamide-chromosomal and chromatid aberration in mice. It was shown that bone marrow cells with cytogenetic damage have altered susceptibility to normal spleen cells-effectors cytotoxic action.
993. [The effect of a black tea extract on the tumor-like growth of the fungus Fusarium bulbigenum var. blasticola].
The antiblastogenic activity of black tea is predicted with a 98% credibility basing on the observation of its inhibitory or preventive effect on spontaneous or carcinogen-induced tumor development in the culture of mycelial fungus Fusarium bulbigenum var. blasticola.
994. [14Co-dimetinur distribution in mice in relation to the stage of the development of tumor process].
作者: L A Ostrovskaia.;V A Rykova.;A A Kondarov.;L Etvesh.;E Shimon-Trompler.;I S Sokolova.;D B Korman.
来源: Eksp Onkol. 1990年12卷1期70-4页
Pharmacokinetics of the antitumour agent 14CO-dimetinur (100 mg/kg) after oral administration to the intact mice and those with solid leukemia P 388 is characterized by its rapid delivery to organs and tumours with the achievement of maximum radioactivity 5 hours later and the further gradually decline during 4 days. The increased accumulation of the 14CO-products in kidneys and their retarded output from the brain and lungs against a background of the relatively equal distribution of radioactivity between other tested organs have been established. The same level of carbamoylated products in large tumours (the 16th day after leukemia transplantation) as well as in small tumours (the 9th day after inoculation) is in agreement with the conservation of the initial marked inhibitory effect of the drug against advanced tumours.
995. [Long-term consequences of the damaging effect of cytostatic drugs on hematopoiesis and lymphoid tissue].
作者: E D Gol'dberg.;V V Novitskiĭ.;O B Zapuskalova.;M Iu Klimova.
来源: Vestn Akad Med Nauk SSSR. 1990年9期52-7页
The evidence on the changes detectable in remote periods (at 1, 3, and 6 months) is presented. It shows that the quantitative and functional defects are retained in the hemopoietic and lymphoid tissues within 3-6 months after exposure to the effects of various cytostatic agents. These defects may be corrected by means of immunomodulators.
996. [The results of a clinical study of the preparation hydrazine sulfate].
作者: V A Filov.;L A Danova.;M L Gershanovich.;B A Ivin.;N P Dement'eva.;P V Breĭvis.;V P Ragaĭshene.;I V Kas'ianenko.;A M Lisitsa.;S S Mindlin.
来源: Vopr Onkol. 1990年36卷6期721-6页
The paper discusses results of a cooperative study of effectiveness of hydrazine sulfate therapy in 740 patients with primary advanced, recurrent and metastatic solid tumors and malignant lymphomas who had failed all other treatment modalities. Both objective response and symptomatic effect were assessed. Objective response was observed in neuroblastoma, recurrent desmoid, Hodgkin's disease, lung cancer, fibrosarcoma and other tumors. Since hydrazine sulfate provided relief of a wide spectrum of cancer symptoms, it may be recommended for patients with end-stage cancer.
997. [The quantitative characteristics of the metabolism of antitumor compounds].
Methodical approaches to quantitative study of biotransformation of antitumor drugs have been described and classified. Most widely used types of models have been described. Proposed algorithm of interpretation of obtained experimental data may be used for selection of suitable model description of a compound and characterization of its pharmacokinetic properties.
998. [Blood thymus hormone content in different types of neoplastic process and its changes as a result of chemotherapy and surgical removal of tumors].
作者: I S Nikol'skiĭ.;Iu A Grinevich.;G D Bendiug.;S V Martynenko.;V V Ovsienko.;G A Zamotaeva.;V P Shevchenko.
来源: Eksp Onkol. 1990年12卷3期65-7页
Levels of thymic hormones in blood serum were found to decrease during the development of Guerin's carcinoma, methylcholanthrene- and DMBA-induced carcinogenesis, soft tissue sarcomas, mammary cancer, in children with tumors of the urinary-genital tract, that evidences for the suppression of the thymic endocrine function in neoplastic processes. A decrease in the level of substances, active in the test under study is not revealed in patients with different forms of leukemias. The tumour elimination normalizes the thymic endocrine function, while multiagent chemotherapy increases the insufficiency. The data obtained suggest the immunotherapy for malignant neoplasms with thymic hormones.
999. [The results of a comparative clinical study of the antiestrogenic preparations toremifene and tamoxifen in locally advanced and disseminated breast cancer].
A randomized clinical trial performed in 50 female patients with advanced breast cancer showed 60 mg/day and 240 mg/day toremifene and 40 mg/day tamoxifen to be nearly equally effective. Partial, with few exceptions, response lasting 5-31 months was observed in 35-50% of cases whereas another 35-50% of patients showed no change. Toxicity was low.
1000. [Antitumor effectiveness and nephrotoxicity of oxoplatinum].
Studies on such transplantable murine tumors as MOPC-21 plasmacytoma and Krebs-2 carcinoma showed oxoplatinum course administration to produce necrosis in solid tumors and pronounced alterations in surviving tumor cells. Single applications of 15 or 20 mg/kg were followed by an increase in the mean survival of Krebs-2 ascites carcinoma--bearing mice by one half. Oxoplatinum--induced changes in the renal tissue ranged from moderate under continuous administration to acute renal failure after high--dose treatment. Such diuretics as diacarb, furosemide and, particularly, mannitol did not interfere with oxoplatinum activity against solid and ascites tumors but assured less pronounced structural disorders in the kidney as compared to oxoplatinum alone.
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