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781. [The characteristics of the action of immunodepressive preparations on the killer activity of the blood leukocytes in patients with multiple myeloma].
Overall twenty patients with multiple myeloma (MM) were studied during the advanced stage of the disease before the initiation of the cytostatic therapy. The results obtained suggest that cytostatic drugs and prednizolon have suppressive action on blood leucocyte killer activity. Following in vitro vincristin exposure of MM patients' leucocytes cytolytic activity of blood leucocyte lymphoid population appeared to be suppressed whereas incubation of leucocytes with the solution of cyclophosphane leads to preponderant decrease in the killer function of neutrophils. In vitro prednizolon exposure of MM patients' leucocytes results in suppression of activity of the antibody-dependent cellular cytotoxicity.
782. [Antitumor activity and toxicity of combined doxorubicin and disodium salt of methylene-1,1-diphosphonic acid].
作者: A N Stukov.;T N Mironiuk.;S A Kon'kov.;I M Krylova.;V V Reztsova.;V A Filov.;B A Ivin.
来源: Vopr Onkol. 1998年44卷1期100-2页
In experiments using mice and rats with transplantable Ehrlich ascites tumors, sarcoma-180 and adenocarcinoma of Walker, antitumor activity of doxorubicin in combination with disodium salt of 1,1-methylenediphosphonic acid proved higher than that of doxorubicin alone. Most advantage was gained with daily treatment. The toxic effect of said complex treatment seemed to differ slightly from that of doxorubicin as judged on the basis of survival, changes in body mass and peripheral blood count.
783. [Alkyl nitrosoureidodioxans and alkyl nitrosoureidopropane diols -- new groups of antitumor compounds].
作者: S A Kon'kov.;A N Stukov.;V V Reztsova.;I M Krylova.;B A Ivin.; VA Filov.
来源: Vopr Onkol. 1998年44卷1期97-9页
1,3-dioxan- and 1,3-propane diol derivatives of alkyl nitrosourea have been synthesized and studied. Like other 2/chloroethylnitrosoureas, they exerted pronounced influence on a wide range of transplantable tumors, including those transplanted intracranially. Antitumor effect was found to depend on C5 and C2 atom substituent in the 1,3-dioxan cycle and 1,3-propane diol, respectively. The therapeutic effect and toxicity of 1,3-propane diol derivatives were higher than those of 1,3-dioxan. The substances lost all antitumor properties if a methyl group was substituted for the 2-chloroethyl one, even though a nitroso group was retained in their structure.
784. [Experimental study of the biopreparation Lymphotilin as an antiproliferative and antitumor agent].
作者: Iu V Tiagotin.;A E Polotskiĭ.;T Ia Vakhitov.;I Iu Tutova.;L P Rybakova.
来源: Vopr Onkol. 1998年44卷1期92-6页
We found in experiments involving the use of a biopreparation lymphotilin that its administration was followed by a decrease in proliferative activity of cultured tumor cells and a longer survival of mice bearing transplantable leukemia. An intensified intercalation of ethidium bromide in nucleic acids of tumor cells in lymphotilin culture points to the drug activity on nuclear level. Tumor cell inhibition by lymphotilin holds much promise for the practice of hematology.
785. [New means for the prophylaxis of colon cancer with the use of beta-glucuronidase inhibitors].
Experiments involving the use of 1,2-dimethylhydrazine-induced colonic tumors in rats showed long-term treatment with a newly synthesized drug EDE-10g to inhibit an enzyme of enteric beta-glucuronidase, to suppress carcinogenesis and to prolong lifespan of animals.
786. [The mechanisms of the hepatotoxic action of the antitumor preparation vepesid].
作者: T V Vetoshkina.;T Iu Dubskaia.;E A Timina.;V E Gol'dberg.
来源: Eksp Klin Farmakol. 1998年61卷1期54-6页
It was shown in experiments on rats that intravenous infusion of the antitumor drug vepesid in a maximum tolerated dose causes stimulation of free-radical oxidation and changes in the fractional composition of lipids and phospholipids in the hepatic tissue. Changes in the activity of aminotransferases and alkaline phosphatase in the blood were recorded.
787. [Tetrapyrroles: diversity, biosynthesis, biotechnology].
Various aspects of metabolism and biotechnology of tetrapyrroles are reviewed. Structures and properties of newly discovered tetrapyrrole pigments, biosynthesis of most important functional tetrapyrroles (hemes, chlorophylls, corrinoids, siroheme, and methanogenesis factor F430), and biotechnological methods of production of porphyrins and corrinoids are discussed. 5-Aminolevulinic acid is shown to be a promising anticancer preparation.
788. [Effect of the novel antineoplastic agent cycloplatam on the structure and synthesis of DNA].
作者: A G Tikhomirov.;I S Sokolova.;L Iu Dederer.;L B Gorbacheva.
来源: Biull Eksp Biol Med. 1998年125卷2期197-9页 789. [Synthesis and biological properties of 3,5-cyclophosphates- and -amidophosphates of 1,2-O-alkylydene-6-deoxy-6-halogeno-alpha -D-glucofuranoses].
作者: M P Koroteev.;N M Pugashova.;S B Khrebtova.;E E Nifant'ev.;O S Zhukova.;T P Ivanova.;N M Peretolchina.;G K Gerasimova.
来源: Bioorg Khim. 1998年24卷1期58-63页
3,5-Cyclic phosphates and phosphoramides of 6-halogenated glucofuranoses were synthesized via interaction of 3,5,6-bicyclophosphites of 1,2-O-alkylidene-alpha-D-glucofuranoses with halogens (followed by treatment with nucleophilic reagents) and N-chloroamines. 3,5-Cyclic trans-dibutylphosphoramides of 6-chloro-6-deoxy-1,2-O-isopropylidene- and 6-chloro-6-deoxy-(R)-(2,2,2)-trichloroethylidene)-alpha-D-glucofuranoses were shown to possess antiproliferative activity against CaOv human ovarian carcinoma cells in vitro (CE50 of approximately 10(-5) M). Cyclic trans-dibutylphosphoramide of 6-chloro-6-deoxy-1,2,-O-isopropylidene-alpha-D-glucofuranose also displayed marked antitumor effect on P-388 transplantable murine leukemia in vivo (the maximum increase in life span of 100% was reached at the quintuple injection of 100 mg/kg daily).
790. [Methods of in vitro assessment of the degree of complement activation by the classical pathway].
A sensitive a simple method is proposed for assessing the complement activation degree by the monospecific classical route. The alternative pathway of the complement activation proposed by Adachi et al. in 1990 is taken account of. The specific features of the proposed method are 1) use of commercial dry complement of guinea pigs with the regulatory protein defect needed for the alternative pathway of complement activation; 2) absence of EGTA in GVB and presence of Ca2+; 3) use of sensitized sheep red blood cells as the target cells. These conditions prevent the alternative pathway of complement activation and permit only the classical pathway. Effects of some drugs on the classical pathway of complement activation by the new method and on Adachi's alternative method are investigated. Estradurin and fosfestrol affect the complement activation by both pathways.
791. [Certain biological properties of mutant human tumor necrosis factor-alpha].
作者: L S Sandakhchiev.;N V Merzlikin.;N M Pustoshilova.;N N Istomina.;L R Lebedev.;M I Sviatchenko.;E D Danilenko.;V I Masycheva.;S V Usova.
来源: Biull Eksp Biol Med. 1998年125卷1期89-92页 792. [Study of mouse synaptonemal complex after camptothecin administration].793. [The action of epidermal growth factor on the migration of A-431 cells].
作者: E A Voroteliak.;A V Samarova.;A V Vasil'ev.;V V Terskikh.
来源: Izv Akad Nauk Ser Biol. 1997年6期724-7页
It has been demonstrated that the epidermal growth factor (EGF) stimulates migration of A-431 cells into the wound created in a monolayer in the absence of any significant effect on the incorporation of labeled thymidine into cells. The effect of EGF on migration is stimulated by the simultaneous addition of insulin. Cell treatment with mitomycin C completely eliminates the stimulating effect of EGF, without, however, affecting baseline level of cell migration, which is independent on growth stimulants. These results lead to the conclusion that the effect of EGF on cell migration and cell proliferation in A-431 culture can be partially separated.
794. [Spermatogenesis in rats after administration of the antineoplastic agent vepesid].
作者: E D Gol'dberg.;T G Borovskaia.;E A Timina.;T I Fomina.;V E Gol'dberg.
来源: Biull Eksp Biol Med. 1997年124卷12期645-8页 795. [The role of proliferation and differentiation of the hematopoietic cell precursors during regeneration of hematopoiesis in cytostatic myelosuppression].
作者: A M Dygaĭ.;V V Zhdanov.;M Iu Minakova.;V M Ryzhakov.;E D Gol'dberg.
来源: Biull Eksp Biol Med. 1997年124卷12期616-20页 796. [Effect of the platinum-containing cytostatics on the rat offspring].797. [Molecular basis for the use of polyamine analogs--inhibitors of polyamine synthesis enzymes].798. [In vitro prognostication of individual chemosensitivity of surgically removed and biopsied tumors].799. [Involvement of humoral factors in the regulation of hematopoiesis in cytostatic myelosuppressions].
作者: A M Dygaĭ.;V V Zhdanov.;M Iu Minakova.;E D Gol'dberg.
来源: Biull Eksp Biol Med. 1997年124卷8期161-5页 800. [Role of glutathione antiperoxide system in the mechanism of cytotoxic action of embichin].
Dynamics of changes in the peroxide level, contents of reduced and oxidized glutathione, activity of glutathione peroxidase and glutathione reductase in different organs of a rat under the influence of a single injection of embiquine in the dose of 1/2 DL50 was studied. Alkylating antitumor preparation was shown to cause the decrease of glutathione peroxidase and glutathione reductase activity. Activation glutathione antiperoxide system decreased cytotoxic effects of embiquine by prevention of lipoperoxid accumulation in the liver in the nearest periods of investigation after injection of the preparation, and in the kidney and spleen--during the whole period of investigation.
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